Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Pamidronate disodium 💬 Pamidronic acid [1] 274 💬
2 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Pamidronic acid 💬 Pamidronic acid [1] 274 💬
3 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Risedronate sodium 💬 Risedronic acid [7] 46, 50, 93, 95, 107, 113, 274 💬
4 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate disodium 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬
5 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬
6 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Risedronic acid 💬 Risedronic acid [7] 46, 50, 93, 95, 107, 113, 274 💬
7 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid hemipentahydrate 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬
8 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Risedronate sodium monohydrate 💬 Risedronic acid [7] 46, 50, 93, 95, 107, 113, 274 💬
9 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Alendronic acid 💬 Alendronic acid [5] 19, 46, 223, 274, 299 💬
10 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate trisodium 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬
11 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Alendronate sodium 💬 Alendronic acid [5] 19, 46, 223, 274, 299 💬
12 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬
13 MS4A1 💬 [1] Hematopoietic cell lineage Rituximab 💬 Rituximab [54] 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 88, 93, 94, 96, 97, 162, 172, 222, 223, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
14 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Tranexamic acid 💬 Tranexamic acid [7] 46, 65, 70, 215, 227, 274, 299 💬
15 PTH1R 💬 [4] Neuroactive ligand-receptor interaction, Hormone signaling, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption Teriparatide acetate 💬 Teriparatide [7] 46, 68, 70, 71, 172, 235, 274 💬
16 PTH1R 💬 [4] Neuroactive ligand-receptor interaction, Hormone signaling, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption Teriparatide acetate 💬 Teriparatide [7] 46, 68, 70, 71, 172, 235, 274 💬
17 PTH1R 💬 [4] Neuroactive ligand-receptor interaction, Hormone signaling, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption Teriparatide 💬 Teriparatide [7] 46, 68, 70, 71, 172, 235, 274 💬
18 SOST 💬 [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action Romosozumab 💬 Romosozumab [2] 46, 274 💬
19 SOST 💬 [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action Setrusumab 💬 Setrusumab [1] 274 💬
20 TGFB1 💬 [36] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Efferocytosis, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Integrin signaling, Th17 cell differentiation, Intestinal immune network for IgA production, Relaxin signaling pathway, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [3] 51, 222, 274 💬
21 TGFB2 💬 [31] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [3] 51, 222, 274 💬
22 TGFB3 💬 [28] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [3] 51, 222, 274 💬
23 TNFSF11 💬 [8] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Chemical carcinogenesis - receptor activation, Breast cancer, Rheumatoid arthritis Denosumab 💬 Denosumab [11] 46, 50, 70, 75, 77, 93, 95, 96, 223, 274, 299 💬