Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
5 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 Alzheimer disease 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
8 Alzheimer disease 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
9 Alzheimer disease 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
10 Apelin signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
11 Apelin signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
12 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
13 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
14 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
15 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
16 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
17 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
18 Calcium signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Calcium signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
20 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
21 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
22 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
23 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
24 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
25 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
27 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
28 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
29 Cushing syndrome 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
30 Cushing syndrome 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
31 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
32 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
33 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
34 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
35 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
36 Human papillomavirus infection 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
37 Human papillomavirus infection 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
38 Human papillomavirus infection 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
39 IL-17 signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
40 IL-17 signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
41 IL-17 signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
42 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
43 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
44 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
45 Leishmaniasis 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
46 Leishmaniasis 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
47 Leishmaniasis 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
48 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
49 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
50 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
51 MicroRNAs in cancer 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
52 MicroRNAs in cancer 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
53 MicroRNAs in cancer 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
54 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
55 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
56 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
57 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
58 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
59 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
60 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
61 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
62 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
63 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
64 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
65 Pathways in cancer 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
66 Pathways in cancer 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
67 Pathways in cancer 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
68 Pathways in cancer 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
69 Pathways in cancer 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
70 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
71 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
72 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
73 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
74 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
75 Platelet activation 💬
 [1] PTGS1 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
76 Platelet activation 💬
 [1] PTGS1 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
77 Platelet activation 💬
 [1] PTGS1 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
78 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
79 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
80 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
81 Renin secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
82 Renin secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
83 Renin-angiotensin system 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
84 Renin-angiotensin system 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
85 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
86 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
87 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
88 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
89 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
90 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
91 Small cell lung cancer 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
92 Small cell lung cancer 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
93 Small cell lung cancer 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
94 TNF signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
95 TNF signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
96 TNF signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
97 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
98 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
99 VEGF signaling pathway 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
100 VEGF signaling pathway 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
101 VEGF signaling pathway 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬

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