Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 ACR-16 [0] ---[1] 8 💬
2 Alprazolam [1] Alprazolam[1] Alprazolam 💬 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬 		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 8, 75 💬
3 Amantadine [3] Amantadine; AMANTADINE HYDROCHLORIDE; GOCOVRI[1] Amantadine 💬 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[4] 6, 8, 13, 127 💬
4 AMT-130 [2] AMT-130; RAAV5-miHTT---[1] 8 💬
5 ANX005 [1] ANX005---[3] 2, 8, 61 💬
6 Atomoxetine [2] Atomoxetine; Strattera[1] Atomoxetine 💬 [1] SLC6A2 💬 [1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17 💬
7 Bevantolol [1] Bevantolol---[1] 8 💬
8 Biotin [4] Biotin; Biotina; D-BIOTIN; Vitamin B7[1] Biotin 💬 --[5] 2, 8, 10, 13, 20 💬
9 Branaplam [1] Branaplam[1] Branaplam 💬 [1] SMN2 💬 -[2] 3, 8 💬
10 Bupropion [2] Bupropion; Bupropion Hydrochloride[1] Bupropion 💬 [2] SLC6A2,
SLC6A3 💬 		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[5] 8, 18, 21, 96, 171 💬
11 Cannabidiol [4] CANNABIDIOL; Epidiolex; Epidyolex; SATIVEX[1] Cannabidiol 💬 [2] CNR1,
CNR2 💬 		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
12 Cholesterol [1] Cholesterol[1] Cholesterol 💬 --[6] 8, 19, 90, 160, 222, 310 💬
13 Citalopram [1] Citalopram[1] Citalopram 💬 [1] SLC6A4 💬 [2] Serotonergic synapse, Synaptic vesicle cycle 💬[7] 6, 8, 13, 18, 46, 98, 127 💬
14 Creatine [1] Creatine---[11] 1, 2, 5, 6, 8, 46, 49, 50, 113, 156, 201 💬
15 Cysteamine [8] 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; CYSTAGON; Cysteamine; Mercaptamina; Mercaptamine; PROCYSBI[1] Cysteamine 💬 --[4] 8, 19, 21, 299 💬
16 Deutetrabenazine [1] Deutetrabenazine[1] Deutetrabenazine 💬 [1] SLC18A2 💬 [7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
17 Dextromethorphan [4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta[1] Dextromethorphan 💬 [6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬 		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
18 Digoxin [1] Digoxin[1] Digoxin 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 8, 46, 210 💬
19 Dronabinol [4] Delta-9-tetrahydrocannabinol; Dronabinol; Sativex; Tetrahydrocannabinol[1] Dronabinol 💬 [2] CNR1,
CNR2 💬 		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[8] 2, 8, 13, 36, 46, 96, 271, 298 💬
20 Epigallocatechin [1] Epigallocatechin---[5] 8, 13, 28, 85, 113 💬
21 Epigallocatechin gallate [3] EGCG; Epigallocatechin gallate; Epigallocatechin-3-gallate---[9] 6, 8, 13, 17, 28, 85, 113, 206, 299 💬
22 Fenofibrate [1] Fenofibrate[1] Fenofibrate 💬 [1] PPARA 💬 [10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[6] 8, 79, 93, 94, 97, 265 💬
23 GSK-356278 [0] ---[1] 8 💬
24 Haloperidol [1] Haloperidol[1] Haloperidol 💬 [1] DRD2 💬 [8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 8 💬
25 Icosapent [2] Eicosapentaenoic acid; Icosapent[1] Icosapent 💬 --[11] 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338 💬
26 Icosapent ethyl [2] Ethyl-EPA; Icosapent[1] Icosapent ethyl 💬 --[2] 8, 296 💬
27 Idebenone [2] Idebenone; Raxone[1] Idebenone 💬 --[6] 6, 8, 13, 18, 113, 302 💬
28 Indopan [0] ---[4] 8, 46, 97, 321 💬
29 Ketoconazole [2] Ketoconazole; NIZORAL[1] Ketoconazole 💬 [1] CYP17A1 💬 [6] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis 💬[3] 8, 13, 75 💬
30 Laquinimod [1] LAQUINIMOD---[4] 8, 13, 49, 96 💬
31 Latrepirdine [2] Dimebon; Latrepirdine[1] Latrepirdine 💬 [6] ACHE,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[22] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 8 💬
32 LAX-101 [1] LAX-101---[1] 8 💬
33 Lithium citrate [2] Lithium; LITHIUM CITRATE[1] Lithium citrate 💬 --[5] 2, 5, 6, 7, 8 💬
34 Manganese citrate [1] Release---[12] 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299 💬
35 Melatonin [2] Circadin; Melatonin[1] Melatonin 💬 [2] MTNR1A,
MTNR1B 💬 		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[12] 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
36 Memantine [3] Ebixa; Memantine; MEMANTINE HYDROCHLORIDE[1] Memantine 💬 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
37 Metformin [5] Metformin; Metformin HCl; METFORMIN HYDROCHLORIDE; METFORMINA; Metformine[1] Metformin 💬 [2] PRKAA1,
PRKAA2 💬 		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
38 Minocycline [3] Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin[1] Minocycline 💬 --[14] 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299 💬
39 Neflamapimod [1] Neflamapimod[1] Neflamapimod 💬 [4] MAPK11,
MAPK12,
MAPK13,
MAPK14 💬 		[62] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Endocrine resistance, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬[1] 8 💬
40 Nilotinib [2] Nilotinib; TASIGNA[1] Nilotinib 💬 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬 		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86 💬
41 Olanzapine [2] OLANZAPINE; Zyprexa[1] Olanzapine 💬 [11] ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2A,
HTR2B,
HTR2C,
HTR6 💬 		[16] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 8 💬
42 Omeprazole [4] Losec; Omeprazol; Omeprazole; OMEPRAZOLE MAGNESIUM[1] Omeprazole 💬 [2] ATP4A,
ATP4B 💬 		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬
43 Phenylbutyric acid [4] 4-phenylbutyrate; Pheburane; Phenylbutyrate; Sodium phenylbutyrate---[14] 2, 3, 6, 8, 15, 21, 93, 94, 231, 244, 251, 297, 299, 338 💬
44 Pridopidine [1] Pridopidine[1] Pridopidine 💬 [1] DRD2 💬 [8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 8 💬
45 Quinidine [4] Nuedexta; Quinidina; Quinidine; Quinidine Sulfate[1] Quinidine 💬 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 2, 8, 13 💬
46 Ramelteon [2] Ramelteon; ROZEREM[1] Ramelteon 💬 [2] MTNR1A,
MTNR1B 💬 		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[3] 6, 8, 46 💬
47 Resveratrol [1] Resveratrol---[6] 2, 8, 18, 89, 97, 113 💬
48 Rilmenidine [2] HYPERIUM; Rilmenidine[1] Rilmenidine 💬 [3] ADRA2A,
ADRA2B,
ADRA2C 💬 		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 8 💬
49 Riluzole [2] Rilutek; Riluzole[1] Riluzole 💬 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
50 Risperidone [1] Risperidone[1] Risperidone 💬 [2] DRD2,
HTR2A 💬 		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[5] 8, 156, 179, 187, 206 💬
51 Rolipram [1] Rolipram[1] Rolipram 💬 [4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬 		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[2] 8, 13 💬
52 Selisistat [1] Selisistat---[1] 8 💬
53 SRX-246 [0] ---[1] 8 💬
54 Tetrabenazine [2] Tetrabenazine; Xenazine[1] Tetrabenazine 💬 [1] SLC18A2 💬 [7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
55 Thiamine [2] THIAMINE; Vitamin B1[1] Thiamine 💬 --[4] 8, 93, 145, 265 💬
56 Tiapride [0] [1] Tiapride 💬 [1] DRD2 💬 [8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 8 💬
57 Triheptanoin [1] Triheptanoin[1] Triheptanoin 💬 --[10] 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 💬
58 Ubidecarenone [3] Coenzyme Q-10; Coenzyme Q10; CoQ10[1] Ubidecarenone 💬 --[12] 2, 5, 6, 8, 10, 18, 46, 57, 86, 113, 214, 215 💬
59 Ubiquinol [1] Ubiquinol---[3] 6, 8, 17 💬
60 Ursodeoxycholic acid [4] UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk[1] Ursodiol 💬 [1] NR1H4 💬 [1] Bile secretion 💬[14] 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
61 Valbenazine [1] Valbenazine[1] Valbenazine 💬 [1] SLC18A2 💬 [7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8 💬
62 Warfarin [2] Warfarin; Warfarin Sodium[1] Warfarin 💬 [2] NQO1,
VKORC1 💬 		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬