Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Sacubitril [1] Sacubitril[1] Sacubitril 💬 [1] MME 💬 [4] Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬[3] 58, 210, 222 💬
2 Safinamide [2] Safinamida; Safinamide[2] Safinamide ,
Safinamide mesylate 💬 		[1] MAO 💬 [13] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[2] 6, 17 💬
3 Sage [0] ---[1] 6 💬
4 Salmeterol [1] Salmeterol[2] Salmeterol xinafoate ,
Salmeterol 💬 		[1] ADRB2 💬 [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 299 💬
5 Salmon, unspecified [1] Salmon---[3] 96, 97, 225 💬
6 Salsalate [1] Salsalate[1] Salsalate 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 5 💬
7 Sapropterin [4] 6R-BH4; Sapropterin; Sapropterin dihydrochloride; Tetrahydrobiopterin[2] Sapropterin dihydrochloride ,
Sapropterin 💬 		--[3] 86, 124, 240 💬
8 Saquinavir [1] Saquinavir[2] Saquinavir ,
Saquinavir mesylate 💬 		--[2] 86, 265 💬
9 SAR421869 [1] SAR421869---[2] 90, 303 💬
10 SAR422459 [1] SAR422459---[1] 301 💬
11 SAR443122 [1] SAR443122[1] Eclitasertib 💬 [1] RIPK1 💬 [16] Alcoholic liver disease, Apoptosis, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Hepatitis C, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Necroptosis, Pathogenic Escherichia coli infection, RIG-I-like receptor signaling pathway, Salmonella infection, Shigellosis, TNF signaling pathway, Toll-like receptor signaling pathway 💬[1] 97 💬
12 Saracatinib [1] Saracatinib[1] Saracatinib 💬 [2] ABL1,
SRC 💬 		[48] Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Hormone signaling, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[3] 6, 89, 272 💬
13 Sarcosine [0] ---[1] 6 💬
14 Sargramostim [1] Sargramostim[1] Sargramostim 💬 [1] CSF2RA 💬 [4] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬[7] 6, 28, 60, 62, 96, 229, 285 💬
15 Sarilumab [3] REGN88; SAR153191; Sarilumab[1] Sarilumab 💬 [1] IL6R 💬 [11] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[5] 41, 46, 84, 107, 271 💬
16 Sarizotan [2] Sarizotan; Sarizotan hydrochloride[1] Sarizotan hydrochloride 💬 [2] DRD2,
HTR1 💬 		[12] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 156 💬
17 Saroglitazar [0] [2] Saroglitazar ,
Saroglitazar magnesium 💬 		[3] NR1C1,
NR1C2,
NR1C3 💬 		[22] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Efferocytosis, Glucagon signaling pathway, Hepatitis C, Huntington disease, Insulin resistance, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Wnt signaling pathway, cAMP signaling pathway 💬[1] 93 💬
18 SARS-CoV-2 mRNA vaccine [1] SARS-COV-2 mrna vaccine---[1] 13 💬
19 Satavaptan [1] Satavaptan---[1] 72 💬
20 Satralizumab [2] Sapelizumab; Satralizumab[1] Satralizumab 💬 [1] IL6R 💬 [11] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[4] 11, 13, 86, 113 💬
21 Saxagliptin [1] Saxagliptin[2] Saxagliptin ,
Saxagliptin hydrochloride 💬 		[1] DPP4 💬 [2] Protein digestion and absorption, Virion - Hepatitis viruses 💬[1] 299 💬
22 SB-509 [1] SB-509---[1] 2 💬
23 SBT101 [1] SBT101---[1] 20 💬
24 SC12267 [1] SC12267---[3] 46, 96, 97 💬
25 Scopolamine [1] Scopolamine[1] Scopolamine 💬 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬 		[14] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 2 💬
26 Scutellaria baicalensis root [1] Scutellaria baicalensis[1] Scutellaria root 💬 --[1] 224 💬
27 Sebelipase alfa [2] SBC-102; Sebelipase alfa[1] Sebelipase alfa 💬 [1] LIPA 💬 [4] Cholesterol metabolism, Efferocytosis, Lysosome, Steroid biosynthesis 💬[1] 19 💬
28 Sebetralstat [1] Sebetralstat[1] Sebetralstat 💬 [1] KLKB1 💬 [1] Complement and coagulation cascades 💬[1] 65 💬
29 Secretin human [2] Human secretin; Secretin[1] Secretin 💬 [1] SCTR 💬 [3] Bile secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion 💬[1] 298 💬
30 Secukinumab [1] Secukinumab[1] Secukinumab 💬 [1] IL17A 💬 [6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[8] 13, 37, 41, 46, 107, 160, 269, 271 💬
31 SEL-302 [1] SEL-302---[1] 246 💬
32 Seladelpar [1] Seladelpar[2] Seladelpar ,
Seladelpar lysine 💬 		[1] NR1C3 💬 [12] AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[2] 93, 94 💬
33 Selegiline [1] Selegiline[2] Selegiline hydrochloride ,
Selegiline 💬 		[1] MAO 💬 [13] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6 💬
34 Selenium [1] Selenium---[4] 13, 96, 278, 298 💬
35 Selexipag [1] Selexipag[1] Selexipag 💬 [1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 47, 51, 70, 84, 86, 88 💬
36 Seliciclib [2] R-roscovitine; Seliciclib---[2] 75, 299 💬
37 Selinexor [1] Selinexor[1] Selinexor 💬 [1] XPO1 💬 [5] Human T-cell leukemia virus 1 infection, Influenza A, Nucleocytoplasmic transport, Ribosome biogenesis in eukaryotes, Viral life cycle - HIV-1 💬[1] 28 💬
38 Selisistat [1] Selisistat---[1] 8 💬
39 Selonsertib [1] Selonsertib[1] Selonsertib 💬 [1] MAP3K5 💬 [19] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬[1] 86 💬
40 Selumetinib [2] Selumetinib; Selumetinib sulfate[2] Selumetinib ,
Selumetinib sulfate 💬 		[2] MAP2K1,
MAP2K2 💬 		[88] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, B cell receptor signaling pathway, Bladder cancer, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, Efferocytosis, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway, Vascular smooth muscle contraction, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 34 💬
41 Semaglutide [1] Semaglutide[1] Semaglutide 💬 [1] GLP1R 💬 [4] Hormone signaling, Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[4] 6, 51, 84, 299 💬
42 Semapimod [1] Semapimod---[1] 96 💬
43 Senicapoc [1] Senicapoc[1] Senicapoc 💬 [1] KCNN4 💬 [4] GnRH secretion, Insulin secretion, Protein digestion and absorption, Salivary secretion 💬[1] 85 💬
44 Senna leaf [1] Senna[2] Senna ,
Senna leaf 💬 		--[1] 291 💬
45 SEP-363856 [1] SEP-363856---[1] 6 💬
46 Sepiapterin [1] Sepiapterin[1] Sepiapterin 💬 --[1] 240 💬
47 SER-287 [1] SER-287---[1] 97 💬
48 Seralutinib [1] Seralutinib[1] Seralutinib 💬 [2] PDGFRA,
PDGFRB 💬 		[20] Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Endocytosis, Focal adhesion, Gap junction, Glioma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton 💬[1] 86 💬
49 Serine [1] Serine[1] Serine 💬 --[1] 86 💬
50 Serlopitant [0] [1] Serlopitant 💬 [1] TACR1 💬 [3] Calcium signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[1] 36 💬
51 Serotonin [1] Serotonin---[1] 2 💬
52 Sertraline [1] Sertraline[2] Sertraline hydrochloride ,
Sertraline 💬 		[1] SLC6A4 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 158, 206 💬
53 Sesame oil [0] [1] Sesame oil 💬 --[1] 3 💬
54 Setanaxib [1] Setanaxib---[2] 93, 218 💬
55 Setmelanotide [1] Setmelanotide[2] Setmelanotide ,
Setmelanotide acetate 💬 		[1] MC4R 💬 [3] Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[4] 134, 193, 202, 265 💬
56 Setrusumab [1] Setrusumab[1] Setrusumab 💬 [1] SOST 💬 [2] Parathyroid hormone synthesis, secretion and action, Wnt signaling pathway 💬[1] 274 💬
57 Sevasemten [1] Sevasemten[1] Sevasemten 💬 [8] MYH1s,
MYH1s,
MYH1s,
MYH1s,
MYH1s,
MYH1s,
MYH1s,
MYH1s 💬 		[2] Cytoskeleton in muscle cells, Motor proteins 💬[1] 113 💬
58 Sevelamer [1] Sevelamer[3] Sevelamer hydrochloride ,
Sevelamer carbonate ,
Sevelamer 💬 		--[2] 235, 238 💬
59 Sevoflurane [1] Sevoflurane[1] Sevoflurane 💬 --[8] 6, 21, 22, 34, 70, 98, 225, 296 💬
60 Sibeprenlimab [1] Sibeprenlimab[1] Sibeprenlimab 💬 [1] TNFSF13 💬 [3] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis 💬[1] 66 💬
61 Sibofimloc [1] Sibofimloc[1] Sibofimloc 💬 --[1] 96 💬
62 Sifalimumab [1] Sifalimumab[1] Sifalimumab 💬 [13] IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA,
IFNA 💬 		[25] Alcoholic liver disease, Autoimmune thyroid disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, PI3K-Akt signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Tuberculosis 💬[1] 49 💬
63 Sildenafil [3] Sildenafil; Sildenafil citrate; Sildenafilo[2] Sildenafil citrate ,
Sildenafil 💬 		[1] PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[14] 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
64 Silodosin [1] Silodosin[1] Silodosin 💬 [1] ADRA1A 💬 [9] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 6 💬
65 Siltuximab [1] Siltuximab[1] Siltuximab 💬 [1] IL6 💬 [49] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Alcoholic liver disease, Alzheimer disease, Amoebiasis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Malaria, Measles, NOD-like receptor signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Salmonella infection, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection 💬[2] 28, 331 💬
66 Silver [1] Silver---[2] 35, 162 💬
67 Simethicone [1] Simethicone[1] Simethicone 💬 --[2] 13, 96 💬
68 Simtuzumab [2] GS-6624; Simtuzumab---[2] 85, 94 💬
69 Simvastatin [2] Simvastatin; Simvastatine[1] Simvastatin 💬 [1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
70 Sinecatechins [1] Polyphenon E[1] Sinecatechins 💬 --[3] 13, 36, 97 💬
71 Sinomenine [1] Sinomenine---[2] 46, 222 💬
72 Siplizumab [1] Siplizumab[1] Siplizumab 💬 [1] CD2 💬 [2] Cell adhesion molecules, Hematopoietic cell lineage 💬[2] 94, 95 💬
73 Siponimod [1] Siponimod[2] Siponimod fumarate ,
Siponimod 💬 		[2] S1PR1,
S1PR5 💬 		[4] Efferocytosis, FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[2] 13, 50 💬
74 Sirolimus [2] Rapamycin; Sirolimus[1] Sirolimus 💬 [1] MTOR 💬 [49] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[46] 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
75 Sirukumab [1] Sirukumab[1] Sirukumab 💬 [1] IL6 💬 [49] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Alcoholic liver disease, Alzheimer disease, Amoebiasis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Malaria, Measles, NOD-like receptor signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Salmonella infection, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection 💬[2] 41, 46 💬
76 Sitagliptin [1] Sitagliptin[3] Sitagliptin phosphate ,
Sitagliptin ,
Sitagliptin phosphate 💬 		[1] DPP4 💬 [2] Protein digestion and absorption, Virion - Hepatitis viruses 💬[5] 6, 75, 77, 233, 299 💬
77 Sitaxentan [3] Sitaxentan; Sitaxentan sodium; Sitaxsentan[2] Sitaxentan ,
Sitaxentan sodium 💬 		[1] EDNRA 💬 [7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
78 Sivelestat [1] Sivelestat[1] Sivelestat 💬 [1] ELANE 💬 [3] Neutrophil extracellular trap formation, Systemic lupus erythematosus, Transcriptional misregulation in cancer 💬[3] 13, 85, 96 💬
79 Skin-derived ABCB5-positive Mesenchymal Stem cells [1] ALLO-APZ2-EB---[1] 36 💬
80 Smilagenin [1] Smilagenin---[1] 6 💬
81 SNSP113 [1] SNSP113---[1] 299 💬
82 Sobetirome [1] Sobetirome[1] Sobetirome 💬 [1] THRB 💬 [3] Hormone signaling, Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[1] 20 💬
83 Sodium acetate [1] Sodium acetate[1] Sodium acetate 💬 --[1] 251 💬
84 Sodium ascorbate [1] Sodium ascorbate[1] Sodium ascorbate 💬 --[1] 97 💬
85 Sodium aurothiomalate [1] Sodium aurothiomalate[1] Gold sodium thiomalate 💬 --[1] 46 💬
86 Sodium bicarbonate [1] Sodium bicarbonate[1] Sodium bicarbonate 💬 --[4] 67, 97, 226, 299 💬
87 Sodium chloride [2] Natriumchlorid; Sodium chloride[1] Sodium chloride 💬 --[23] 2, 11, 13, 14, 34, 41, 46, 51, 53, 60, 67, 70, 96, 97, 193, 214, 215, 226, 227, 228, 288, 298, 299 💬
88 Sodium citrate [1] Sodium citrate[2] Sodium citrate hydrate ,
Sodium citrate 💬 		--[4] 67, 214, 215, 235 💬
89 Sodium dichloroacetate [1] Dichloroacetate sodium---[1] 86 💬
90 Sodium fluoride [0] [1] Sodium fluoride 💬 --[1] 51 💬
91 Sodium lauryl sulfate [0] [1] Sodium lauryl sulfate 💬 --[1] 2 💬
92 Sodium nitrate [1] Sodium nitrate---[2] 58, 113 💬
93 Sodium oxybate [1] Sodium oxybate[1] Sodium oxybate 💬 --[2] 6, 149 💬
94 Sodium sulfate [1] Sodium sulphate anhydrous[2] Anhydous sodium sulfate ,
Sodium sulfate 💬 		--[1] 97 💬
95 Sodium tetradecyl sulfate [0] [1] Sodium tetradecyl sulfate 💬 --[3] 50, 51, 52 💬
96 Solifenacin [2] Solifenacin; Solifenacin succinate[2] Solifenacin succinate ,
Solifenacin 💬 		[1] CHRM3 💬 [12] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13 💬
97 Solriamfetol [1] Solriamfetol[2] Solriamfetol ,
Solriamfetol hydrochloride 💬 		[2] SLC6A2,
SLC6A3 💬 		[8] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Neuroactive ligand signaling, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[1] 13 💬
98 Solrikitug [0] [1] Solrikitug 💬 [1] TSLPR 💬 [2] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway 💬[1] 98 💬
99 Somapacitan [1] Somapacitan[1] Somapacitan 💬 [1] GHR 💬 [6] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 195 💬
100 Somatorelin [1] Somatorelin[1] Somatorelin 💬 [1] GHRHR 💬 [3] Growth hormone synthesis, secretion and action, Hormone signaling, Neuroactive ligand-receptor interaction 💬[1] 13 💬
101 Somatostatin [1] Somatostatin[1] Somatostatin 💬 [5] SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬 		[5] Gastric acid secretion, Growth hormone synthesis, secretion and action, Hormone signaling, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 77 💬
102 Somatotropin [7] Growth hormone; Human growth hormone; Recombinant human growth hormone; Rhgh; Somatotropin; Somatropin; Somatropina[1] Somatropin 💬 [1] GHR 💬 [6] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[28] 2, 3, 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
103 Sonlicromanol [2] KH176; Sonlicromanol---[2] 21, 302 💬
104 Soquelitinib [1] Soquelitinib[1] Soquelitinib 💬 [1] ITK 💬 [3] Chemokine signaling pathway, Leukocyte transendothelial migration, T cell receptor signaling pathway 💬[1] 65 💬
105 Sorafenib [1] Sorafenib[2] Sorafenib tosylate ,
Sorafenib 💬 		[8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬 		[87] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86 💬
106 Soraprazan [1] Soraprazan---[1] 301 💬
107 Sorbitol [2] D-glucitol; Sorbitol[1] Sorbitol solution 💬 --[3] 10, 28, 97 💬
108 Sotagliflozin [1] Sotagliflozin[1] Sotagliflozin 💬 [1] SLC5A1 💬 [3] Bile secretion, Carbohydrate digestion and absorption, Mineral absorption 💬[2] 58, 84 💬
109 Sotatercept [1] Sotatercept[1] Sotatercept 💬 [1] ACVR2A 💬 [4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[2] 86, 284 💬
110 Soticlestat [1] Soticlestat[1] Soticlestat 💬 [1] CYP46A1 💬 [1] Primary bile acid biosynthesis 💬[2] 140, 144 💬
111 Sotrastaurin [0] [2] Sotrastaurin ,
Sotrastaurin acetate 💬 		[4] PRKCD,
PRKCE,
PRKCH,
PRKCQ 💬 		[29] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Aldosterone synthesis and secretion, Apelin signaling pathway, Autophagy - animal, C-type lectin receptor signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemokine signaling pathway, Diabetic cardiomyopathy, Estrogen signaling pathway, Fc gamma R-mediated phagocytosis, GnRH signaling pathway, Inflammatory mediator regulation of TRP channels, Insulin resistance, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Prion disease, Shigellosis, Sphingolipid signaling pathway, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 97 💬
112 Soybean [0] ---[1] 97 💬
113 SP-101 [0] ---[1] 299 💬
114 Sparsentan [1] Sparsentan[1] Sparsentan 💬 [2] AGTR1,
EDNRA 💬 		[18] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 66, 218, 222 💬
115 Spectinomycin [0] [2] Spectinomycin hydrochloride ,
Spectinomycin 💬 		--[1] 13 💬
116 Spesolimab [1] Spesolimab[1] Spesolimab 💬 [1] IL1RL2 💬 [1] Cytokine-cytokine receptor interaction 💬[5] 37, 96, 97, 160, 269 💬
117 SPG302 [1] SPG302---[1] 2 💬
118 SPG601 [1] SPG601---[1] 206 💬
119 Spheramine [1] Spheramine---[1] 6 💬
120 Spironolactone [1] Spironolactone[1] Spironolactone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
121 Spirulina platensis [1] Spirulina platensis---[1] 299 💬
122 SRP-6004 [1] SRP-6004---[1] 113 💬
123 SRP-9005 [1] SRP-9005---[1] 113 💬
124 ST-36 [2] ST 36; ST36---[3] 6, 46, 49 💬
125 Stamulumab [1] MYO-029[1] Stamulumab 💬 [1] MSTN 💬 [1] Cytokine-cytokine receptor interaction 💬[1] 113 💬
126 Stannsoporfin [1] TIN mesoporphyrin[1] Stannsoporfin 💬 [2] HMOX1,
HMOX2 💬 		[9] Chemical carcinogenesis - reactive oxygen species, Ferroptosis, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatocellular carcinoma, MicroRNAs in cancer, Mineral absorption, Pathways in cancer, Porphyrin metabolism 💬[1] 254 💬
127 Stanozolol [1] Stanozolol[1] Stanozolol 💬 [1] AR 💬 [4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[1] 60 💬
128 Starch, corn [2] Corn starch; Cornstarch[1] Corn starch 💬 --[4] 49, 90, 97, 257 💬
129 Stavudine [1] Stavudine[1] Stavudine 💬 --[1] 265 💬
130 STG-001 [1] STG-001---[1] 301 💬
131 Stiripentol [1] Stiripentol[1] Stiripentol 💬 --[2] 140, 234 💬
132 Strimvelis [1] Strimvelis---[1] 65 💬
133 Succimer [1] Dmsa[1] Succimer 💬 --[1] 171 💬
134 Sucralfate [1] Sucralfate[1] Sucralfate 💬 --[1] 98 💬
135 Sufentanil [1] Sufentanil[2] Sufentanil citrate ,
Sufentanil 💬 		[1] OPRM1 💬 [5] Estrogen signaling pathway, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[4] 11, 22, 70, 280 💬
136 Sugammadex [1] Sugammadex[1] Sugammadex sodium 💬 --[1] 11 💬
137 Sulfadoxine [1] Sulfadoxine[1] Sulfadoxine 💬 --[1] 65 💬
138 Sulfamethoxazole [2] Sulfamethoxazole; Sulphamethoxazole[1] Sulfamethoxazole 💬 --[2] 85, 299 💬
139 Sulfanilamide [0] [1] Sulfanilamide 💬 --[1] 298 💬
140 Sulfasalazine [4] Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazin; Sulfasalazine[1] Sulfasalazine 💬 --[8] 46, 49, 54, 86, 94, 107, 270, 271 💬
141 Sulfate ion [1] Sulfate[1] Sulfuric acid 💬 --[8] 2, 3, 11, 49, 53, 64, 222, 224 💬
142 Sulforaphane [1] Sulforaphane---[2] 6, 205 💬
143 Sulfur hexafluoride [2] Sulfur hexafluoride; Sulphur hexafluoride[1] Sulfur hexafluoride 💬 --[3] 96, 97, 215 💬
144 Sulindac [0] [1] Sulindac 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206 💬
145 Sumanirole [1] Sumanirole---[1] 6 💬
146 Sunflower oil [1] Sunflower OIL[1] Sunflower oil 💬 --[2] 46, 299 💬
147 Sunitinib [2] Sunitinib; Sunitinib malate[2] Sunitinib malate ,
Sunitinib 💬 		[9] CSF1R,
FLT1,
FLT3,
FLT4,
KDR,
KIT,
PDGFRA,
PDGFRB,
RET 💬 		[35] Acute myeloid leukemia, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, Endocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, Gap junction, Glioma, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Thyroid cancer, Transcriptional misregulation in cancer, VEGF signaling pathway, Viral protein interaction with cytokine and cytokine receptor 💬[2] 28, 34 💬
148 Suplatast [2] Suplatast; Suplatast tosilate[1] Suplatast tosilate 💬 --[2] 85, 226 💬
149 Suramin [1] Suramin---[1] 331 💬
150 Susoctocog alfa [1] Susoctocog alfa[1] Susoctocog alfa 💬 [1] F8 💬 [1] Complement and coagulation cascades 💬[1] 288 💬
151 Sutimlimab [1] Sutimlimab[1] Sutimlimab 💬 [1] C1S 💬 [5] Complement and coagulation cascades, Coronavirus disease - COVID-19, Pertussis, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[1] 61 💬
152 Suvecaltamide [1] Suvecaltamide[1] Suvecaltamide 💬 [3] CACNA1G,
CACNA1H,
CACNA1I 💬 		[8] Aldosterone synthesis and secretion, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GnRH secretion, MAPK signaling pathway, Type II diabetes mellitus 💬[1] 6 💬
153 Suvodirsen [1] Suvodirsen---[1] 113 💬
154 Suvorexant [1] Suvorexant[1] Suvorexant 💬 [2] HCRTR1,
HCRTR2 💬 		[2] Hormone signaling, Neuroactive ligand-receptor interaction 💬[3] 5, 6, 13 💬
155 SYNB1020 [1] SYNB1020---[1] 251 💬
156 SYNB1353 [1] SYNB1353---[1] 337 💬