Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Abatacept 1件: Abatacept1件: Abatacept 💬 2件: CD80,
CD86 💬 		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬27件: 2, 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
2 Adalimumab 1件: Adalimumab1件: Adalimumab 💬 1件: TNF 💬 66件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
3 Alefacept 1件: Alefacept1件: Alefacept 💬 1件: CD58 💬 2件: Cell adhesion molecules, Epstein-Barr virus infection 💬6件: 37, 60, 65, 164, 284, 285 💬
4 Alemtuzumab 1件: Alemtuzumab1件: Alemtuzumab 💬 --20件: 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 107, 164, 283, 284, 285, 326 💬
5 Busulfan 2件: Busulfan; Busulfano1件: Busulfan 💬 --14件: 19, 20, 28, 34, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 💬
6 Cyclophosphamide 5件: Ciclofosfamida; Ciclofosfamide; Cyclophosphamid; Cyclophosphamide; Cyclophosphamide monohydrate2件: Cyclophosphamide ,
Cyclophosphamide 💬 		--46件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 93, 96, 162, 164, 172, 205, 220, 221, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
7 Cyclosporine 6件: Ciclosporin; Ciclosporina; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine1件: Cyclosporine 💬 5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
8 Erythromycin 1件: Erythromycin7件: Erythromycin ,
Erythromycin estolate ,
Erythromycin ethylsuccinate ,
Erythromycin lactobionate ,
Erythromycin stearate ,
Erythromycin gluceptate ,
Erythromycin thiocyanate 💬 		--5件: 2, 6, 164, 228, 291 💬
9 Etoposide 1件: Etoposide2件: Etoposide ,
Etoposide phosphate 💬 		--12件: 11, 13, 14, 26, 28, 34, 54, 60, 65, 85, 164, 331 💬
10 Filgrastim 3件: Filgrastim; G-CSF; Granulocyte colony stimulating factor1件: Filgrastim 💬 1件: CSF3R 💬 5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬29件: 2, 6, 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
11 Fludarabine 2件: Fludarabine; Fludarabine phosphate2件: Fludarabine phosphate ,
Fludarabine 💬 		1件: RRM1 💬 4件: Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism 💬25件: 11, 13, 19, 28, 34, 35, 36, 44, 46, 49, 51, 60, 61, 62, 65, 85, 96, 107, 164, 222, 283, 284, 285, 286, 326 💬
12 Infliximab 1件: Infliximab1件: Infliximab 💬 1件: TNF 💬 66件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
13 Levodopa 2件: L-dopa; Levodopa1件: Levodopa 💬 5件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬 		13件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬6件: 6, 17, 90, 140, 164, 201 💬
14 Losartan 2件: Losartan; Losartan potassium2件: Losartan potassium ,
Losartan 💬 		1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
15 Lutein 1件: Lutein---3件: 13, 90, 164 💬
16 Melphalan 2件: Melphalan; Melphalan hydrochloride2件: Melphalan ,
Melphalan hydrochloride 💬 		--19件: 11, 13, 14, 19, 20, 28, 34, 46, 60, 62, 65, 96, 107, 164, 222, 234, 284, 285, 299 💬
17 Mesalazine 6件: 5-aminosalicylic acid; 5-ASA; Mesalamine; Mesalazina; Mesalazine; Mesalazinum1件: Mesalamine 💬 --5件: 46, 96, 97, 98, 164 💬
18 Methotrexate 5件: Methotrexat; Methotrexate; Methotrexate sodium; Metotrexato; Méthotrexate2件: Methotrexate ,
Methotrexate sodium 💬 		2件: DHFR,
DHFR 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬39件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬
19 Methylprednisolone 3件: Methylprednisolon; Methylprednisolone; Methylprednisolone acetate2件: Methylprednisolone ,
Methylprednisolone acetate 💬 		1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
20 Mycophenolate mofetil 1件: Mycophenolate mofetil2件: Mycophenolate mofetil ,
Mycophenolate mofetil hydrochloride 💬 		2件: IMPDH,
IMPDH 💬 		2件: Drug metabolism - other enzymes, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 93, 95, 96, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
21 Mycophenolic acid 5件: Acido micofenolico; Micofenolico acido; Mycophenolate; Mycophenolate sodium; Mycophenolic acid2件: Mycophenolate sodium ,
Mycophenolic acid 💬 		2件: IMPDH,
IMPDH 💬 		2件: Drug metabolism - other enzymes, Purine metabolism 💬37件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 84, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
22 Nitisinone 1件: Nitisinone1件: Nitisinone 💬 1件: HPD 💬 3件: Phenylalanine metabolism, Tyrosine metabolism, Ubiquinone and other terpenoid-quinone biosynthesis 💬3件: 6, 164, 241 💬
23 Pirfenidone 1件: Pirfenidone1件: Pirfenidone 💬 6件: CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬 		83件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, Efferocytosis, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 Pravastatin 2件: Pravastatin; Pravastatin sodium2件: Pravastatin sodium ,
Pravastatin 💬 		1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
25 Prednisone 2件: Prednisona; Prednisone1件: Prednisone 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬54件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
26 Tacrolimus 1件: Tacrolimus2件: Tacrolimus ,
Tacrolimus 💬 		5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬33件: 2, 6, 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
27 Zileuton 1件: Zileuton1件: Zileuton 💬 1件: ALOX5 💬 6件: Arachidonic acid metabolism, Efferocytosis, Fc epsilon RI signaling pathway, Ovarian steroidogenesis, Serotonergic synapse, Toxoplasmosis 💬3件: 85, 160, 164 💬