Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 ABC transporters 💬
 [1] ABCC8 💬 D00418 💬 Minoxidil [1] 179 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6 Alcoholism 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
7 Alcoholism 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
8 Alcoholism 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
9 Alcoholism 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
10 Alcoholism 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
11 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
12 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
13 Amphetamine addiction 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
14 Amphetamine addiction 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
15 Apelin signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
16 Apelin signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
17 Calcium signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
18 Calcium signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Calcium signaling pathway 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
20 cAMP signaling pathway 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
21 cAMP signaling pathway 💬
 [2] DRD2, HTR1A 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
22 cAMP signaling pathway 💬
 [2] DRD2, HTR1A 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
23 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
24 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
25 Cocaine addiction 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
26 Cocaine addiction 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
27 Cocaine addiction 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
28 Cocaine addiction 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
29 Cocaine addiction 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
30 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
31 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
32 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
33 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
34 Cushing syndrome 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
35 Cushing syndrome 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
36 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
37 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
38 Dopaminergic synapse 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
39 Dopaminergic synapse 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
40 Dopaminergic synapse 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
41 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
42 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
43 Gap junction 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
44 Gap junction 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
45 Gap junction 💬
 [2] DRD2, HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
46 GnRH secretion 💬
 [1] KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
47 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
48 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
49 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
50 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
51 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR1A 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
52 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR1A 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
53 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
54 Parkinson disease 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
55 Parkinson disease 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
56 Parkinson disease 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
57 Parkinson disease 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
58 Parkinson disease 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
59 Pathways in cancer 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
60 Pathways in cancer 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
61 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
62 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
63 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
64 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
65 Rap1 signaling pathway 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
66 Rap1 signaling pathway 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
67 Rap1 signaling pathway 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
68 Renin secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
69 Renin secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
70 Renin-angiotensin system 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
71 Renin-angiotensin system 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
72 Serotonergic synapse 💬
 [1] HTR1A 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
73 Serotonergic synapse 💬
 [1] HTR1A 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
74 Serotonergic synapse 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
75 Serotonergic synapse 💬
 [1] SLC6A4 💬 D00326 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
76 Serotonergic synapse 💬
 [1] SLC6A4 💬 D00823 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
77 Synaptic vesicle cycle 💬
 [2] SLC6A2, SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
78 Synaptic vesicle cycle 💬
 [2] SLC6A2, SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
79 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 D00326 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
80 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 D00823 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
81 Taste transduction 💬
 [1] HTR1A 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
82 Taste transduction 💬
 [1] HTR1A 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
83 Type II diabetes mellitus 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
84 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
85 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

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