Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole sodium 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
2 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
3 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole magnesium 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
4 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole magnesium 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
5 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
6 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole sodium 💬 Omeprazole 16件: 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
7 AVPR1A 💬 5件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 2件: 210, 225 💬
8 AVPR1B 💬 5件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 2件: 210, 225 💬
9 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Vasopressin 💬 Vasopressin 2件: 210, 225 💬
10 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Tolvaptan 💬 Tolvaptan 4件: 67, 72, 86, 225 💬
11 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Desmopressin 💬 Desmopressin 6件: 6, 64, 72, 75, 225, 288 💬
12 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Desmopressin acetate 💬 Desmopressin 6件: 6, 64, 72, 75, 225, 288 💬
13 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
14 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
15 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
16 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
17 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
18 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
19 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
20 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
21 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
22 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
23 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
24 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
25 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
26 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
27 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
28 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
29 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
30 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
31 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
32 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
33 CA 💬 1件: Nitrogen metabolism Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
34 CA 💬 1件: Nitrogen metabolism Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
35 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
36 CA2 💬 6件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
37 CA4 💬 2件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation Acetazolamide sodium 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
38 CA4 💬 2件: Nitrogen metabolism, Proximal tubule bicarbonate reclamation Acetazolamide 💬 Acetazolamide 6件: 13, 90, 115, 155, 225, 230 💬
39 F8 💬 1件: Complement and coagulation cascades Desmopressin 💬 Desmopressin 6件: 6, 64, 72, 75, 225, 288 💬
40 F8 💬 1件: Complement and coagulation cascades Desmopressin acetate 💬 Desmopressin 6件: 6, 64, 72, 75, 225, 288 💬
41 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
42 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
43 GUCY1B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
44 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
45 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin calcium 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
46 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Spironolactone 💬 Spironolactone 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
47 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil citrate 💬 Sildenafil 14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
48 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil 14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
49 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
50 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
51 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
52 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
53 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Indomethacin sodium 💬 Indomethacin 3件: 225, 271, 298 💬
54 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬
55 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Indomethacin sodium 💬 Indomethacin 3件: 225, 271, 298 💬
56 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Indomethacin 💬 Indomethacin 3件: 225, 271, 298 💬
57 SCNN1A 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride hydrochloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
58 SCNN1A 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
59 SCNN1B 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride hydrochloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
60 SCNN1B 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
61 SCNN1G 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride hydrochloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
62 SCNN1G 💬 2件: Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride 4件: 13, 67, 225, 299 💬
63 SLC12A3 💬 1件: Parathyroid hormone synthesis, secretion and action Chlorothiazide 💬 Chlorothiazide 1件: 225 💬
64 SLC12A3 💬 1件: Parathyroid hormone synthesis, secretion and action Hydrochlorothiazide 💬 Hydrochlorothiazide 4件: 13, 67, 225, 235 💬
65 SLC12A3 💬 1件: Parathyroid hormone synthesis, secretion and action Chlorothiazide sodium 💬 Chlorothiazide 1件: 225 💬