Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adherens junction 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
2 Adherens junction 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D01450 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
6 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
7 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00358 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
8 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D02086 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
9 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08127 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
11 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
12 AMPK signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
13 AMPK signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
14 Apelin signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
15 Autophagy - animal 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
16 Autophagy - animal 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
17 Breast cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
18 Breast cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
19 Calcium signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
20 Calcium signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
21 cAMP signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
22 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
23 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
24 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
25 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
26 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
27 Cushing syndrome 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
28 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
29 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
30 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
31 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
32 Dopaminergic synapse 💬
 [1] SCN1A 💬 D01450 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
33 Dopaminergic synapse 💬
 [1] SCN1A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
34 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00358 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
35 Dopaminergic synapse 💬
 [1] SCN1A 💬 D02086 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
36 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08127 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
37 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
38 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
39 Endocrine resistance 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
40 Endocrine resistance 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
41 Endocytosis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
42 Endocytosis 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
43 Focal adhesion 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
44 Focal adhesion 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
45 FoxO signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
46 FoxO signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
47 Gap junction 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
48 Glioma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
49 Glioma 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
50 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
51 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
52 Hepatocellular carcinoma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
53 Hepatocellular carcinoma 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
54 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
55 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
56 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
57 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
58 Long-term depression 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
59 Long-term depression 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
60 Longevity regulating pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
61 Longevity regulating pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
62 Longevity regulating pathway - multiple species 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
63 Longevity regulating pathway - multiple species 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
64 MAPK signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
65 MAPK signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
66 Melanoma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
67 Melanoma 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
68 mTOR signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
69 mTOR signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
70 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
71 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
72 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
73 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
74 Oocyte meiosis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
75 Oocyte meiosis 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
76 Ovarian steroidogenesis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
77 Ovarian steroidogenesis 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
78 Pathways in cancer 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
79 Pathways in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
80 Pathways in cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
81 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
82 PI3K-Akt signaling pathway 💬
 [2] GHR, IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
83 PI3K-Akt signaling pathway 💬
 [2] GHR, IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
84 Progesterone-mediated oocyte maturation 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
85 Progesterone-mediated oocyte maturation 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
86 Prostate cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
87 Prostate cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
88 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
89 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
90 Rap1 signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
91 Rap1 signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
92 Ras signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
93 Ras signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
94 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
95 Renin secretion 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
96 Renin secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
97 Renin-angiotensin system 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
98 Salivary secretion 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
99 Signaling pathways regulating pluripotency of stem cells 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
100 Signaling pathways regulating pluripotency of stem cells 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
101 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D01450 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
102 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
103 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D00358 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
104 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D02086 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
105 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D08127 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
106 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
107 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
108 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬

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