Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 BDKRB2 💬 [10] Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Endocrine and other factor-regulated calcium reabsorption, Chagas disease, Pathways in cancer Icatibant acetate 💬 Icatibant [1] 65 💬
2 BDKRB2 💬 [10] Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Endocrine and other factor-regulated calcium reabsorption, Chagas disease, Pathways in cancer Deucrictibant 💬 Deucrictibant [1] 65 💬
3 C1R 💬 [6] Phagosome, Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [2] 61, 65 💬
4 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Sutimlimab 💬 Sutimlimab [1] 61 💬
5 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [2] 61, 65 💬
6 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Riliprubart 💬 Riliprubart [1] 14 💬
7 C2 💬 [6] Complement and coagulation cascades, Alcoholic liver disease, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Empasiprubart 💬 Empasiprubart [2] 14, 50 💬
8 C3 💬 [17] Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Shigellosis, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Viral carcinogenesis, Systemic lupus erythematosus Pegcetacoplan 💬 Pegcetacoplan [4] 2, 61, 62, 222 💬
9 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Eculizumab 💬 Eculizumab [8] 11, 13, 14, 61, 62, 109, 221, 222 💬
10 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Gefurulimab 💬 Gefurulimab [1] 11 💬
11 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
12 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Nomacopan 💬 Nomacopan [3] 62, 109, 162 💬
13 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Crovalimab 💬 Crovalimab [2] 62, 109 💬
14 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Ravulizumab 💬 Ravulizumab [7] 2, 11, 13, 50, 62, 66, 109 💬
15 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Zilucoplan sodium 💬 Zilucoplan [2] 11, 62 💬
16 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Avacincaptad pegol sodium 💬 Avacincaptad pegol [1] 301 💬
17 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Pozelimab 💬 Pozelimab [3] 11, 15, 62 💬
18 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Zilucoplan 💬 Zilucoplan [2] 11, 62 💬
19 C5AR1 💬 [6] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Avacopan 💬 Avacopan [4] 43, 44, 66, 222 💬
20 CFB 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Iptacopan 💬 Iptacopan [6] 11, 61, 62, 66, 109, 222 💬
21 CFB 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Iptacopan hydrochloride 💬 Iptacopan [6] 11, 61, 62, 66, 109, 222 💬
22 CFD 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Danicopan 💬 Danicopan [2] 62, 222 💬
23 F10 💬 [1] Complement and coagulation cascades Edoxaban 💬 Edoxaban [2] 46, 88 💬
24 F10 💬 [1] Complement and coagulation cascades Edoxaban tosylate 💬 Edoxaban [2] 46, 88 💬
25 F10 💬 [1] Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban [6] 46, 49, 56, 91, 210, 271 💬
26 F10 💬 [1] Complement and coagulation cascades Edoxaban tosilate hydrate 💬 Edoxaban [2] 46, 88 💬
27 F10 💬 [1] Complement and coagulation cascades Apixaban 💬 Apixaban [4] 96, 97, 222, 279 💬
28 F10 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
29 F12 💬 [1] Complement and coagulation cascades Garadacimab 💬 Garadacimab [1] 65 💬
30 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
31 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
32 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
33 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran etexilate mesylate 💬 Dabigatran etexilate [2] 51, 75 💬
34 F7 💬 [1] Complement and coagulation cascades Eptacog alfa 💬 Coagulation factor VIIa Recombinant Human [1] 288 💬
35 F8 💬 [1] Complement and coagulation cascades Rurioctocog alfa pegol 💬 Rurioctocog alfa pegol [1] 288 💬
36 F8 💬 [1] Complement and coagulation cascades Efanesoctocog alfa 💬 Efanesoctocog alfa [1] 288 💬
37 F8 💬 [1] Complement and coagulation cascades Desmopressin 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
38 F8 💬 [1] Complement and coagulation cascades Desmopressin acetate 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
39 F8 💬 [1] Complement and coagulation cascades Susoctocog alfa 💬 Susoctocog alfa [1] 288 💬
40 F8 💬 [1] Complement and coagulation cascades Octocog alfa 💬 Antihemophilic factor, human recombinant [1] 288 💬
41 F9 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
42 KLKB1 💬 [1] Complement and coagulation cascades Berotralstat hydrochloride 💬 Berotralstat [1] 65 💬
43 KLKB1 💬 [1] Complement and coagulation cascades Lanadelumab 💬 Lanadelumab [1] 65 💬
44 KLKB1 💬 [1] Complement and coagulation cascades Conestat alfa 💬 Conestat alfa [2] 61, 65 💬
45 KLKB1 💬 [1] Complement and coagulation cascades Berotralstat 💬 Berotralstat [1] 65 💬
46 KLKB1 💬 [1] Complement and coagulation cascades Ecallantide 💬 Ecallantide [1] 65 💬
47 KLKB1 💬 [1] Complement and coagulation cascades Sebetralstat 💬 Sebetralstat [1] 65 💬
48 MASP2 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Narsoplimab 💬 Narsoplimab [2] 66, 222 💬
49 PLAT 💬 [5] Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
50 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Tranexamic acid 💬 Tranexamic acid [8] 46, 65, 70, 215, 227, 274, 288, 299 💬
51 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
52 SERPINA1 💬 [1] Complement and coagulation cascades alpha 1-Antitrypsin 💬 Alpha-1-proteinase inhibitor [3] 231, 298, 299 💬
53 SERPINC1 💬 [1] Complement and coagulation cascades Enoxaparin sodium 💬 Enoxaparin [1] 46 💬
54 SERPINC1 💬 [1] Complement and coagulation cascades Dalteparin sodium 💬 Dalteparin [1] 222 💬
55 SERPINC1 💬 [1] Complement and coagulation cascades Heparin calcium 💬 Heparin [10] 47, 60, 65, 70, 79, 84, 107, 226, 280, 299 💬
56 SERPINC1 💬 [1] Complement and coagulation cascades Heparin sodium 💬 Heparin [10] 47, 60, 65, 70, 79, 84, 107, 226, 280, 299 💬
57 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Enoxaparin [1] 46 💬
58 VWF 💬 [8] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Complement and coagulation cascades, Platelet activation, Neutrophil extracellular trap formation, Human papillomavirus infection, Coronavirus disease - COVID-19 Caplacizumab 💬 Caplacizumab [2] 63, 64 💬