Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 JAK-STAT signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
2 JAK-STAT signaling pathway 💬
 [1] CSF2 💬 Otilimab 💬 Otilimab [1] 46 💬
3 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 Mavrilimumab 💬 Mavrilimumab [2] 41, 46 💬
4 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 Molgramostim 💬 Molgramostim [3] 97, 229, 299 💬
5 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 Regramostim 💬 Regramostim [1] 229 💬
6 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 Sargramostim 💬 Sargramostim [7]  6 , 28, 60, 62, 96, 229, 285 💬
7 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
8 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
9 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Pegfilgrastim 💬 Pegfilgrastim [1] 60 💬
10 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
11 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
12 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
13 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
14 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
15 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
16 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
17 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 Peginesatide 💬 Peginesatide [1] 283 💬
18 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
19 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
20 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
21 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
22 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
23 JAK-STAT signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
24 JAK-STAT signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
25 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab [3] 46, 49, 53 💬
26 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
27 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a [1] 56 💬
28 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b [2] 25, 34 💬
29 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
30 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b [1] 13 💬
31 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a [1] 13 💬
32 JAK-STAT signaling pathway 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬
33 JAK-STAT signaling pathway 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬
34 JAK-STAT signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
35 JAK-STAT signaling pathway 💬
 [2] IL10, IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
36 JAK-STAT signaling pathway 💬
 [1] IL11RA 💬 Oprelvekin 💬 Oprelvekin [2] 96, 288 💬
37 JAK-STAT signaling pathway 💬
 [3] IL12A, IL12B, IL23A 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
38 JAK-STAT signaling pathway 💬
 [1] IL13 💬 Anrukinzumab 💬 Anrukinzumab [1] 97 💬
39 JAK-STAT signaling pathway 💬
 [1] IL13 💬 Lebrikizumab 💬 Lebrikizumab [1] 85 💬
40 JAK-STAT signaling pathway 💬
 [1] IL13 💬 Tralokinumab 💬 Tralokinumab [2] 85, 97 💬
41 JAK-STAT signaling pathway 💬
 [1] IL20 💬 Fletikumab 💬 Fletikumab [1] 46 💬
42 JAK-STAT signaling pathway 💬
 [1] IL22 💬 Efmarodocokin alfa 💬 Efmarodocokin alfa [2] 96, 97 💬
43 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 Brazikumab 💬 Brazikumab [2] 96, 97 💬
44 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 Guselkumab 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
45 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 Mirikizumab 💬 Mirikizumab [3] 37, 96, 97 💬
46 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 Risankizumab 💬 Risankizumab [4] 37, 96, 97, 271 💬
47 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 Tildrakizumab 💬 Tildrakizumab [2] 162, 271 💬
48 JAK-STAT signaling pathway 💬
 [1] IL2RA 💬 Basiliximab 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
49 JAK-STAT signaling pathway 💬
 [1] IL2RA 💬 Daclizumab 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
50 JAK-STAT signaling pathway 💬
 [3] IL2RA, IL2RB, IL2RG 💬 Aldesleukin 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
51 JAK-STAT signaling pathway 💬
 [1] IL31RA 💬 Nemolizumab 💬 Nemolizumab [1] 51 💬
52 JAK-STAT signaling pathway 💬
 [1] IL4 💬 Binetrakin 💬 Binetrakin [1] 46 💬
53 JAK-STAT signaling pathway 💬
 [1] IL4R 💬 Dupilumab 💬 Dupilumab [5] 51, 97, 98, 160, 162 💬
54 JAK-STAT signaling pathway 💬
 [1] IL5 💬 Mepolizumab 💬 Mepolizumab [4] 44, 45, 98, 162 💬
55 JAK-STAT signaling pathway 💬
 [1] IL5 💬 Reslizumab 💬 Reslizumab [2] 44, 98 💬
56 JAK-STAT signaling pathway 💬
 [1] IL5RA 💬 Benralizumab 💬 Benralizumab [5] 44, 45, 98, 162, 299 💬
57 JAK-STAT signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
58 JAK-STAT signaling pathway 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
59 JAK-STAT signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
60 JAK-STAT signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
61 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
62 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [3] 11, 13, 86 💬
63 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
64 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬
65 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
66 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬
67 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
68 JAK-STAT signaling pathway 💬
 [2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
69 JAK-STAT signaling pathway 💬
 [2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
70 JAK-STAT signaling pathway 💬
 [3] JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib [1] 46 💬
71 JAK-STAT signaling pathway 💬
 [4] JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
72 JAK-STAT signaling pathway 💬
 [1] LEPR 💬 Metreleptin 💬 Metreleptin [1] 265 💬
73 JAK-STAT signaling pathway 💬
 [1] MPL 💬 Avatrombopag 💬 Avatrombopag [2] 60, 63 💬
74 JAK-STAT signaling pathway 💬
 [1] MPL 💬 Romiplostim 💬 Romiplostim [4] 60, 63, 64, 65 💬
75 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
76 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
77 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
78 JAK-STAT signaling pathway 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
79 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
80 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
81 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
82 JAK-STAT signaling pathway 💬
 [1] PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
83 JAK-STAT signaling pathway 💬
 [1] PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
84 JAK-STAT signaling pathway 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
85 JAK-STAT signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
86 JAK-STAT signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
87 JAK-STAT signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
88 JAK-STAT signaling pathway 💬
 [1] PRL 💬 Bromocriptine 💬 Bromocriptine [2]  6 , 74 💬
89 JAK-STAT signaling pathway 💬
 [1] PRL 💬 Cabergoline 💬 Cabergoline [3]  6 , 74, 75 💬
90 JAK-STAT signaling pathway 💬
 [1] PRL 💬 Terguride 💬 Terguride [2] 51, 86 💬
91 JAK-STAT signaling pathway 💬
 [1] TSLP 💬 Tezepelumab 💬 Tezepelumab [1] 98 💬
92 JAK-STAT signaling pathway 💬
 [1] TYK2 💬 Deucravacitinib 💬 Deucravacitinib [3] 49, 96, 97 💬