Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 PI3K-Akt signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
2 PI3K-Akt signaling pathway 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
3 PI3K-Akt signaling pathway 💬
 [1] CD19 💬 Inebilizumab 💬 Inebilizumab [4] 11, 13, 51, 300 💬
4 PI3K-Akt signaling pathway 💬
 [1] CD19 💬 Obexelimab 💬 Obexelimab [1] 300 💬
5 PI3K-Akt signaling pathway 💬
 [2] CDK4, CDK6 💬 Abemaciclib 💬 Abemaciclib [1] 34 💬
6 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Atropine 💬 Atropine [2]  2 , 299 💬
7 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Blarcamesine 💬 Blarcamesine [1] 156 💬
8 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
9 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Oxybutynin 💬 Oxybutynin [3]  6 , 13, 53 💬
10 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Propiverine 💬 Propiverine [1] 226 💬
11 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Scopolamine 💬 Scopolamine [1]  2  💬
12 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Trihexyphenidyl 💬 Trihexyphenidyl [2]  5 ,  6  💬
13 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Tropicamide 💬 Tropicamide [1]  6  💬
14 PI3K-Akt signaling pathway 💬
 [1] CHRM2 💬 Fesoterodine 💬 Fesoterodine [1]  6  💬
15 PI3K-Akt signaling pathway 💬
 [1] CHRM2 💬 Pilocarpine 💬 Pilocarpine [3]  6 , 53, 299 💬
16 PI3K-Akt signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
17 PI3K-Akt signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
18 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
19 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
20 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Pegfilgrastim 💬 Pegfilgrastim [1] 60 💬
21 PI3K-Akt signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
22 PI3K-Akt signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
23 PI3K-Akt signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
24 PI3K-Akt signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
25 PI3K-Akt signaling pathway 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
26 PI3K-Akt signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Neratinib 💬 Neratinib [1] 34 💬
27 PI3K-Akt signaling pathway 💬
 [4] EGFR, ERBB2, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
28 PI3K-Akt signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
29 PI3K-Akt signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
30 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 Peginesatide 💬 Peginesatide [1] 283 💬
31 PI3K-Akt signaling pathway 💬
 [1] FGF23 💬 Burosumab 💬 Burosumab [1] 238 💬
32 PI3K-Akt signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
33 PI3K-Akt signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
34 PI3K-Akt signaling pathway 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [5] 13, 36, 38, 39, 65 💬
35 PI3K-Akt signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
36 PI3K-Akt signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
37 PI3K-Akt signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
38 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
39 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
40 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
41 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
42 PI3K-Akt signaling pathway 💬
 [2] GHR, IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
43 PI3K-Akt signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
44 PI3K-Akt signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
45 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab [3] 46, 49, 53 💬
46 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
47 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a [1] 56 💬
48 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b [2] 25, 34 💬
49 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
50 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b [1] 13 💬
51 PI3K-Akt signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a [1] 13 💬
52 PI3K-Akt signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
53 PI3K-Akt signaling pathway 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
54 PI3K-Akt signaling pathway 💬
 [1] IL2RA 💬 Basiliximab 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
55 PI3K-Akt signaling pathway 💬
 [1] IL2RA 💬 Daclizumab 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
56 PI3K-Akt signaling pathway 💬
 [3] IL2RA, IL2RB, IL2RG 💬 Aldesleukin 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
57 PI3K-Akt signaling pathway 💬
 [1] IL4 💬 Binetrakin 💬 Binetrakin [1] 46 💬
58 PI3K-Akt signaling pathway 💬
 [1] IL4R 💬 Dupilumab 💬 Dupilumab [5] 51, 97, 98, 160, 162 💬
59 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
60 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
61 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
62 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
63 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
64 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
65 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [3] 11, 13, 86 💬
66 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
67 PI3K-Akt signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
68 PI3K-Akt signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
69 PI3K-Akt signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
70 PI3K-Akt signaling pathway 💬
 [1] ITGA4 💬 Firategrast 💬 Firategrast [1] 13 💬
71 PI3K-Akt signaling pathway 💬
 [1] ITGA4 💬 Natalizumab 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
72 PI3K-Akt signaling pathway 💬
 [2] ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬
73 PI3K-Akt signaling pathway 💬
 [2] ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬
74 PI3K-Akt signaling pathway 💬
 [1] ITGB7 💬 Etrolizumab 💬 Etrolizumab [2] 96, 97 💬
75 PI3K-Akt signaling pathway 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬
76 PI3K-Akt signaling pathway 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
77 PI3K-Akt signaling pathway 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬
78 PI3K-Akt signaling pathway 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
79 PI3K-Akt signaling pathway 💬
 [2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
80 PI3K-Akt signaling pathway 💬
 [2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
81 PI3K-Akt signaling pathway 💬
 [3] JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib [1] 46 💬
82 PI3K-Akt signaling pathway 💬
 [3] JAK1, JAK2, JAK3 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
83 PI3K-Akt signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
84 PI3K-Akt signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
85 PI3K-Akt signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
86 PI3K-Akt signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
87 PI3K-Akt signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
88 PI3K-Akt signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
89 PI3K-Akt signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
90 PI3K-Akt signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
91 PI3K-Akt signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
92 PI3K-Akt signaling pathway 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
93 PI3K-Akt signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
94 PI3K-Akt signaling pathway 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
95 PI3K-Akt signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
96 PI3K-Akt signaling pathway 💬
 [1] NGF 💬 Tanezumab 💬 Tanezumab [2] 226, 298 💬
97 PI3K-Akt signaling pathway 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [2] 53, 90 💬
98 PI3K-Akt signaling pathway 💬
 [3] PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
99 PI3K-Akt signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
100 PI3K-Akt signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
101 PI3K-Akt signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
102 PI3K-Akt signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
103 PI3K-Akt signaling pathway 💬
 [1] PRL 💬 Bromocriptine 💬 Bromocriptine [2]  6 , 74 💬
104 PI3K-Akt signaling pathway 💬
 [1] PRL 💬 Cabergoline 💬 Cabergoline [3]  6 , 74, 75 💬
105 PI3K-Akt signaling pathway 💬
 [1] PRL 💬 Terguride 💬 Terguride [2] 51, 86 💬
106 PI3K-Akt signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
107 PI3K-Akt signaling pathway 💬
 [1] RXRA 💬 Acitretin 💬 Acitretin [1] 37 💬
108 PI3K-Akt signaling pathway 💬
 [1] RXRA 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
109 PI3K-Akt signaling pathway 💬
 [1] RXRA 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬
110 PI3K-Akt signaling pathway 💬
 [1] SYK 💬 Fostamatinib 💬 Fostamatinib [4] 46, 49, 61, 66 💬
111 PI3K-Akt signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
112 PI3K-Akt signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬
113 PI3K-Akt signaling pathway 💬
 [1] VWF 💬 Caplacizumab 💬 Caplacizumab [1] 64 💬