Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ARSB 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Galsulfase 💬 Galsulfase [1] 19 💬
2 CTSC 💬 [2] Lysosome biogenesis, Apoptosis Brensocatib 💬 Brensocatib [1] 299 💬
3 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Duvoglustat 💬 Duvoglustat [1] 256 💬
4 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Avalglucosidase alfa 💬 Avalglucosidase alfa [1] 256 💬
5 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Duvoglustat hydrochloride 💬 Duvoglustat [1] 256 💬
6 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Cipaglucosidase alfa 💬 Cipaglucosidase alfa [1] 256 💬
7 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Acarbose 💬 Acarbose [1] 298 💬
8 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Clervonafusp alfa 💬 Clervonafusp alfa [1] 309 💬
9 GAA 💬 [3] Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Alglucosidase alfa 💬 Alglucosidase alfa [1] 256 💬
10 GALNS 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Elosulfase alfa 💬 Elosulfase alfa [1] 19 💬
11 GBA1 💬 [4] Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Velaglucerase alfa 💬 Velaglucerase alfa [1] 19 💬
12 GBA1 💬 [4] Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Alglucerase 💬 Imiglucerase [1] 19 💬
13 GBA1 💬 [4] Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Taliglucerase alfa 💬 Taliglucerase alfa [1] 19 💬
14 GBA1 💬 [4] Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Imiglucerase 💬 Imiglucerase [1] 19 💬
15 GLA 💬 [5] Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Agalsidase alfa 💬 Agalsidase alfa [1] 19 💬
16 GLA 💬 [5] Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Agalsidase beta 💬 Agalsidase beta [1] 19 💬
17 GLA 💬 [5] Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Migalastat hydrochloride 💬 Migalastat [1] 19 💬
18 GLA 💬 [5] Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Pegunigalsidase alfa 💬 Pegunigalsidase alfa [1] 19 💬
19 GUSB 💬 [6] Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Glycosaminoglycan degradation, Porphyrin metabolism, Drug metabolism - other enzymes, Lysosome biogenesis Vestronidase alfa 💬 Vestronidase alfa [1] 19 💬
20 IDS 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Pabinafusp alfa 💬 Pabinafusp alfa [1] 19 💬
21 IDS 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Idursulfase 💬 Idursulfase [1] 19 💬
22 IDS 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Tividenofusp alfa 💬 Tividenofusp alfa [1] 19 💬
23 IDS 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Idursulfase beta 💬 Idursulfase beta [1] 19 💬
24 IDUA 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Laronidase 💬 Laronidase [2] 19, 256 💬
25 LIPA 💬 [4] Steroid biosynthesis, Lysosome biogenesis, Efferocytosis, Cholesterol metabolism Sebelipase alfa 💬 Sebelipase alfa [1] 19 💬
26 MAN2B1 💬 [2] Other glycan degradation, Lysosome biogenesis Velmanase alfa 💬 Velmanase alfa [1] 19 💬
27 MTOR 💬 [52] ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Everolimus 💬 Everolimus [12] 34, 67, 89, 96, 137, 157, 158, 228, 277, 278, 279, 280 💬
28 MTOR 💬 [52] ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus [46] 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 54, 57, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 97, 98, 111, 127, 137, 157, 158, 192, 222, 223, 227, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
29 MTOR 💬 [52] ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Temsirolimus 💬 Temsirolimus [4] 13, 34, 89, 331 💬
30 NAGLU 💬 [2] Glycosaminoglycan degradation, Lysosome biogenesis Tralesinidase alfa 💬 Tralesinidase alfa [1] 19 💬
31 SLC29A2 💬 [2] Lysosome biogenesis, Alcoholism Clervonafusp alfa 💬 Clervonafusp alfa [1] 309 💬
32 SMPD1 💬 [4] Sphingolipid metabolism, Sphingolipid signaling pathway, Lysosome biogenesis, Necroptosis Olipudase alfa 💬 Olipudase alfa [1] 19 💬
33 SORT1 💬 [3] Lysosome biogenesis, Neurotrophin signaling pathway, Cholesterol metabolism Latozinemab 💬 Latozinemab [1] 127 💬
34 TLR7 💬 [6] Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Measles, Influenza A, Coronavirus disease Imiquimod 💬 Imiquimod [2] 34, 51 💬
35 TLR7 💬 [6] Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Measles, Influenza A, Coronavirus disease Enpatoran 💬 Enpatoran [1] 49 💬
36 TLR8 💬 [4] Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Coronavirus disease Enpatoran 💬 Enpatoran [1] 49 💬
37 TLR9 💬 [10] Lysosome biogenesis, Toll-like receptor signaling pathway, Salmonella infection, Chagas disease, African trypanosomiasis, Malaria, Tuberculosis, Measles, Herpes simplex virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer Cobitolimod 💬 Cobitolimod [1] 97 💬
38 TPP1 💬 [1] Lysosome biogenesis Cerliponase alfa 💬 Cerliponase alfa [1] 19 💬