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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
2	Adrenergic signaling in cardiomyocytes 💬	[1] KCNQ1 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬
3	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D00354 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
4	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D05775 💬	Rufinamide	[1] 144 💬
5	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
6	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
7	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
8	Amphetamine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
9	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
10	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
11	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
12	Bile secretion 💬	[1] CA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
13	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
14	Calcium signaling pathway 💬	[3] HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
15	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
16	cAMP signaling pathway 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
17	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
18	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
19	Cellular senescence 💬	[1] CACNA1D 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
20	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
21	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
22	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
23	Cholinergic synapse 💬	[5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬
24	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
25	Circadian entrainment 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
26	Circadian entrainment 💬	[2] MTNR1A, MTNR1B 💬	D08170 💬	Melatonin	[12] 6 , 8 , 13, 37, 46, 49, 90, 97, 144, 145, 149, 202 💬
27	Cocaine addiction 💬	[1] GRIA2 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
28	Cocaine addiction 💬	[1] GRIA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
29	Collecting duct acid secretion 💬	[1] CA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
30	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
31	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
32	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
33	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
34	Dopaminergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
35	Dopaminergic synapse 💬	[1] SCN1A 💬	D00354 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
36	Dopaminergic synapse 💬	[1] SCN1A 💬	D05775 💬	Rufinamide	[1] 144 💬
37	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
38	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	[2] 140, 144 💬
39	Gap junction 💬	[3] HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
40	Gastric acid secretion 💬	[1] CA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
41	Gastric acid secretion 💬	[1] KCNQ1 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬
42	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
43	Glutamatergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
44	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
45	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
46	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
47	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
48	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
49	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
50	Inflammatory mediator regulation of TRP channels 💬	[3] HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
51	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
52	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
53	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
54	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
55	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
56	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
57	Metabolic pathways 💬	[2] CA2, CA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
58	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	[2] 140, 144 💬
59	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
60	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬	D10915 💬	Cannabidiol	[19] 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
61	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	[2] 140, 144 💬
62	Neuroactive ligand-receptor interaction 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
63	Neuroactive ligand-receptor interaction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
64	Neuroactive ligand-receptor interaction 💬	[3] HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
65	Neuroactive ligand-receptor interaction 💬	[2] MTNR1A, MTNR1B 💬	D08170 💬	Melatonin	[12] 6 , 8 , 13, 37, 46, 49, 90, 97, 144, 145, 149, 202 💬
66	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	[2] 140, 144 💬
67	Nicotine addiction 💬	[20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
68	Nicotine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
69	Nitrogen metabolism 💬	[2] CA2, CA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
70	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
71	Pancreatic secretion 💬	[1] CA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
72	Pancreatic secretion 💬	[1] KCNQ1 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬
73	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
74	Pathways of neurodegeneration - multiple diseases 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
75	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
76	Protein digestion and absorption 💬	[1] KCNQ1 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬
77	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
78	Rap1 signaling pathway 💬	[1] CNR1 💬	D10915 💬	Cannabidiol	[19] 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
79	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
80	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
81	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬	D10915 💬	Cannabidiol	[19] 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
82	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	[2] 140, 144 💬
83	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
84	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
85	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬	D01253 💬	Clobazam	[2] 140, 144 💬
86	Serotonergic synapse 💬	[4] HTR2A, HTR2B, HTR2C, SLC6A4 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
87	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
88	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
89	Synaptic vesicle cycle 💬	[1] SLC6A4 💬	D07945 💬	Fenfluramine	[4] 140, 144, 145, 149 💬
90	Taste transduction 💬	[10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
91	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬	D01253 💬	Clobazam	[2] 140, 144 💬
92	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬	D00354 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
93	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬	D05775 💬	Rufinamide	[1] 144 💬
94	Thermogenesis 💬	[1] CNR1 💬	D10915 💬	Cannabidiol	[19] 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
95	Tight junction 💬	[1] CACNA1D 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
96	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
97	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
98	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
99	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
100	Vibrio cholerae infection 💬	[1] KCNQ1 💬	D09569 💬	Ezogabine	[2] 2 , 144 💬