Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
2 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
3 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
4 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
5 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
6 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
7 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
8 ATP1A 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
9 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dorzolamide 💬 Dorzolamide 1件: 90 💬
10 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dichlorphenamide 💬 Diclofenamide 1件: 114 💬
11 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
12 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dorzolamide hydrochloride 💬 Dorzolamide 1件: 90 💬
13 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
14 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
15 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Navocaftor 💬 Navocaftor 1件: 299 💬
16 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Deutivacaftor 💬 Deutivacaftor 1件: 299 💬
17 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Elexacaftor 💬 Elexacaftor 1件: 299 💬
18 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Lumacaftor 💬 Lumacaftor 1件: 299 💬
19 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Galicaftor 💬 Galicaftor 1件: 299 💬
20 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Tezacaftor 💬 Tezacaftor 1件: 299 💬
21 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Vanzacaftor 💬 Vanzacaftor 1件: 299 💬
22 CFTR 💬 8件: ABC transporters, cAMP signaling pathway, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Ivacaftor 💬 Ivacaftor 2件: 299, 340 💬
23 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
24 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pitavastatin calcium 💬 Pitavastatin 1件: 49 💬
25 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
26 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
27 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin sodium 💬 Pravastatin 10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
28 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin 💬 Fluvastatin 2件: 79, 222 💬
29 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin sodium 💬 Fluvastatin 2件: 79, 222 💬
30 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin calcium 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
31 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin calcium 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
32 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
33 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pitavastatin magnesium 💬 Pitavastatin 1件: 49 💬
34 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Lovastatin 💬 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
35 NR1H4 💬 1件: Bile secretion Ursodiol 💬 Ursodeoxycholic acid 14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
36 NR1H4 💬 1件: Bile secretion Obeticholic acid 💬 Obeticholic acid 3件: 93, 265, 296 💬
37 NR1H4 💬 1件: Bile secretion Tropifexor 💬 Tropifexor 1件: 93 💬
38 NR1H4 💬 1件: Bile secretion Chenodiol 💬 Chenodeoxycholic acid 4件: 20, 96, 234, 263 💬
39 NR1H4 💬 1件: Bile secretion Cholic acid 💬 Cholic Acid 4件: 20, 234, 265, 310 💬
40 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Acitretin 💬 Acitretin 1件: 37 💬
41 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Bexarotene 💬 Bexarotene 2件: 13, 75 💬
42 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Alitretinoin 💬 Alitretinoin 1件: 49 💬
43 SCTR 💬 3件: Neuroactive ligand-receptor interaction, Pancreatic secretion, Bile secretion Secretin 💬 Secretin human 1件: 298 💬
44 SLC10A1 💬 3件: Virion - Hepatitis viruses, Bile secretion, Hepatitis B Maralixibat 💬 Maralixibat 4件: 296, 297, 299, 338 💬
45 SLC10A2 💬 1件: Bile secretion Maralixibat chloride 💬 Maralixibat 4件: 296, 297, 299, 338 💬
46 SLC10A2 💬 1件: Bile secretion Elobixibat 💬 Elobixibat 1件: 6 💬
47 SLC10A2 💬 1件: Bile secretion Linerixibat 💬 Linerixibat 1件: 93 💬
48 SLC10A2 💬 1件: Bile secretion Odevixibat 💬 Odevixibat 3件: 296, 297, 338 💬
49 SLC10A2 💬 1件: Bile secretion Maralixibat 💬 Maralixibat 4件: 296, 297, 299, 338 💬
50 SLC5A1 💬 3件: Carbohydrate digestion and absorption, Bile secretion, Mineral absorption Sotagliflozin 💬 Sotagliflozin 2件: 58, 84 💬
51 SLC9A3 💬 4件: Proximal tubule bicarbonate reclamation, Protein digestion and absorption, Bile secretion, Mineral absorption Tenapanor 💬 Tenapanor 2件: 6, 299 💬
52 SLC9A3 💬 4件: Proximal tubule bicarbonate reclamation, Protein digestion and absorption, Bile secretion, Mineral absorption Tenapanor hydrochloride 💬 Tenapanor 2件: 6, 299 💬