Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
2 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
3 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
4 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
5 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
6 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
7 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
8 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
9 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
10 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
11 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
12 cAMP signaling pathway 💬
 [2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [2] 75, 205 💬
13 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
14 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
15 cAMP signaling pathway 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
16 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
17 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
18 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
19 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
20 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
21 Cushing syndrome 💬
 [2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [2] 75, 205 💬
22 Cushing syndrome 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
23 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
24 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
25 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone [1] 205 💬
26 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
27 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
28 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
29 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
30 Long-term depression 💬
 [1] CRHR1 💬 D03905 💬 Corticorelin [2] 75, 205 💬
31 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
32 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
33 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone [1] 205 💬
34 Neuroactive ligand-receptor interaction 💬
 [2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [2] 75, 205 💬
35 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone [1] 205 💬
36 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
37 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
38 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
39 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [48]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
40 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone [1] 205 💬
41 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
42 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
43 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
44 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
45 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
46 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
47 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
48 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
49 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
50 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
51 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone [1] 205 💬
52 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 D11149 💬 Brexanolone [1] 205 💬
53 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
54 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
55 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
56 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
57 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D11149 💬 Brexanolone [1] 205 💬

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