Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Breast cancer 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
2 Breast cancer 💬
 [4] BRAF, FLT4, KIT, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
3 Breast cancer 💬
 [4] BRAF, FLT4, KIT, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
4 Breast cancer 💬
 [2] CDK4, CDK6 💬 D10688 💬 Abemaciclib [1] 34 💬
5 Breast cancer 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
6 Breast cancer 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
7 Breast cancer 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
8 Breast cancer 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
9 Breast cancer 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
10 Breast cancer 💬
 [2] EGFR, ERBB2 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
11 Breast cancer 💬
 [2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
12 Breast cancer 💬
 [3] EGFR, ERBB2, FLT4 💬 D11772 💬 Tesevatinib [1] 67 💬
13 Breast cancer 💬
 [1] ESR1 💬 D00554 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
14 Breast cancer 💬
 [2] ESR1, ESR2 💬 D00962 💬 Clomifene [1] 74 💬
15 Breast cancer 💬
 [2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
16 Breast cancer 💬
 [2] ESR1, ESR2 💬 D11513 💬 Estetrol [1] 53 💬
17 Breast cancer 💬
 [2] ESR1, ESR2 💬 D11514 💬 Estetrol [1] 53 💬
18 Breast cancer 💬
 [2] ESR1, ESR2 💬 D00105 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
19 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01413 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
20 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01617 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
21 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01953 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
22 Breast cancer 💬
 [2] ESR1, ESR2 💬 D04061 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
23 Breast cancer 💬
 [2] ESR1, ESR2 💬 D04063 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
24 Breast cancer 💬
 [2] ESR1, ESR2 💬 D04064 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
25 Breast cancer 💬
 [2] ESR1, ESR2 💬 D04065 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
26 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01413 💬 Estradiol valerate [1] 65 💬
27 Breast cancer 💬
 [2] ESR1, ESR2 💬 D00185 💬 Estriol [2] 13, 227 💬
28 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01986 💬 Estriol [2] 13, 227 💬
29 Breast cancer 💬
 [2] ESR1, ESR2 💬 D01161 💬 Fulvestrant [2] 49, 86 💬
30 Breast cancer 💬
 [2] ESR1, ESR2 💬 D00575 💬 Mestranol [2] 46, 49 💬
31 Breast cancer 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
32 Breast cancer 💬
 [2] ESR1, ESR2 💬 D02217 💬 Raloxifene [1] 46 💬
33 Breast cancer 💬
 [2] ESR1, ESR2 💬 D08465 💬 Raloxifene [1] 46 💬
34 Breast cancer 💬
 [2] ESR1, ESR2 💬 D00966 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
35 Breast cancer 💬
 [2] ESR1, ESR2 💬 D08559 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
36 Breast cancer 💬
 [2] ESR1, PGR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
37 Breast cancer 💬
 [2] ESR1, PGR 💬 D02367 💬 Desogestrel [1] 230 💬
38 Breast cancer 💬
 [1] FGF23 💬 D10913 💬 Burosumab [1] 238 💬
39 Breast cancer 💬
 [1] FGFR1 💬 D11589 💬 Infigratinib [1] 276 💬
40 Breast cancer 💬
 [2] FGFR1, FLT4 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
41 Breast cancer 💬
 [1] FLT4 💬 D03218 💬 Axitinib [1] 34 💬
42 Breast cancer 💬
 [1] FLT4 💬 D08881 💬 Cediranib [1] 34 💬
43 Breast cancer 💬
 [2] FLT4, KIT 💬 D06402 💬 Sunitinib [2] 28, 34 💬
44 Breast cancer 💬
 [2] FLT4, KIT 💬 D08552 💬 Sunitinib [2] 28, 34 💬
45 Breast cancer 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
46 Breast cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
47 Breast cancer 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
48 Breast cancer 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
49 Breast cancer 💬
 [1] KIT 💬 D03658 💬 Dasatinib [2] 51, 85 💬
50 Breast cancer 💬
 [1] KIT 💬 D06414 💬 Dasatinib [2] 51, 85 💬
51 Breast cancer 💬
 [1] KIT 💬 D01441 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
52 Breast cancer 💬
 [1] KIT 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
53 Breast cancer 💬
 [1] KIT 💬 D10229 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
54 Breast cancer 💬
 [1] KIT 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
55 Breast cancer 💬
 [1] KIT 💬 D11270 💬 Pexidartinib [1] 34 💬
56 Breast cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
57 Breast cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
58 Breast cancer 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
59 Breast cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
60 Breast cancer 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
61 Breast cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
62 Breast cancer 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
63 Breast cancer 💬
 [1] PGR 💬 D01217 💬 Dydrogesterone [1] 13 💬
64 Breast cancer 💬
 [1] PGR 💬 D00950 💬 Levonorgestrel [1] 13 💬
65 Breast cancer 💬
 [1] PGR 💬 D00951 💬 Medroxyprogesterone acetate [6] 13, 35, 46, 49, 51, 60 💬
66 Breast cancer 💬
 [1] PGR 💬 D08166 💬 Medroxyprogesterone acetate [6] 13, 35, 46, 49, 51, 60 💬
67 Breast cancer 💬
 [1] PGR 💬 D00952 💬 Megestrol acetate [1] 76 💬
68 Breast cancer 💬
 [1] PGR 💬 D08167 💬 Megestrol acetate [1] 76 💬
69 Breast cancer 💬
 [1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
70 Breast cancer 💬
 [1] PGR 💬 D07222 💬 Nomegestrol [1] 13 💬
71 Breast cancer 💬
 [1] PGR 💬 D08281 💬 Nomegestrol acetate [1] 13 💬
72 Breast cancer 💬
 [1] PGR 💬 D00182 💬 Norethisterone [4] 13, 46, 49, 299 💬
73 Breast cancer 💬
 [1] PGR 💬 D00953 💬 Norethisterone [4] 13, 46, 49, 299 💬
74 Breast cancer 💬
 [1] PGR 💬 D05209 💬 Norgestimate [1] 299 💬
75 Breast cancer 💬
 [1] PGR 💬 D00066 💬 Progesterone [1] 76 💬
76 Breast cancer 💬
 [1] PGR 💬 D09567 💬 Ulipristal [1] 10 💬
77 Breast cancer 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
78 Breast cancer 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
79 Breast cancer 💬
 [1] TNFSF11 💬 D03684 💬 Denosumab [7] 46, 50, 93, 95, 96, 274, 299 💬