Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ABCC8 💬 3件: ABC transporters, Insulin secretion, Type II diabetes mellitus Diazoxide 💬 Diazoxide 2件: 13, 193 💬
2 ABCC8 💬 3件: ABC transporters, Insulin secretion, Type II diabetes mellitus Diazoxide choline 💬 Diazoxide 2件: 13, 193 💬
3 ADRA2A 💬 4件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Guanfacine hydrochloride 💬 Guanfacine 1件: 193 💬
4 ADRA2A 💬 4件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Guanfacine 💬 Guanfacine 1件: 193 💬
5 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol tartrate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
6 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
7 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol succinate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
8 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol fumarate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
9 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
10 CA4 💬 2件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
11 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
12 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
13 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
14 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
15 CNR1 💬 4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling Cannabidiol 💬 Cannabidiol 20件: 6, 8, 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
16 CNR1 💬 4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling Rimonabant 💬 Rimonabant 1件: 193 💬
17 CNR2 💬 1件: Neuroactive ligand-receptor interaction Cannabidiol 💬 Cannabidiol 20件: 6, 8, 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
18 CYP19A 💬 2件: Steroid hormone biosynthesis, Ovarian steroidogenesis Anastrozole 💬 Anastrozole 3件: 78, 86, 193 💬
19 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
20 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
21 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
22 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
23 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
24 GABRA 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
25 GABRB 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
26 GABRB 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
27 GABRB 💬 7件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
28 GABRD 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
29 GABRE 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
30 GABRG 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
31 GABRG 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
32 GABRG 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
33 GABRP 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
34 GABRQ 💬 6件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
35 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Somatropin 💬 Somatotropin 28件: 2, 3, 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
36 GIPR 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling Tirzepatide 💬 Tirzepatide 5件: 67, 96, 97, 193, 233 💬
37 GLP1R 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Liraglutide 💬 Liraglutide 5件: 6, 13, 75, 77, 193 💬
38 GLP1R 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Exenatide 💬 Exenatide 5件: 6, 17, 78, 193, 233 💬
39 GLP1R 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Tirzepatide 💬 Tirzepatide 5件: 67, 96, 97, 193, 233 💬
40 GRIA1 💬 15件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
41 GRIA2 💬 16件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
42 GRIA3 💬 14件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction, Transcriptional misregulation in cancer Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
43 GRIA4 💬 11件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
44 GRIK1 💬 3件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Glutamatergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
45 GRIK2 💬 3件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Glutamatergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
46 GRIK3 💬 3件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Glutamatergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
47 GRIK4 💬 3件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Glutamatergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
48 GRIK5 💬 3件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Glutamatergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
49 HRH3 💬 2件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling Pitolisant hydrochloride 💬 Pitolisant 3件: 6, 113, 193 💬
50 HRH3 💬 2件: Neuroactive ligand-receptor interaction, Neuroactive ligand signaling Pitolisant 💬 Pitolisant 3件: 6, 113, 193 💬
51 KCNJ11 💬 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus Diazoxide choline 💬 Diazoxide 2件: 13, 193 💬
52 KCNJ11 💬 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus Diazoxide 💬 Diazoxide 2件: 13, 193 💬
53 MC4R 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Setmelanotide acetate 💬 Setmelanotide 4件: 134, 193, 202, 265 💬
54 MC4R 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Setmelanotide 💬 Setmelanotide 4件: 134, 193, 202, 265 💬
55 MTOR 💬 49件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus 46件: 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
56 OXTR 💬 5件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Oxytocin signaling pathway Oxytocin 💬 Oxytocin 8件: 6, 70, 72, 127, 168, 193, 206, 226 💬
57 OXTR 💬 5件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Oxytocin signaling pathway Carbetocin 💬 Carbetocin 1件: 193 💬
58 SCN1A 💬 1件: Dopaminergic synapse Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
59 SCN2A 💬 1件: Taste transduction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
60 SCN3A 💬 1件: Taste transduction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
61 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
62 SCN9A 💬 1件: Taste transduction Topiramate 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
63 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide pamoate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
64 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
65 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
66 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬