Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Abatacept 1件: Abatacept1件: Abatacept 💬 2件: CD80,
CD86 💬 		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬27件: 2, 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
2 Acetaminophen 2件: Acetaminophen; Paracetamol1件: Acetaminophen 💬 2件: PTGS1,
PTGS2 💬 		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
3 Adalimumab 1件: Adalimumab1件: Adalimumab 💬 1件: TNF 💬 66件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
4 Albumin human 3件: Albumin; Human albumin; Serum albumin2件: Albumin human ,
Human serum albumin 💬 		--7件: 2, 11, 50, 96, 97, 222, 296 💬
5 Aldosterone 1件: Aldosterone1件: Aldosterone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬1件: 222 💬
6 Aliskiren 1件: Aliskiren2件: Aliskiren ,
Aliskiren fumarate 💬 		1件: REN 💬 3件: Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬3件: 66, 167, 222 💬
7 Angiotensin II 2件: Angiotensin; Angiotensin II3件: Angiotensin II ,
Angiotensin II ,
Angiotensin II acetate 💬 		2件: AGTR1,
AGTR2 💬 		17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬7件: 17, 46, 49, 66, 218, 222, 224 💬
8 Apixaban 1件: Apixaban1件: Apixaban 💬 1件: F10 💬 1件: Complement and coagulation cascades 💬4件: 96, 97, 222, 279 💬
9 Atacicept 2件: Atacicept; TACI-FC51件: Atacicept 💬 2件: TNFSF13,
TNFSF13B 💬 		4件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬5件: 13, 46, 49, 66, 222 💬
10 Atrasentan 1件: Atrasentan1件: Atrasentan hydrochloride 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 66, 218, 222 💬
11 Avacopan 1件: Avacopan1件: Avacopan 💬 1件: C5AR1 💬 6件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬4件: 43, 44, 66, 222 💬
12 Bardoxolone 0件: 1件: Bardoxolone 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
13 Bardoxolone methyl 1件: Bardoxolone methyl1件: Bardoxolone methyl 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
14 Basiliximab 1件: Basiliximab1件: Basiliximab 💬 1件: IL2RA 💬 11件: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬5件: 2, 50, 97, 222, 228 💬
15 Belimumab 1件: Belimumab1件: Belimumab 💬 1件: TNFSF13B 💬 4件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬14件: 11, 13, 43, 44, 46, 48, 49, 51, 53, 63, 66, 95, 222, 296 💬
16 Bleselumab 1件: Bleselumab1件: Bleselumab 💬 1件: TNFRSF5 💬 17件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis 💬1件: 222 💬
17 Bortezomib 1件: Bortezomib1件: Bortezomib 💬 1件: PSMB5 💬 8件: Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬18件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 172, 222, 228, 256, 283, 288, 331 💬
18 Butyric Acid 4件: Butanoic acid; Butyrate; Butyric acid; Sodium butyrate1件: Sodium butyrate 💬 --5件: 46, 97, 156, 222, 291 💬
19 Calcium 2件: Calcio; Calcium---24件: 6, 13, 19, 46, 49, 51, 53, 68, 75, 84, 93, 95, 96, 97, 156, 186, 214, 215, 222, 235, 271, 274, 298, 299 💬
20 CDX-1135 1件: CDX-1135---1件: 222 💬
21 Cefadroxil 0件: 2件: Cefadroxil ,
Cefadroxil 💬 		--3件: 98, 222, 240 💬
22 Cholesterol 1件: Cholesterol1件: Cholesterol 💬 --5件: 19, 90, 160, 222, 310 💬
23 Corticotropin 3件: Acth; Adrenocorticotropic hormone; Corticotropin2件: Corticotropin ,
Corticotropin, repository 💬 		1件: MC2R 💬 6件: Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Hormone signaling, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
24 Creatinine 1件: Creatinine1件: Creatinine 💬 --6件: 2, 46, 60, 66, 70, 222 💬
25 CXA-10 1件: CXA-10---2件: 86, 222 💬
26 Cyclophosphamide 5件: Ciclofosfamida; Ciclofosfamide; Cyclophosphamid; Cyclophosphamide; Cyclophosphamide monohydrate2件: Cyclophosphamide ,
Cyclophosphamide 💬 		--46件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 93, 96, 162, 164, 172, 205, 220, 221, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
27 Cyclosporine 6件: Ciclosporin; Ciclosporina; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine1件: Cyclosporine 💬 5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
28 Dalteparin 1件: Dalteparin1件: Dalteparin sodium 💬 1件: SERPINC1 💬 1件: Complement and coagulation cascades 💬1件: 222 💬
29 Danicopan 2件: ACH-0144471; Danicopan1件: Danicopan 💬 1件: CFD 💬 3件: Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬2件: 62, 222 💬
30 Dapagliflozin 1件: Dapagliflozin1件: Dapagliflozin 💬 --13件: 6, 19, 28, 49, 66, 67, 86, 88, 97, 210, 215, 218, 222 💬
31 Dexamethasone 2件: Dexamethasone; Dexamethasone sodium phosphate3件: Dexamethasone ,
Dexamethasone sodium phosphate ,
Dexamethasone phosphate 💬 		1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬25件: 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬
32 Diphenhydramine 2件: Diphenhydramine; Diphenhydramine hydrochloride4件: Diphenhydramine ,
Diphenhydramine hydrochloride ,
Diphenhydramine salicylate ,
Diphenhydramine citrate 💬 		1件: HRH1 💬 4件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
33 Eculizumab 1件: Eculizumab1件: Eculizumab 💬 1件: C5 💬 11件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬8件: 11, 13, 14, 61, 62, 109, 221, 222 💬
34 Enalapril 2件: Enalapril; Enalapril maleate2件: Enalapril maleate ,
Enalapril 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬8件: 13, 19, 46, 66, 113, 210, 222, 279 💬
35 Evolocumab 1件: Evolocumab1件: Evolocumab 💬 1件: PCSK9 💬 1件: Cholesterol metabolism 💬2件: 79, 222 💬
36 Felzartamab 1件: Felzartamab---2件: 66, 222 💬
37 Filgotinib 2件: Filgotinib; Filgotinib maleate2件: Filgotinib ,
Filgotinib maleate 💬 		4件: JAK1,
JAK2,
JAK3,
TYK2 💬 		39件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, Efferocytosis, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
38 Finerenone 1件: Finerenone1件: Finerenone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬4件: 66, 218, 222, 224 💬
39 Fludarabine 2件: Fludarabine; Fludarabine phosphate2件: Fludarabine phosphate ,
Fludarabine 💬 		1件: RRM1 💬 4件: Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism 💬25件: 11, 13, 19, 28, 34, 35, 36, 44, 46, 49, 51, 60, 61, 62, 65, 85, 96, 107, 164, 222, 283, 284, 285, 286, 326 💬
40 Fluvastatin 1件: Fluvastatin2件: Fluvastatin sodium ,
Fluvastatin 💬 		1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬2件: 79, 222 💬
41 Fosfomycin 1件: Fosfomycin3件: Fosfomycin tromethamine ,
Fosfomycin sodium ,
Fosfomycin 💬 		--3件: 96, 97, 222 💬
42 Fresolimumab 2件: Fresolimumab; GC10081件: Fresolimumab 💬 3件: TGFB1,
TGFB2,
TGFB3 💬 		36件: AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, Cell cycle, Cellular senescence, Chagas disease, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Diabetic cardiomyopathy, Dilated cardiomyopathy, Efferocytosis, FoxO signaling pathway, Gastric cancer, Hepatitis B, Hepatocellular carcinoma, Hippo signaling pathway, Human T-cell leukemia virus 1 infection, Hypertrophic cardiomyopathy, Inflammatory bowel disease, Intestinal immune network for IgA production, Leishmaniasis, MAPK signaling pathway, Malaria, MicroRNAs in cancer, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬4件: 51, 85, 222, 274 💬
43 Frexalimab 1件: Frexalimab1件: Frexalimab 💬 1件: TNFSF5 💬 14件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, T cell receptor signaling pathway, Toxoplasmosis, Viral myocarditis 💬2件: 13, 222 💬
44 Galactose 1件: Galactose1件: Galactose 💬 --2件: 171, 222 💬
45 Hydroxychloroquine 2件: Hydroxychloroquine; Hydroxychloroquine sulfate2件: Hydroxychloroquine sulfate ,
Hydroxychloroquine 💬 		--27件: 6, 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299 💬
46 Iptacopan 1件: Iptacopan2件: Iptacopan ,
Iptacopan hydrochloride 💬 		1件: CFB 💬 3件: Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬6件: 11, 61, 62, 66, 109, 222 💬
47 Irbesartan 1件: Irbesartan1件: Irbesartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬4件: 66, 167, 168, 222 💬
48 L-Glutamine 2件: Glutamine; L-glutamine1件: Glutamine 💬 --11件: 21, 87, 89, 96, 97, 113, 214, 215, 222, 245, 299 💬
49 Lanraplenib 1件: Lanraplenib1件: Lanraplenib 💬 --2件: 53, 222 💬
50 Lansoprazole 1件: Lansoprazole1件: Lansoprazole 💬 2件: ATP4A,
ATP4B 💬 		3件: Collecting duct acid secretion, Gastric acid secretion, Oxidative phosphorylation 💬6件: 63, 71, 85, 166, 222, 299 💬
51 Levamisole 2件: Levamisole; Levamisole hydrochloride2件: Levamisole hydrochloride ,
Levamisole 💬 		--4件: 60, 61, 62, 222 💬
52 Lisinopril 1件: Lisinopril2件: Lisinopril ,
Lisinopril 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 19, 46, 49, 66, 67, 113, 222 💬
53 Losartan 2件: Losartan; Losartan potassium2件: Losartan potassium ,
Losartan 💬 		1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
54 Losmapimod 1件: Losmapimod1件: Losmapimod 💬 4件: P38,
P38,
P38,
P38 💬 		62件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Efferocytosis, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬2件: 113, 222 💬
55 Melphalan 2件: Melphalan; Melphalan hydrochloride2件: Melphalan ,
Melphalan hydrochloride 💬 		--19件: 11, 13, 14, 19, 20, 28, 34, 46, 60, 62, 65, 96, 107, 164, 222, 234, 284, 285, 299 💬
56 Metformin 3件: Metformin; Metformin hydrochloride; Metformina2件: Metformin hydrochloride ,
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
57 Methylprednisolone 3件: Methylprednisolon; Methylprednisolone; Methylprednisolone acetate2件: Methylprednisolone ,
Methylprednisolone acetate 💬 		1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
58 Methylprednisone 1件: Methylprednisone---3件: 46, 85, 222 💬
59 Mizoribine 1件: Mizoribine1件: Mizoribine 💬 2件: IMPDH,
IMPDH 💬 		2件: Drug metabolism - other enzymes, Purine metabolism 💬8件: 46, 49, 51, 53, 66, 94, 222, 224 💬
60 Monomethyl fumarate 1件: Monomethyl fumarate1件: Monomethyl fumarate 💬 --17件: 13, 35, 40, 46, 49, 50, 51, 53, 56, 60, 65, 66, 84, 107, 222, 224, 226 💬
61 Mycophenolate mofetil 1件: Mycophenolate mofetil2件: Mycophenolate mofetil ,
Mycophenolate mofetil hydrochloride 💬 		2件: IMPDH,
IMPDH 💬 		2件: Drug metabolism - other enzymes, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 93, 95, 96, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
62 Mycophenolic acid 5件: Acido micofenolico; Micofenolico acido; Mycophenolate; Mycophenolate sodium; Mycophenolic acid2件: Mycophenolate sodium ,
Mycophenolic acid 💬 		2件: IMPDH,
IMPDH 💬 		2件: Drug metabolism - other enzymes, Purine metabolism 💬37件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 84, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
63 N-acetylmannosamine 1件: Mannac---1件: 222 💬
64 Narsoplimab 1件: Narsoplimab1件: Narsoplimab 💬 1件: MASP2 💬 3件: Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬2件: 66, 222 💬
65 Obinutuzumab 1件: Obinutuzumab1件: Obinutuzumab 💬 1件: MS4A1 💬 1件: Hematopoietic cell lineage 💬5件: 43, 44, 49, 63, 222 💬
66 Panax notoginseng root 1件: Sanqi1件: Panax notoginseng root 💬 --2件: 222, 224 💬
67 Pegcetacoplan 1件: Pegcetacoplan1件: Pegcetacoplan 💬 1件: C3 💬 17件: Alcoholic liver disease, Chagas disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Phagosome, Shigellosis, Staphylococcus aureus infection, Systemic lupus erythematosus, Tuberculosis, Viral carcinogenesis 💬4件: 2, 61, 62, 222 💬
68 Peginterferon alfa-2a 0件: 1件: Peginterferon alfa-2a 💬 2件: IFNAR1,
IFNAR2 💬 		18件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬1件: 222 💬
69 Pentoxifylline 1件: Pentoxifylline1件: Pentoxifylline 💬 --12件: 6, 26, 56, 84, 93, 96, 97, 113, 220, 222, 296, 298 💬
70 Perindopril 2件: Perindopril; Perindopril arginine3件: Perindopril erbumine ,
Perindopril ,
Perindopril arginine 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬4件: 58, 113, 167, 222 💬
71 Pirfenidone 1件: Pirfenidone1件: Pirfenidone 💬 6件: CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬 		83件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, Efferocytosis, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
72 Povetacicept 1件: Povetacicept1件: Povetacicept 💬 1件: TNFRSF13B 💬 3件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Primary immunodeficiency 💬3件: 61, 63, 222 💬
73 Prednisolone 3件: Prednisolona; Prednisolone; Prednisolonum1件: Prednisolone 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬41件: 3, 11, 13, 14, 18, 25, 26, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 54, 56, 60, 61, 63, 64, 66, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 251, 269, 271, 296, 299, 300 💬
74 Prednisolone acetate 1件: Prednisolone acetate1件: Prednisolone acetate 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬1件: 222 💬
75 Prednisone 2件: Prednisona; Prednisone1件: Prednisone 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬54件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
76 Prednisone acetate 2件: Cortancyl; Prednisone acetate1件: Prednisone acetate 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬9件: 35, 40, 41, 46, 49, 63, 162, 222, 224 💬
77 Propagermanium 1件: Repagermanium1件: Propagermanium 💬 --1件: 222 💬
78 R3R01 1件: R3r01---2件: 218, 222 💬
79 Resiniferatoxin 0件: ---4件: 13, 65, 222, 240 💬
80 Rilzabrutinib 1件: Rilzabrutinib1件: Rilzabrutinib 💬 1件: BTK 💬 7件: B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬5件: 35, 61, 63, 222, 300 💬
81 Rituximab 1件: Rituximab1件: Rituximab 💬 1件: MS4A1 💬 1件: Hematopoietic cell lineage 💬52件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
82 Rosiglitazone 2件: Rosiglitazone; Rosiglitazone maleate2件: Rosiglitazone maleate ,
Rosiglitazone 💬 		1件: NR1C3 💬 12件: AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬6件: 46, 75, 77, 97, 222, 265 💬
83 Sacubitril 1件: Sacubitril1件: Sacubitril 💬 1件: MME 💬 4件: Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬3件: 58, 210, 222 💬
84 Sinomenine 1件: Sinomenine---2件: 46, 222 💬
85 Sirolimus 2件: Rapamycin; Sirolimus1件: Sirolimus 💬 1件: MTOR 💬 49件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬46件: 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
86 Sparsentan 1件: Sparsentan1件: Sparsentan 💬 2件: AGTR1,
EDNRA 💬 		18件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 66, 218, 222 💬
87 Sulfate ion 1件: Sulfate1件: Sulfuric acid 💬 --8件: 2, 3, 11, 49, 53, 64, 222, 224 💬
88 Tacrolimus 1件: Tacrolimus2件: Tacrolimus ,
Tacrolimus 💬 		5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬33件: 2, 6, 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
89 Telitacicept 1件: Telitacicept---11件: 11, 13, 46, 48, 49, 51, 53, 63, 66, 222, 300 💬
90 Tetracosactide 3件: Cosyntropin; Tetracosactide acetate; Tetracosactrin2件: Cosyntropin ,
Tetracosactide acetate 💬 		1件: MC2R 💬 6件: Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Hormone signaling, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬5件: 78, 83, 113, 145, 222 💬
91 Tripterygium wilfordii whole 2件: Tripterygium; Tripterygium wilfordii---8件: 46, 66, 67, 96, 162, 222, 224, 271 💬
92 TRU-015 1件: TRU-015---3件: 46, 49, 222 💬
93 Valproic acid 3件: Valproate; Valproate sodium; Valproic acid3件: Divalproex sodium ,
Valproic acid ,
Valproate sodium 💬 		7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
E4.1.1.15,
E4.1.1.15 💬 		16件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬13件: 2, 3, 5, 6, 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
94 Valsartan 1件: Valsartan1件: Valsartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬8件: 57, 58, 66, 75, 86, 210, 222, 224 💬
95 Vitamin D 2件: Calciferol; Vitamin D---22件: 6, 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 274, 298, 299 💬
96 Voclosporin 1件: Voclosporin1件: Voclosporin 💬 5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬2件: 49, 222 💬
97 Zanubrutinib 1件: Zanubrutinib1件: Zanubrutinib 💬 1件: BTK 💬 7件: B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬6件: 13, 61, 63, 222, 300, 331 💬
98 ZUBERITAMAB 1件: Zuberitamab---2件: 63, 222 💬