Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acamprosate 2件: Acamprosate; Acamprosate calcium2件: Acamprosate calcium ,
Acamprosate 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬3件: 2, 6, 206 💬
2 Acetate 1件: Acetate---52件: 1, 2, 6, 10, 11, 13, 22, 35, 40, 46, 49, 51, 60, 63, 64, 65, 66, 67, 70, 71, 73, 75, 76, 77, 78, 79, 81, 83, 85, 86, 88, 89, 90, 96, 97, 113, 145, 156, 158, 162, 171, 206, 222, 223, 224, 225, 227, 235, 251, 265, 298, 299 💬
3 Arbaclofen 2件: Arbaclofen; Baclofen1件: Arbaclofen 💬 2件: GABBR1,
GABBR2 💬 		8件: Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬2件: 13, 206 💬
4 Aripiprazole 1件: Aripiprazole1件: Aripiprazole 💬 4件: DRD2,
DRD3,
HTR1A,
HTR2A 💬 		14件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬3件: 6, 74, 206 💬
5 Ascorbic acid 2件: Ascorbic acid; Vitamin C1件: Ascorbic acid 💬 --4件: 10, 97, 206, 298 💬
6 AZD-7325 0件: ---1件: 206 💬
7 Baclofen 1件: Baclofen1件: Baclofen 💬 2件: GABBR1,
GABBR2 💬 		8件: Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬8件: 2, 10, 13, 18, 65, 70, 149, 206 💬
8 Cannabidiol 1件: CANNABIDIOL1件: Cannabidiol 💬 2件: CNR1,
CNR2 💬 		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬20件: 6, 8, 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
9 CX516 1件: CX516---1件: 206 💬
10 Donepezil 2件: Donepezil; Donepezil Hydrochloride2件: Donepezil hydrochloride ,
Donepezil 💬 		1件: ACHE 💬 3件: Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬8件: 5, 6, 13, 46, 124, 127, 156, 206 💬
11 Ergoloid mesylate 1件: Ergoloid Mesylate1件: Ergoloid mesylates 💬 6件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C 💬 		9件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 206 💬
12 Flumazenil 1件: Flumazenil1件: Flumazenil 💬 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬 		9件: Cadherin signaling, GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬5件: 6, 13, 17, 18, 206 💬
13 Gaboxadol 1件: Gaboxadol1件: Gaboxadol 💬 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬 		9件: Cadherin signaling, GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 201, 206 💬
14 Ganaxolone 1件: GANAXOLONE1件: Ganaxolone 💬 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬 		9件: Cadherin signaling, GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬4件: 145, 152, 158, 206 💬
15 Gold 1件: Gold---71件: 2, 5, 6, 11, 13, 17, 19, 21, 22, 28, 34, 35, 46, 49, 50, 53, 54, 56, 57, 58, 60, 63, 64, 65, 66, 68, 71, 75, 76, 77, 79, 84, 85, 86, 88, 91, 93, 95, 96, 97, 98, 107, 113, 127, 137, 158, 162, 167, 171, 193, 206, 215, 218, 222, 223, 224, 226, 227, 228, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318, 331, 340 💬
16 Lovastatin 1件: Lovastatin1件: Lovastatin 💬 1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
17 Mavoglurant 1件: Mavoglurant---2件: 6, 206 💬
18 Memantine 2件: MEMANTINE; Memantine hydrochloride2件: Memantine hydrochloride ,
Memantine 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206 💬
19 Metformin 4件: Metformin; Metformin hydrochloride; Metformina; Metformine2件: Metformin hydrochloride ,
Metformin 💬 		2件: PRKAA1,
PRKAA2 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬31件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 74, 75, 77, 81, 84, 85, 86, 97, 113, 127, 158, 206, 218, 222, 225, 233, 265, 285, 298, 299, 301 💬
20 Methylphenidate 2件: Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE2件: Methylphenidate hydrochloride ,
Methylphenidate 💬 		2件: SLC6A2,
SLC6A3 💬 		8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬7件: 6, 13, 34, 84, 113, 179, 206 💬
21 Minocycline 2件: Minocycline; Minocycline hydrochloride2件: Minocycline hydrochloride ,
Minocycline 💬 		--14件: 2, 6, 8, 13, 46, 85, 90, 94, 97, 162, 201, 206, 280, 299 💬
22 Oxytocin 1件: Oxytocin1件: Oxytocin 💬 1件: OXTR 💬 5件: Calcium signaling pathway, Hormone signaling, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬8件: 6, 70, 72, 127, 168, 193, 206, 226 💬
23 Psilocybin 2件: Psilocybin; Psilocybine1件: Psilocybin 💬 1件: HTR2A 💬 6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Serotonergic synapse 💬5件: 2, 6, 13, 149, 206 💬
24 Riluzole 1件: Riluzole1件: Riluzole 💬 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		24件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
25 Risperidone 1件: Risperidone1件: Risperidone 💬 2件: DRD2,
HTR2A 💬 		13件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬6件: 8, 74, 156, 179, 187, 206 💬
26 Roflumilast 1件: Roflumilast1件: Roflumilast 💬 4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬 		4件: Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬5件: 46, 84, 97, 206, 299 💬
27 Sertraline 1件: Sertraline2件: Sertraline hydrochloride ,
Sertraline 💬 		1件: SLC6A4 💬 3件: Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬3件: 6, 158, 206 💬
28 SPG601 1件: SPG601---1件: 206 💬
29 SRX-246 0件: ---2件: 8, 206 💬
30 STX-107 0件: ---1件: 206 💬
31 Sulindac 1件: Sulindac1件: Sulindac 💬 2件: PTGS1,
PTGS2 💬 		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 206 💬
32 Tocopherol 1件: Tocopherol1件: Tocopherol 💬 --7件: 13, 49, 71, 206, 215, 257, 298 💬
33 Vitamin E 1件: Vitamin E1件: Vitamin E 💬 --12件: 2, 6, 13, 19, 20, 46, 90, 96, 97, 206, 299, 317 💬
34 Water 1件: Water1件: Water 💬 --36件: 2, 3, 5, 6, 13, 17, 19, 22, 35, 46, 49, 51, 53, 56, 57, 62, 63, 64, 65, 66, 67, 70, 72, 85, 86, 96, 97, 206, 215, 225, 226, 230, 240, 274, 278, 299 💬
35 Zatolmilast 1件: Zatolmilast1件: Zatolmilast 💬 1件: PDE4D 💬 4件: Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 206 💬