Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Systemic lupus erythematosus 💬
 [2] C1R, C1S 💬 D10845 💬 Conestat alfa [1] 61 💬
2 Systemic lupus erythematosus 💬
 [1] C1S 💬 D11530 💬 Sutimlimab [1] 61 💬
3 Systemic lupus erythematosus 💬
 [1] C3 💬 D11613 💬 Pegcetacoplan [3]  2 , 62, 222 💬
4 Systemic lupus erythematosus 💬
 [1] C5 💬 D11696 💬 Crovalimab [2] 62, 109 💬
5 Systemic lupus erythematosus 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
6 Systemic lupus erythematosus 💬
 [1] C5 💬 D11473 💬 Nomacopan [3] 62, 109, 162 💬
7 Systemic lupus erythematosus 💬
 [1] C5 💬 D11477 💬 Pozelimab [2] 11, 62 💬
8 Systemic lupus erythematosus 💬
 [1] C5 💬 D11054 💬 Ravulizumab [7]  2 , 11, 13, 50, 62, 66, 109 💬
9 Systemic lupus erythematosus 💬
 [1] C5 💬 D11838 💬 Vilobelimab [3] 43, 44, 269 💬
10 Systemic lupus erythematosus 💬
 [1] CD40 💬 D11357 💬 Bleselumab [1] 222 💬
11 Systemic lupus erythematosus 💬
 [1] CD40 💬 D11610 💬 Iscalimab [2] 49, 53 💬
12 Systemic lupus erythematosus 💬
 [1] CD40 💬 D11597 💬 Ravagalimab [2] 53, 97 💬
13 Systemic lupus erythematosus 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
14 Systemic lupus erythematosus 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
15 Systemic lupus erythematosus 💬
 [2] CD80, CD86 💬 D03222 💬 Belatacept [1] 46 💬
16 Systemic lupus erythematosus 💬
 [1] ELANE 💬 D03788 💬 Sivelestat [3] 13, 85, 96 💬
17 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D02780 💬 Acamprosate [2]  6 , 206 💬
18 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
19 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D00777 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
20 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
21 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D00848 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
22 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
23 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D03744 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
24 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
25 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
26 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
27 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D09917 💬 Latrepirdine [1]  8  💬
28 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
29 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
30 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
31 Systemic lupus erythematosus 💬
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
32 Systemic lupus erythematosus 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
33 Systemic lupus erythematosus 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
34 Systemic lupus erythematosus 💬
 [2] IL10, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
35 Systemic lupus erythematosus 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
36 Systemic lupus erythematosus 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
37 Systemic lupus erythematosus 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
38 Systemic lupus erythematosus 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
39 Systemic lupus erythematosus 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
40 Systemic lupus erythematosus 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
41 Systemic lupus erythematosus 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
42 Systemic lupus erythematosus 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
43 Systemic lupus erythematosus 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
44 Systemic lupus erythematosus 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬