Gene

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

Pathways in cancer 💬

[4] ABL1, KIT, PDGFRA, PDGFRB 💬

Name	Full Name
ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

Pathways in cancer 💬

[3] ABL1, KIT, PDGFRB 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Pathways in cancer 💬

[3] ABL1, KIT, PDGFRB 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Pathways in cancer 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Pathways in cancer 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Pathways in cancer 💬

[1] AGTR1 💬

Candesartan 💬

Candesartan

[2] 58, 67 💬

Pathways in cancer 💬

[1] AGTR1 💬

Candesartan cilexetil 💬

Candesartan cilexetil

[1] 67 💬

Pathways in cancer 💬

[1] AGTR1 💬

Irbesartan 💬

Irbesartan

[4] 66, 167, 168, 222 💬

Pathways in cancer 💬

[1] AGTR1 💬

Losartan 💬

Losartan

[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
36	Epidermolysis bullosa;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
167	Marfan syndrome;
179	Williams syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Pathways in cancer 💬

[1] AGTR1 💬

Telmisartan 💬

Telmisartan

[2] 66, 67 💬

Pathways in cancer 💬

[1] AGTR1 💬

Valsartan 💬

Valsartan

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Pathways in cancer 💬

[2] AGTR1, EDNRA 💬

Sparsentan 💬

Sparsentan

[3] 66, 218, 222 💬

Pathways in cancer 💬

[1] ALK 💬

Brigatinib 💬

Brigatinib

[1] 34 💬

Pathways in cancer 💬

[1] ALK 💬

Crizotinib 💬

Crizotinib

[1] 34 💬

Pathways in cancer 💬

[1] AR 💬

Calusterone 💬

Calusterone

[1] 2 💬

Pathways in cancer 💬

[1] AR 💬

Flutamide 💬

Flutamide

[1] 81 💬

Pathways in cancer 💬

[1] AR 💬

Nandrolone 💬

Nandrolone

[2] 60, 85 💬

Pathways in cancer 💬

[1] AR 💬

Nandrolone decanoate 💬

Nandrolone decanoate

[2] 60, 85 💬

Pathways in cancer 💬

[1] AR 💬

Oxandrolone 💬

Oxandrolone

[2] 211, 285 💬

Pathways in cancer 💬

[1] AR 💬

Stanozolol 💬

Stanozolol

[1] 60 💬

Pathways in cancer 💬

[1] AR 💬

Testosterone 💬

Testosterone

[8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬

Disease ID	Name
1	Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy-Alter-Sung syndrome;
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
60	Aplastic anemia;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
113	Muscular dystrophy;

Pathways in cancer 💬

[1] AR 💬

Testosterone decanoate 💬

Testosterone decanoate

[1] 113 💬

Pathways in cancer 💬

[1] AR 💬

Testosterone enanthate 💬

Testosterone enanthate

[1] 113 💬

Pathways in cancer 💬

[1] AR 💬

Testosterone phenylpropionate 💬

Testosterone phenylpropionate

[1] 113 💬

Pathways in cancer 💬

[1] AR 💬

Testosterone propionate 💬

Testosterone propionate

[1] 113 💬

Pathways in cancer 💬

[1] AR 💬

Testosterone undecanoate 💬

Testosterone undecanoate

[2] 13, 60 💬

Pathways in cancer 💬

[2] AR, ESR1 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

Pathways in cancer 💬

[3] AR, ESR1, ESR2 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

Pathways in cancer 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

Pathways in cancer 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

Pathways in cancer 💬

[7] BRAF, FLT3, FLT4, KIT, PDGFRB, RAF1, RET 💬

Name	Full Name
BRAF	B-Raf proto-oncogene, serine/threonine kinase
FLT3	fms related receptor tyrosine kinase 3
FLT4	fms related receptor tyrosine kinase 4
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRB	platelet derived growth factor receptor beta
RAF1	Raf-1 proto-oncogene, serine/threonine kinase
RET	ret proto-oncogene

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Pathways in cancer 💬

[1] CASP9 💬

Rimiducid 💬

Rimiducid

[6] 19, 60, 65, 284, 285, 326 💬

Pathways in cancer 💬

[2] CDK4, CDK6 💬

Abemaciclib 💬

Abemaciclib

[1] 34 💬

Pathways in cancer 💬

[7] CSF1R, FLT3, FLT4, KIT, PDGFRA, PDGFRB, RET 💬

Name	Full Name
CSF1R	colony stimulating factor 1 receptor
FLT3	fms related receptor tyrosine kinase 3
FLT4	fms related receptor tyrosine kinase 4
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta
RET	ret proto-oncogene

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

Pathways in cancer 💬

[3] CSF1R, FLT3, KIT 💬

Pexidartinib 💬

Pexidartinib

[1] 34 💬

Pathways in cancer 💬

[1] CSF2RA 💬

Mavrilimumab 💬

Mavrilimumab

[2] 41, 46 💬

Pathways in cancer 💬

[1] CSF2RA 💬

Molgramostim 💬

Molgramostim

[3] 97, 229, 299 💬

Disease ID	Name
97	Ulcerative colitis;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
299	Cystic fibrosis;

Pathways in cancer 💬

[1] CSF2RA 💬

Regramostim 💬

Regramostim

[1] 229 💬

Pathways in cancer 💬

[1] CSF2RA 💬

Sargramostim 💬

Sargramostim

[7] 6 , 28, 60, 62, 96, 229, 285 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
28	Systemic amyloidosis;AL amyloidosis;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
96	Crohn disease;Terminal ileitis;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
285	Fanconi anemia;

Pathways in cancer 💬

[1] CSF3R 💬

Filgrastim 💬

Name	Other Names
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

Filgrastim

[35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
47	Buerger disease;Thromboangiitis obliterans;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
296	Biliary atresia;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Pathways in cancer 💬

[1] CSF3R 💬

Lenograstim 💬

Lenograstim

[7] 2 , 13, 16, 18, 19, 57, 65 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
16	Crow-Fukase syndrome;POEMS syndrome;
18	Spinocerebellar degeneration;SCD;
19	Lysosomal storage disease;Lysosomal disease;
57	Idiopathic dilated cardiomyopathy;
65	Primary immunodeficiency;

Pathways in cancer 💬

[1] CSF3R 💬

Pegfilgrastim 💬

Name	Other Names
Pegfilgrastim	Pegfilgrastim (USAN/INN) Pegfilgrastim (genetical recombination) (JAN) Pegfilgrastim-cbqv Pegfilgrastim-bmez Neulasta (TN) G-lasta (TN) Udenyca (TN) FULPHILA FYLNETRA NYVEPRIA STIMUFEND ZIEXTENZO

Pegfilgrastim

[1] 60 💬

Pathways in cancer 💬

[1] CXCR4 💬

Plerixafor 💬

Plerixafor

[5] 19, 20, 65, 285, 299 💬

Pathways in cancer 💬

[1] EDNRA 💬

Ambrisentan 💬

Ambrisentan

[7] 51, 84, 85, 86, 88, 210, 211 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;

Pathways in cancer 💬

[1] EDNRA 💬

Sitaxentan 💬

Sitaxentan

[1] 86 💬

Pathways in cancer 💬

[1] EDNRA 💬

Zibotentan 💬

Zibotentan

[1] 51 💬

Pathways in cancer 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

Pathways in cancer 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

Pathways in cancer 💬

[2] EDNRA, EDNRB 💬

Macitentan 💬

Macitentan

[5] 51, 85, 86, 88, 210 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Pathways in cancer 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

Pathways in cancer 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

Pathways in cancer 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

Pathways in cancer 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

Pathways in cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

Pathways in cancer 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

Pathways in cancer 💬

[3] EGFR, ERBB2, FLT4 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

Pathways in cancer 💬

[1] EPOR 💬

Peginesatide 💬

Peginesatide

[1] 283 💬

Pathways in cancer 💬

[1] ESR1 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

Pathways in cancer 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Clomifene 💬

Clomifene

[1] 74 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estriol 💬

Estriol

[2] 13, 227 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

Pathways in cancer 💬

[2] ESR1, ESR2 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

Pathways in cancer 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Pathways in cancer 💬

[1] F2 💬

Dabigatran etexilate 💬

Dabigatran etexilate

[2] 51, 75 💬

Pathways in cancer 💬

[1] F2 💬

Thrombomodulin alfa 💬

Thrombomodulin Alfa

[1] 85 💬

Pathways in cancer 💬

[1] FGF23 💬

Burosumab 💬

Burosumab

[1] 238 💬

Pathways in cancer 💬

[3] FGFR1, FGFR2, FGFR3 💬

Infigratinib 💬

Infigratinib

[1] 276 💬

Pathways in cancer 💬

[6] FGFR1, FGFR2, FGFR3, FLT4, PDGFRA, PDGFRB 💬

Name	Full Name
FGFR1	fibroblast growth factor receptor 1
FGFR2	fibroblast growth factor receptor 2
FGFR3	fibroblast growth factor receptor 3
FLT4	fms related receptor tyrosine kinase 4
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Pathways in cancer 💬

[1] FGFR2 💬

Palifermin 💬

Palifermin

[5] 13, 36, 38, 39, 65 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
65	Primary immunodeficiency;

Pathways in cancer 💬

[1] FLT4 💬

Axitinib 💬

Axitinib

[1] 34 💬

Pathways in cancer 💬

[1] FLT4 💬

Cediranib 💬

Cediranib

[1] 34 💬

Pathways in cancer 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

Vorinostat

[2] 75, 96 💬

Pathways in cancer 💬

[1] HMOX1 💬

Stannsoporfin 💬

Stannsoporfin

[1] 254 💬

Pathways in cancer 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Rontalizumab 💬

Rontalizumab

[1] 49 💬

Pathways in cancer 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Sifalimumab 💬

Sifalimumab

[1] 49 💬

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Anifrolumab 💬

Anifrolumab

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa 💬

Interferon alfa

[6] 13, 25, 26, 28, 56, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
56	Behcet disease;Behçet disease;BD;
96	Crohn disease;Terminal ileitis;

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2a 💬

Interferon alfa-2a

[1] 56 💬

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2b 💬

Interferon alfa-2b

[2] 25, 34 💬

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1a 💬

Interferon beta-1a

[4] 13, 26, 96, 97 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1b 💬

Interferon beta-1b

[1] 13 💬

Pathways in cancer 💬

[2] IFNAR1, IFNAR2 💬

Peginterferon beta-1a 💬

Peginterferon beta-1a

[1] 13 💬

Pathways in cancer 💬

[1] IFNG 💬

Emapalumab 💬

Emapalumab

[3] 49, 65, 107 💬

Pathways in cancer 💬

[1] IFNG 💬

Fontolizumab 💬

Fontolizumab

[1] 46 💬

Pathways in cancer 💬

[2] IFNGR1, IFNGR2 💬

Interferon gamma-1b 💬

Interferon gamma-1b

[7] 18, 65, 85, 228, 299, 301, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
299	Cystic fibrosis;
301	Macular dystrophy;
326	Osteopetrosis;

Pathways in cancer 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

Pathways in cancer 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

Pathways in cancer 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

100

Pathways in cancer 💬

[3] IL12A, IL12B, IL23A 💬

Ustekinumab 💬

Ustekinumab

[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
162	Pemphigoid;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

101

Pathways in cancer 💬

[1] IL13 💬

Anrukinzumab 💬

Anrukinzumab

[1] 97 💬

102

Pathways in cancer 💬

[1] IL13 💬

Lebrikizumab 💬

Lebrikizumab

[1] 85 💬

103

Pathways in cancer 💬

[1] IL13 💬

Tralokinumab 💬

Tralokinumab

[2] 85, 97 💬

104

Pathways in cancer 💬

[1] IL23A 💬

Brazikumab 💬

Brazikumab

[2] 96, 97 💬

105

Pathways in cancer 💬

[1] IL23A 💬

Guselkumab 💬

Guselkumab

[5] 37, 41, 51, 96, 97 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
41	Giant cell arteritis;Temporal arteritis;
51	Scleroderma;Systemic sclerosis;SSc;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

106

Pathways in cancer 💬

[1] IL23A 💬

Mirikizumab 💬

Mirikizumab

[3] 37, 96, 97 💬

107

Pathways in cancer 💬

[1] IL23A 💬

Risankizumab 💬

Risankizumab

[4] 37, 96, 97, 271 💬

108

Pathways in cancer 💬

[1] IL23A 💬

Tildrakizumab 💬

Tildrakizumab

[2] 162, 271 💬

109

Pathways in cancer 💬

[1] IL2RA 💬

Basiliximab 💬

Basiliximab

[6] 2 , 50, 66, 97, 222, 228 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

110

Pathways in cancer 💬

[1] IL2RA 💬

Daclizumab 💬

Daclizumab

[8] 13, 56, 60, 65, 97, 107, 283, 284 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
65	Primary immunodeficiency;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;

111

Pathways in cancer 💬

[3] IL2RA, IL2RB, IL2RG 💬

Aldesleukin 💬

Aldesleukin

[6] 2 , 35, 49, 65, 96, 97 💬

112

Pathways in cancer 💬

[1] IL4 💬

Binetrakin 💬

Binetrakin

[1] 46 💬

113

Pathways in cancer 💬

[1] IL4R 💬

Dupilumab 💬

Dupilumab

[5] 51, 97, 98, 160, 162 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
160	Congenital ichthyosis;
162	Pemphigoid;

114

Pathways in cancer 💬

[1] IL5 💬

Mepolizumab 💬

Mepolizumab

[4] 44, 45, 98, 162 💬

Disease ID	Name
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;

115

Pathways in cancer 💬

[1] IL5 💬

Reslizumab 💬

Reslizumab

[2] 44, 98 💬

Disease ID	Name
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

116

Pathways in cancer 💬

[1] IL5RA 💬

Benralizumab 💬

Benralizumab

[5] 44, 45, 98, 162, 299 💬

Disease ID	Name
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;
299	Cystic fibrosis;

117

Pathways in cancer 💬

[1] IL6 💬

Olokizumab 💬

Olokizumab

[2] 46, 96 💬

118

Pathways in cancer 💬

[1] IL6 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

119

Pathways in cancer 💬

[1] IL6 💬

Pomalidomide 💬

Pomalidomide

[5] 28, 51, 85, 227, 331 💬

Disease ID	Name
28	Systemic amyloidosis;AL amyloidosis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

120

Pathways in cancer 💬

[1] IL6 💬

Siltuximab 💬

Siltuximab

[2] 28, 331 💬

121

Pathways in cancer 💬

[1] IL6 💬

Sirukumab 💬

Sirukumab

[2] 41, 46 💬

122

Pathways in cancer 💬

[1] IL6R 💬

Sarilumab 💬

Sarilumab

[5] 41, 46, 84, 107, 271 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
84	Sarcoidosis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

123

Pathways in cancer 💬

[1] IL6R 💬

Satralizumab 💬

Satralizumab

[3] 11, 13, 86 💬

124

Pathways in cancer 💬

[1] IL6R 💬

Tocilizumab 💬

Tocilizumab

[21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
54	Adult still disease;Adult-onset Stills disease;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

125

Pathways in cancer 💬

[1] JAK1 💬

Abrocitinib 💬

Abrocitinib

[1] 84 💬

126

Pathways in cancer 💬

[1] JAK1 💬

Filgotinib 💬

Filgotinib

[6] 46, 53, 96, 97, 222, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

127

Pathways in cancer 💬

[1] JAK1 💬

Itacitinib 💬

Itacitinib

[4] 46, 51, 97, 228 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
97	Ulcerative colitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

128

Pathways in cancer 💬

[1] JAK1 💬

Upadacitinib 💬

Upadacitinib

[8] 40, 41, 46, 49, 96, 97, 107, 271 💬

Disease ID	Name
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

129

Pathways in cancer 💬

[2] JAK1, JAK2 💬

Baricitinib 💬

Baricitinib

[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
265	Lipodystrophy;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
325	Hereditary autoinflammatory syndrome;

130

Pathways in cancer 💬

[2] JAK1, JAK2 💬

Ruxolitinib 💬

Ruxolitinib

[3] 60, 65, 228 💬

131

Pathways in cancer 💬

[3] JAK1, JAK2, JAK3 💬

Peficitinib 💬

Peficitinib

[1] 46 💬

132

Pathways in cancer 💬

[3] JAK1, JAK2, JAK3 💬

Tofacitinib 💬

Tofacitinib

[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

133

Pathways in cancer 💬

[1] KEAP1 💬

Dimethyl fumarate 💬

Dimethyl fumarate

[5] 13, 49, 51, 86, 296 💬

134

Pathways in cancer 💬

[1] KIT 💬

Masitinib 💬

Masitinib

[6] 2 , 5 , 6 , 13, 46, 96 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;

135

Pathways in cancer 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

136

Pathways in cancer 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

137

Pathways in cancer 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

138

Pathways in cancer 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

139

Pathways in cancer 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

140

Pathways in cancer 💬

[1] MET 💬

Cabozantinib 💬

Cabozantinib

[1] 34 💬

141

Pathways in cancer 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

142

Pathways in cancer 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

143

Pathways in cancer 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

144

Pathways in cancer 💬

[1] NFE2L2 💬

Omaveloxolone 💬

Omaveloxolone

[1] 18 💬

145

Pathways in cancer 💬

[1] NFKB1 💬

Iguratimod 💬

Iguratimod

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

146

Pathways in cancer 💬

[1] NQO1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

147

Pathways in cancer 💬

[3] PGF, VEGFA, VEGFB 💬

Aflibercept 💬

Aflibercept

[2] 90, 166 💬

148

Pathways in cancer 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

149

Pathways in cancer 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

150

Pathways in cancer 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

151

Pathways in cancer 💬

[3] PML, RARA, RARB 💬

Tretinoin 💬

Tretinoin

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

152

Pathways in cancer 💬

[1] PPARG 💬

Bocidelpar 💬

Bocidelpar

[1] 113 💬

153

Pathways in cancer 💬

[1] PPARG 💬

Leriglitazone 💬

Leriglitazone

[1] 20 💬

154

Pathways in cancer 💬

[1] PPARG 💬

Pioglitazone 💬

Pioglitazone

[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
20	Adrenoleukodystrophy;ALD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
265	Lipodystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

155

Pathways in cancer 💬

[1] PPARG 💬

Rosiglitazone 💬

Rosiglitazone

[5] 46, 75, 97, 222, 265 💬

156

Pathways in cancer 💬

[1] PPARG 💬

Seladelpar 💬

Seladelpar

[2] 93, 94 💬

157

Pathways in cancer 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

158

Pathways in cancer 💬

[1] PTGER1 💬

Alprostadil 💬

Alprostadil

[2] 51, 70 💬

159

Pathways in cancer 💬

[1] PTGER1 💬

Limaprost 💬

Limaprost

[1] 70 💬

160

Pathways in cancer 💬

[3] PTGER2, PTGER3, PTGER4 💬

Misoprostol 💬

Misoprostol

[3] 46, 70, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

161

Pathways in cancer 💬

[1] PTGS2 💬

Aceclofenac 💬

Aceclofenac

[1] 46 💬

162

Pathways in cancer 💬

[1] PTGS2 💬

Acetaminophen 💬

Acetaminophen

[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
337	Homocystinuria;

163

Pathways in cancer 💬

[1] PTGS2 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

164

Pathways in cancer 💬

[1] PTGS2 💬

Celecoxib 💬

Celecoxib

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

165

Pathways in cancer 💬

[1] PTGS2 💬

Diclofenac 💬

Diclofenac

[5] 13, 34, 46, 78, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

166

Pathways in cancer 💬

[1] PTGS2 💬

Diflunisal 💬

Diflunisal

[1] 28 💬

167

Pathways in cancer 💬

[1] PTGS2 💬

Etodolac 💬

Etodolac

[1] 46 💬

168

Pathways in cancer 💬

[1] PTGS2 💬

Etoricoxib 💬

Etoricoxib

[2] 46, 271 💬

169

Pathways in cancer 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

170

Pathways in cancer 💬

[1] PTGS2 💬

Ibuprofen 💬

Ibuprofen

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

171

Pathways in cancer 💬

[1] PTGS2 💬

Indomethacin 💬

Indomethacin

[3] 225, 271, 298 💬

Disease ID	Name
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;

172

Pathways in cancer 💬

[1] PTGS2 💬

Ketoprofen 💬

Ketoprofen

[1] 46 💬

173

Pathways in cancer 💬

[1] PTGS2 💬

Ketorolac 💬

Ketorolac

[2] 70, 226 💬

174

Pathways in cancer 💬

[1] PTGS2 💬

Loxoprofen 💬

Loxoprofen

[2] 46, 271 💬

175

Pathways in cancer 💬

[1] PTGS2 💬

Lumiracoxib 💬

Lumiracoxib

[1] 46 💬

176

Pathways in cancer 💬

[1] PTGS2 💬

Meloxicam 💬

Meloxicam

[4] 46, 49, 271, 296 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
296	Biliary atresia;

177

Pathways in cancer 💬

[1] PTGS2 💬

Naproxen 💬

Naproxen

[4] 13, 46, 107, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

178

Pathways in cancer 💬

[1] PTGS2 💬

Nimesulide 💬

Nimesulide

[1] 46 💬

179

Pathways in cancer 💬

[1] PTGS2 💬

Parecoxib 💬

Parecoxib

[2] 46, 271 💬

180

Pathways in cancer 💬

[1] PTGS2 💬

Rofecoxib 💬

Rofecoxib

[1] 46 💬

181

Pathways in cancer 💬

[1] PTGS2 💬

Salsalate 💬

Salsalate

[1] 5 💬

182

Pathways in cancer 💬

[1] PTGS2 💬

Sulindac 💬

Sulindac

[1] 206 💬

183

Pathways in cancer 💬

[1] PTGS2 💬

Tolfenamic acid 💬

Tolfenamic acid

[1] 5 💬

184

Pathways in cancer 💬

[1] PTGS2 💬

Valdecoxib 💬

Valdecoxib

[1] 46 💬

185

Pathways in cancer 💬

[1] RARA 💬

Tamibarotene 💬

Tamibarotene

[2] 26, 96 💬

186

Pathways in cancer 💬

[2] RARA, RARB 💬

Fenretinide 💬

Fenretinide

[1] 299 💬

187

Pathways in cancer 💬

[2] RARA, RARB 💬

Isotretinoin 💬

Isotretinoin

[4] 36, 39, 159, 160 💬

188

Pathways in cancer 💬

[2] RARA, RARB 💬

Vitamin A 💬

Vitamin A

[3] 13, 53, 90 💬

189

Pathways in cancer 💬

[5] RARA, RARB, RXRA, RXRB, RXRG 💬

Acitretin 💬

Acitretin

[1] 37 💬

190

Pathways in cancer 💬

[5] RARA, RARB, RXRA, RXRB, RXRG 💬

Alitretinoin 💬

Alitretinoin

[1] 49 💬

191

Pathways in cancer 💬

[1] RELA 💬

Edasalonexent 💬

Edasalonexent

[1] 113 💬

192

Pathways in cancer 💬

[2] ROCK1, ROCK2 💬

Fasudil 💬

Fasudil

[4] 2 , 5 , 7 , 51 💬

193

Pathways in cancer 💬

[1] ROCK2 💬

Belumosudil 💬

Belumosudil

[2] 51, 85 💬

194

Pathways in cancer 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

Bexarotene

[2] 13, 75 💬

195

Pathways in cancer 💬

[1] SMO 💬

Taladegib 💬

Taladegib

[1] 85 💬

196

Pathways in cancer 💬

[1] SMO 💬

Vismodegib 💬

Vismodegib

[1] 85 💬

197

Pathways in cancer 💬

[3] TGFB1, TGFB2, TGFB3 💬

Fresolimumab 💬

Fresolimumab

[3] 51, 85, 222 💬

198

Pathways in cancer 💬

[1] VEGFA 💬

Bevacizumab 💬

Name

Other Names

Bevacizumab

Bevacizumab (USAN)
Bevacizumab (genetical recombination) (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 1] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 2] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 3] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 4] (JAN)
Bevacizumab-awwb
Bevacizumab-bvzr
Avastin (TN)
Mvasi (TN)
ALYMSYS
ZIRABEV

Bevacizumab

[6] 13, 34, 85, 87, 227, 280 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
85	Idiopathic interstitial pneumonia;IIPs;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

199

Pathways in cancer 💬

[1] VEGFA 💬

Ranibizumab 💬

Name	Other Names
Ranibizumab	Ranibizumab (USAN/INN) Ranibizumab (genetical recombination) (JAN) Ranibizumab (genetical recombination) [Ranibizumab biosimilar 1] (JAN) Ranibizumab-nuna Lucentis (TN) Byooviz (TN) Susvimo (TN) Ximluci (TN) CIMERLI

Ranibizumab

[4] 34, 166, 227, 301 💬