Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 PDE10A [1] Purine metabolism D00227 Aminophylline [1] 63
2 PDE10A [1] Purine metabolism D00371 Theophylline [2] 236, 299
3 PDE10A [1] Purine metabolism D06103 Theophylline [2] 236, 299
4 PDE10A [1] Purine metabolism D07546 Bucladesine [1] 246
5 PDE10A [1] Purine metabolism D07961 Flavoxate [1] 226
6 PDE7B [1] Purine metabolism D00227 Aminophylline [1] 63
7 PDE7B [1] Purine metabolism D00371 Theophylline [2] 236, 299
8 PDE7B [1] Purine metabolism D06103 Theophylline [2] 236, 299
9 PDE7B [1] Purine metabolism D07546 Bucladesine [1] 246
10 PDE7B [1] Purine metabolism D07961 Flavoxate [1] 226
11 GUCY1A2 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
12 GUCY1A2 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
13 GUCY1A1 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
14 GUCY1A1 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
15 GUCY1B1 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
16 GUCY1B1 [4] Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
17 GUCY2C [1] Purine metabolism D09355 Linaclotide [2] 6, 97
18 HPRT1 [1] Purine metabolism D00161 Mercaptopurine [4] 65, 96, 97, 164
19 HPRT1 [1] Purine metabolism D04931 Mercaptopurine [4] 65, 96, 97, 164
20 HPRT1 [1] Purine metabolism D08603 Tioguanine [2] 13, 37
21 IMPDH1 [1] Purine metabolism D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
22 IMPDH1 [1] Purine metabolism D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
23 IMPDH1 [1] Purine metabolism D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
24 IMPDH2 [1] Purine metabolism D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
25 IMPDH2 [1] Purine metabolism D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
26 IMPDH2 [1] Purine metabolism D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
27 NPR1 [5] Purine metabolism, Vascular smooth muscle contraction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion D04051 Erythrityl tetranitrate [1] 46
28 NPR1 [5] Purine metabolism, Vascular smooth muscle contraction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion D05147 Nesiritide [2] 46, 58
29 NPR2 [2] Purine metabolism, Vascular smooth muscle contraction D04051 Erythrityl tetranitrate [1] 46
30 NPR2 [2] Purine metabolism, Vascular smooth muscle contraction D11190 Vosoritide [1] 276
31 PDE11A [1] Purine metabolism D00227 Aminophylline [1] 63
32 PDE11A [1] Purine metabolism D00371 Theophylline [2] 236, 299
33 PDE11A [1] Purine metabolism D06103 Theophylline [2] 236, 299
34 PDE11A [1] Purine metabolism D07546 Bucladesine [1] 246
35 PDE11A [1] Purine metabolism D07961 Flavoxate [1] 226
36 PDE1A [3] Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline [1] 63
37 PDE1A [3] Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline [2] 236, 299
38 PDE1A [3] Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline [2] 236, 299
39 PDE1A [3] Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine [1] 246
40 PDE1A [3] Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate [1] 226
41 PDE1C [3] Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline [1] 63
42 PDE1C [3] Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline [2] 236, 299
43 PDE1C [3] Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline [2] 236, 299
44 PDE1C [3] Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine [1] 246
45 PDE1C [3] Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate [1] 226
46 PDE2A [1] Purine metabolism D00227 Aminophylline [1] 63
47 PDE2A [1] Purine metabolism D00371 Theophylline [2] 236, 299
48 PDE2A [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
49 PDE2A [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
50 PDE2A [1] Purine metabolism D06103 Theophylline [2] 236, 299
51 PDE2A [1] Purine metabolism D07546 Bucladesine [1] 246
52 PDE2A [1] Purine metabolism D07961 Flavoxate [1] 226
53 PDE3A [2] Purine metabolism, Renin secretion D00227 Aminophylline [1] 63
54 PDE3A [2] Purine metabolism, Renin secretion D00371 Theophylline [2] 236, 299
55 PDE3A [2] Purine metabolism, Renin secretion D00417 Milrinone [1] 294
56 PDE3A [2] Purine metabolism, Renin secretion D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
57 PDE3A [2] Purine metabolism, Renin secretion D01385 Ibudilast [2] 2, 13
58 PDE3A [2] Purine metabolism, Renin secretion D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
59 PDE3A [2] Purine metabolism, Renin secretion D01896 Cilostazol [3] 46, 51, 70
60 PDE3A [2] Purine metabolism, Renin secretion D04720 Levosimendan [1] 2
61 PDE3A [2] Purine metabolism, Renin secretion D06103 Theophylline [2] 236, 299
62 PDE3A [2] Purine metabolism, Renin secretion D07546 Bucladesine [1] 246
63 PDE3A [2] Purine metabolism, Renin secretion D07961 Flavoxate [1] 226
64 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00227 Aminophylline [1] 63
65 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00371 Theophylline [2] 236, 299
66 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00417 Milrinone [1] 294
67 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
68 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01385 Ibudilast [2] 2, 13
69 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
70 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01896 Cilostazol [3] 46, 51, 70
71 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D04720 Levosimendan [1] 2
72 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D06103 Theophylline [2] 236, 299
73 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D07546 Bucladesine [1] 246
74 PDE3B [3] Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D07961 Flavoxate [1] 226
75 PDE4A [1] Purine metabolism D00227 Aminophylline [1] 63
76 PDE4A [1] Purine metabolism D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
77 PDE4A [1] Purine metabolism D00371 Theophylline [2] 236, 299
78 PDE4A [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
79 PDE4A [1] Purine metabolism D01385 Ibudilast [2] 2, 13
80 PDE4A [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
81 PDE4A [1] Purine metabolism D01783 Rolipram [2] 8, 13
82 PDE4A [1] Purine metabolism D05744 Roflumilast [4] 84, 97, 206, 299
83 PDE4A [1] Purine metabolism D06103 Theophylline [2] 236, 299
84 PDE4A [1] Purine metabolism D07546 Bucladesine [1] 246
85 PDE4A [1] Purine metabolism D07961 Flavoxate [1] 226
86 PDE4A [1] Purine metabolism D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
87 PDE4B [1] Purine metabolism D00227 Aminophylline [1] 63
88 PDE4B [1] Purine metabolism D00371 Theophylline [2] 236, 299
89 PDE4B [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
90 PDE4B [1] Purine metabolism D01385 Ibudilast [2] 2, 13
91 PDE4B [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
92 PDE4B [1] Purine metabolism D01783 Rolipram [2] 8, 13
93 PDE4B [1] Purine metabolism D05744 Roflumilast [4] 84, 97, 206, 299
94 PDE4B [1] Purine metabolism D06103 Theophylline [2] 236, 299
95 PDE4B [1] Purine metabolism D07546 Bucladesine [1] 246
96 PDE4B [1] Purine metabolism D07961 Flavoxate [1] 226
97 PDE4B [1] Purine metabolism D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
98 PDE4C [1] Purine metabolism D00227 Aminophylline [1] 63
99 PDE4C [1] Purine metabolism D00371 Theophylline [2] 236, 299
100 PDE4C [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
101 PDE4C [1] Purine metabolism D01385 Ibudilast [2] 2, 13
102 PDE4C [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
103 PDE4C [1] Purine metabolism D01783 Rolipram [2] 8, 13
104 PDE4C [1] Purine metabolism D05744 Roflumilast [4] 84, 97, 206, 299
105 PDE4C [1] Purine metabolism D06103 Theophylline [2] 236, 299
106 PDE4C [1] Purine metabolism D07546 Bucladesine [1] 246
107 PDE4C [1] Purine metabolism D07961 Flavoxate [1] 226
108 PDE4C [1] Purine metabolism D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
109 PDE4D [1] Purine metabolism D00227 Aminophylline [1] 63
110 PDE4D [1] Purine metabolism D00371 Theophylline [2] 236, 299
111 PDE4D [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
112 PDE4D [1] Purine metabolism D01385 Ibudilast [2] 2, 13
113 PDE4D [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
114 PDE4D [1] Purine metabolism D01783 Rolipram [2] 8, 13
115 PDE4D [1] Purine metabolism D05744 Roflumilast [4] 84, 97, 206, 299
116 PDE4D [1] Purine metabolism D06103 Theophylline [2] 236, 299
117 PDE4D [1] Purine metabolism D07546 Bucladesine [1] 246
118 PDE4D [1] Purine metabolism D07961 Flavoxate [1] 226
119 PDE4D [1] Purine metabolism D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
120 PDE4D [1] Purine metabolism D12173 Zatolmilast [1] 206
121 PDE7A [1] Purine metabolism D00227 Aminophylline [1] 63
122 PDE7A [1] Purine metabolism D00371 Theophylline [2] 236, 299
123 PDE7A [1] Purine metabolism D06103 Theophylline [2] 236, 299
124 PDE7A [1] Purine metabolism D07546 Bucladesine [1] 246
125 PDE7A [1] Purine metabolism D07961 Flavoxate [1] 226
126 PDE8A [1] Purine metabolism D00227 Aminophylline [1] 63
127 PDE8A [1] Purine metabolism D00371 Theophylline [2] 236, 299
128 PDE8A [1] Purine metabolism D06103 Theophylline [2] 236, 299
129 PDE8A [1] Purine metabolism D07546 Bucladesine [1] 246
130 PDE8A [1] Purine metabolism D07961 Flavoxate [1] 226
131 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline [1] 63
132 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline [2] 236, 299
133 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
134 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
135 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline [2] 236, 299
136 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine [1] 246
137 PDE1B [3] Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate [1] 226
138 RRM1 [2] Purine metabolism, Pyrimidine metabolism D01370 Cladribine [3] 11, 13, 94
139 RRM1 [2] Purine metabolism, Pyrimidine metabolism D03546 Clofarabine [5] 19, 20, 60, 234, 326
140 RRM1 [2] Purine metabolism, Pyrimidine metabolism D07966 Fludarabine [20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
141 RRM2 [2] Purine metabolism, Pyrimidine metabolism D00341 Hydroxyurea [8] 3, 13, 19, 20, 65, 85, 86, 284
142 XDH [1] Purine metabolism D00224 Allopurinol [7] 6, 46, 57, 60, 66, 96, 97
143 XDH [1] Purine metabolism D01206 Febuxostat [3] 2, 6, 13
144 PDE8B [1] Purine metabolism D00227 Aminophylline [1] 63
145 PDE8B [1] Purine metabolism D00371 Theophylline [2] 236, 299
146 PDE8B [1] Purine metabolism D06103 Theophylline [2] 236, 299
147 PDE8B [1] Purine metabolism D07546 Bucladesine [1] 246
148 PDE8B [1] Purine metabolism D07961 Flavoxate [1] 226
149 PDE5A [1] Purine metabolism D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
150 PDE5A [1] Purine metabolism D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
151 PDE5A [1] Purine metabolism D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
152 PDE5A [1] Purine metabolism D02008 Tadalafil [7] 6, 51, 75, 84, 86, 113, 210
153 PDE5A [1] Purine metabolism D08514 Sildenafil [17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
154 PDE5A [1] Purine metabolism D08668 Vardenafil [3] 13, 86, 299
155 PDE5A [1] Purine metabolism D10027 Udenafil [2] 86, 210