Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acetylsalicylic acid 2件: Acetylsalicylic acid; Aspirin1件: Aspirin 💬 2件: PTGS1,
PTGS2 💬 		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬15件: 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
2 Ambrisentan 1件: Ambrisentan1件: Ambrisentan 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 51, 66, 84, 85, 86, 88, 210, 211 💬
3 Ascorbic acid 2件: Ascorbic acid; Vitamin C1件: Ascorbic acid 💬 --8件: 10, 97, 192, 206, 210, 211, 212, 298 💬
4 Bosentan 2件: Bosentan; Bosentan monohydrate2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 Carvedilol 1件: Carvedilol2件: Carvedilol ,
Carvedilol phosphate 💬 		5件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬 		15件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 46, 57, 86, 113, 210 💬
6 Colchicine 1件: Colchicine1件: Colchicine 💬 9件: TUBB,
TUBB,
TUBB,
TUBB,
TUBB,
TUBB,
TUBB,
TUBB,
TUBB 💬 		11件: Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Motor proteins, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
7 Dapagliflozin 1件: Dapagliflozin1件: Dapagliflozin 💬 --13件: 6, 19, 28, 49, 66, 67, 86, 88, 97, 210, 215, 218, 222 💬
8 Digoxin 1件: Digoxin1件: Digoxin 💬 4件: ATP1A,
ATP1A,
ATP1A,
ATP1A 💬 		19件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 8, 46, 210 💬
9 Enalapril 2件: Enalapril; Enalapril maleate2件: Enalapril maleate ,
Enalapril 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬8件: 13, 19, 46, 66, 113, 210, 222, 279 💬
10 Eplerenone 1件: Eplerenone1件: Eplerenone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬4件: 75, 113, 210, 215 💬
11 Liothyronine 2件: Liothyronine; Liothyronine sodium2件: Liothyronine sodium ,
Liothyronine 💬 		2件: THRA,
THRB 💬 		3件: Hormone signaling, Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬3件: 13, 210, 212 💬
12 Liothyronine I-131 1件: Liothyronine I 1311件: Liothyronine I 131 💬 --2件: 210, 212 💬
13 Macitentan 1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 51, 85, 86, 88, 210 💬
14 Nitric Oxide 1件: Nitric oxide1件: Nitric oxide 💬 --9件: 51, 85, 86, 88, 97, 210, 251, 294, 299 💬
15 Pravastatin 2件: Pravastatin; Pravastatin sodium2件: Pravastatin sodium ,
Pravastatin 💬 		1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
16 Rexlemestrocel-L 2件: Neofuse; Rexlemestrocel-L---3件: 70, 210, 211 💬
17 Rivaroxaban 1件: Rivaroxaban1件: Rivaroxaban 💬 1件: F10 💬 1件: Complement and coagulation cascades 💬6件: 46, 49, 56, 91, 210, 271 💬
18 Sacubitril 1件: Sacubitril1件: Sacubitril 💬 1件: MME 💬 4件: Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬3件: 58, 210, 222 💬
19 Sildenafil 3件: Sildenafil; Sildenafil citrate; Sildenafilo2件: Sildenafil citrate ,
Sildenafil 💬 		1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
20 Spironolactone 1件: Spironolactone1件: Spironolactone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
21 Tadalafil 2件: Tadalafil; Tadalafilo1件: Tadalafil 💬 1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬8件: 6, 51, 75, 77, 84, 86, 113, 210 💬
22 Treprostinil 3件: Treprostinil; Treprostinil diolamine; Treprostinil sodium3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬5件: 51, 85, 86, 88, 210 💬
23 Udenafil 1件: Udenafil1件: Udenafil 💬 1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬2件: 86, 210 💬
24 Valsartan 1件: Valsartan1件: Valsartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬8件: 57, 58, 66, 75, 86, 210, 222, 224 💬
25 Vasopressin 1件: Vasopressin1件: Vasopressin 💬 3件: AVPR1A,
AVPR1B,
AVPR2 💬 		6件: Calcium signaling pathway, Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬2件: 210, 225 💬