Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Acetylcysteine [1] Acetylcysteine[1] Acetylcysteine 💬 --[12] 8, 34, 51, 53, 85, 90, 94, 97, 193, 233, 298, 299 💬
2 Alprazolam [1] Alprazolam[1] Alprazolam 💬 [16] GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ 💬 		[8] GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 8, 75 💬
3 Amantadine [3] Amantadine; Amantadine hydrochloride; Amantadine sulfate[2] Amantadine hydrochloride ,
Amantadine 💬 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[5] 2, 6, 8, 13, 127 💬
4 AMT-130 [2] AMT-130; RAAV5-mihtt---[1] 8 💬
5 Atomoxetine [2] Atomoxetina; Atomoxetine[2] Atomoxetine hydrochloride ,
Atomoxetine 💬 		[1] SLC6A2 💬 [2] Neuroactive ligand signaling, Synaptic vesicle cycle 💬[4] 6, 8, 13, 230 💬
6 Bevantolol [1] Bevantolol hydrochloride[1] Bevantolol hydrochloride 💬 [8] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		[44] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gap junction, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hormone signaling, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 8 💬
7 Biotin [3] Biotin; Biotina; Vitamin B7[1] Biotin 💬 --[3] 2, 8, 13 💬
8 Branaplam [1] Branaplam[1] Branaplam 💬 --[2] 3, 8 💬
9 Bupropion [2] Bupropion; Bupropion hydrochloride[3] Bupropion hydrochloride ,
Bupropion ,
Bupropion hydrobromide 💬 		[2] SLC6A2,
SLC6A3 💬 		[8] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[6] 8, 18, 21, 96, 97, 171 💬
10 Cannabidiol [1] Cannabidiol[1] Cannabidiol 💬 [2] CNR1,
CNR2 💬 		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[20] 6, 8, 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
11 CKD-504 [1] CKD-504---[1] 8 💬
12 Creatine [3] Acetic acid; Creatine; Creatine monohydrate---[14] 1, 2, 6, 8, 13, 21, 46, 49, 50, 97, 113, 156, 201, 337 💬
13 Cysteamine [6] 2-aminoethanethiol; Cysteamine; Cysteamine bitartrate; Cysteamine hydrochloride; Mercaptamina; Mercaptamine[3] Cysteamine ,
Cysteamine hydrochloride ,
Cysteamine bitartrate 💬 		--[4] 8, 19, 21, 299 💬
14 Deutetrabenazine [1] Deutetrabenazine[1] Deutetrabenazine 💬 [1] SLC18A1_2 💬 [8] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
15 Dextromethorphan [2] Dextromethorphan; Dextromethorphan hydrobromide[3] Dextromethorphan hydrobromide ,
Dextromethorphan ,
Daunorubicin 💬 		[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
16 Digoxin [1] Digoxin[1] Digoxin 💬 [4] ATP1A,
ATP1A,
ATP1A,
ATP1A 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 8, 46, 210 💬
17 Dronabinol [3] Delta-9-tetrahydrocannabinol; Dronabinol; Tetrahydrocannabinol[1] Dronabinol 💬 [2] CNR1,
CNR2 💬 		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[8] 2, 8, 13, 36, 46, 96, 271, 298 💬
18 Epigallocatechin [1] Epigallocatechin---[5] 8, 13, 28, 85, 113 💬
19 Epigallocatechin gallate [2] Egcg; Epigallocatechin-3-gallate---[8] 6, 8, 13, 17, 28, 85, 206, 299 💬
20 ER2001 [0] ---[1] 8 💬
21 Fenofibrate [1] Fenofibrate[1] Fenofibrate 💬 [1] NR1C1 💬 [10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[6] 8, 79, 93, 94, 97, 265 💬
22 Fludeoxyglucose (18F) [2] 18F-FDG; Fludeoxyglucose F 18[1] Fludeoxyglucose F 18 💬 --[12] 5, 6, 7, 8, 34, 41, 46, 84, 85, 96, 127, 300 💬
23 Haloperidol [0] [3] Haloperidol ,
Haloperidol decanoate ,
Haloperidol lactate 💬 		[1] DRD2 💬 [10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 8 💬
24 Icosapent ethyl [1] Ethyl-EPA[1] Icosapent ethyl 💬 --[1] 8 💬
25 Idebenone [1] Idebenone[1] Idebenone 💬 --[7] 6, 8, 13, 18, 21, 113, 302 💬
26 Indopan [0] ---[5] 2, 8, 19, 46, 97 💬
27 Laquinimod [1] Laquinimod[1] Laquinimod sodium 💬 --[4] 8, 13, 49, 96 💬
28 Latrepirdine [2] Dimebon; Latrepirdine[2] Latrepirdine ,
Latrepirdine dihydrochloride 💬 		[6] ACHE,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 8 💬
29 LAX-101 [1] LAX-101---[1] 8 💬
30 Melatonin [1] Melatonin[1] Melatonin 💬 [2] MTNR1A,
MTNR1B 💬 		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[17] 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
31 Memantine [2] Memantine; Memantine hydrochloride[2] Memantine hydrochloride ,
Memantine 💬 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
32 Metformin [3] Metformin; Metformin hydrochloride; Metformina[2] Metformin hydrochloride ,
Metformin 💬 		[2] PRKAA,
PRKAA 💬 		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
33 Minocycline [3] Minocycline; Minocycline hydrochloride; Minomycin[2] Minocycline hydrochloride ,
Minocycline 💬 		--[15] 2, 6, 8, 13, 46, 84, 85, 90, 94, 97, 162, 201, 206, 280, 299 💬
34 Neflamapimod [1] Neflamapimod[1] Neflamapimod 💬 [4] P38,
P38,
P38,
P38 💬 		[62] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Efferocytosis, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬[1] 8 💬
35 Nicotinamide [2] Niacinamide; Nicotinamide[1] Niacinamide 💬 --[20] 2, 5, 6, 7, 8, 13, 17, 18, 21, 46, 49, 60, 63, 65, 67, 85, 97, 107, 162, 191 💬
36 Nicotinamide riboside [2] Nicotinamide riboside; Nicotinamide riboside chloride---[14] 2, 5, 6, 7, 8, 17, 18, 21, 49, 60, 65, 85, 97, 191 💬
37 Nilotinib [2] Nilotinib; Nilotinib hydrochloride monohydrate[1] Nilotinib 💬 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬 		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86 💬
38 Olanzapine [1] Olanzapine[2] Olanzapine ,
Olanzapine pamoate 💬 		[11] ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2,
HTR2,
HTR2,
HTR6 💬 		[18] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 8 💬
39 Phenylbutyric acid [2] Phenylbutyrate; Sodium phenylbutyrate[1] Sodium phenylbutyrate 💬 --[10] 2, 3, 8, 15, 93, 94, 244, 251, 297, 338 💬
40 Pridopidine [2] Pridopidine; Pridopidine hydrochloride[2] Pridopidine ,
Pridopidine hydrochloride 💬 		[1] DRD2 💬 [10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 8 💬
41 Quinidine [2] Quinidine; Quinidine sulfate[4] Quinidine gluconate ,
Quinidine polygalacturonate ,
Quinidine sulfate ,
Quinidine 💬 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[2] 8, 13 💬
42 Ramelteon [1] Ramelteon[1] Ramelteon 💬 [2] MTNR1A,
MTNR1B 💬 		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[3] 6, 8, 46 💬
43 Resveratrol [1] Resveratrol---[6] 8, 18, 89, 97, 113, 299 💬
44 Rilmenidine [2] Hyperium; Rilmenidine[1] Rilmenidine 💬 [3] ADRA2A,
ADRA2B,
ADRA2C 💬 		[4] Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 8 💬
45 Riluzole [1] Riluzole[1] Riluzole 💬 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[24] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[8] 2, 3, 5, 8, 13, 17, 203, 206 💬
46 Risperidone [1] Risperidone[1] Risperidone 💬 [2] DRD2,
HTR2 💬 		[13] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[3] 8, 156, 187 💬
47 Rolipram [1] Rolipram[1] Rolipram 💬 [4] PDE4,
PDE4,
PDE4,
PDE4 💬 		[4] Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[2] 8, 13 💬
48 Selisistat [1] Selisistat---[1] 8 💬
49 Tetrabenazine [1] Tetrabenazine[1] Tetrabenazine 💬 [1] SLC18A1_2 💬 [8] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
50 Tominersen [1] Tominersen[1] Tominersen 💬 [1] HD 💬 [2] Huntington disease, Pathways of neurodegeneration - multiple diseases 💬[1] 8 💬
51 Triheptanoin [1] Triheptanoin[1] Triheptanoin 💬 --[10] 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 💬
52 Ubidecarenone [2] Coenzyme Q10; COQ10[1] Ubidecarenone 💬 --[14] 2, 5, 6, 8, 10, 46, 57, 86, 96, 107, 113, 193, 214, 215 💬
53 Ubiquinol [1] Ubiquinol---[3] 6, 8, 17 💬
54 Ursodeoxycholic acid [3] Udca; Ursodeoxycholic acid; Ursodiol[1] Ursodiol 💬 [1] NR1H4 💬 [1] Bile secretion 💬[14] 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
55 Valbenazine [1] Valbenazine[2] Valbenazine ,
Valbenazine tosylate 💬 		[1] SLC18A1_2 💬 [8] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
56 VO659 [1] VO659---[1] 8 💬
57 Warfarin [3] Warfarin; Warfarin potassium; Warfarin sodium[3] Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		[2] NQO1,
VKORC1 💬 		[5] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
58 WVE-003 [1] WVE-003---[1] 8 💬