Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Abacavir
(Synonym: Apo-abacavir-lamivudine-zidovudine)		[4] Abacavir; Abacavir sulfate; Triumeq; Ziagen[1] D07057 --[5] 2, 135, 256, 265, 325
2 Abiraterone
(Synonym: Apo-abiraterone Film Coated Tablets)		[3] Abiraterone; Abiraterone Acetate; ZYTIGA---[2] 75, 81
3 Acetaminophen
(Synonym: Apap)		[4] Acetaminophen; Paracetamol; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
4 Acetylsalicylic acid
(Synonym: Apo Asa Tab 325mg)		[2] Acetylsalicylic Acid; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
5 Acyclovir
(Synonym: Apo-acyclovir)		[3] ACICLOVIR; Acycloguanosine; Acyclovir[1] D00222 --[5] 13, 28, 46, 53, 60
6 Adenosine
(Synonym: Aprilskin Magic Snow Fixing Foundation 22 Pink Beige)		[2] Adenosine; Ginseng[1] D00045 [4] ADORA1,
ADORA2A,
ADORA2B,
ADORA3 💬		[12] Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 13, 58, 65
7 Alendronic acid
(Synonym: Apo-alendronate/vitamin D3)		[3] Alendronate; Alendronate sodium; ALENDRONIC ACID[1] D07119 [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[7] 19, 41, 46, 50, 271, 274, 299
8 Alfuzosin
(Synonym: Apo-alfuzosin)		[1] Alfuzosin[1] D07124 [1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 13
9 Allopurinol
(Synonym: Apo-allopurinol)		[2] Allopurinol; ALLOPURINOL SODIUM[1] D00224 [1] XDH 💬[6] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Peroxisome, Purine metabolism 💬[7] 6, 46, 57, 60, 66, 96, 97
10 Alprazolam
(Synonym: Apo-alpraz)		[1] Alprazolam[1] D00225 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 8, 75
11 Ambrisentan
(Synonym: Apo-ambrisentan)		[3] AMBRISENTAN; Letairis; VOLIBRIS[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
12 Aminopterin
(Synonym: APGA)		[1] Aminopterin---[1] 46
13 Amiodarone
(Synonym: Apo-amiodarone Tablets)		[1] AMIODARONE[1] D02910 [16] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
KCND3,
KCNJ11,
KCNJ12,
KCNJ3,
KCNJ5,
KCNJ8,
KCNQ1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[32] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy, Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 28, 127
14 Amitriptyline
(Synonym: Apo Peram Tab 3-15)		[3] Amitriptylin; AMITRIPTYLINE; Amitriptyline hydrochloride[1] D07448 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 78, 97, 226, 299
15 Amlodipine
(Synonym: Apo-amlodipine-atorvastatin)		[1] Amlodipine[1] D07450 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298
16 Amoxicillin
(Synonym: Apo-amoxicillin)		[4] Amoxicilina; AMOXICILLIN; Amoxycillin; Augmentin[2] D00229 ,
D07452 		--[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
17 Ampicillin
(Synonym: Apo Ampi Liq 250mg/5ml)		[1] ABPC[1] D00204 --[5] 2, 6, 13, 84, 299
18 Anastrozole
(Synonym: Apo-anastrozole)		[2] Anastrozole; Arimidex[1] D00960 [1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193
19 Apabetalone [1] Apabetalone[1] D11131 (Name: Apabetalone)[4] BRD2,
BRD3,
BRD4,
BRDT 💬		-[1] 86
20 Apadamtase alfa [1] Apadamtase alfa---[1] 64
21 Apigenin [1] Apigenin---[2] 6, 97
22 Apitegromab [1] Apitegromab[1] D11797 (Name: Apitegromab)[1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 3
23 Apixaban [2] Apixaban; Eliquis[1] D03213 (Name: Apixaban)[1] F10 💬[1] Complement and coagulation cascades 💬[1] 222
24 Aplindore [1] Aplindore---[1] 6
25 Apomorphine [4] APOKYN; Apomorfina; Apomorphine; Apomorphine Hydrocloride[1] D07460 (Name: Apomorphine)[2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7
26 Apraclonidine [1] Apraclonidine[1] D07461 (Name: Apraclonidine)[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 11
27 Apratastat [1] Apratastat[1] D08859 (Name: Apratastat)[2] ADAM17,
MMP13 💬		[7] Alzheimer disease, Coronavirus disease - COVID-19, Epithelial cell signaling in Helicobacter pylori infection, IL-17 signaling pathway, Notch signaling pathway, Parathyroid hormone synthesis, secretion and action, Relaxin signaling pathway 💬[1] 46
28 Apremilast [2] APREMILAST; Otezla[1] D08860 (Name: Apremilast)[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[7] 46, 50, 56, 97, 107, 162, 271
29 Aprotinin [1] Aprotinin[1] D02971 (Name: Aprotinin)--[1] 28
30 Aripiprazole
(Synonym: Apo-aripiprazole)		[1] Aripiprazole[1] D01164 [4] DRD2,
DRD3,
HTR1A,
HTR2A 💬		[12] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 206
31 Ascorbic acid
(Synonym: C-apnto-B6 Vitamins W Magnesium Tab)		[4] Acidum ascorbicum; Ascorbic acid; Iron; Vitamin C[1] D00018 --[8] 10, 97, 192, 206, 210, 211, 212, 298
32 Atazanavir
(Synonym: Apo-atazanavir)		[2] Atazanavir; Reyataz[1] D07471 --[1] 265
33 Atenolol
(Synonym: Apo-atenol Tab 100mg)		[1] ATENOLOL[1] D00235 [1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 167
34 Atomoxetine
(Synonym: Apo-atomoxetine)		[2] Atomoxetine; Strattera[1] D07473 [1] SLC6A2 💬[1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17
35 Atorvastatin
(Synonym: Apo-amlodipine-atorvastatin)		[3] Atorvastatin; Atorvastatin Calcium; Lipitor[1] D07474 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
36 Atovaquone
(Synonym: Apo-atovaquone)		[1] ATOVAQUONE[1] D00236 --[1] 61
37 Azathioprine
(Synonym: Apo-azathioprine)		[3] Azathioprine; Azatioprina; Imuran[1] D00238 --[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
38 Azithromycin
(Synonym: Apo-azithromycin)		[5] AZITHROMYCIN; AZITHROMYCIN DIHYDRATE; Azithromycin monohydrate; AZITHROMYCINE; Zithromax[2] D06390 ,
D07486 		--[6] 13, 84, 85, 96, 228, 299
39 Baclofen
(Synonym: Apo-baclofen)		[2] Baclofen; Kemstro[1] D00241 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[8] 2, 10, 13, 18, 65, 70, 149, 206
40 Beclomethasone dipropionate
(Synonym: Apo-beclomethasone Nasal Spray)		[2] BECLOMETASONE DIPROPIONATE; Beclomethasone dipropionate[1] D00689 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 85, 97, 98
41 Bisacodyl
(Synonym: Apo-bisacodyl Sup 10mg)		[1] Bisacodyl[1] D00245 --[1] 13
42 Bisoprolol
(Synonym: Apo-bisoprolol)		[2] Bisoprolol; Bisoprolol Fumarate[1] D02342 [1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 67, 86, 113
43 Bosentan
(Synonym: Apo-bosentan)		[2] Bosentan; TRACLEER[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
44 Brimonidine
(Synonym: Apo-brimonidine)		[2] Brimonidine; Brimonidine tartrate[1] D07540 [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[2] 13, 90
45 Bupropion
(Synonym: Aplenzin ER)		[2] Bupropion; Bupropion Hydrochloride[1] D07591 [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[5] 8, 18, 21, 96, 171
46 Buspirone
(Synonym: Apo-buspirone)		[2] Buspirone; Buspirone Hydrochloride[1] D07593 [2] DRD2,
HTR1A 💬		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 51
47 Cabergoline
(Synonym: Apo-cabergoline)		[3] CABERGOLINA; Cabergoline; DOSTINEX[1] D00987 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 6, 74, 75
48 Cabotegravir
(Synonym: Apretude)		[1] Cabotegravir[1] D10548 (Name: APRETUDE)--[1] 256
49 Caffeine
(Synonym: Apo-acetaco #1)		[1] Caffeine[2] D00528 ,
D01453 		[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 2, 6, 21, 46, 78, 96, 97, 265
50 Calcium carbonate
(Synonym: Apcal)		[3] Calcio carbonato; Calcium; Calcium carbonate[2] D00932 ,
D10802 		--[9] 13, 19, 46, 53, 75, 96, 235, 274, 299
51 Candesartan cilexetil
(Synonym: Apo-candesartan)		[1] CANDESARTAN[1] D00626 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 67
52 Capsaicin
(Synonym: Capsaicin No-Fuss Applicator)		[2] Capsaicin; Qutenza[1] D00250 [1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[3] 6, 86, 226
53 Captopril
(Synonym: Apo-capto Tab 50mg)		[1] Captopril[1] D00251 (Name: Apopril (TN))[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[8] 6, 17, 46, 86, 96, 97, 107, 271
54 Carbamazepine
(Synonym: Apo-carbamazepine CR)		[1] Carbamazepine[1] D00252 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 6, 13, 231
55 Carbidopa
(Synonym: Apo-levocarb - Tab 25mg/250mg)		[8] Carbidopa; Carbidopa-Levodopa; DUODOPA; Lodosyn; PARCOPA; SINEMET; SINEMET CR; Stalevo[1] D00558 [1] DDC 💬[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 6, 13, 17, 90, 140, 164, 201
56 Carvedilol
(Synonym: Apo-carvedilol)		[1] CARVEDILOL[1] D00255 [5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 86, 113, 210
57 Cefadroxil
(Synonym: Apo-cefadroxil)		[0] [2] D00257 ,
D02353 		--[2] 222, 240
58 Cefepime
(Synonym: Apo-cefepime)		[1] Cefepime[1] D02376 --[2] 60, 299
59 Cefuroxime
(Synonym: Apo-cefuroxime)		[2] Cefuroxim; Cefuroxime[1] D00262 --[2] 97, 299
60 Celecoxib
(Synonym: Apo-celecoxib)		[2] Celebrex; CELECOXIB[1] D00567 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
61 Cephalexin
(Synonym: Apo-cephalex)		[2] CEFALEXIN; Cephalexin[2] D00263 ,
D00906 		--[1] 299
62 Cetirizine
(Synonym: Apo-cetirizine)		[3] Cetirizina; Cetirizine; CETIRIZINE HYDROCHLORIDE[1] D07662 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 28, 35, 300
63 Chlorhexidine
(Synonym: Aplicare Antiseptic Chlorhexidine Gluconate)		[2] Chlorhexidine; Chlorhexidine Gluconate[1] D07668 --[2] 86, 299
64 Chlorpheniramine
(Synonym: Aphedrid Cold and Allergy)		[1] Clorfenamina[1] D07398 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 14
65 Chlorpromazine
(Synonym: Apo Chlorpromazine)		[2] Chlorpromazine; Chlorpromazine Hydrochloride[1] D00270 [13] ADRA2A,
ADRA2B,
ADRA2C,
CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5,
DRD2,
HRH1,
HTR2A,
HTR2B,
HTR2C 💬		[22] Alcoholism, Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Cocaine addiction, Dopaminergic synapse, Gap junction, Gastric acid secretion, Inflammatory mediator regulation of TRP channels, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Rap1 signaling pathway, Regulation of actin cytoskeleton, Salivary secretion, Serotonergic synapse, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 254
66 Cholecalciferol
(Synonym: Apo-alendronate/vitamin D3)		[5] Cholecalciferol; COLECALCIFEROL; Multivitamin; Vitamin D; Vitamin D3[1] D00188 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[24] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
67 Ciclesonide
(Synonym: Apo-ciclesonide)		[1] Ciclesonide[1] D01703 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 84
68 Cilazapril
(Synonym: Apo-cilazapril/hctz)		[1] Cilazapril[2] D01069 ,
D07699 		[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 66
69 Cimetidine
(Synonym: Apo-cimetidine Oral Solution)		[1] Cimetidine[1] D00295 [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[2] 2, 254
70 Cinacalcet
(Synonym: Apo-cinacalcet)		[1] Cinacalcet[1] D03504 [1] CASR 💬[2] NOD-like receptor signaling pathway, Parathyroid hormone synthesis, secretion and action 💬[1] 238
71 Ciprofloxacin
(Synonym: Apo-ciproflox)		[2] Ciprofloxacin; Ciprofloxacin hydrochloride[1] D00186 --[5] 2, 60, 96, 97, 299
72 Citalopram
(Synonym: Apo-citalopram)		[1] Citalopram[1] D07704 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[7] 6, 8, 13, 18, 46, 98, 127
73 Clarithromycin
(Synonym: Apo-clarithromycin)		[1] Clarithromycin[1] D00276 --[8] 6, 63, 84, 96, 97, 222, 228, 299
74 Clavulanic acid
(Synonym: Apo-amoxi Clav)		[4] AMOXICILLIN; Augmentin; Clavulanate; CLAVULANIC ACID[1] D07711 --[1] 299
75 Clindamycin
(Synonym: Apo-clindamycin)		[2] CLINDAMYCIN; Dalacin C phosphate[1] D00277 --[2] 46, 299
76 Clobazam
(Synonym: Apo-clobazam)		[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 140, 144
77 Clobetasol propionate
(Synonym: Cormax Scalp Application)		[1] Clobetasol Propionate[1] D01272 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[2] 46, 162
78 Clonazepam
(Synonym: Apo-clonazepam)		[1] Clonazepam[1] D00280 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 6
79 Clonidine
(Synonym: Apo-clonidine)		[4] Clonidin; Clonidina; Clonidine; Clonidine hydrochloride[1] D00281 [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 6, 65, 70, 78
80 Clopidogrel
(Synonym: Clopidogrel Apotex)		[1] Clopidogrel[3] D07729 ,
D10823 ,
D10824 		[1] P2RY12 💬[1] Platelet activation 💬[3] 49, 51, 86
81 Colesevelam
(Synonym: Apo-colesevelam)		[2] Cholestagel; Colesevelam[1] D07743 --[2] 96, 260
82 Cromoglicic acid
(Synonym: Apo-cromolyn Nasal Spray)		[4] Cromoglicate; Cromoglycate; Cromolyn; Cromolyn Sodium[1] D07753 --[3] 2, 85, 98
83 Cyclosporine
(Synonym: Apo-cyclosporine Oral Solution)		[10] Ciclosporin; Ciclosporina; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine; Cyclosporine A; Ikervis; Neoral; RESTASIS[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
84 D-glucose
(Synonym: SUEROLYTE Oral Electrolyte Solution Apple Flavor)		[2] D-glucose; Glucose[1] D00009 --[3] 49, 86, 88
85 Dabigatran etexilate
(Synonym: Apo-dabigatran)		[1] Dabigatran Etexilate[1] D07144 [1] F2 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton 💬[2] 51, 75
86 Dalfampridine
(Synonym: 4-AP)		[7] 4-Aminopyridine; 4-AP; Ampyra; Dalfampridine; FAMPRIDINA; FAMPRIDINE; FAMPYRA[1] D04127 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[5] 3, 4, 6, 13, 14
87 Darifenacin
(Synonym: Apo-darifenacin)		[2] Darifenacin; Emselex[1] D03654 [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
88 Darunavir
(Synonym: Apo-darunavir)		[1] Darunavir[1] D03656 --[1] 2
89 Dasatinib
(Synonym: Apo-dasatinib)		[1] Dasatinib[2] D03658 ,
D06414 		[8] ABL1,
EPHA2,
FYN,
KIT,
LCK,
PDGFRB,
SRC,
YES1 💬		[77] Acute myeloid leukemia, Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, Glioma, GnRH signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Mitophagy - animal, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Primary immunodeficiency, Prion disease, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Sphingolipid signaling pathway, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[2] 51, 85
90 Deferasirox
(Synonym: Apo-deferasirox)		[2] Deferasirox; Exjade[1] D03669 --[3] 254, 284, 286
91 Desmopressin
(Synonym: Apo-desmopressin)		[5] DDAVP; Desmopressin; Desmopressin acetate; Desmopressine; Minirin[1] D00291 [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[6] 6, 64, 72, 75, 225, 288
92 Desogestrel
(Synonym: Apri 28 Day)		[2] Desogestrel; Désogestrel[1] D02367 [2] ESR1,
PGR 💬		[11] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 230
93 Dexamethasone
(Synonym: Apo-dexamethasone)		[5] Decadron; Dexametasona; Dexamethasone; Dexamethasone sodium phosphate; Maxidex[1] D00292 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299
94 Dextromethorphan
(Synonym: AP-Hist DM)		[4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta[1] D03742 [6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
95 Diclofenac
(Synonym: Apo-diclofenac)		[3] Diclofenac; Diclofenac Sodium; Diclofenac SR[1] D07816 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[5] 13, 34, 46, 78, 271
96 Digoxin
(Synonym: Apo-digoxin)		[1] Digoxin[1] D00298 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		[18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 8, 46, 210
97 Diltiazem
(Synonym: Apo-diltiaz TZ)		[2] Diltiazem; Diltiazem Hydrochloride[1] D07845 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
98 Dimethyl fumarate
(Synonym: Apo-dimethyl Fumarate)		[3] DIMETHYL FUMARATE; Dimethylfumarat; TECFIDERA[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296
99 Diphenhydramine
(Synonym: Aphenap)		[2] Diphenhydramine; Diphenhydramine hydrochloride[1] D00300 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[8] 11, 13, 49, 51, 70, 86, 222, 256
100 Dipivefrin
(Synonym: Apo-dipivefrin)		[2] Dipivefrin; Dipivefrine[1] D02349 [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
101 Dipyridamole
(Synonym: Apo-dipyridamole-SC Tab 50mg)		[1] Dipyridamole[1] D00302 [2] PDE4A,
PDE5A 💬		[6] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 46, 49, 51, 66, 96, 224
102 Domperidone
(Synonym: Apo-domperidone - Tab 10mg)		[1] Domperidone[2] D01745 ,
D07868 		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
103 Donepezil
(Synonym: Apo-donepezil)		[3] Aricept; Donepezil; Donepezil Hydrochloride[1] D07869 [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
104 Dorzolamide
(Synonym: Apo-dorzo-timop)		[1] Dorzolamide[1] D07871 [13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[1] 90
105 Doxazosin
(Synonym: Apo-doxazosin)		[2] CARDURA; DOXAZOSIN[1] D07874 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 57, 67
106 Doxycycline
(Synonym: Apo-doxy Cap 100mg)		[4] Doxycyclin; DOXYCYCLINE; DOXYCYCLINE HYCLATE; Doxycycline Tablets[2] D00307 ,
D07876 		--[17] 13, 23, 28, 34, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
107 Duloxetine
(Synonym: Apo-duloxetine)		[3] Cymbalta; DULOXETINE; Duloxetine hydrochloride[1] D07880 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
108 Dutasteride
(Synonym: Apo-dutasteride)		[2] Dutasterida; Dutasteride[1] D03820 [2] SRD5A1,
SRD5A2 💬		[3] Metabolic pathways, Prostate cancer, Steroid hormone biosynthesis 💬[2] 1, 2
109 Efavirenz
(Synonym: Apo-efavirenz-emtricitabine-tenofovir)		[2] Efavirenz; SUSTIVA[1] D00896 --[1] 265
110 Emtricitabine
(Synonym: Apo-emtricitabine-tenofovir)		[2] Emtricitabine; TRUVADA[1] D01199 --[4] 25, 93, 265, 325
111 Enalapril
(Synonym: Apo-enalapril Tab 5mg)		[2] Enalapril; Enalapril Maleate[1] D07892 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[6] 19, 46, 66, 113, 210, 222
112 Entacapone
(Synonym: Apo-entacapone)		[5] COMTAN; Comtess; ENTACAPONA; ENTACAPONE; Stalevo[1] D00781 [1] COMT 💬[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism 💬[2] 6, 17
113 Entecavir
(Synonym: Apo-entecavir)		[1] Entecavir[2] D04008 ,
D07896 		--[6] 46, 56, 96, 97, 107, 271
114 Eplerenone
(Synonym: Apo-eplerenone)		[1] Eplerenone[1] D01115 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[4] 75, 113, 210, 215
115 Erlotinib
(Synonym: Apo-erlotinib)		[1] Erlotinib[1] D07907 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 94
116 Escitalopram
(Synonym: Apo-escitalopram)		[3] Citalopram; Escitalopram; Escitalopram oxalate[1] D07913 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 2, 6, 13, 46
117 Esomeprazole
(Synonym: Apo-esomeprazole)		[3] Esomeprazole; Nexium; Omeprazole[1] D07917 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[8] 13, 46, 86, 98, 107, 113, 298, 299
118 Ethanol
(Synonym: Applelicious)		[3] Alcohol; Ethanol; PREDNISONE[1] D06542 --[5] 58, 97, 279, 280, 298
119 Ethinylestradiol
(Synonym: Apri 28)		[3] Ethinyl estradiol; ETHINYLESTRADIOL; Ortho-Novum 777[1] D00554 [1] ESR1 💬[9] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[4] 13, 46, 49, 299
120 Etidronic acid
(Synonym: Apo-etidronate)		[1] Etidronate[1] D02373 --[1] 27
121 Ezetimibe
(Synonym: Apo-ezetimibe)		[2] Ezetimibe; Ezetrol[1] D01966 [1] NPC1L1 💬[1] Fat digestion and absorption 💬[4] 49, 79, 93, 260
122 Factor IX Complex (Human)
(Synonym: APCC)		[1] Prothrombin Complex Concentrate---[1] 288
123 Famciclovir
(Synonym: Apo-famciclovir)		[1] Famciclovir[1] D00317 --[2] 11, 13
124 Famotidine
(Synonym: Apo-famotidine Tab 40mg USP)		[2] FAMOTIDINA; Famotidine[1] D00318 [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[6] 6, 46, 61, 86, 98, 107
125 Fentanyl
(Synonym: Apo-fentanyl Matrix)		[1] Fentanyl[1] D00320 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[3] 46, 70, 215
126 Fesoterodine
(Synonym: Apo-fesoterodine)		[1] Fesoterodine[1] D07226 [2] CHRM2,
CHRM3 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 6
127 Finasteride
(Synonym: Apo-finasteride)		[1] Finasteride[1] D00321 [1] SRD5A2 💬[3] Metabolic pathways, Prostate cancer, Steroid hormone biosynthesis 💬[1] 6
128 Fingolimod
(Synonym: Apo-fingolimod)		[3] Fingolimod; FINGOLIMOD HYDROCHLORIDE; Gilenya[1] D10001 [1] S1PR1 💬[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 14, 156
129 Flavoxate
(Synonym: Apo-flavoxate)		[1] Flavoxate[1] D07961 [16] PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		[18] Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 226
130 Flecainide
(Synonym: Apo-flecainide)		[3] Flecainide; FLECAINIDE ACETATE; Flecainidum[1] D07962 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 6
131 Fluconazole
(Synonym: Apo-fluconazole-150)		[2] Diflucan; FLUCONAZOLE[1] D00322 --[2] 96, 225
132 Fluoxetine
(Synonym: Apo-fluoxetine)		[5] Fluoxetin; FLUOXETINE; FLUOXETINE HYDROCHLORIDE; Fluoxétine; PROZAC[1] D00326 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[6] 13, 17, 78, 86, 179, 206
133 Fluticasone propionate
(Synonym: Apo-fluticasone HFA)		[3] Flovent; Fluticasone; Fluticasone propionate[1] D01708 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[2] 98, 228
134 Fulvestrant
(Synonym: Apo-fulvestrant)		[2] Faslodex; Fulvestrant[1] D01161 [2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[2] 49, 86
135 Furosemide
(Synonym: Apo-furosemide)		[2] Furosemide; Furosemide Injection[1] D00331 [1] SLC12A2 💬[3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬[2] 6, 86
136 Gabapentin
(Synonym: Apo-gabapentin)		[4] Gabapentin; GABAPENTINA; Gabapentine; NEURONTIN[1] D00332 [5] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		[9] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[5] 6, 13, 19, 70, 298
137 Galantamine
(Synonym: Apo-galantamine)		[2] GALANTAMINE; Galantamine hydrobromide[1] D04292 [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[2] 6, 127
138 Gefitinib
(Synonym: Apo-gefitinib)		[1] Gefitinib[1] D01977 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 75
139 Glycerin
(Synonym: Pure Hydrogel Apple Zone)		[2] Bee venom; Glycerol[1] D00028 --[5] 6, 13, 79, 316, 317
140 Guanfacine
(Synonym: Apo-guanfacine XR)		[1] Guanfacine[1] D08031 [1] ADRA2A 💬[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 193
141 Haloperidol
(Synonym: Apo-haloperidol Tab 2mg)		[1] Haloperidol[1] D00136 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 8
142 Hydralazine
(Synonym: Ser-Ap-Es)		[1] Hydralazine[1] D08044 [1] AOC3 💬[5] Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism 💬[1] 67
143 Hydrochlorothiazide
(Synonym: Apo-cilazapril/hctz)		[2] Esidrix; Hydrochlorothiazide[1] D00340 [1] SLC12A3 💬-[4] 13, 67, 225, 235
144 Hydrocortisone
(Synonym: Apres Peel Soothing Balm)		[6] Cortef; Cortisol; Cortisone; Hydrocortisone; Hydrocortisone cream; Hydrocortisonum[1] D00088 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[10] 6, 41, 46, 53, 75, 78, 81, 83, 97, 299
145 Hydromorphone
(Synonym: Apo-hydromorphone)		[1] Hydromorphone[1] D08047 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
146 Hydroxychloroquine
(Synonym: Apo-hydroxyquine)		[3] Hydroxychloroquine; HYDROXYCHLOROQUINE SULFATE; PLAQUENIL[1] D08050 --[27] 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299
147 Hydroxyurea
(Synonym: Apo-hydroxyurea)		[1] Hydroxyurea[1] D00341 [1] RRM2 💬[7] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[8] 3, 13, 19, 20, 65, 85, 86, 284
148 Ibuprofen
(Synonym: Apo-ibuprofen Caplet)		[2] Ibuprofen; IBUPROFEN 200MG[1] D00126 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
149 Imatinib
(Synonym: Apo-imatinib)		[4] Gleevec; GLIVEC; Imatinib; IMATINIB MESYLATE[1] D08066 [3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
150 Imiquimod
(Synonym: Apo-imiquimod)		[1] Imiquimod[1] D02500 [1] TLR7 💬[5] Coronavirus disease - COVID-19, Influenza A, Measles, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway 💬[2] 34, 51
151 Indapamide
(Synonym: Apo-perindopril-indapamide)		[1] Indapamide[1] D00345 [1] SLC12A3 💬-[1] 13
152 Indomethacin
(Synonym: Apo Indomethacin Cap 50mg)		[2] INDOMETACIN; Indomethacin[1] D00141 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
153 Ipratropium
(Synonym: Apo-ipravent Sterules)		[1] Ipratropium---[2] 6, 86
154 Irbesartan
(Synonym: Aprovel)		[2] Aprovel; IRBESARTAN[1] D00523 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222
155 Ketoconazole
(Synonym: Apo-ketoconazole)		[2] KETOCONAZOLE; NIZORAL[1] D00351 [1] CYP17A1 💬[6] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis 💬[3] 8, 13, 75
156 Ketorolac
(Synonym: Apo-ketorolac Injectable)		[2] Ketorolac; Ketorolac Tromethamine[1] D08104 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[2] 70, 226
157 Lacosamide
(Synonym: Apo-lacosamide)		[1] Lacosamide[1] D07299 [2] SCN3A,
SCN9A 💬		[1] Taste transduction 💬[4] 2, 46, 149, 298
158 Lamivudine
(Synonym: Apo-lamivudine Hbv)		[4] COMBIVIR; Epivir; Lamivudine; Triumeq[1] D00353 --[8] 2, 26, 42, 46, 135, 256, 265, 325
159 Lamotrigine
(Synonym: Apo-lamotrigine)		[2] Lamictal; Lamotrigine[1] D00354 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[5] 13, 34, 38, 114, 144
160 Lansoprazole
(Synonym: Apo-lansoprazole)		[1] Lansoprazole[1] D00355 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[7] 63, 71, 85, 98, 166, 222, 299
161 Leflunomide
(Synonym: Apo-leflunomide)		[3] ARAVA; Leflunomide; Leflunomidum[1] D00749 [1] DHODH 💬[3] Biosynthesis of cofactors, Metabolic pathways, Pyrimidine metabolism 💬[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
162 Lenalidomide
(Synonym: Apo-lenalidomide)		[2] Lenalidomide; REVLIMID[1] D04687 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[8] 16, 26, 28, 34, 49, 284, 300, 331
163 Letrozole
(Synonym: Apo-letrozole)		[1] Letrozole[1] D00964 [1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[2] 81, 89
164 Levetiracetam
(Synonym: Apo-levetiracetam)		[2] KEPPRA; Levetiracetam[1] D00709 [1] SV2A 💬[1] ECM-receptor interaction 💬[5] 2, 4, 6, 13, 307
165 Levodopa
(Synonym: Apo-levocarb - Tab 10mg/100mg)		[9] Carbidopa-Levodopa; DUODOPA; Inbrija; L-DOPA; Levodopa; PARCOPA; SINEMET; SINEMET CR; Stalevo[1] D00059 [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[6] 6, 17, 90, 140, 164, 201
166 Levofloxacin
(Synonym: Apo-levofloxacin)		[2] Levaquin; Levofloxacin[2] D00588 ,
D08120 		--[5] 46, 53, 84, 85, 299
167 Lidocaine
(Synonym: Apicaine-X)		[4] Aloe; Lidocaine; Lignocaine; Xylocaine[2] D00358 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
168 Linezolid
(Synonym: Apo-linezolid)		[1] LINEZOLID[1] D00947 --[1] 299
169 Lisinopril
(Synonym: Apo-lisinopril/hctz)		[2] Lisinopril; Zestril[2] D00362 ,
D08131 		[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222
170 Lithium carbonate
(Synonym: Apo-lithium Carbonate)		[2] Lithium; LITHIUM CARBONATE[1] D00801 --[5] 2, 13, 17, 18, 127
171 Loperamide
(Synonym: Apo-loperamide)		[2] LOPERAMIDE; Loperamide hydrochloride[1] D08144 [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 13, 97
172 Loratadine
(Synonym: Apo-loratadine)		[2] Loratadina; Loratadine[1] D00364 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 46, 89, 98
173 Lorazepam
(Synonym: Apo-lorazepam Tab 2mg)		[1] Lorazepam[1] D00365 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 36
174 Losartan
(Synonym: Apo-losartan/hctz)		[3] Cozaar; Losartan; LOSARTAN POTASSIUM[1] D08146 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
175 Magnesium oxide
(Synonym: C-apnto-B6 Vitamins W Magnesium Tab)		[1] Magnesium oxide[1] D01167 --[3] 6, 166, 291
176 Medroxyprogesterone acetate
(Synonym: Apo-medroxy)		[1] Medroxyprogesterone[1] D00951 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[8] 13, 35, 46, 49, 50, 51, 60, 107
177 Megestrol acetate
(Synonym: Apo-megestrol)		[1] Megestrol acetate[1] D00952 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 76
178 Meloxicam
(Synonym: Apo-meloxicam)		[1] Meloxicam[1] D00969 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[4] 46, 49, 271, 296
179 Memantine
(Synonym: Apo-memantine)		[3] Ebixa; Memantine; Memantine hydrochloride[1] D08174 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 6, 8, 13, 49, 127, 205, 206
180 Mesalazine
(Synonym: Apriso)		[10] 5-AminoSalicylic Acid; 5-ASA; ASACOL; Mesalamine; MESALAZINA; MESALAZINE; Mesalazinum; MEZAVANT; Pentasa; Salofalk[1] D00377 (Name: Apriso (TN))--[5] 46, 96, 97, 98, 164
181 Metformin
(Synonym: Appformin)		[5] Metformin; Metformin HCl; Metformin Hydrochloride; METFORMINA; Metformine[1] D04966 [2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
182 Methimazole
(Synonym: Apo-methimazole)		[1] Methimazole[1] D00401 [1] TPO 💬[4] Autoimmune thyroid disease, Metabolic pathways, Thyroid hormone synthesis, Tyrosine metabolism 💬[1] 50
183 Methotrexate
(Synonym: Apo-methotrexate)		[6] Methotrexat; Methotrexate; METHOTREXATE SODIUM; Metoject; METOTREXATO; Méthotrexate[1] D00142 [2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
184 Methylphenidate
(Synonym: Apo-methylphenidate ER)		[3] Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin[1] D04999 [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
185 Metoclopramide
(Synonym: Apo-metoclop Tab 5mg)		[1] METOCLOPRAMIDE[1] D00726 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 46, 51
186 Metoprolol
(Synonym: Apo-metoprolol)		[2] Metoprolol; METOPROLOL SUCCINATE[1] D02358 [1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226
187 Metronidazole
(Synonym: Apo-metronidazole)		[3] Flagyl; Metronidazol; METRONIDAZOLE[1] D00409 --[7] 46, 51, 63, 94, 96, 97, 291
188 Midazolam
(Synonym: Apo-midazolam Injectable 1 mg/ml)		[2] Midazolam; Midazolam injection[1] D00550 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299
189 Midodrine
(Synonym: Apo-midodrine)		[2] Midodrine; MIDODRINE HYDROCHLORIDE[1] D08220 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[3] 6, 17, 58
190 Milrinone
(Synonym: Apo-milrinone Injectable)		[1] Milrinone[1] D00417 [2] PDE3A,
PDE3B 💬		[11] Apelin signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 294
191 Mineral oil
(Synonym: Apj Hemorrhoidal)		[1] Paraffin Oil[1] D05042 --[1] 291
192 Minoxidil
(Synonym: Apo-gain Liq 20mg/ml)		[1] MINOXIDIL[1] D00418 [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[1] 179
193 Modafinil
(Synonym: Apo-modafinil)		[2] Modafinil; Provigil[1] D01832 --[5] 6, 13, 49, 93, 113
194 Mometasone furoate
(Synonym: Apo-mometasone)		[3] Mometasone; MOMETASONE FUROATE; Nasonex[1] D00690 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[2] 98, 162
195 Montelukast
(Synonym: Apo-montelukast Sodium Chewable)		[3] Montelukast; MONTELUKAST SODIUM; Singulair[1] D08229 [1] CYSLTR1 💬[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction 💬[8] 6, 13, 46, 61, 63, 85, 98, 228
196 Moxifloxacin
(Synonym: Apo-moxifloxacin)		[2] Moxifloxacin; Moxifloxacin hydrochloride[1] D08237 --[9] 2, 6, 46, 49, 85, 86, 113, 240, 299
197 Mycophenolate mofetil
(Synonym: Apo-mycophenolate Mofetil)		[3] CELLCEPT; Mycophenolate Mofetil; Mycophenolate mofetil TEVA[1] D00752 [2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
198 Mycophenolic acid
(Synonym: Apo-mycophenolic Acid)		[5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; Mycophenolic acid; Myfortic[1] D05096 [2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
199 Nabilone
(Synonym: Apo-nabilone)		[1] NABILONE[1] D05099 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[3] 6, 13, 127
200 Nadolol
(Synonym: Apo-nadolol)		[1] Nadolol[1] D00432 [2] ADRB1,
ADRB2 💬		[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
201 Naltrexone
(Synonym: Apo-naltrexone)		[2] Naltrexone; Naltrexone hydrochloride[1] D05113 [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
202 Naproxen
(Synonym: Apo-naproxen)		[5] Naprosyn; NAPROXEN; Naproxen oral suspension; NAPROXEN SODIUM; Propanoic acid[1] D00118 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[4] 13, 46, 107, 271
203 Nebivolol
(Synonym: Apo-nebivolol)		[1] Nebivolol[1] D05127 [1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 17, 85, 113, 167
204 Neomycin
(Synonym: Antibiotic Application)		[1] Neomycin[1] D08260 --[3] 96, 97, 296
205 Nevirapine
(Synonym: Apo-zidovudine-lamivudine-nevirapine)		[1] Nevirapine[1] D00435 --[1] 265
206 Nicotinamide
(Synonym: Aplin Spot All Kill)		[3] Multivitamin; Niacinamide; NICOTINAMIDE[1] D00036 --[10] 2, 5, 6, 18, 49, 67, 97, 107, 162, 191
207 Nifedipine
(Synonym: Apo-nifed Pa)		[1] Nifedipine[1] D00437 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 50, 81
208 Nitroglycerin
(Synonym: Apo-nitroglycerin)		[2] Nitroglycerin; Nitroglycerine[1] D00515 --[2] 46, 51
209 Nortriptyline
(Synonym: Apo-nortriptyline - Cap 10mg)		[2] Nortriptyline; Nortriptyline hydrochloride[1] D08288 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 226
210 Olanzapine
(Synonym: Olanzapine Apotex)		[2] Olanzapine; Zyprexa[1] D00454 [11] ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2A,
HTR2B,
HTR2C,
HTR6 💬		[16] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 8
211 Olive oil
(Synonym: Rhodd Ato Repair Body So Ap)		[1] Olive oil[1] D03311 --[5] 13, 35, 49, 53, 162
212 Omeprazole
(Synonym: Apo-omeprazole)		[4] Losec; Omeprazol; Omeprazole; OMEPRAZOLE MAGNESIUM[1] D00455 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
213 Ondansetron
(Synonym: Apo-ondansetron)		[1] Ondansetron[1] D00456 [5] HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E 💬		[2] Serotonergic synapse, Taste transduction 💬[3] 6, 97, 107
214 Oxcarbazepine
(Synonym: Apo-oxcarbazepine)		[2] Oxcarbazepine; Trileptal[1] D00533 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 13
215 Oxybutynin
(Synonym: Apo-oxybutynin)		[1] Oxybutynin[1] D00465 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
216 Oxycodone
(Synonym: Oxycodone/APAP)		[2] Oxycodone; OXYCODONE HYDROCHLORIDE[1] D05312 [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 13, 70, 226, 298
217 Paclitaxel
(Synonym: Apo-paclitaxel Injectable)		[1] Paclitaxel[1] D00491 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[2] 46, 85
218 Pantoprazole
(Synonym: Apo-pantoprazole)		[1] PANTOPRAZOLE[1] D05353 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 13, 65
219 Paroxetine
(Synonym: Apo-paroxetine)		[1] Paroxetine[1] D02362 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
220 Pectin
(Synonym: SMITH BROS WARM APPLE PIE WITH CINNAMON FLAVOR Warming Throat)		[1] Pectin[1] D02316 --[1] 96
221 Pegfilgrastim
(Synonym: pegfilgrastim-apgf)		[1] Pegfilgrastim[1] D06889 [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[1] 60
222 Perindopril
(Synonym: Apo-perindopril)		[2] Coversyl; Perindopril[1] D03753 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 58, 113, 167, 222
223 Petrolatum
(Synonym: Apj Hemorrhoidal)		[1] Petrolatum[1] D05331 --[1] 158
224 Phenoxymethylpenicillin
(Synonym: Apo Pen Vk)		[0] [1] D05411 --[1] 97
225 Phenylephrine
(Synonym: Apj Hemorrhoidal)		[1] Phenylephrine[1] D08365 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 22
226 Pioglitazone
(Synonym: Apo-pioglitazone)		[1] Pioglitazone[1] D08378 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
227 Posaconazole
(Synonym: Apo-posaconazole)		[2] Noxafil; POSACONAZOLE[1] D02555 --[3] 60, 65, 299
228 Pramipexole
(Synonym: Apo-pramipexole)		[7] Mirapex; Mirapex ER; Mirapexin; Pramipexol; Pramipexole; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL[1] D05575 [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 20
229 Pravastatin
(Synonym: Apo-pravastatin)		[2] Pravastatin; Pravastatin sodium[1] D08410 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[9] 13, 46, 49, 67, 79, 96, 164, 265, 333
230 Prednisone
(Synonym: Apo Prednisone Tab 50mg)		[3] Prednisona; Prednisone; RAYOS[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
231 Pregabalin
(Synonym: Apo-pregabalin Capsules)		[2] Lyrica; Pregabalin[1] D02716 [4] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[5] 13, 36, 46, 70, 298
232 Propranolol
(Synonym: Apo-propranolol)		[2] Propanolol; Propranolol[1] D08443 [3] ADRB1,
ADRB2,
ADRB3 💬		[12] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 158, 167, 227, 278, 296
233 Prucalopride
(Synonym: Apo-prucalopride)		[2] PRUCALOPRIDE; Resolor[1] D09205 [1] HTR4 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, cAMP signaling pathway 💬[3] 13, 51, 96
234 Pseudoephedrine
(Synonym: Aprodine)		[1] Pseudoephedrine[1] D08449 [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 17
235 Pyridoxine
(Synonym: C-apnto-B6 Vitamins W Magnesium Tab)		[2] PYRIDOXINE; Vitamin B6[1] D08454 --[5] 6, 93, 145, 206, 320
236 Quetiapine
(Synonym: Apo-quetiapine XR)		[2] Quetiapine; Seroquel[1] D08456 [2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[2] 6, 13
237 Quinapril
(Synonym: Apo-quinapril/hctz)		[1] Accuretic[1] D03752 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 19
238 Quinidine
(Synonym: Apo-quin-G Tab 325mg)		[4] Nuedexta; Quinidina; Quinidine; Quinidine Sulfate[1] D08458 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 2, 8, 13
239 Quinine
(Synonym: Apo-quinine)		[0] [2] D08460 ,
D08461 		--[1] 6
240 Rabeprazole
(Synonym: Apo-rabeprazole)		[1] Rabeprazole[1] D08463 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 2, 51
241 Raloxifene
(Synonym: Apo-raloxifene)		[2] Raloxifene; Raloxifene hydrochloride[1] D08465 [2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 46
242 Ramipril
(Synonym: Apo-ramipril/hctz)		[1] RAMIPRIL[1] D00421 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 46, 49, 66, 67, 113, 218, 257
243 Ranitidine
(Synonym: Apo-ranitidine Tablet 300mg)		[1] Ranitidine[1] D00422 [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[2] 13, 65
244 Rasagiline
(Synonym: Apo-rasagiline)		[4] Azilect; Rasagilina; Rasagiline; RASAGILINE MESYLATE[2] D08469 ,
D10829 		[1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[6] 2, 5, 6, 17, 58, 66
245 Repaglinide
(Synonym: Apo-repaglinide)		[1] Repaglinide[1] D00594 [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[4] 6, 21, 46, 299
246 Riboflavin
(Synonym: Appedrine)		[2] Riboflavin; Vitamin B2[1] D00050 --[7] 38, 46, 96, 97, 162, 168, 265
247 Riluzole
(Synonym: Apo-riluzole)		[2] RILUTEK; Riluzole[1] D00775 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[9] 2, 3, 5, 8, 13, 17, 18, 203, 206
248 Risedronic acid
(Synonym: Apo-risedronate)		[3] Risedronate; Risedronate sodium; Risedronic acid[1] D08484 [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[9] 46, 50, 66, 93, 95, 96, 107, 113, 274
249 Risperidone
(Synonym: Apo-risperidone)		[1] Risperidone[1] D00426 [2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[5] 8, 156, 179, 187, 206
250 Rivastigmine
(Synonym: Apo-rivastigmine)		[3] Exelon; Rivastigmine; Rivastigmine Transdermal System[1] D03822 [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[3] 5, 6, 13
251 Ropinirole
(Synonym: Apo-ropinirole)		[3] REQUIP; ROPINIROLE; Ropinirole Hydrochloride[1] D08489 [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 2, 6, 74, 309
252 Rosuvastatin
(Synonym: Apo-rosuvastatin)		[3] Crestor; Rosuvastatin; ROSUVASTATIN CALCIUM[1] D08492 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
253 Royal jelly
(Synonym: Apis Mellifera Secretion)		[1] Royal jelly[1] D09754 --[1] 49
254 Salbutamol
(Synonym: Apo-salvent-ipravent Sterules)		[3] Albuterol; Salbutamol; Ventolin[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299
255 Salicylic acid
(Synonym: Medicated Apricot Scrub)		[2] 2-Hydroxybenzoic acid; Salicylic acid[1] D00097 --[1] 97
256 Saxagliptin
(Synonym: Apo-saxagliptin)		[1] Saxagliptin[1] D08996 [1] DPP4 💬[1] Protein digestion and absorption 💬[1] 299
257 Sertraline
(Synonym: Apo-sertraline)		[1] Sertraline[1] D02360 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 206
258 Sildenafil
(Synonym: Apo-sildenafil)		[6] Mysildecard; Revatio; Sildenafil; Sildenafil citrate; SILDENAFILO; VIAGRA[1] D08514 (Name: Aphrodil (TN))[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
259 Silodosin
(Synonym: Apo-silodosin)		[2] Silodosin; Silodyx[1] D01965 [1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 6, 13
260 Simvastatin
(Synonym: Apo-simvastatin)		[3] Simvastatin; Simvastatina; Simvastatine[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
261 Sitagliptin
(Synonym: Apo-sitagliptin)		[1] Sitagliptin[1] D08516 [1] DPP4 💬[1] Protein digestion and absorption 💬[4] 6, 75, 233, 299
262 Sodium bicarbonate
(Synonym: Not Applicable)		[1] Sodium Bicarbonate[1] D01203 --[1] 299
263 Sodium chloride
(Synonym: SUEROLYTE Oral Electrolyte Solution Apple Flavor)		[6] Lactated Ringers; Natriumchlorid; REBIF; Saline; Sodium Chloride; Sporanox[1] D02056 --[20] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 168, 193, 227, 228, 288, 299
264 Sodium fluoride
(Synonym: Scotts Select APF Foam Fluoride)		[1] Sodium fluoride[1] D00943 --[1] 51
265 Solifenacin
(Synonym: Apo-solifenacin)		[2] Solifenacin; Solifenacin Succinate[1] D08522 [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[3] 6, 13, 53
266 Sorafenib
(Synonym: Apo-sorafenib)		[2] Nexavar; Sorafenib[1] D08524 [8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬		[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86
267 Spironolactone
(Synonym: Apo-spirozide Tab)		[1] Spironolactone[1] D00443 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225
268 Streptococcus pneumoniae type 1 capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
269 Streptococcus pneumoniae type 10a capsular polysaccharide antigen
(Synonym: Apexxnar)		[1] Pneumovax 23---[2] 46, 50
270 Streptococcus pneumoniae type 11a capsular polysaccharide antigen
(Synonym: Apexxnar)		[1] Pneumovax 23---[2] 46, 50
271 Streptococcus pneumoniae type 12f capsular polysaccharide antigen
(Synonym: Apexxnar)		[1] Pneumovax 23---[2] 46, 50
272 Streptococcus pneumoniae type 14 capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
273 Streptococcus pneumoniae type 15b capsular polysaccharide antigen
(Synonym: Apexxnar)		[1] Pneumovax 23---[2] 46, 50
274 Streptococcus pneumoniae type 18c capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
275 Streptococcus pneumoniae type 19a capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
276 Streptococcus pneumoniae type 19f capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
277 Streptococcus pneumoniae type 23f capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
278 Streptococcus pneumoniae type 4 capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
279 Streptococcus pneumoniae type 5 capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
280 Streptococcus pneumoniae type 6b capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
281 Streptococcus pneumoniae type 7f capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
282 Streptococcus pneumoniae type 8 capsular polysaccharide antigen
(Synonym: Apexxnar)		[1] Pneumovax 23---[2] 46, 50
283 Streptococcus pneumoniae type 9v capsular polysaccharide antigen
(Synonym: Apexxnar)		[2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
284 Sucralfate
(Synonym: Apo-sucralfate - Tab 1g)		[1] Sucralfate[1] D00446 --[1] 98
285 Sulfamethoxazole
(Synonym: Apo Sulfamethoxazole Tab 500mg)		[3] Bactrim; Sulfamethoxazole; Sulphamethoxazole[1] D00447 --[5] 44, 49, 61, 85, 299
286 Sulfasalazine
(Synonym: Apo Sulfasalazine Tab 500mg)		[3] Salazosulfapyridine; Salicylazosulfapyridine; SULFASALAZINE[1] D00448 --[6] 46, 86, 94, 107, 270, 271
287 Sulindac
(Synonym: Apo-sulin Tab 150mg)		[1] Sulindac[1] D00120 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206
288 Tacrolimus
(Synonym: Apo-tacrolimus)		[2] Prograf; TACROLIMUS[2] D00107 ,
D08556 		[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
289 Tadalafil
(Synonym: Apo-tadalafil)		[4] Adcirca; Cialis; Tadalafil; TADALAFILO[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210
290 Tamoxifen
(Synonym: Apo-tamox Tab 10mg)		[2] Tamoxifen; TAMOXIFEN CITRATE[1] D08559 [2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[3] 2, 113, 227
291 Tamsulosin
(Synonym: Apo-tamsulosin CR)		[1] Tamsulosin[1] D08560 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 13
292 Telmisartan
(Synonym: Apo-telmisartan)		[1] Telmisartan[1] D00627 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 66, 67
293 Temozolomide
(Synonym: Apo-temozolomide)		[1] Temozolomide[1] D06067 --[1] 34
294 Tenofovir disoproxil
(Synonym: Apo-tenofovir)		[4] Tenofovir; Tenofovir disoproxil; Tenofovir Disoproxil Fumarate; TRUVADA---[2] 93, 265
295 Terazosin
(Synonym: Apo-terazosin)		[1] Terazosin[1] D08569 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 6
296 Terbinafine
(Synonym: Apo-terbinafine)		[1] Terbinafine[1] D02375 --[3] 96, 97, 271
297 Teriflunomide
(Synonym: Apo-teriflunomide)		[2] AUBAGIO; Teriflunomide[1] D10172 [1] DHODH 💬[3] Biosynthesis of cofactors, Metabolic pathways, Pyrimidine metabolism 💬[3] 13, 25, 26
298 Teriparatide
(Synonym: Apo-teriparatide Injection)		[4] Forsteo; Forteo; PTH 1-34; Teriparatide[1] D06078 [1] PTH1R 💬[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[7] 46, 65, 68, 70, 71, 235, 274
299 Tetrabenazine
(Synonym: Apo-tetrabenazine)		[2] Tetrabenazine; Xenazine[1] D08575 [1] SLC18A2 💬[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8
300 Tetracycline
(Synonym: APT T3X Tetracycline Hydrochloride First Aid Antibiotic)		[2] Tetracyclin; Tetracycline[1] D00201 --[5] 13, 36, 46, 53, 97
301 Theophylline
(Synonym: Apo-theo ER)		[1] Theophylline[2] D00371 ,
D06103 		[18] ADORA1,
ADORA2B,
PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		[23] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 236, 299
302 Thiamine
(Synonym: Appedrine)		[2] Thiamine; Vitamin B1[1] D08580 --[4] 8, 93, 145, 265
303 Ticagrelor
(Synonym: Apo-ticagrelor)		[1] Ticagrelor[1] D09017 [1] P2RY12 💬[1] Platelet activation 💬[3] 36, 46, 85
304 Timolol
(Synonym: Apo-timop)		[2] Timolol; TIMOLOL MALEATE[2] D00378 ,
D08600 		[2] ADRB1,
ADRB2 💬		[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 157, 227
305 Tipranavir
(Synonym: Aptivus)		[1] Tipranavir[1] D08605 (Name: Aptivus (TN))--[1] 265
306 Tobramycin
(Synonym: Apo-tobramycin)		[9] Bethkis; TOBI; TOBI PODHALER; TOBRAMICINA; TOBRAMYCIN; Tobramycin inhalation solution; TOBRAMYCIN SULFATE; Tobramycine; Tobramycinum[1] D00063 --[1] 299
307 Tolterodine
(Synonym: Apo-tolterodine)		[1] Tolterodine[1] D00646 [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 17, 53
308 Topiramate
(Synonym: Apo-topiramate)		[2] TOPAMAX; Topiramate[1] D00537 [36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 97, 140, 144, 156, 193
309 Tramadol
(Synonym: Apo-tramadol/acet)		[2] Tramadol; Ultracet[1] D08623 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 46, 70, 78, 226, 271
310 Trazodone
(Synonym: Apo-trazodone D Tablets 150mg)		[1] Trazodone[1] D08626 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 2
311 Triamcinolone
(Synonym: Apo-triamcinolone AQ)		[4] Kenalog; Naltrexone; Triamcinolone; TRIAMCINOLONE ACETONIDE[1] D00385 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[11] 35, 46, 53, 56, 70, 90, 96, 107, 162, 226, 298
312 Trifluoperazine [1] Trifluoperazine[2] D01448 ,
D08636 (Name: Apo-trifluoperazine (TN))		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 283, 284
313 Trihexyphenidyl
(Synonym: Aparkane Tab 2mg)		[1] Trihexyphenidyl[1] D08638 (Name: Apo-trihex (TN))[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6
314 Trimethoprim
(Synonym: Apo-sulfatrim Oral Suspension)		[2] Bactrim; TRIMETHOPRIM[1] D00145 --[8] 36, 44, 49, 60, 61, 85, 298, 299
315 Tryptophan
(Synonym: Apo-tryptophan)		[2] Propanoic acid; Tryptophan[1] D00020 --[2] 6, 75
316 Tyrosine
(Synonym: Appbutamone)		[4] Alanine; L-tyrosine; Propanoic acid; Tyrosine[1] D00022 --[5] 6, 75, 86, 111, 298
317 Urea
(Synonym: Not Applicable)		[1] Urea[2] D00023 ,
D01749 		--[2] 72, 251
318 Valaciclovir
(Synonym: Apo-valacyclovir)		[1] Valacyclovir[2] D08664 ,
D10518 		--[1] 65
319 Valganciclovir
(Synonym: Apo-valganciclovir)		[1] Valganciclovir[1] D02495 --[4] 85, 97, 299, 331
320 Valproic acid
(Synonym: Apo-valproic Acid Oral Solution)		[3] Valproate; VALPROATE SODIUM; Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
321 Valsartan
(Synonym: Apo-valsartan/hctz)		[3] Diovan; Entresto; Valsartan[1] D00400 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 57, 58, 66, 75, 218, 222, 224
322 Vardenafil
(Synonym: Apo-vardenafil)		[3] Levitra; Vardenafil; Vardenafilo[1] D08668 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 13, 86, 299
323 Varenicline
(Synonym: Apo-varenicline)		[2] Champix; Varenicline[1] D08669 [2] CHRNA4,
CHRNB2 💬		[4] Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction 💬[3] 6, 18, 53
324 Venlafaxine
(Synonym: Apo-venlafaxine XR)		[2] Venlafaxine; VENLAFAXINE HYDROCHLORIDE[1] D08670 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 13, 46
325 Verapamil
(Synonym: Apo-verap Tablet 120mg)		[3] Verapamil; VERAPAMIL HYDROCHLORIDE; Verapamil SR[1] D02356 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 96, 140, 167
326 Vitamin A
(Synonym: Appedrine)		[1] Vitamin A[1] D06543 [2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[3] 13, 53, 90
327 Vitamin D
(Synonym: Appedrine)		[3] Calciferol; Cod liver oil; Vitamin D---[20] 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 179, 222, 228, 235, 274, 298, 299
328 Voriconazole
(Synonym: Apo-voriconazole)		[2] Vfend; VORICONAZOLE[1] D00578 --[2] 60, 299
329 Warfarin
(Synonym: Apo-warfarin)		[2] Warfarin; Warfarin Sodium[1] D08682 [2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
330 Zidovudine
(Synonym: Apo-zidovudine)		[3] COMBIVIR; Retrovir; Zidovudine[1] D00413 --[7] 25, 26, 94, 135, 265, 325, 331
331 Zinc
(Synonym: SUEROLYTE Oral Electrolyte Solution Apple Flavor)		[3] Nicotinamide; Wilzin; Zinc---[4] 2, 113, 171, 299
332 Zinc oxide
(Synonym: Lbel Clarite Makeup Foundation for A Clearer Appearance SPF 30 110-C)		[1] Zinc oxide[1] D01170 --[1] 156
333 Zolmitriptan
(Synonym: Apo-zolmitriptan Rapid)		[1] Zolmitriptan[1] D00415 [2] HTR1B,
HTR1D 💬		[4] Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[1] 6
334 Zolpidem
(Synonym: Apo-zolpidem ODT)		[2] Zolpidem; Zolpidem Tartrate[1] D08690 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46
335 Zopiclone
(Synonym: Apo-zopiclone)		[1] Zopiclone[1] D01372 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 6