Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Water [1] Water[9] AVONEX; ENBREL; Glucagon; Hiberix; Indocyanine Green; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION; --[23] 2, 5, 6, 13, 17, 19, 22, 35, 46, 51, 53, 56, 57, 63, 65, 67, 78, 84, 96, 97, 226, 278, 299
2 Oxygen [1] Oxygen[3] Medical air; Nitrogen; Oxygen; --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
3 Alanine [1] Alanine[2] Alanine; L-alanine; --[5] 6, 13, 251, 298, 299
4 Glutathione [1] Glutathione[2] Glutathione; Reduced Glutathione; --[2] 6, 299
5 Serine [1] Serine[2] L-Serine; Serine; --[4] 2, 6, 86, 96
6 Tryptophan [1] Tryptophan[2] Propanoic acid; Tryptophan; --[2] 6, 75
7 Tyrosine [1] Tyrosine[4] Alanine; L-Tyrosine; Propanoic acid; Tyrosine; --[5] 6, 75, 86, 111, 298
8 L-Cysteine [1] Cysteine[2] Cysteine; Cysteine hydrochloride; --[11] 6, 13, 19, 34, 84, 85, 88, 90, 254, 296, 310
9 Glycerin [1] Glycerin[3] Bee venom; Glycerine; Glycerol; --[6] 6, 13, 79, 265, 316, 317
10 Leucine [1] Leucine[2] L-leucine; Leucine; --[11] 5, 6, 7, 19, 65, 96, 97, 127, 283, 284, 299
11 Oxiglutatione [1] Glutathione[2] GLUTATHIONE; Reduced glutathione; --[2] 6, 299
12 Niacinamide [1] Nicotinamide[4] Ginseng; Multivitamin; Niacinamide; NICOTINAMIDE; --[11] 2, 5, 6, 13, 18, 49, 65, 67, 107, 162, 191
13 Anhydrous lactose [1] Lactose[1] Lactose; --[6] 2, 6, 13, 97, 228, 310
14 Niacin [1] Niacin[2] Niacin; Nicotinic acid; --[4] 6, 78, 79, 265
15 Inosine [1] Inosine[1] Inosine; --[6] 2, 6, 13, 17, 85, 122
16 Citicoline [1] Citicoline[1] Citicolina; --[1] 6
17 Levodopa [1] Levodopa[8] DUODOPA; Inbrija; L-DOPA; Levodopa; PARCOPA; SINEMET; SINEMET CR; Stalevo; [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[8] 2, 4, 6, 17, 90, 140, 164, 201
18 Mannitol [1] Mannitol[4] Aridol; Bronchitol; Mannite; Mannitol; --[7] 6, 13, 28, 60, 96, 113, 299
19 Folic acid [1] Folic acid[5] Acide folique; Folate; Folic acid; Multivitamin; Nicotinamide; --[6] 6, 13, 41, 46, 49, 84
20 Nitric oxide [1] Nitric Oxide[3] INOmax; Nitric Oxide; Nitrosyl; --[16] 6, 13, 46, 58, 85, 86, 96, 97, 98, 210, 222, 226, 251, 294, 299, 321
21 Nitrogen [1] Nitrogen[1] Nitrogen; --[6] 5, 6, 17, 171, 211, 299
22 Hydrocortisone [1] Hydrocortisone[6] Cortef; Cortisol; Cortisone; Hydrocortisone; Hydrocortisone cream; Hydrocortisonum; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[11] 6, 41, 46, 53, 75, 78, 81, 83, 97, 98, 299
23 Oxytocin [1] Oxytocin[2] Oxytocin; Syntocinon; [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[6] 6, 72, 127, 193, 206, 226
24 Sorbitol solution [1] Sorbitol[3] D-glucitol; D-SORBITOL; Sorbitol; --[4] 6, 10, 28, 299
25 Tacrolimus [1] Tacrolimus[2] Prograf; Tacrolimus; [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
26 Albendazole [1] Albendazole[2] Albendazole; Eskazole; --[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127
27 Erythromycin [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
28 Cyanocobalamin [1] Cyanocobalamin[2] Cianocobalamina; Vitamin B12; --[5] 6, 13, 201, 229, 299
29 Cholecalciferol [1] Cholecalciferol[5] Cholecalciferol; COLECALCIFEROL; Multivitamin; Vitamin D; Vitamin D3; [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[25] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
30 Ampicillin [1] Ampicillin[1] ABPC; --[5] 2, 6, 13, 84, 299
31 Rifampin [1] Rifampicin[2] Rifampicin; Rifampin; --[9] 6, 13, 17, 46, 84, 86, 93, 299, 338
32 Acetaminophen [1] Acetaminophen[5] Acetaminophen; Oxycodone/Acetaminophen; Paracetamol; Tylenol; Ultracet; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
33 Acetohydroxamic acid [1] Acetohydroxamic acid[1] Acetohydroxamic Acid; --[2] 6, 251
34 Acetylcysteine [1] Acetylcysteine[3] Acetylcysteine; Mucomyst; N-acetylcysteine; --[20] 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
35 Allopurinol [1] Allopurinol[2] Allopurinol; ALLOPURINOL SODIUM; [1] XDH 💬[5] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine metabolism 💬[6] 6, 46, 57, 66, 96, 97
36 Amoxicillin [1] Amoxicillin[4] Amoxicilina; Amoxicillin; Amoxycillin; Augmentin; --[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
37 Azathioprine [1] Azathioprine[3] Azathioprine; Azatioprina; Imuran; --[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
38 Bumetanide [1] Bumetanide[1] Bumetanide; [1] SLC12A2 💬[3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬[2] 6, 158
39 Capsaicin [1] Capsaicin[2] Capsaicin; Qutenza; [1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[5] 2, 6, 19, 86, 226
40 Captopril [1] Captopril[1] Captopril; [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[8] 6, 17, 46, 86, 96, 97, 107, 271
41 Carvedilol [1] Carvedilol[1] Carvedilol; [5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 57, 86, 113, 210
42 Clarithromycin [1] Clarithromycin[1] Clarithromycin; --[8] 6, 63, 84, 96, 97, 222, 228, 299
43 Clonazepam [1] Clonazepam[1] Clonazepam; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 6
44 Clonidine [1] Clonidine[4] Clonidin; Clonidina; Clonidine; Clonidine hydrochloride; [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 6, 65, 70, 78
45 Clozapine [1] Clozapine[1] CLOZAPINE; [11] ADRA2A,
ADRA2B,
ADRA2C,
DRD4,
HTR2A,
HTR2C,
HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E 💬		[8] Calcium signaling pathway, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction, cGMP-PKG signaling pathway 💬[1] 6
46 Desmopressin [1] Desmopressin[5] DDAVP; Desmopressin; Desmopressin Acetate; Desmopressine; Minirin; [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[6] 6, 64, 72, 75, 225, 288
47 Dihydrotachysterol [1] Dihydrotachysterol[0] [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[2] 6, 85
48 Famotidine [1] Famotidine[2] FAMOTIDINA; Famotidine; [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[7] 6, 46, 61, 86, 98, 107, 300
49 Finasteride [1] Finasteride[1] Finasteride; [1] SRD5A2 💬[3] Metabolic pathways, Prostate cancer, Steroid hormone biosynthesis 💬[1] 6
50 Furosemide [1] Furosemide[2] Furosemide; Furosemide Injection; [1] SLC12A2 💬[3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬[1] 6
51 Gabapentin [1] Gabapentin[4] Gabapentin; GABAPENTINA; Gabapentine; NEURONTIN; [5] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		[9] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[5] 6, 13, 19, 70, 298
52 Isradipine [1] Isradipine[1] Isradipine; [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
53 Lidocaine [1] Lidocaine[4] Aloe; Lidocaine; Lignocaine; Xylocaine; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
54 Lovastatin [1] Lovastatin[1] Lovastatin; [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
55 Tropicamide [1] Tropicamide[1] Tropicamide; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 19
56 Valproic acid [1] Valproic acid[3] Valproate; VALPROATE SODIUM; Valproic Acid; [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
57 Methylprednisolone [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
58 Zolmitriptan [1] Zolmitriptan[1] Zolmitriptan; [2] HTR1B,
HTR1D 💬		[4] Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[1] 6
59 Nadolol [1] Nadolol[1] Nadolol; [2] ADRB1,
ADRB2 💬		[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
60 Simvastatin [1] Simvastatin[3] Simvastatin; Simvastatina; Simvastatine; [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
61 Omeprazole [1] Omeprazole[5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM; [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
62 Ondansetron [1] Ondansetron[1] Ondansetron; [5] HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E 💬		[2] Serotonergic synapse, Taste transduction 💬[4] 6, 97, 107, 231
63 Quetiapine fumarate [1] Quetiapine[2] Quetiapine; Seroquel; [2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[2] 6, 13
64 Oxybutynin [1] Oxybutynin[1] Oxybutynin; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
65 Prednisone [1] Prednisone[3] PREDNISONA; Prednisone; RAYOS; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
66 Propranolol hydrochloride [1] Propranolol[3] Propanolol; Propranolol; Propranolol Hydrochloride; [3] ADRB1,
ADRB2,
ADRB3 💬		[12] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 158, 167, 215, 227, 278, 296
67 Pyridostigmine bromide [1] Pyridostigmine[3] Mestinon; PYRIDOSTIGMINE; Pyridostigmine Bromide; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[4] 3, 6, 11, 256
68 Pyrimethamine [1] Pyrimethamine[2] Daraprim; PYRIMETHAMINE; --[11] 2, 4, 6, 13, 19, 46, 51, 65, 96, 97, 265
69 Pergolide mesylate [1] Pergolide[1] PERGOLIDE; [2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
70 Phenelzine sulfate [1] Phenelzine[1] Nardil; [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
71 Dexmedetomidine [1] Dexmedetomidine[4] Dexdor; DEXMEDETOMIDINA; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[13] 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
72 Pilocarpine [1] Pilocarpine[2] Pilocarpine; Pilocarpine Hydrochloride; [2] CHRM2,
CHRM3 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 53, 299
73 Caffeine [1] Caffeine[1] Caffeine; [11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
74 Montelukast sodium [1] Montelukast[3] Montelukast; MONTELUKAST SODIUM; Singulair; [1] CYSLTR1 💬[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction 💬[8] 6, 13, 46, 61, 63, 85, 98, 228
75 Topiramate [1] Topiramate[2] TOPAMAX; Topiramate; [36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 97, 140, 144, 156, 193
76 Zonisamide [1] Zonisamide[2] Zonegran; Zonisamide; [8] CACNA1G,
CACNA1H,
CACNA1I,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[11] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dopaminergic synapse, GnRH secretion, MAPK signaling pathway, Taste transduction, Type II diabetes mellitus 💬[1] 6
77 Isoflurane [1] Isoflurane[1] Isoflurane; --[1] 6
78 Sevoflurane [1] Sevoflurane[1] Sevoflurane; --[7] 6, 21, 22, 34, 98, 225, 296
79 Etomidate [1] Etomidate[1] Etomidate; [1] GABRA1 💬[6] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Taste transduction 💬[1] 6
80 Propofol [1] Propofol[2] Propofol; Propofol Injection; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[10] 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
81 Midazolam [1] Midazolam[2] Midazolam; Midazolam injection; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
82 Carbidopa [1] Carbidopa[7] Carbidopa; DUODOPA; Lodosyn; PARCOPA; SINEMET; SINEMET CR; Stalevo; [1] DDC 💬[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[9] 2, 4, 6, 13, 17, 90, 140, 164, 201
83 Pramipexole dihydrochloride [1] Pramipexole[7] Mirapex; Mirapex ER; Mirapexin; Pramipexol; PRAMIPEXOLE; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 20
84 Warfarin sodium [1] Warfarin[2] Warfarin; Warfarin Sodium; [2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
85 Repaglinide [1] Repaglinide[1] Repaglinide; [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[3] 6, 21, 299
86 Clonidine hydrochloride [1] Clonidine[4] Clonidin; Clonidina; Clonidine; CLONIDINE HYDROCHLORIDE; [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 6, 65, 70, 78
87 Terazosin hydrochloride [1] Terazosin[1] Terazosin; [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 6
88 Dopamine hydrochloride [1] Dopamine[2] Dopamina; Dopamine; [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 6, 7, 74, 299
89 Flecainide acetate [1] Flecainide[3] Flecainide; FLECAINIDE ACETATE; Flecainidum; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 6
90 Donepezil hydrochloride [1] Donepezil[3] ARICEPT; DONEPEZIL; Donepezil hydrochloride; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
91 Ondansetron hydrochloride hydrate [1] Ondansetron[1] Ondansetron; [5] HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E 💬		[2] Serotonergic synapse, Taste transduction 💬[4] 6, 97, 107, 231
92 Midazolam hydrochloride [1] Midazolam[2] Midazolam; Midazolam injection; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
93 Flumazenil [1] Flumazenil[1] Flumazenil; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[5] 6, 13, 17, 18, 206
94 Buspirone hydrochloride [1] Buspirone[2] Buspirone; Buspirone Hydrochloride; [2] DRD2,
HTR1A 💬		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[3] 6, 51, 179
95 Zolpidem tartrate [1] Zolpidem[2] Zolpidem; Zolpidem Tartrate; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46
96 Levetiracetam [1] Levetiracetam[2] KEPPRA; Levetiracetam; [1] SV2A 💬[1] ECM-receptor interaction 💬[5] 2, 4, 6, 13, 307
97 Ketamine hydrochloride [1] Ketamine[2] Ketamine; NMDA; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 4, 6, 13, 70, 113, 156, 215
98 Oxybutynin chloride [1] Oxybutynin[1] Oxybutynin; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
99 Ursodiol [1] Ursodeoxycholic acid[4] UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk; [1] NR1H4 💬[1] Bile secretion 💬[14] 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299
100 Methylprednisolone sodium succinate [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; Methylprednisolone acetate; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
101 Sirolimus [1] Sirolimus[3] Rapamune; Rapamycin; Sirolimus; [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[41] 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
102 Amantadine hydrochloride [1] Amantadine[3] AMANTADINE; AMANTADINE HYDROCHLORIDE; GOCOVRI; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[4] 6, 8, 13, 127
103 Bromocriptine mesylate [1] Bromocriptine[1] BROMOCRIPTINE; [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 74
104 Entacapone [1] Entacapone[5] COMTAN; Comtess; ENTACAPONA; Entacapone; Stalevo; [1] COMT 💬[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism 💬[2] 6, 17
105 Botulinum toxin type A [1] Botulinum toxin type A[8] Botox; Botulinum toxin A; BOTULINUM TOXIN TYPE A; BTX-A; Dysport; IncobotulinumtoxinA; OnabotulinumtoxinA; Xeomin; [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226
106 Ropinirole hydrochloride [1] Ropinirole[3] Requip; Ropinirole; ROPINIROLE HYDROCHLORIDE; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 2, 6, 74, 309
107 Selegiline hydrochloride [1] Selegiline[2] SELEGILINE; Zelapar; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
108 Tolcapone [1] Tolcapone[3] Tasmar; Tolcapon; TOLCAPONE; [1] COMT 💬[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism 💬[3] 6, 28, 127
109 Trihexyphenidyl hydrochloride [1] Trihexyphenidyl[1] Trihexyphenidyl; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6
110 Doxepin hydrochloride [1] Doxepin[1] Doxepin; [3] HRH1,
SLC6A2,
SLC6A4 💬		[5] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 6
111 Nortriptyline hydrochloride [1] Nortriptyline[2] Nortriptyline; Nortriptyline hydrochloride; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 226
112 Venlafaxine hydrochloride [1] Venlafaxine[2] Venlafaxine; VENLAFAXINE HYDROCHLORIDE; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 13, 46
113 Citalopram hydrobromide [1] Citalopram[1] Citalopram; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[7] 6, 8, 13, 18, 46, 98, 127
114 Sertraline hydrochloride [1] Sertraline[1] Sertraline; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 206
115 Dextromethorphan hydrobromide [1] Dextromethorphan[4] Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta; [6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
116 Minocycline hydrochloride [1] Minocycline[3] Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin; --[14] 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
117 Erythromycin estolate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
118 Moxifloxacin hydrochloride [1] Moxifloxacin[2] Moxifloxacin; Moxifloxacin Hydrochloride; --[9] 2, 6, 46, 49, 85, 86, 113, 240, 299
119 Cycloserine [1] Cycloserine[0] --[1] 6
120 Ceftriaxone sodium [1] Ceftriaxone[1] Ceftriaxone; --[3] 2, 6, 97
121 Metformin hydrochloride [1] Metformin[5] METFORMIN; Metformin HCl; Metformin hydrochloride; METFORMINA; Metformine; [2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
122 Pioglitazone hydrochloride [1] Pioglitazone[1] Pioglitazone; [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
123 Hydrocortisone cypionate [1] Hydrocortisone cypionate[1] Cortef; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 6, 81, 83
124 Methylprednisolone acetate [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
125 Fludrocortisone acetate [1] Fludrocortisone[1] Fludrocortisone; [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[3] 6, 17, 81
126 Cabergoline [1] Cabergoline[3] CABERGOLINA; Cabergoline; DOSTINEX; [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 6, 74, 75
127 Ubidecarenone [1] Ubidecarenone[3] Coenzyme Q-10; Coenzyme Q10; CoQ10; --[13] 2, 5, 6, 8, 10, 18, 46, 57, 86, 113, 193, 214, 215
128 Exametazime [1] Exametazime[1] Exametazime; --[1] 6
129 Aripiprazole [1] Aripiprazole[1] Aripiprazole; [4] DRD2,
DRD3,
HTR1A,
HTR2A 💬		[12] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 206
130 Magnesium oxide [1] Magnesium oxide[1] Magnesium oxide; --[3] 6, 166, 291
131 Remifentanil hydrochloride [1] Remifentanil[2] Remifentanil; Remifentanyl; [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[2] 6, 70
132 Duloxetine hydrochloride [1] Duloxetine[3] Cymbalta; DULOXETINE; Duloxetine hydrochloride; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
133 Dexmedetomidine hydrochloride [1] Dexmedetomidine[4] Dexdor; DEXMEDETOMIDINA; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[13] 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
134 Febuxostat [1] Febuxostat[1] Febuxostat; [1] XDH 💬[5] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine metabolism 💬[3] 2, 6, 13
135 Omeprazole sodium [1] Omeprazole[5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM; [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
136 Sulpiride [1] Sulpiride[0] [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 2, 6, 17, 46, 70
137 Josamycin [1] Josamycin[0] --[2] 6, 13
138 Ampicillin hydrate [1] Ampicillin[1] ABPC; --[5] 2, 6, 13, 84, 299
139 Solifenacin succinate [1] Solifenacin[2] Solifenacin; Solifenacin Succinate; [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[3] 6, 13, 53
140 Droxidopa [1] Droxidopa[4] DOPS; Droxidopa; L-DOPS; Northera; [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 5, 6, 17, 169, 170
141 Warfarin potassium [1] Warfarin[2] Warfarin; Warfarin Sodium; [2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
142 Methylphenidate hydrochloride [1] Methylphenidate[3] Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin; [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
143 Midodrine hydrochloride [1] Midodrine[2] Midodrine; MIDODRINE HYDROCHLORIDE; [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[3] 6, 17, 58
144 Naloxone hydrochloride [1] Naloxone[2] Naloxone; NALOXONE HYDROCHLORIDE; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 6, 226
145 Erythromycin ethylsuccinate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
146 Zopiclone [1] Zopiclone[1] Zopiclone; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 6
147 Hydrocortisone succinate [1] Hydrocortisone succinate[2] HYDROCORTISONE HYDROGEN SUCCINATE; Solu-Cortef; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 6, 81, 83
148 Caffeine hydrate [1] Caffeine[1] Caffeine; [11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
149 Lisuride maleate [1] Lisuride[1] LISURIDE; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 86
150 Darifenacin hydrobromide [1] Darifenacin[2] Darifenacin; Emselex; [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
151 Domperidone [1] Domperidone[1] Domperidone; [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
152 Idebenone [1] Idebenone[2] Idebenone; Raxone; --[6] 6, 8, 13, 18, 113, 302
153 Benoxinate hydrochloride [1] Oxybuprocaine[1] Oxybuprocaine; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 6
154 Modafinil [1] Modafinil[2] Modafinil; Provigil; --[5] 6, 13, 49, 93, 113
155 Rosuvastatin calcium [1] Rosuvastatin[3] Crestor; Rosuvastatin; Rosuvastatin calcium; [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
156 Silodosin [1] Silodosin[2] Silodosin; Silodyx; [1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 6, 13
157 Zoledronic acid [1] Zoledronic acid[4] Aclasta; Zoledronate; Zoledronic acid; Zometa; [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
158 Apomorphine hydrochloride [1] Apomorphine[3] APOKYN; Apomorfina; Apomorphine; [2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7
159 Tadalafil [1] Tadalafil[4] Adcirca; Cialis; Tadalafil; TADALAFILO; [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210
160 Erythromycin lactobionate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
161 Potassium carbonate [1] Potassium carbonate[0] --[3] 6, 96, 291
162 Sodium chloride [1] Sodium chloride[6] Lactated Ringers; Natriumchlorid; REBIF; Saline; Sodium chloride; SPORANOX; --[21] 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 168, 193, 227, 228, 271, 288, 299
163 Lidocaine hydrochloride [1] Lidocaine[4] Aloe; Lidocaine; Lignocaine; Xylocaine; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
164 Naltrexone hydrochloride [1] Naltrexone[2] Naltrexone; Naltrexone Hydrochloride; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
165 Ampicillin sodium [1] Ampicillin[1] ABPC; --[5] 2, 6, 13, 84, 299
166 Tulobuterol [1] Tulobuterol[1] Tulobuterol; [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
167 Galantamine hydrobromide [1] Galantamine[2] Galantamine; Galantamine hydrobromide; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[2] 6, 127
168 Pyridoxine hydrochloride [1] Pyridoxine[2] Pyridoxine; Vitamin B6; --[5] 6, 93, 145, 206, 320
169 Erythromycin stearate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
170 Pilocarpine hydrochloride [1] Pilocarpine[2] Pilocarpine; Pilocarpine Hydrochloride; [2] CHRM2,
CHRM3 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 53, 299
171 Ipratropium bromide [1] Ipratropium[1] Ipratropium; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 86
172 Sildenafil citrate [1] Sildenafil[6] Mysildecard; Revatio; Sildenafil; Sildenafil citrate; SILDENAFILO; Viagra; [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
173 Desmopressin acetate [1] Desmopressin[5] DDAVP; Desmopressin; Desmopressin Acetate; Desmopressine; Minirin; [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[6] 6, 64, 72, 75, 225, 288
174 Paroxetine hydrochloride hemihydrate [1] Paroxetine[1] Paroxetine; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
175 Ergoloid mesylates [1] Ergoloid mesylate[2] Dihydroergotoxine Mesylate; Ergoloid Mesylate; [6] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 6, 206
176 Propionic acid [1] Propanoic acid[1] Propanoic acid; --[2] 6, 271
177 Cysteine hydrochloride [1] Cysteine[2] Cysteine; Cysteine hydrochloride; --[11] 6, 13, 19, 34, 84, 85, 88, 90, 254, 296, 310
178 Maltodextrin [1] Maltodextrin[1] Maltodextrin; --[4] 6, 13, 96, 97
179 Vitamin E [1] Vitamin E[2] Alpha-tocopherol; Vitamin E; --[12] 2, 6, 13, 20, 46, 49, 90, 96, 97, 206, 299, 317
180 Dipivefrin [1] Dipivefrin[2] Dipivefrin; Dipivefrine; [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
181 Sertraline [1] Sertraline[1] Sertraline; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 206
182 Paroxetine [1] Paroxetine[1] Paroxetine; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
183 Aspartame [1] Aspartame[0] [2] TAS1R2,
TAS1R3 💬		[2] Carbohydrate digestion and absorption, Taste transduction 💬[5] 6, 13, 67, 86, 230
184 Erythromycin acistrate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
185 Erythromycin gluceptate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
186 Erythromycin propionate [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
187 Rifaximin [1] Rifaximin[3] Rifaximin; RIFAXIMINA; Xifaxan; --[8] 6, 65, 93, 94, 96, 97, 99, 296
188 Rivastigmine tartrate [1] Rivastigmine[3] EXELON; Rivastigmine; Rivastigmine Transdermal System; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[3] 5, 6, 13
189 Moclobemide [1] Moclobemide[1] MOCLOBEMIDE; [1] MAOA 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
190 Rasagiline mesylate [1] Rasagiline[4] AZILECT; Rasagilina; Rasagiline; Rasagiline mesylate; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 2, 5, 6, 13, 17, 58, 66
191 Escitalopram oxalate [1] Escitalopram[3] Citalopram; Escitalopram; Escitalopram oxalate; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 2, 6, 13
192 Atomoxetine hydrochloride [1] Atomoxetine[2] Atomoxetine; Strattera; [1] SLC6A2 💬[1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17
193 Agomelatine [1] Agomelatine[1] Agomelatine; [3] HTR2C,
MTNR1A,
MTNR1B 💬		[6] Calcium signaling pathway, Circadian entrainment, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse 💬[1] 6
194 Iproniazid [1] Iproniazid[1] IPRONIAZID; [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
195 Eszopiclone [1] Eszopiclone[2] Eszopiclone; Zopiclone; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 6, 13, 46
196 Ramelteon [1] Ramelteon[2] Ramelteon; ROZEREM; [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[3] 6, 8, 46
197 Talampanel [1] Talampanel[1] Talampanel; [4] GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		[16] Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[2] 2, 6
198 Trimethobenzamide hydrochloride [1] Trimethobenzamide[3] Tigan; Trimethobenzamide; Trimethobenzamide Hydrochloride; --[1] 6
199 Rimabotulinumtoxin B [1] Botulinum toxin type B[3] Botulinum toxin type B; NEUROBLOC; RimabotulinumtoxinB; [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[4] 2, 6, 13, 51
200 Acamprosate calcium [1] Acamprosate[1] Acamprosate; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[2] 6, 206
201 Amoxicillin sodium [1] Amoxicillin[4] Amoxicilina; Amoxicillin; Amoxycillin; Augmentin; --[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
202 Rituximab [1] Rituximab[6] MabThera; Rituxan; RITUXIMAB; Rixathon; Ruxience; Truxima; [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
203 Azathioprine sodium [1] Azathioprine[3] Azathioprine; Azatioprina; Imuran; --[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
204 Benserazide [1] Benserazide[1] BENSERAZIDE; [1] DDC 💬[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
205 Bromocriptine [1] Bromocriptine[1] BROMOCRIPTINE; [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 74
206 Armodafinil [1] Armodafinil[2] Armodafinil; Modafinil; [1] SLC6A3 💬[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[3] 6, 13, 84
207 Lactose [1] Lactose[1] Lactose; --[6] 2, 6, 13, 97, 228, 310
208 Epoetin alfa [1] Erythropoietin[4] Epoetin alfa; Epoetin beta; Erythropoietin; NeoRecormon; [1] EPOR 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[10] 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
209 Filgrastim [1] Filgrastim[7] Filgrastim; Filgrastim Hexal; G-CSF; Granulocyte Colony Stimulating Factor; NEUPOGEN; TEVAGRASTIM; ZARZIO; [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[34] 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
210 Nicotine [1] Nicotine[2] NICOTINE; Nicotine gum; [16] CHRNA1,
CHRNA10,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNA6,
CHRNA7,
CHRNA9,
CHRNB1,
CHRNB2,
CHRNB3,
CHRNB4,
CHRND,
CHRNE,
CHRNG 💬		[7] Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases 💬[3] 6, 13, 84
211 Polyethylene glycol 3350 [1] Polyethylene glycol[4] Macrogol; Macrogol 4000; Polyethylene glycol; Polyethylene Glycol 3350; --[14] 6, 13, 41, 46, 65, 78, 96, 97, 140, 144, 235, 240, 276, 299
212 Carvedilol phosphate [1] Carvedilol[1] Carvedilol; [5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 57, 86, 113, 210
213 Cyanocobalamin Co 57 [1] Cyanocobalamin[2] Cianocobalamina; Vitamin B12; --[5] 6, 13, 201, 229, 299
214 Cyanocobalamin Co 58 [1] Cyanocobalamin[2] Cianocobalamina; Vitamin B12; --[5] 6, 13, 201, 229, 299
215 Cyanocobalamin Co 60 [1] Cyanocobalamin[2] Cianocobalamina; Vitamin B12; --[5] 6, 13, 201, 229, 299
216 Darifenacin [1] Darifenacin[2] Darifenacin; Emselex; [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
217 Selegiline [1] Selegiline[2] SELEGILINE; Zelapar; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
218 Dextromethorphan [1] Dextromethorphan[4] Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta; [6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
219 Dextromethorphan polistirex [1] Dextromethorphan[4] Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta; [6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
220 Oxycodone terephthalate [1] Oxycodone[3] Oxycodone; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
221 Rivastigmine [1] Rivastigmine[3] EXELON; Rivastigmine; Rivastigmine Transdermal System; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[3] 5, 6, 13
222 Erythromycin salnacedin [1] Erythromycin[1] Erythromycin; --[5] 6, 36, 164, 228, 291
223 Exenatide [1] Exenatide[3] Bydureon; Byetta; Exenatide; [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[6] 6, 17, 72, 78, 193, 233
224 Dalfampridine [1] Dalfampridine[7] 4-Aminopyridine; 4-AP; Ampyra; Dalfampridine; FAMPRIDINA; FAMPRIDINE; FAMPYRA; [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[5] 3, 4, 6, 13, 14
225 Fenamole [1] Fenamole[0] --[3] 6, 13, 160
226 Galantamine [1] Galantamine[2] GALANTAMINE; Galantamine hydrobromide; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[2] 6, 127
227 Lactobacillus casei [1] Lactobacillus casei[2] Fusion; Lactobacillus casei; --[10] 6, 11, 13, 46, 49, 69, 70, 97, 271, 296
228 Guar gum [1] Guar gum[1] Guar gum; --[1] 6
229 Istradefylline [1] Istradefylline[1] ISTRADEFYLLINE; [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
230 Lecithin [1] Phosphatidyl serine[0] --[4] 6, 46, 90, 97
231 Liatermin [1] Liatermin[2] Liatermin; R-metHuGDNF; --[1] 6
232 Lithium citrate [1] Lithium citrate[2] Lithium; LITHIUM CITRATE; --[5] 2, 5, 6, 7, 8
233 Lubiprostone [1] Lubiprostone[1] Lubiprostone; [1] CLCN2 💬[1] Mineral absorption 💬[4] 6, 13, 290, 299
234 Memantine hydrochloride [1] Memantine[3] EBIXA; Memantine; Memantine hydrochloride; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 6, 8, 13, 49, 127, 205
235 Metformin [1] Metformin[5] Metformin; Metformin HCl; Metformin Hydrochloride; METFORMINA; Metformine; [2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
236 Methylphenidate [1] Methylphenidate[3] Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin; [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
237 Methylprednisolone hemisuccinate [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; Methylprednisolone acetate; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
238 Methylprednisolone sodium phosphate [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
239 Methylprednisolone suleptanate [1] Methylprednisolone[4] Medrol; Methylprednisolon; Methylprednisolone; Methylprednisolone acetate; [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
240 Midazolam maleate [1] Midazolam[2] Midazolam; Midazolam injection; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
241 Minocycline [1] Minocycline[3] Minocycline; Minocycline Hydrochloride; Minomycin; --[14] 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
242 Nabilone [1] Nabilone[1] Nabilone; [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 6, 13
243 Nalmefene [1] Nalmefene[1] Nalmefene; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
244 Naltrexone [1] Naltrexone[2] Naltrexone; Naltrexone Hydrochloride; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
245 Nicotine bitartrate [1] Nicotine[2] Nicotine; Nicotine gum; [16] CHRNA1,
CHRNA10,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNA6,
CHRNA7,
CHRNA9,
CHRNB1,
CHRNB2,
CHRNB3,
CHRNB4,
CHRND,
CHRNE,
CHRNG 💬		[7] Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases 💬[3] 6, 13, 84
246 Nicotine polacrilex [1] Nicotine[2] Nicotine; Nicotine gum; [16] CHRNA1,
CHRNA10,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNA6,
CHRNA7,
CHRNA9,
CHRNB1,
CHRNB2,
CHRNB3,
CHRNB4,
CHRND,
CHRNE,
CHRNG 💬		[7] Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases 💬[3] 6, 13, 84
247 Nitisinone [1] Nitisinone[2] Nitisinone; Orfadin; [1] HPD 💬[5] Biosynthesis of cofactors, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism, Ubiquinone and other terpenoid-quinone biosynthesis 💬[3] 6, 164, 241
248 Omeprazole magnesium [1] Omeprazole[5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM; [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
249 Omeprazole sodium injection [1] Omeprazole[5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM; [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
250 Oxycodone [1] Oxycodone[3] Oxycodone; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
251 Paroxetine hydrochloride [1] Paroxetine[1] Paroxetine; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
252 Paroxetine mesylate [1] Paroxetine[1] Paroxetine; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
253 Oxycodone hydrochloride hydrate [1] Oxycodone[3] Oxycodone; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
254 Pilocarpine nitrate [1] Pilocarpine[2] Pilocarpine; Pilocarpine Hydrochloride; [2] CHRM2,
CHRM3 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 53, 299
255 Plantago seed [1] Plantago seed[2] Psyllium; Psyllium husk; --[3] 6, 28, 97
256 Pramipexole [1] Pramipexole[7] Mirapex; Mirapex ER; Mirapexin; Pramipexol; Pramipexole; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 20
257 Rotigotine [1] Rotigotine[3] NEUPRO; ROTIGOTINA; Rotigotine; [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 127
258 Sargramostim [1] Sargramostim[2] Leukine; Sargramostim; [1] CSF2RA 💬[4] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬[7] 6, 28, 60, 62, 96, 229, 285
259 Sodium oxybate [1] Sodium oxybate[1] Sodium Oxybate; --[2] 6, 149
260 Sulfachlorpyridazine [1] Sulfachlorpyridazine[0] --[1] 6
261 Zoledronate disodium [1] Zoledronic acid[4] Aclasta; Zoledronate; Zoledronic acid; Zometa; [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
262 Zoledronate trisodium [1] Zoledronic acid[4] Aclasta; Zoledronate; Zoledronic acid; Zometa; [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
263 Liraglutide [1] Liraglutide[2] LIRAGLUTIDE; Saxenda; [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[3] 6, 75, 193
264 Wheat [1] Wheat[1] Wheat; --[3] 6, 98, 266
265 Green tea leaf [1] Green tea leaf[4] Green Tea; Green Tea Extract; GREEN TEA LEAF; Tea Extract; --[5] 6, 17, 28, 46, 96
266 Acamprosate [1] Acamprosate[1] Acamprosate; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[2] 6, 206
267 Ademetionine [1] Ademetionine[2] SAM-e; SAMe; --[2] 6, 93
268 Heptaminol [1] Heptaminol[1] Heptaminol; --[1] 6
269 Fesoterodine [1] Fesoterodine[1] Fesoterodine; [2] CHRM2,
CHRM3 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 6
270 Melevodopa [1] Melevodopa[1] Melevodopa; --[1] 6
271 Piribedil [1] Piribedil[1] Piribedil; [2] DRD2,
DRD3 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
272 Melperone [1] Melperone[1] Melperone; [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
273 Deferiprone [1] Deferiprone[2] Deferiprone; Ferriprox; --[6] 2, 6, 18, 120, 122, 233
274 Amantadine [1] Amantadine[3] Amantadine; AMANTADINE HYDROCHLORIDE; GOCOVRI; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[4] 6, 8, 13, 127
275 Ambroxol [1] Ambroxol[1] Ambroxol; --[2] 6, 19
276 Amoxicillin [1] Amoxicillin[4] Amoxicilina; Amoxicillin; Amoxycillin; Augmentin; --[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
277 Apomorphine [1] Apomorphine[3] APOKYN; Apomorfina; Apomorphine; [2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7
278 Atomoxetine [1] Atomoxetine[2] Atomoxetine; Strattera; [1] SLC6A2 💬[1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17
279 Buspirone [1] Buspirone[2] Buspirone; Buspirone Hydrochloride; [2] DRD2,
HTR1A 💬		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[3] 6, 51, 179
280 Ceftriaxone [1] Ceftriaxone[1] Ceftriaxone; --[3] 2, 6, 97
281 Citalopram [2] Citalopram,
Escitalopram		[3] Citalopram; Escitalopram; Escitalopram oxalate; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[10] 2, 6, 6, 8, 13, 13, 18, 46, 98, 127
282 Clenbuterol [1] Clenbuterol[1] Clenbuterol; [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 1, 2, 6, 13, 256
283 Deanol [1] Deanol[1] Deanol; --[1] 6
284 Delorazepam [1] Delorazepam[0] [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 6, 46, 97
285 Dihydroergotoxine [1] Dihydroergotoxine[1] Dihydroergotoxine; --[1] 6
286 Domperidone maleate [1] Domperidone[1] Domperidone; [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
287 Donepezil [1] Donepezil[3] ARICEPT; Donepezil; Donepezil hydrochloride; [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
288 Dopamine [1] Dopamine[2] Dopamina; Dopamine; [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 6, 7, 74, 299
289 Doxepin [1] Doxepin[1] Doxepin; [3] HRH1,
SLC6A2,
SLC6A4 💬		[5] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 6
290 Duloxetine [1] Duloxetine[3] Cymbalta; DULOXETINE; Duloxetine hydrochloride; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
291 Escitalopram [1] Escitalopram[3] Citalopram; Escitalopram; Escitalopram oxalate; [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 2, 6, 13
292 Flecainide [1] Flecainide[3] Flecainide; FLECAINIDE ACETATE; Flecainidum; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 6
293 Fludrocortisone [1] Fludrocortisone[1] Fludrocortisone; [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[3] 6, 17, 81
294 Ketamine [1] Ketamine[2] KETAMINE; NMDA; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 4, 6, 13, 70, 113, 156, 215
295 Lidocaine hydrochloride monohydrate [1] Lidocaine[4] Aloe; Lidocaine; Lignocaine; Xylocaine; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
296 Lisuride [1] Lisuride[1] LISURIDE; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 86
297 Melatonin [1] Melatonin[2] Circadin; Melatonin; [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[12] 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
298 Memantine [1] Memantine[3] Ebixa; MEMANTINE; MEMANTINE HYDROCHLORIDE; [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 6, 8, 13, 49, 127, 205
299 Midodrine [1] Midodrine[2] Midodrine; MIDODRINE HYDROCHLORIDE; [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[3] 6, 17, 58
300 Montelukast [1] Montelukast[3] Montelukast; MONTELUKAST SODIUM; Singulair; [1] CYSLTR1 💬[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction 💬[8] 6, 13, 46, 61, 63, 85, 98, 228
301 Moxifloxacin [1] Moxifloxacin[2] Moxifloxacin; Moxifloxacin Hydrochloride; --[9] 2, 6, 46, 49, 85, 86, 113, 240, 299
302 Naloxone [1] Naloxone[2] Naloxone; NALOXONE HYDROCHLORIDE; [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 6, 226
303 Nortriptyline [1] Nortriptyline[2] Nortriptyline; Nortriptyline hydrochloride; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 226
304 Oxybuprocaine [1] Oxybuprocaine[1] Oxybuprocaine; [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 6
305 Pergolide [1] Pergolide[1] PERGOLIDE; [2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
306 Phenelzine [1] Phenelzine[1] Nardil; [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
307 Pioglitazone [1] Pioglitazone[1] Pioglitazone; [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
308 Propranolol [1] Propranolol[3] Propanolol; Propranolol; Propranolol Hydrochloride; [3] ADRB1,
ADRB2,
ADRB3 💬		[12] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 158, 167, 215, 227, 278, 296
309 Pyridoxine [1] Pyridoxine[2] PYRIDOXINE; Vitamin B6; --[5] 6, 93, 145, 206, 320
310 Quetiapine [1] Quetiapine[2] Quetiapine; Seroquel; [2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[2] 6, 13
311 Rasagiline [1] Rasagiline[4] Azilect; Rasagilina; Rasagiline; Rasagiline mesylate; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 2, 5, 6, 13, 17, 58, 66
312 Remifentanil [1] Remifentanil[2] Remifentanil; Remifentanyl; [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[2] 6, 70
313 Ropinirole [1] Ropinirole[3] Requip; Ropinirole; ROPINIROLE HYDROCHLORIDE; [3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 2, 6, 74, 309
314 Rosuvastatin [1] Rosuvastatin[3] Crestor; Rosuvastatin; Rosuvastatin calcium; [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
315 Sildenafil [1] Sildenafil[6] Mysildecard; Revatio; Sildenafil; SILDENAFIL CITRATE; SILDENAFILO; Viagra; [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
316 Sitagliptin [1] Sitagliptin[1] Sitagliptin; [1] DPP4 💬[1] Protein digestion and absorption 💬[4] 6, 75, 233, 299
317 Solifenacin [1] Solifenacin[2] Solifenacin; Solifenacin Succinate; [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[3] 6, 13, 53
318 Sulfanilamide [1] Sulfanilamide[0] --[5] 6, 30, 60, 118, 298
319 Sultopride [1] Sulpiride[0] [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 2, 6, 17, 46, 70
320 Tacrolimus [1] Tacrolimus[2] Prograf; Tacrolimus; [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
321 Terazosin [1] Terazosin[1] Terazosin; [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 6
322 Trihexyphenidyl [1] Trihexyphenidyl[1] Trihexyphenidyl; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6
323 Trimethobenzamide [1] Trimethobenzamide[3] Tigan; Trimethobenzamide; Trimethobenzamide Hydrochloride; --[1] 6
324 Varenicline [1] Varenicline[2] Champix; Varenicline; [2] CHRNA4,
CHRNB2 💬		[4] Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction 💬[2] 6, 18
325 Venlafaxine [1] Venlafaxine[2] Venlafaxine; VENLAFAXINE HYDROCHLORIDE; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 13, 46
326 Warfarin [1] Warfarin[2] Warfarin; Warfarin Sodium; [2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
327 Yohimbine [1] Yohimbine[1] Yohimbine; [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 6
328 Zoledronic acid [1] Zoledronic acid[4] Aclasta; Zoledronate; Zoledronic acid; Zometa; [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
329 Zolpidem [1] Zolpidem[2] Zolpidem; Zolpidem Tartrate; [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46
330 Nilotinib [1] Nilotinib[2] Nilotinib; TASIGNA; [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86
331 Perampanel [1] Perampanel[2] Fycompa; Perampanel; [4] GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		[16] Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[3] 2, 6, 144
332 Levomefolic acid [1] Levomefolic acid[1] L-methylfolate; --[1] 6
333 Linaclotide [1] Linaclotide[1] Linaclotide; [1] GUCY2C 💬[2] Metabolic pathways, Purine metabolism 💬[2] 6, 97
334 Pardoprunox [1] Pardoprunox[1] Pardoprunox; [3] DRD2,
DRD3,
HTR1A 💬		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[1] 6
335 Mirabegron [1] Mirabegron[1] Mirabegron; [1] ADRB3 💬[8] Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cGMP-PKG signaling pathway 💬[4] 6, 13, 53, 226
336 Nelotanserin [1] Nelotanserin[1] Nelotanserin; [1] HTR2A 💬[5] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse 💬[1] 6
337 Saracatinib [1] Saracatinib[1] Saracatinib; [2] ABL1,
SRC 💬		[49] Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[3] 6, 89, 272
338 Carbon monoxide [1] Carbon monoxide[1] Carbon Monoxide; --[8] 6, 13, 53, 70, 85, 86, 149, 298
339 Preladenant [1] Preladenant[1] Preladenant; [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
340 Lixisenatide [1] Lixisenatide[1] Lixisenatide; [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 6
341 Bavisant [1] Bavisant[1] Bavisant; [1] HRH3 💬[1] Neuroactive ligand-receptor interaction 💬[1] 6
342 Pridopidine [1] Pridopidine[1] Pridopidine; [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 8
343 Semaglutide [1] Semaglutide[1] Semaglutide; [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 6
344 Suvorexant [1] Suvorexant[1] Suvorexant; [2] HCRTR1,
HCRTR2 💬		[1] Neuroactive ligand-receptor interaction 💬[3] 5, 6, 13
345 Glycerol phenylbutyrate [1] Glycerol phenylbutyrate[3] Glycerol Phenylbutyrate; GT4P; Ravicti; --[3] 6, 251, 299
346 Safinamide [1] Safinamide[3] Safinamida; SAFINAMIDE; Xadago; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[2] 6, 17
347 Tozadenant [1] Tozadenant[1] TOZADENANT; [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
348 Vortioxetine [1] Vortioxetine[1] Vortioxetine; [7] HTR1A,
HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E,
SLC6A4 💬		[5] Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[1] 6
349 Masitinib [1] Masitinib[1] Masitinib; [1] KIT 💬[11] Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬[6] 2, 5, 6, 13, 46, 96
350 Pitolisant [1] Pitolisant[1] Pitolisant; [1] HRH3 💬[1] Neuroactive ligand-receptor interaction 💬[3] 6, 113, 193
351 Elobixibat [1] Elobixibat[1] Elobixibat; [1] SLC10A2 💬[1] Bile secretion 💬[1] 6
352 Opicapone [1] Opicapone[2] Ongentys; OPICAPONE; [1] COMT 💬[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism 💬[1] 6
353 Rasagiline tartrate [1] Rasagiline[4] Azilect; Rasagilina; Rasagiline; Rasagiline mesylate; [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 2, 5, 6, 13, 17, 58, 66
354 Cannabidiol [1] Cannabidiol[3] CANNABIDIOL; Epidyolex; Sativex; [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[19] 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
355 Prasinezumab [1] Prasinezumab[1] Prasinezumab; [1] SNCA 💬[3] Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬[1] 6
356 Tavapadon [1] Tavapadon[2] PF-06649751; TAVAPADON; [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
357 Venglustat [1] Venglustat[2] GENZ-682452; Venglustat; [1] UGCG 💬[2] Metabolic pathways, Sphingolipid metabolism 💬[3] 6, 19, 67
358 Ampreloxetine [1] Ampreloxetine[1] Ampreloxetine; [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 17
359 Foslevodopa [1] Foslevodopa[1] Foslevodopa; [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
360 Foscarbidopa [1] Foscarbidopa[1] Foscarbidopa; --[1] 6