Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Cytokine-cytokine receptor interaction 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Cytokine-cytokine receptor interaction 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

Cytokine-cytokine receptor interaction 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬

Hematopoietic cell lineage 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Hematopoietic cell lineage 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

Hematopoietic cell lineage 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬

JAK-STAT signaling pathway 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

JAK-STAT signaling pathway 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

JAK-STAT signaling pathway 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬

Pathways in cancer 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Pathways in cancer 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

Pathways in cancer 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬

PI3K-Akt signaling pathway 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

PI3K-Akt signaling pathway 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

PI3K-Akt signaling pathway 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬