Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acetylcysteine 1件: Acetylcysteine1件: Acetylcysteine 💬 --12件: 8, 34, 51, 53, 85, 90, 94, 97, 193, 233, 298, 299 💬
2 Alprazolam 1件: Alprazolam1件: Alprazolam 💬 16件: GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ 💬 		8件: GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 8, 75 💬
3 Amantadine 3件: Amantadine; Amantadine hydrochloride; Amantadine sulfate2件: Amantadine hydrochloride ,
Amantadine 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬5件: 2, 6, 8, 13, 127 💬
4 AMT-130 2件: AMT-130; RAAV5-mihtt---1件: 8 💬
5 Atomoxetine 2件: Atomoxetina; Atomoxetine2件: Atomoxetine hydrochloride ,
Atomoxetine 💬 		1件: SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle 💬4件: 6, 8, 13, 230 💬
6 Bevantolol 1件: Bevantolol hydrochloride1件: Bevantolol hydrochloride 💬 8件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		44件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gap junction, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hormone signaling, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 8 💬
7 Biotin 3件: Biotin; Biotina; Vitamin B71件: Biotin 💬 --3件: 2, 8, 13 💬
8 Branaplam 1件: Branaplam1件: Branaplam 💬 --2件: 3, 8 💬
9 Bupropion 2件: Bupropion; Bupropion hydrochloride3件: Bupropion hydrochloride ,
Bupropion ,
Bupropion hydrobromide 💬 		2件: SLC6A2,
SLC6A3 💬 		8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬6件: 8, 18, 21, 96, 97, 171 💬
10 Cannabidiol 1件: Cannabidiol1件: Cannabidiol 💬 2件: CNR1,
CNR2 💬 		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬20件: 6, 8, 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
11 CKD-504 1件: CKD-504---1件: 8 💬
12 Creatine 3件: Acetic acid; Creatine; Creatine monohydrate---14件: 1, 2, 6, 8, 13, 21, 46, 49, 50, 97, 113, 156, 201, 337 💬
13 Cysteamine 6件: 2-aminoethanethiol; Cysteamine; Cysteamine bitartrate; Cysteamine hydrochloride; Mercaptamina; Mercaptamine3件: Cysteamine ,
Cysteamine hydrochloride ,
Cysteamine bitartrate 💬 		--4件: 8, 19, 21, 299 💬
14 Deutetrabenazine 1件: Deutetrabenazine1件: Deutetrabenazine 💬 1件: SLC18A1_2 💬 8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
15 Dextromethorphan 2件: Dextromethorphan; Dextromethorphan hydrobromide3件: Dextromethorphan hydrobromide ,
Dextromethorphan ,
Daunorubicin 💬 		6件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬10件: 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
16 Digoxin 1件: Digoxin1件: Digoxin 💬 4件: ATP1A,
ATP1A,
ATP1A,
ATP1A 💬 		19件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 8, 46, 210 💬
17 Dronabinol 3件: Delta-9-tetrahydrocannabinol; Dronabinol; Tetrahydrocannabinol1件: Dronabinol 💬 2件: CNR1,
CNR2 💬 		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬8件: 2, 8, 13, 36, 46, 96, 271, 298 💬
18 Epigallocatechin 1件: Epigallocatechin---5件: 8, 13, 28, 85, 113 💬
19 Epigallocatechin gallate 2件: Egcg; Epigallocatechin-3-gallate---8件: 6, 8, 13, 17, 28, 85, 206, 299 💬
20 ER2001 0件: ---1件: 8 💬
21 Fenofibrate 1件: Fenofibrate1件: Fenofibrate 💬 1件: NR1C1 💬 10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬6件: 8, 79, 93, 94, 97, 265 💬
22 Fludeoxyglucose (18F) 2件: 18F-FDG; Fludeoxyglucose F 181件: Fludeoxyglucose F 18 💬 --12件: 5, 6, 7, 8, 34, 41, 46, 84, 85, 96, 127, 300 💬
23 Haloperidol 0件: 3件: Haloperidol ,
Haloperidol decanoate ,
Haloperidol lactate 💬 		1件: DRD2 💬 10件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 8 💬
24 Icosapent ethyl 1件: Ethyl-EPA1件: Icosapent ethyl 💬 --1件: 8 💬
25 Idebenone 1件: Idebenone1件: Idebenone 💬 --7件: 6, 8, 13, 18, 21, 113, 302 💬
26 Indopan 0件: ---5件: 2, 8, 19, 46, 97 💬
27 Laquinimod 1件: Laquinimod1件: Laquinimod sodium 💬 --4件: 8, 13, 49, 96 💬
28 Latrepirdine 2件: Dimebon; Latrepirdine2件: Latrepirdine ,
Latrepirdine dihydrochloride 💬 		6件: ACHE,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 8 💬
29 LAX-101 1件: LAX-101---1件: 8 💬
30 Melatonin 1件: Melatonin1件: Melatonin 💬 2件: MTNR1A,
MTNR1B 💬 		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬17件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
31 Memantine 2件: Memantine; Memantine hydrochloride2件: Memantine hydrochloride ,
Memantine 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206 💬
32 Metformin 3件: Metformin; Metformin hydrochloride; Metformina2件: Metformin hydrochloride ,
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
33 Minocycline 3件: Minocycline; Minocycline hydrochloride; Minomycin2件: Minocycline hydrochloride ,
Minocycline 💬 		--15件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 97, 162, 201, 206, 280, 299 💬
34 Neflamapimod 1件: Neflamapimod1件: Neflamapimod 💬 4件: P38,
P38,
P38,
P38 💬 		62件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Efferocytosis, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬1件: 8 💬
35 Nicotinamide 2件: Niacinamide; Nicotinamide1件: Niacinamide 💬 --20件: 2, 5, 6, 7, 8, 13, 17, 18, 21, 46, 49, 60, 63, 65, 67, 85, 97, 107, 162, 191 💬
36 Nicotinamide riboside 2件: Nicotinamide riboside; Nicotinamide riboside chloride---14件: 2, 5, 6, 7, 8, 17, 18, 21, 49, 60, 65, 85, 97, 191 💬
37 Nilotinib 2件: Nilotinib; Nilotinib hydrochloride monohydrate1件: Nilotinib 💬 4件: ABL1,
KIT,
PDGFRA,
PDGFRB 💬 		32件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬5件: 6, 8, 34, 51, 86 💬
38 Olanzapine 1件: Olanzapine2件: Olanzapine ,
Olanzapine pamoate 💬 		11件: ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2,
HTR2,
HTR2,
HTR6 💬 		18件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 2, 8 💬
39 Phenylbutyric acid 2件: Phenylbutyrate; Sodium phenylbutyrate1件: Sodium phenylbutyrate 💬 --10件: 2, 3, 8, 15, 93, 94, 244, 251, 297, 338 💬
40 Pridopidine 2件: Pridopidine; Pridopidine hydrochloride2件: Pridopidine ,
Pridopidine hydrochloride 💬 		1件: DRD2 💬 10件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 2, 6, 8 💬
41 Quinidine 2件: Quinidine; Quinidine sulfate4件: Quinidine gluconate ,
Quinidine polygalacturonate ,
Quinidine sulfate ,
Quinidine 💬 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬2件: 8, 13 💬
42 Ramelteon 1件: Ramelteon1件: Ramelteon 💬 2件: MTNR1A,
MTNR1B 💬 		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬3件: 6, 8, 46 💬
43 Resveratrol 1件: Resveratrol---6件: 8, 18, 89, 97, 113, 299 💬
44 Rilmenidine 2件: Hyperium; Rilmenidine1件: Rilmenidine 💬 3件: ADRA2A,
ADRA2B,
ADRA2C 💬 		4件: Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 8 💬
45 Riluzole 1件: Riluzole1件: Riluzole 💬 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		24件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬8件: 2, 3, 5, 8, 13, 17, 203, 206 💬
46 Risperidone 1件: Risperidone1件: Risperidone 💬 2件: DRD2,
HTR2 💬 		13件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬3件: 8, 156, 187 💬
47 Rolipram 1件: Rolipram1件: Rolipram 💬 4件: PDE4,
PDE4,
PDE4,
PDE4 💬 		4件: Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬2件: 8, 13 💬
48 Selisistat 1件: Selisistat---1件: 8 💬
49 Tetrabenazine 1件: Tetrabenazine1件: Tetrabenazine 💬 1件: SLC18A1_2 💬 8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
50 Tominersen 1件: Tominersen1件: Tominersen 💬 1件: HD 💬 2件: Huntington disease, Pathways of neurodegeneration - multiple diseases 💬1件: 8 💬
51 Triheptanoin 1件: Triheptanoin1件: Triheptanoin 💬 --10件: 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 💬
52 Ubidecarenone 2件: Coenzyme Q10; COQ101件: Ubidecarenone 💬 --14件: 2, 5, 6, 8, 10, 46, 57, 86, 96, 107, 113, 193, 214, 215 💬
53 Ubiquinol 1件: Ubiquinol---3件: 6, 8, 17 💬
54 Ursodeoxycholic acid 3件: Udca; Ursodeoxycholic acid; Ursodiol1件: Ursodiol 💬 1件: NR1H4 💬 1件: Bile secretion 💬14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
55 Valbenazine 1件: Valbenazine2件: Valbenazine ,
Valbenazine tosylate 💬 		1件: SLC18A1_2 💬 8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
56 VO659 1件: VO659---1件: 8 💬
57 Warfarin 3件: Warfarin; Warfarin potassium; Warfarin sodium3件: Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		2件: NQO1,
VKORC1 💬 		5件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
58 WVE-003 1件: WVE-003---1件: 8 💬