Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 MAPK signaling pathway 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
2 MAPK signaling pathway 💬
 [7] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
3 MAPK signaling pathway 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
4 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
5 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
6 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
7 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
8 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
9 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
10 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
11 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
12 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
13 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
14 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Flunarizine 💬 Flunarizine [1] 149 💬
15 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
16 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
17 MAPK signaling pathway 💬
 [2] CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin [1] 70 💬
18 MAPK signaling pathway 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
19 MAPK signaling pathway 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
20 MAPK signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
21 MAPK signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
22 MAPK signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
23 MAPK signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
24 MAPK signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
25 MAPK signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
26 MAPK signaling pathway 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
27 MAPK signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Neratinib 💬 Neratinib [1] 34 💬
28 MAPK signaling pathway 💬
 [4] EGFR, ERBB2, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
29 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
30 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
31 MAPK signaling pathway 💬
 [1] FGF23 💬 Burosumab 💬 Burosumab [1] 238 💬
32 MAPK signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
33 MAPK signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
34 MAPK signaling pathway 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [5] 13, 36, 38, 39, 65 💬
35 MAPK signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
36 MAPK signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
37 MAPK signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
38 MAPK signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
39 MAPK signaling pathway 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
40 MAPK signaling pathway 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
41 MAPK signaling pathway 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
42 MAPK signaling pathway 💬
 [3] IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
43 MAPK signaling pathway 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
44 MAPK signaling pathway 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
45 MAPK signaling pathway 💬
 [1] IL1R1 💬 Anakinra 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
46 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
47 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
48 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
49 MAPK signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
50 MAPK signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
51 MAPK signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
52 MAPK signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
53 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
54 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
55 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
56 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
57 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
58 MAPK signaling pathway 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
59 MAPK signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
60 MAPK signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
61 MAPK signaling pathway 💬
 [1] MAPT 💬 Flortaucipir F 18 💬 Flortaucipir [3]  5 ,  7 , 127 💬
62 MAPK signaling pathway 💬
 [1] MAPT 💬 Gosuranemab 💬 Gosuranemab [1]  5  💬
63 MAPK signaling pathway 💬
 [1] MAPT 💬 Hydromethylthionine mesylate 💬 Hydromethylthionine mesylate [1] 127 💬
64 MAPK signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
65 MAPK signaling pathway 💬
 [1] NGF 💬 Tanezumab 💬 Tanezumab [2] 226, 298 💬
66 MAPK signaling pathway 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [2] 53, 90 💬
67 MAPK signaling pathway 💬
 [3] PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
68 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
69 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
70 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
71 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
72 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
73 MAPK signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
74 MAPK signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
75 MAPK signaling pathway 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
76 MAPK signaling pathway 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
77 MAPK signaling pathway 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
78 MAPK signaling pathway 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
79 MAPK signaling pathway 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
80 MAPK signaling pathway 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
81 MAPK signaling pathway 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
82 MAPK signaling pathway 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
83 MAPK signaling pathway 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
84 MAPK signaling pathway 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
85 MAPK signaling pathway 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
86 MAPK signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
87 MAPK signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬