Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CACNA1B 💬 15件: MAPK signaling pathway, Calcium signaling pathway, Synaptic vesicle cycle, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Type II diabetes mellitus, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Morphine addiction, Nicotine addiction, Chemical carcinogenesis - receptor activation Cilnidipine 💬 Cilnidipine 1件: 67 💬
2 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Tetrabenazine 💬 Tetrabenazine 1件: 8 💬
3 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Midomafetamine hydrochloride 💬 Midomafetamine 1件: 72 💬
4 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Valbenazine tosylate 💬 Valbenazine 1件: 8 💬
5 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Deutetrabenazine 💬 Deutetrabenazine 1件: 8 💬
6 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Midomafetamine 💬 Midomafetamine 1件: 72 💬
7 SLC18A1_2 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Valbenazine 💬 Valbenazine 1件: 8 💬
8 SLC6A1 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, GABAergic synapse Gabapentin 💬 Gabapentin 5件: 6, 13, 19, 70, 298 💬
9 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Doxepin hydrochloride 💬 Doxepin 1件: 6 💬
10 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Phentermine hydrochloride 💬 Phentermine 1件: 97 💬
11 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Amoxapine 💬 Amoxapine 1件: 46 💬
12 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Venlafaxine 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
13 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Bupropion 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
14 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Desipramine 💬 Desipramine 1件: 121 💬
15 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Nortriptyline hydrochloride 💬 Nortriptyline 2件: 6, 226 💬
16 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Bupropion hydrobromide 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
17 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Solriamfetol 💬 Solriamfetol 1件: 13 💬
18 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Nortriptyline 💬 Nortriptyline 2件: 6, 226 💬
19 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Lisdexamfetamine 💬 Lisdexamfetamine 1件: 13 💬
20 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Amitriptyline hydrochloride 💬 Amitriptyline 3件: 97, 226, 299 💬
21 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Atomoxetine 💬 Atomoxetine 4件: 6, 8, 13, 230 💬
22 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Desipramine hydrochloride 💬 Desipramine 1件: 121 💬
23 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Venlafaxine besylate monohydrate 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
24 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Duloxetine 💬 Duloxetine 2件: 6, 13 💬
25 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Milnacipran 💬 Milnacipran 2件: 46, 49 💬
26 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Ampreloxetine 💬 Ampreloxetine 2件: 6, 17 💬
27 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Phentermine 💬 Phentermine 1件: 97 💬
28 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Milnacipran hydrochloride 💬 Milnacipran 2件: 46, 49 💬
29 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Methylphenidate 💬 Methylphenidate 7件: 6, 13, 34, 84, 113, 179, 206 💬
30 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Duloxetine hydrochloride 💬 Duloxetine 2件: 6, 13 💬
31 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Venlafaxine hydrochloride 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
32 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Doxepin 💬 Doxepin 1件: 6 💬
33 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Atomoxetine hydrochloride 💬 Atomoxetine 4件: 6, 8, 13, 230 💬
34 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Amitriptyline 💬 Amitriptyline 3件: 97, 226, 299 💬
35 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Lisdexamfetamine dimesylate 💬 Lisdexamfetamine 1件: 13 💬
36 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Solriamfetol hydrochloride 💬 Solriamfetol 1件: 13 💬
37 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Midomafetamine hydrochloride 💬 Midomafetamine 1件: 72 💬
38 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Midomafetamine 💬 Midomafetamine 1件: 72 💬
39 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Bupropion hydrochloride 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
40 SLC6A2 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Methylphenidate hydrochloride 💬 Methylphenidate 7件: 6, 13, 34, 84, 113, 179, 206 💬
41 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Armodafinil 💬 Armodafinil 3件: 6, 13, 84 💬
42 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion hydrochloride 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
43 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Solriamfetol hydrochloride 💬 Solriamfetol 1件: 13 💬
44 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Midomafetamine hydrochloride 💬 Midomafetamine 1件: 72 💬
45 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Lisdexamfetamine 💬 Lisdexamfetamine 1件: 13 💬
46 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Phentermine hydrochloride 💬 Phentermine 1件: 97 💬
47 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion hydrobromide 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
48 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Methylphenidate hydrochloride 💬 Methylphenidate 7件: 6, 13, 34, 84, 113, 179, 206 💬
49 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Lisdexamfetamine dimesylate 💬 Lisdexamfetamine 1件: 13 💬
50 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Methylphenidate 💬 Methylphenidate 7件: 6, 13, 34, 84, 113, 179, 206 💬
51 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Phentermine 💬 Phentermine 1件: 97 💬
52 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion 💬 Bupropion 6件: 8, 18, 21, 96, 97, 171 💬
53 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Midomafetamine 💬 Midomafetamine 1件: 72 💬
54 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Solriamfetol 💬 Solriamfetol 1件: 13 💬
55 SLC6A3 💬 8件: Neuroactive ligand signaling, Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Ioflupane I 123 💬 Ioflupane I-123 1件: 6 💬
56 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Doxepin hydrochloride 💬 Doxepin 1件: 6 💬
57 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Venlafaxine besylate monohydrate 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
58 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Trazodone hydrochloride 💬 Trazodone 1件: 2 💬
59 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Escitalopram oxalate 💬 Escitalopram 5件: 2, 6, 13, 46, 77 💬
60 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Escitalopram 💬 Escitalopram 5件: 2, 6, 13, 46, 77 💬
61 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Desipramine 💬 Desipramine 1件: 121 💬
62 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Trazodone 💬 Trazodone 1件: 2 💬
63 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine 💬 Paroxetine 4件: 6, 13, 46, 85 💬
64 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Amoxapine 💬 Amoxapine 1件: 46 💬
65 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
66 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine hydrochloride 💬 Paroxetine 4件: 6, 13, 46, 85 💬
67 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fluoxetine hydrochloride 💬 Fluoxetine 3件: 13, 17, 86 💬
68 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Nortriptyline hydrochloride 💬 Nortriptyline 2件: 6, 226 💬
69 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Doxepin 💬 Doxepin 1件: 6 💬
70 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Desipramine hydrochloride 💬 Desipramine 1件: 121 💬
71 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Milnacipran 💬 Milnacipran 2件: 46, 49 💬
72 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Duloxetine hydrochloride 💬 Duloxetine 2件: 6, 13 💬
73 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Citalopram 💬 Citalopram 5件: 6, 13, 46, 98, 127 💬
74 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fenfluramine hydrochloride 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
75 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Venlafaxine hydrochloride 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
76 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Midomafetamine 💬 Midomafetamine 1件: 72 💬
77 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Venlafaxine 💬 Venlafaxine 4件: 6, 13, 46, 97 💬
78 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Phentermine 💬 Phentermine 1件: 97 💬
79 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Milnacipran hydrochloride 💬 Milnacipran 2件: 46, 49 💬
80 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Citalopram hydrobromide 💬 Citalopram 5件: 6, 13, 46, 98, 127 💬
81 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Sertraline hydrochloride 💬 Sertraline 3件: 6, 158, 206 💬
82 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine hydrochloride hemihydrate 💬 Paroxetine 4件: 6, 13, 46, 85 💬
83 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Duloxetine 💬 Duloxetine 2件: 6, 13 💬
84 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Amitriptyline hydrochloride 💬 Amitriptyline 3件: 97, 226, 299 💬
85 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Midomafetamine hydrochloride 💬 Midomafetamine 1件: 72 💬
86 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Vortioxetine 💬 Vortioxetine 2件: 6, 127 💬
87 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Phentermine hydrochloride 💬 Phentermine 1件: 97 💬
88 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Vortioxetine hydrobromide 💬 Vortioxetine 2件: 6, 127 💬
89 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Nortriptyline 💬 Nortriptyline 2件: 6, 226 💬
90 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Ampreloxetine 💬 Ampreloxetine 2件: 6, 17 💬
91 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Amitriptyline 💬 Amitriptyline 3件: 97, 226, 299 💬
92 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fluoxetine 💬 Fluoxetine 3件: 13, 17, 86 💬
93 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine mesylate 💬 Paroxetine 4件: 6, 13, 46, 85 💬
94 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Sertraline 💬 Sertraline 3件: 6, 158, 206 💬
95 SLC6A5_9 💬 2件: Neuroactive ligand signaling, Synaptic vesicle cycle Bitopertin 💬 Bitopertin 1件: 284 💬
96 SNAP25 💬 2件: Synaptic vesicle cycle, Insulin secretion Prabotulinumtoxin A 💬 Botulinum toxin type A 14件: 2, 5, 6, 7, 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
97 SNAP25 💬 2件: Synaptic vesicle cycle, Insulin secretion Botulinum toxin type A 💬 Botulinum toxin type A 14件: 2, 5, 6, 7, 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
98 SNAP25 💬 2件: Synaptic vesicle cycle, Insulin secretion Rimabotulinumtoxin B 💬 Botulinum toxin type B 3件: 2, 6, 51 💬