Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ATP1A1 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
2 ATP1A1 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
3 ATP1A2 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
4 ATP1A2 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
5 ATP1A3 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
6 ATP1A3 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
7 ATP1A4 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
8 ATP1A4 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digitoxin 💬 Digitoxin 1件: 299 💬
9 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide sodium 💬 Acetazolamide 8件: 13, 67, 90, 115, 155, 222, 225, 230 💬
10 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide 💬 Acetazolamide 8件: 13, 67, 90, 115, 155, 222, 225, 230 💬
11 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dorzolamide 💬 Dorzolamide 1件: 90 💬
12 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
13 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dorzolamide hydrochloride 💬 Dorzolamide 1件: 90 💬
14 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Ivacaftor 💬 Ivacaftor 3件: 298, 299, 340 💬
15 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Icenticaftor 💬 Icenticaftor 1件: 299 💬
16 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Vanzacaftor calcium 💬 Vanzacaftor 1件: 299 💬
17 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Galicaftor 💬 Galicaftor 1件: 299 💬
18 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Lumacaftor 💬 Lumacaftor 1件: 299 💬
19 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Elexacaftor 💬 Elexacaftor 1件: 299 💬
20 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Tezacaftor 💬 Tezacaftor 1件: 299 💬
21 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Navocaftor 💬 Navocaftor 1件: 299 💬
22 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Deutivacaftor 💬 Deutivacaftor 1件: 299 💬
23 CFTR 💬 9件: ABC transporters, cAMP signaling pathway, Phagocytosis, AMPK signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection Vanzacaftor 💬 Vanzacaftor 1件: 299 💬
24 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin 💬 Fluvastatin 4件: 48, 79, 218, 222 💬
25 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin calcium 💬 Atorvastatin 21件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
26 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pitavastatin magnesium 💬 Pitavastatin 4件: 49, 71, 79, 90 💬
27 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin 16件: 6, 18, 46, 49, 51, 56, 57, 62, 65, 67, 79, 94, 96, 97, 271, 299 💬
28 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
29 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin sodium 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
30 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Lovastatin 💬 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
31 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 22件: 6, 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬
32 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pitavastatin calcium 💬 Pitavastatin 4件: 49, 71, 79, 90 💬
33 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 21件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
34 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin calcium 💬 Rosuvastatin 16件: 6, 18, 46, 49, 51, 56, 57, 62, 65, 67, 79, 94, 96, 97, 271, 299 💬
35 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin sodium 💬 Fluvastatin 4件: 48, 79, 218, 222 💬
36 NR1H4 💬 1件: Bile secretion Chenodiol 💬 Chenodeoxycholic acid 5件: 20, 86, 96, 234, 263 💬
37 NR1H4 💬 1件: Bile secretion Norucholic acid 💬 norUrsodeoxycholic acid 1件: 94 💬
38 NR1H4 💬 1件: Bile secretion Ursodiol 💬 Ursodeoxycholic acid 10件: 6, 46, 67, 84, 93, 94, 95, 96, 97, 296 💬
39 NR1H4 💬 1件: Bile secretion Cholic acid 💬 Cholic Acid 4件: 20, 234, 265, 310 💬
40 NR1H4 💬 1件: Bile secretion Obeticholic acid 💬 Obeticholic acid 3件: 93, 265, 296 💬
41 NR1H4 💬 1件: Bile secretion Tropifexor 💬 Tropifexor 1件: 93 💬
42 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Alitretinoin 💬 Alitretinoin 1件: 49 💬
43 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Bexarotene 💬 Bexarotene 2件: 13, 75 💬
44 RXRA 💬 18件: PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Acitretin 💬 Acitretin 1件: 37 💬
45 SLC10A1 💬 3件: Virion - Hepatitis viruses, Bile secretion, Hepatitis B Maralixibat 💬 Maralixibat 4件: 296, 297, 299, 338 💬
46 SLC10A2 💬 1件: Bile secretion Odevixibat 💬 Odevixibat 3件: 296, 297, 338 💬
47 SLC10A2 💬 1件: Bile secretion Linerixibat 💬 Linerixibat 1件: 93 💬
48 SLC10A2 💬 1件: Bile secretion Elobixibat 💬 Elobixibat 1件: 6 💬
49 SLC10A2 💬 1件: Bile secretion Odevixibat hydrate 💬 Odevixibat 3件: 296, 297, 338 💬
50 SLC10A2 💬 1件: Bile secretion Maralixibat 💬 Maralixibat 4件: 296, 297, 299, 338 💬
51 SLC10A2 💬 1件: Bile secretion Maralixibat chloride 💬 Maralixibat 4件: 296, 297, 299, 338 💬
52 SLC5A1 💬 3件: Carbohydrate digestion and absorption, Bile secretion, Mineral absorption Sotagliflozin 💬 Sotagliflozin 2件: 58, 84 💬
53 SLC9A3 💬 4件: Proximal tubule bicarbonate reclamation, Protein digestion and absorption, Bile secretion, Mineral absorption Tenapanor hydrochloride 💬 Tenapanor 2件: 6, 299 💬
54 SLC9A3 💬 4件: Proximal tubule bicarbonate reclamation, Protein digestion and absorption, Bile secretion, Mineral absorption Tenapanor 💬 Tenapanor 2件: 6, 299 💬