Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Alanine, aspartate and glutamate metabolism 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Aldosterone synthesis and secretion 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

beta-Alanine metabolism 💬

[3] ABAT, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Butanoate metabolism 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Calcium signaling pathway 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Circadian entrainment 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Cortisol synthesis and secretion 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Cushing syndrome 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

GABAergic synapse 💬

[3] ABAT, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

GnRH secretion 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

MAPK signaling pathway 💬

[3] CACNA1G, CACNA1H, CACNA1I 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Metabolic pathways 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Propanoate metabolism 💬

[1] ABAT 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Taurine and hypotaurine metabolism 💬

[2] GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Type I diabetes mellitus 💬

[2] GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Type II diabetes mellitus 💬

[1] CACNA1G 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Valine, leucine and isoleucine degradation 💬

[1] ABAT 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;