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Target Gene/Pathway Pathway / Gene

Search results

No.

KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus

Riliprubart 💬

[1] 14 💬

2

[6] Complement and coagulation cascades, Alcoholic liver disease, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus

Empasiprubart 💬

[2] 14, 50 💬

3

[11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus

Eculizumab 💬

[8] 11, 13, 14, 61, 62, 109, 221, 222 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
61	Autoimmune hemolytic anemia
62	Paroxysmal nocturnal hemoglobinuria
109	Atypical hemolytic uremic syndrome
221	Anti-glomerular basement membrane disease
222	Primary nephrotic syndrome

4

[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels

Chlorphenamine 💬

Chlorpheniramine

[1] 14 💬

5

[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels

Chlorpheniramine maleate 💬

Chlorpheniramine

[1] 14 💬

6

[2] Cortisol synthesis and secretion, Cushing syndrome

Dalfampridine 💬

[4] 3, 4, 13, 14 💬

7

[1] Spinocerebellar ataxia

Dalfampridine 💬

[4] 3, 4, 13, 14 💬

8

[1] Serotonergic synapse

Dalfampridine 💬

[4] 3, 4, 13, 14 💬

9

[1] Spinocerebellar ataxia

Dalfampridine 💬

[4] 3, 4, 13, 14 💬

10

[1] Hematopoietic cell lineage

Name	Other Names
Rituximab	Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RIABNI RITUXAN RUXIENCE TRUXIMA

[52] 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
19	Lysosomal storage disease
26	HTLV-1-associated myelopathy
34	Neurofibromatosis
35	Pemphigus
36	Epidermolysis bullosa
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
52	Mixed connective tissue disease
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
61	Autoimmune hemolytic anemia
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
66	IgA nephropathy
83	Addison disease
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
93	Primary biliary cholangitis
94	Primary sclerosing cholangitis
96	Crohn disease
97	Ulcerative colitis
162	Pemphigoid
172	Hypophosphatasia
220	Rapidly progressive glomerulonephritis
222	Primary nephrotic syndrome
229	Autoimmune pulmonary alveolar proteinosis
256	Muscle glycogenosis
271	Ankylosing spondylitis
274	Osteogenesis Imperfecta
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
288	Autoimmune acquired coagulation factor deficiency
296	Biliary atresia
300	IgG4-related disease
331	Idiopathic multicentric castleman disease

11

[1] Neuroactive ligand-receptor interaction

Prednisone 💬

Name	Other Names
Prednisone	Prednisone (USP) Prednisone monohydrate Deltasone (TN) Meticorten (TN) Rayos (TN) RAYOS P- PACK PREDNISONE 20MG, 7- DAY TAPERING DOSE PACK PREDNISONE PREDNISONE TABLETS, USP, 10 MG PREDNISONE TABLETS, USP, 20 MG PREDNISONE TABLETS, USP, 5 MG

[54] 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
18	Spinocerebellar degeneration
19	Lysosomal storage disease
26	HTLV-1-associated myelopathy
28	Systemic amyloidosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
60	Aplastic anemia
61	Autoimmune hemolytic anemia
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
66	IgA nephropathy
79	Homozygous familial hypercholesterolemia
81	Congenital adrenal hyperplasia
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
90	Retinitis pigmentosa
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
113	Muscular dystrophy
145	West syndrome
162	Pemphigoid
164	Oculocutaneous albinism
205	Fragile X syndrome related disease
222	Primary nephrotic syndrome
224	Purpura nephritis
228	Bronchiolitis obliterans
251	Urea cycle disorder
269	Pyogenic arthritis
283	Acquired pure red cell aplasia
285	Fanconi anemia
288	Autoimmune acquired coagulation factor deficiency
299	Cystic fibrosis
300	IgG4-related disease
303	Usher syndrome
307	Canavan disease
331	Idiopathic multicentric castleman disease

12

[1] Neuroactive ligand-receptor interaction

Prednisolone 💬

[41] 3, 11, 13, 14, 18, 25, 26, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 54, 56, 60, 61, 63, 64, 66, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 251, 269, 271, 296, 299, 300 💬

Disease ID	Name
3	Spinal muscular atrophy
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
18	Spinocerebellar degeneration
25	Progressive multifocal leukoencephalopathy
26	HTLV-1-associated myelopathy
38	Stevens-Johnson syndrome
39	Toxic epidermal necrolysis
40	Takayasu arteritis
41	Giant cell arteritis
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
54	Adult still disease
56	Behcet disease
60	Aplastic anemia
61	Autoimmune hemolytic anemia
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
66	IgA nephropathy
81	Congenital adrenal hyperplasia
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
113	Muscular dystrophy
145	West syndrome
162	Pemphigoid
222	Primary nephrotic syndrome
251	Urea cycle disorder
269	Pyogenic arthritis
271	Ankylosing spondylitis
296	Biliary atresia
299	Cystic fibrosis
300	IgG4-related disease

13

[1] Neuroactive ligand-receptor interaction

Methylprednisolone acetate 💬

Methylprednisolone

[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
18	Spinocerebellar degeneration
19	Lysosomal storage disease
25	Progressive multifocal leukoencephalopathy
26	HTLV-1-associated myelopathy
35	Pemphigus
38	Stevens-Johnson syndrome
39	Toxic epidermal necrolysis
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
66	IgA nephropathy
83	Addison disease
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
127	Frontotemporal lobar degeneration
162	Pemphigoid
164	Oculocutaneous albinism
211	Hypoplastic left heart syndrome
220	Rapidly progressive glomerulonephritis
222	Primary nephrotic syndrome
224	Purpura nephritis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
296	Biliary atresia
300	IgG4-related disease

14

[1] Neuroactive ligand-receptor interaction

Methylprednisolone 💬

Methylprednisolone

[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
11	Myasthenia gravis
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
18	Spinocerebellar degeneration
19	Lysosomal storage disease
25	Progressive multifocal leukoencephalopathy
26	HTLV-1-associated myelopathy
35	Pemphigus
38	Stevens-Johnson syndrome
39	Toxic epidermal necrolysis
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
66	IgA nephropathy
83	Addison disease
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
127	Frontotemporal lobar degeneration
162	Pemphigoid
164	Oculocutaneous albinism
211	Hypoplastic left heart syndrome
220	Rapidly progressive glomerulonephritis
222	Primary nephrotic syndrome
224	Purpura nephritis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
296	Biliary atresia
300	IgG4-related disease

15

[1] Neuroactive ligand-receptor interaction

Dexamethasone sodium phosphate 💬

[25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬

Disease ID	Name
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
16	Crow-Fukase syndrome
19	Lysosomal storage disease
28	Systemic amyloidosis
35	Pemphigus
53	Sjogren syndrome
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
70	Spinal stenosis
74	Prolactin secreting pituitary adenoma
75	Cushing disease
81	Congenital adrenal hyperplasia
84	Sarcoidosis
90	Retinitis pigmentosa
96	Crohn disease
97	Ulcerative colitis
162	Pemphigoid
222	Primary nephrotic syndrome
235	Hypoparathyroidism
257	Hepatic glycogenosis
296	Biliary atresia
299	Cystic fibrosis
331	Idiopathic multicentric castleman disease

16

[1] Neuroactive ligand-receptor interaction

Dexamethasone phosphate 💬

[25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬

Disease ID	Name
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
16	Crow-Fukase syndrome
19	Lysosomal storage disease
28	Systemic amyloidosis
35	Pemphigus
53	Sjogren syndrome
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
70	Spinal stenosis
74	Prolactin secreting pituitary adenoma
75	Cushing disease
81	Congenital adrenal hyperplasia
84	Sarcoidosis
90	Retinitis pigmentosa
96	Crohn disease
97	Ulcerative colitis
162	Pemphigoid
222	Primary nephrotic syndrome
235	Hypoparathyroidism
257	Hepatic glycogenosis
296	Biliary atresia
299	Cystic fibrosis
331	Idiopathic multicentric castleman disease

17

[1] Neuroactive ligand-receptor interaction

Dexamethasone 💬

[25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬

Disease ID	Name
13	Multiple sclerosis
14	Chronic inflammatory demyelinating polyneuropathy
16	Crow-Fukase syndrome
19	Lysosomal storage disease
28	Systemic amyloidosis
35	Pemphigus
53	Sjogren syndrome
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
65	Primary immunodeficiency
70	Spinal stenosis
74	Prolactin secreting pituitary adenoma
75	Cushing disease
81	Congenital adrenal hyperplasia
84	Sarcoidosis
90	Retinitis pigmentosa
96	Crohn disease
97	Ulcerative colitis
162	Pemphigoid
222	Primary nephrotic syndrome
235	Hypoparathyroidism
257	Hepatic glycogenosis
296	Biliary atresia
299	Cystic fibrosis
331	Idiopathic multicentric castleman disease

18

[4] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Efferocytosis

Fingolimod lauryl sulfate 💬

[3] 13, 14, 156 💬

19

[4] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Efferocytosis

Fingolimod 💬

[3] 13, 14, 156 💬

20

[4] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Efferocytosis

Fingolimod hydrochloride 💬

[3] 13, 14, 156 💬