Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cushing syndrome 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
2 Cushing syndrome 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
3 Cushing syndrome 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
4 Cushing syndrome 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬
5 Cushing syndrome 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
6 Cushing syndrome 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 Cushing syndrome 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
8 Cushing syndrome 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
9 Cushing syndrome 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
10 Cushing syndrome 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
11 Cushing syndrome 💬
 [1] BRAF 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
12 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
13 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
14 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
15 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
16 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
17 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
18 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
19 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
20 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
21 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
22 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
23 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Flunarizine 💬 Flunarizine [1] 149 💬
24 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
25 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
26 Cushing syndrome 💬
 [2] CDK4, CDK6 💬 Abemaciclib 💬 Abemaciclib [1] 34 💬
27 Cushing syndrome 💬
 [2] CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin [1] 75 💬
28 Cushing syndrome 💬
 [2] CRHR1, CRHR2 💬 Corticorelin ovine triflutate 💬 Corticorelin ovine triflutate [1] 75 💬
29 Cushing syndrome 💬
 [3] CYP11A1, CYP11B1, CYP17A1 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬
30 Cushing syndrome 💬
 [1] CYP11B1 💬 Metyrapone 💬 Metyrapone [1] 75 💬
31 Cushing syndrome 💬
 [1] CYP17A1 💬 Ketoconazole 💬 Ketoconazole [3]  8 , 13, 75 💬
32 Cushing syndrome 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
33 Cushing syndrome 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
34 Cushing syndrome 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
35 Cushing syndrome 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
36 Cushing syndrome 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
37 Cushing syndrome 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
38 Cushing syndrome 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
39 Cushing syndrome 💬
 [1] KCNA4 💬 Amifampridine 💬 Amifampridine [3]  3 , 11, 12 💬
40 Cushing syndrome 💬
 [1] KCNA4 💬 Dalfampridine 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
41 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
42 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
43 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
44 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
45 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
46 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
47 Cushing syndrome 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
48 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
49 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
50 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
51 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
52 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬