Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 BDKRB2 💬 [10] Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Endocrine and other factor-regulated calcium reabsorption, Chagas disease, Pathways in cancer Icatibant acetate 💬 Icatibant [1] 65 💬
2 BDKRB2 💬 [10] Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Endocrine and other factor-regulated calcium reabsorption, Chagas disease, Pathways in cancer Deucrictibant 💬 Deucrictibant [1] 65 💬
3 C1R 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [1] 65 💬
4 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease, Systemic lupus erythematosus Sutimlimab 💬 Sutimlimab [1] 61 💬
5 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease, Systemic lupus erythematosus Riliprubart 💬 Riliprubart [1] 14 💬
6 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [1] 65 💬
7 C2 💬 [6] Complement and coagulation cascades, Alcoholic liver disease, Pertussis, Staphylococcus aureus infection, Coronavirus disease, Systemic lupus erythematosus Empasiprubart 💬 Empasiprubart [3] 11, 14, 50 💬
8 C3 💬 [18] Neuroactive ligand-receptor interaction, Phagocytosis, Integrin signaling, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Shigellosis, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Coronavirus disease, Viral carcinogenesis, Systemic lupus erythematosus Pegcetacoplan 💬 Pegcetacoplan [4] 2, 61, 62, 223 💬
9 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Ravulizumab 💬 Ravulizumab [8] 2, 11, 13, 50, 62, 66, 109, 224 💬
10 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Zilucoplan 💬 Zilucoplan [3] 2, 11, 62 💬
11 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
12 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Pozelimab 💬 Pozelimab [3] 11, 15, 62 💬
13 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Nomacopan 💬 Nomacopan [1] 162 💬
14 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Eculizumab 💬 Eculizumab [8] 11, 13, 14, 61, 62, 109, 221, 223 💬
15 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Avacincaptad pegol sodium 💬 Avacincaptad pegol [1] 301 💬
16 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Zilucoplan sodium 💬 Zilucoplan [3] 2, 11, 62 💬
17 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Crovalimab 💬 Crovalimab [3] 48, 62, 109 💬
18 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Gefurulimab 💬 Gefurulimab [1] 11 💬
19 C5AR1 💬 [6] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Staphylococcus aureus infection, Coronavirus disease Avacopan 💬 Avacopan [4] 43, 44, 66, 223 💬
20 CFB 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease Iptacopan hydrochloride 💬 Iptacopan [8] 11, 61, 62, 63, 66, 109, 222, 223 💬
21 CFB 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease Iptacopan 💬 Iptacopan [8] 11, 61, 62, 63, 66, 109, 222, 223 💬
22 CFD 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease Danicopan 💬 Danicopan [2] 62, 223 💬
23 F10 💬 [1] Complement and coagulation cascades Apixaban 💬 Apixaban [6] 48, 96, 97, 222, 223, 279 💬
24 F10 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
25 F10 💬 [1] Complement and coagulation cascades Edoxaban tosylate 💬 Edoxaban [4] 46, 71, 88, 222 💬
26 F10 💬 [1] Complement and coagulation cascades Edoxaban tosilate hydrate 💬 Edoxaban [4] 46, 71, 88, 222 💬
27 F10 💬 [1] Complement and coagulation cascades Edoxaban 💬 Edoxaban [4] 46, 71, 88, 222 💬
28 F10 💬 [1] Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban [10] 46, 48, 49, 56, 58, 75, 91, 210, 222, 271 💬
29 F12 💬 [1] Complement and coagulation cascades Garadacimab 💬 Garadacimab [2] 65, 85 💬
30 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease, Pathways in cancer Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
31 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease, Pathways in cancer Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
32 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease, Pathways in cancer Dabigatran etexilate mesylate 💬 Dabigatran etexilate [2] 51, 75 💬
33 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease, Pathways in cancer Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
34 F8 💬 [1] Complement and coagulation cascades Desmopressin acetate 💬 Desmopressin [8] 6, 22, 64, 72, 75, 223, 225, 288 💬
35 F8 💬 [1] Complement and coagulation cascades Susoctocog alfa 💬 Susoctocog alfa [1] 288 💬
36 F8 💬 [1] Complement and coagulation cascades Desmopressin 💬 Desmopressin [8] 6, 22, 64, 72, 75, 223, 225, 288 💬
37 F9 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
38 ITGB2 💬 [21] Rap1 signaling pathway, Phagocytosis, Hippo signaling pathway, Cell adhesion molecule (CAM) interaction, IgSF CAM signaling, Integrin signaling, Complement and coagulation cascades, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Malaria, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Human T-cell leukemia virus 1 infection, Rheumatoid arthritis, Viral myocarditis Marnetegragene autotemcel 💬 RP-L201 [1] 65 💬
39 KLKB1 💬 [1] Complement and coagulation cascades Navenibart 💬 Navenibart [1] 65 💬
40 KLKB1 💬 [1] Complement and coagulation cascades Berotralstat hydrochloride 💬 Berotralstat [1] 65 💬
41 KLKB1 💬 [1] Complement and coagulation cascades Conestat alfa 💬 Conestat alfa [1] 65 💬
42 KLKB1 💬 [1] Complement and coagulation cascades Ecallantide 💬 Ecallantide [1] 65 💬
43 KLKB1 💬 [1] Complement and coagulation cascades Donidalorsen sodium 💬 Donidalorsen [1] 65 💬
44 KLKB1 💬 [1] Complement and coagulation cascades Lanadelumab 💬 Lanadelumab [1] 65 💬
45 KLKB1 💬 [1] Complement and coagulation cascades Berotralstat 💬 Berotralstat [1] 65 💬
46 KLKB1 💬 [1] Complement and coagulation cascades Sebetralstat 💬 Sebetralstat [1] 65 💬
47 MASP2 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease Narsoplimab 💬 Narsoplimab [3] 66, 222, 223 💬
48 PLAT 💬 [5] Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
49 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
50 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Tranexamic acid 💬 Tranexamic acid [7] 46, 65, 70, 215, 227, 274, 299 💬
51 SERPINC1 💬 [1] Complement and coagulation cascades Dalteparin sodium 💬 Dalteparin [3] 222, 223, 327 💬
52 SERPINC1 💬 [1] Complement and coagulation cascades Enoxaparin sodium 💬 Enoxaparin [6] 46, 48, 71, 222, 223, 327 💬
53 SERPINC1 💬 [1] Complement and coagulation cascades Parnaparin sodium 💬 Parnaparin [1] 97 💬
54 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Enoxaparin [6] 46, 48, 71, 222, 223, 327 💬
55 SERPINC1 💬 [1] Complement and coagulation cascades Heparin sodium 💬 Heparin [15] 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
56 SERPINC1 💬 [1] Complement and coagulation cascades Tinzaparin sodium 💬 Tinzaparin [1] 327 💬
57 SERPINC1 💬 [1] Complement and coagulation cascades Danaparoid sodium 💬 Danaparoid [1] 48 💬
58 SERPINC1 💬 [1] Complement and coagulation cascades Heparin calcium 💬 Heparin [15] 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
59 VWF 💬 [9] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Integrin signaling, Complement and coagulation cascades, Platelet activation, Neutrophil extracellular trap formation, Human papillomavirus infection, Coronavirus disease Caplacizumab 💬 Caplacizumab [2] 63, 64 💬