Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ABL1 💬 [11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
2 ABL1 💬 [11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
3 ABL1 💬 [11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Dasatinib 💬 Dasatinib [2] 51, 85 💬
4 ABL1 💬 [11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Dasatinib 💬 Dasatinib [2] 51, 85 💬
5 ADRA2A 💬 [4] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
6 ADRA2B 💬 [4] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
7 ADRA2C 💬 [4] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
8 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
9 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Nebivolol hydrochloride 💬 Nebivolol [4] 17, 85, 113, 167 💬
10 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Formoterol fumarate 💬 Formoterol [3] 85, 228, 306 💬
11 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Albuterol 💬 Albuterol [16] 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
12 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Formoterol 💬 Formoterol [3] 85, 228, 306 💬
13 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Albuterol sulfate 💬 Albuterol [16] 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
14 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Buloxibutid 💬 Buloxibutid [1] 85 💬
15 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Losartan 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
16 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Buloxibutid sodium 💬 Buloxibutid [1] 85 💬
17 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Losartan potassium 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
18 AGTR2 💬 [4] Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Renin-angiotensin system Buloxibutid 💬 Buloxibutid [1] 85 💬
19 AGTR2 💬 [4] Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Renin-angiotensin system Buloxibutid sodium 💬 Buloxibutid [1] 85 💬
20 ALOX5 💬 [6] Arachidonic acid metabolism, Efferocytosis, Fc epsilon RI signaling pathway, Serotonergic synapse, Ovarian steroidogenesis, Toxoplasmosis Zileuton 💬 Zileuton [3] 85, 160, 164 💬
21 AR 💬 [4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
22 AR 💬 [4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Nandrolone 💬 Nandrolone [2] 60, 85 💬
23 ATP4A 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
24 ATP4A 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole sodium 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
25 ATP4A 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Lansoprazole 💬 Lansoprazole [6] 63, 71, 85, 166, 222, 299 💬
26 ATP4A 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole magnesium 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
27 ATP4B 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
28 ATP4B 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole magnesium 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
29 ATP4B 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Lansoprazole 💬 Lansoprazole [6] 63, 71, 85, 166, 222, 299 💬
30 ATP4B 💬 [3] Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Omeprazole sodium 💬 Omeprazole [16] 6, 13, 21, 46, 51, 85, 90, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
31 BCL2 💬 [40] NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, p53 signaling pathway, Autophagy - animal, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Apoptosis - multiple species, Necroptosis, Adrenergic signaling in cardiomyocytes, Hedgehog signaling pathway, Focal adhesion, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Neurotrophin signaling pathway, Cholinergic synapse, Estrogen signaling pathway, Parathyroid hormone synthesis, secretion and action, AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Prostate cancer, Small cell lung cancer, Gastric cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Venetoclax 💬 Venetoclax [2] 28, 85 💬
32 CCL2 💬 [17] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Chagas disease, Malaria, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Rheumatoid arthritis, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
33 CHRM3 💬 [12] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases Tiotropium bromide hydrate 💬 Tiotropium [3] 55, 85, 299 💬
34 CSF1R 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Osteoclast differentiation, Hematopoietic cell lineage, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Axatilimab 💬 Axatilimab [1] 85 💬
35 CTGF 💬 [2] Apelin signaling pathway, Hippo signaling pathway Pamrevlumab 💬 Pamrevlumab [2] 85, 113 💬
36 CYSLTR1 💬 [2] Calcium signaling pathway, Neuroactive ligand-receptor interaction Montelukast sodium 💬 Montelukast [9] 6, 13, 19, 46, 61, 63, 85, 98, 228 💬
37 CYSLTR1 💬 [2] Calcium signaling pathway, Neuroactive ligand-receptor interaction Montelukast 💬 Montelukast [9] 6, 13, 19, 46, 61, 63, 85, 98, 228 💬
38 CYSLTR1 💬 [2] Calcium signaling pathway, Neuroactive ligand-receptor interaction Tipelukast 💬 Tipelukast [1] 85 💬
39 DHFR 💬 [3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism Methotrexate sodium 💬 Methotrexate [39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬
40 DHFR 💬 [3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism Methotrexate 💬 Methotrexate [39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬
41 DHFR 💬 [3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism Methotrexate 💬 Methotrexate [39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬
42 DHFR 💬 [3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism Methotrexate sodium 💬 Methotrexate [39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬
43 EDNRA 💬 [7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
44 EDNRA 💬 [7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
45 EDNRA 💬 [7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
46 EDNRA 💬 [7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
47 EDNRB 💬 [6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
48 EDNRB 💬 [6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
49 EDNRB 💬 [6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
50 ELANE 💬 [3] Neutrophil extracellular trap formation, Transcriptional misregulation in cancer, Systemic lupus erythematosus Sivelestat 💬 Sivelestat [3] 13, 85, 96 💬
51 ENPP2 💬 [1] Ether lipid metabolism Ziritaxestat 💬 Ziritaxestat [2] 51, 85 💬
52 EPHA2 💬 [5] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Axon guidance Dasatinib 💬 Dasatinib [2] 51, 85 💬
53 EPHA2 💬 [5] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Axon guidance Dasatinib 💬 Dasatinib [2] 51, 85 💬
54 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
55 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
56 FGFR1 💬 [16] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, Melanoma, Breast cancer, Central carbon metabolism in cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
57 FGFR1 💬 [16] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, Melanoma, Breast cancer, Central carbon metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
58 FGFR1 💬 [16] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, Melanoma, Breast cancer, Central carbon metabolism in cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
59 FGFR2 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer, Gastric cancer, Central carbon metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
60 FGFR2 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer, Gastric cancer, Central carbon metabolism in cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
61 FGFR2 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer, Gastric cancer, Central carbon metabolism in cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
62 FGFR3 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, MicroRNAs in cancer, Bladder cancer, Central carbon metabolism in cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
63 FGFR3 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, MicroRNAs in cancer, Bladder cancer, Central carbon metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
64 FGFR3 💬 [12] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, MicroRNAs in cancer, Bladder cancer, Central carbon metabolism in cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
65 FGFR4 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer Catequentinib 💬 Anlotinib [1] 85 💬
66 FLT1 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
67 FLT1 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis Catequentinib 💬 Anlotinib [1] 85 💬
68 FLT1 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
69 FLT4 💬 [8] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer, Breast cancer Catequentinib 💬 Anlotinib [1] 85 💬
70 FLT4 💬 [8] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer, Breast cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
71 FLT4 💬 [8] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer, Breast cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
72 FYN 💬 [14] Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, Osteoclast differentiation, Focal adhesion, Adherens junction, Platelet activation, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Cholinergic synapse, Prion disease, Pathogenic Escherichia coli infection, Viral myocarditis Dasatinib 💬 Dasatinib [2] 51, 85 💬
73 FYN 💬 [14] Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, Osteoclast differentiation, Focal adhesion, Adherens junction, Platelet activation, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Cholinergic synapse, Prion disease, Pathogenic Escherichia coli infection, Viral myocarditis Dasatinib 💬 Dasatinib [2] 51, 85 💬
74 GRIN1 💬 [19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
75 GRIN1 💬 [19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
76 GRIN2A 💬 [20] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
77 GRIN2A 💬 [20] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
78 GRIN2B 💬 [21] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
79 GRIN2B 💬 [21] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
80 GRIN2C 💬 [16] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
81 GRIN2C 💬 [16] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
82 GRIN2D 💬 [16] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
83 GRIN2D 💬 [16] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
84 HTR2 💬 [6] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
85 HTR2 💬 [6] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
86 HTR2 💬 [6] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
87 HTR3 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Taste transduction Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
88 HTR3 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Taste transduction Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
89 HTR3 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Taste transduction Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
90 HTR3 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Taste transduction Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
91 HTR3 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Taste transduction Mirtazapine 💬 Mirtazapine [3] 6, 85, 97 💬
92 IFNGR1 💬 [18] Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, Osteoclast differentiation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Chagas disease, Toxoplasmosis, Tuberculosis, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
93 IFNGR2 💬 [17] Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, Osteoclast differentiation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Chagas disease, Toxoplasmosis, Tuberculosis, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
94 IL10 💬 [23] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, Efferocytosis, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, Intestinal immune network for IgA production, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Systemic lupus erythematosus, Allograft rejection Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
95 IL13 💬 [8] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Fc epsilon RI signaling pathway, Pathways in cancer, Asthma, Inflammatory bowel disease Tralokinumab 💬 Tralokinumab [2] 85, 97 💬
96 IL13 💬 [8] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Fc epsilon RI signaling pathway, Pathways in cancer, Asthma, Inflammatory bowel disease Lebrikizumab 💬 Lebrikizumab [1] 85 💬
97 IL1A 💬 [21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescence, Osteoclast differentiation, Hematopoietic cell lineage, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pertussis, Leishmaniasis, Tuberculosis, Measles, Influenza A, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
98 IL1B 💬 [43] MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
99 IL6 💬 [49] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease, African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy, Lipid and atherosclerosis Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
100 IL6 💬 [49] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease, African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy, Lipid and atherosclerosis Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
101 KCNN4 💬 [4] Insulin secretion, GnRH secretion, Salivary secretion, Protein digestion and absorption Senicapoc 💬 Senicapoc [1] 85 💬
102 KDR 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Catequentinib 💬 Anlotinib [1] 85 💬
103 KDR 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
104 KDR 💬 [9] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
105 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
106 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
107 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
108 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
109 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
110 LCK 💬 [10] NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Human T-cell leukemia virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency Dasatinib 💬 Dasatinib [2] 51, 85 💬
111 LCK 💬 [10] NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Human T-cell leukemia virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency Dasatinib 💬 Dasatinib [2] 51, 85 💬
112 LTA 💬 [7] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
113 MS4A1 💬 [1] Hematopoietic cell lineage Rituximab 💬 Rituximab [52] 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
114 MTOR 💬 [49] ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus [46] 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
115 NQO1 💬 [5] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
116 NQO1 💬 [5] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin sodium 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
117 NQO1 💬 [5] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin potassium 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
118 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Beclomethasone dipropionate 💬 Beclomethasone dipropionate [3] 85, 97, 98 💬
119 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Beclometasone 💬 Beclomethasone dipropionate [3] 85, 97, 98 💬
120 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Methylprednisolone acetate 💬 Methylprednisolone [48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
121 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Methylprednisolone 💬 Methylprednisolone [48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
122 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Prednisolone 💬 Prednisolone [41] 3, 11, 13, 14, 18, 25, 26, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 54, 56, 60, 61, 63, 64, 66, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 251, 269, 271, 296, 299, 300 💬
123 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Methylprednisolone sodium succinate 💬 Methylprednisolone hemisuccinate [3] 13, 66, 85 💬
124 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Beclomethasone dipropionate monohydrate 💬 Beclomethasone dipropionate [3] 85, 97, 98 💬
125 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Methylprednisolone hemisuccinate 💬 Methylprednisolone hemisuccinate [3] 13, 66, 85 💬
126 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Prednisone 💬 Prednisone [54] 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
127 OPRD1 💬 [5] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Nalbuphine 💬 Nalbuphine [1] 85 💬
128 OPRD1 💬 [5] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Nalbuphine hydrochloride 💬 Nalbuphine [1] 85 💬
129 OPRK1 💬 [3] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Nalbuphine hydrochloride 💬 Nalbuphine [1] 85 💬
130 OPRK1 💬 [3] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Nalbuphine 💬 Nalbuphine [1] 85 💬
131 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
132 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine sulfate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
133 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Nalbuphine hydrochloride 💬 Nalbuphine [1] 85 💬
134 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine hydrochloride hydrate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
135 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine tartrate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
136 OPRM1 💬 [5] Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Nalbuphine 💬 Nalbuphine [1] 85 💬
137 OSMR 💬 [3] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway Vixarelimab 💬 Vixarelimab [3] 51, 85, 97 💬
138 P2RX3 💬 [4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Taste transduction Gefapixant 💬 Gefapixant [2] 85, 226 💬
139 P2RX3 💬 [4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Taste transduction Gefapixant citrate 💬 Gefapixant [2] 85, 226 💬
140 PDCD1 💬 [3] Cell adhesion molecules, T cell receptor signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer Nivolumab 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
141 PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway Sildenafil citrate 💬 Sildenafil [14] 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
142 PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil [14] 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
143 PDGFRA 💬 [19] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
144 PDGFRA 💬 [19] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
145 PDGFRA 💬 [19] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
146 PDGFRA 💬 [19] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
147 PDGFRA 💬 [19] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
148 PDGFRB 💬 [18] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
149 PDGFRB 💬 [18] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Catequentinib 💬 Anlotinib [1] 85 💬
150 PDGFRB 💬 [18] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
151 PDGFRB 💬 [18] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
152 PDGFRB 💬 [18] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
153 PDL1 💬 [2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer Durvalumab 💬 Durvalumab [1] 85 💬
154 PDL1 💬 [2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer Atezolizumab 💬 Atezolizumab [1] 85 💬
155 PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
156 PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Iloprost 💬 Iloprost [4] 51, 84, 85, 86 💬
157 PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Iloprost tromethamine 💬 Iloprost [4] 51, 84, 85, 86 💬
158 PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil monosodium salt 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
159 PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil diolamine 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
160 RARA 💬 [5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tazarotene 💬 Tazarotene [1] 85 💬
161 RARB 💬 [4] Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer Tazarotene 💬 Tazarotene [1] 85 💬
162 ROCK2 💬 [22] cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Axon guidance, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Human cytomegalovirus infection, Pathways in cancer, Proteoglycans in cancer, Lipid and atherosclerosis Belumosudil 💬 Belumosudil [3] 51, 85, 228 💬
163 ROCK2 💬 [22] cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Axon guidance, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Human cytomegalovirus infection, Pathways in cancer, Proteoglycans in cancer, Lipid and atherosclerosis Belumosudil mesylate 💬 Belumosudil [3] 51, 85, 228 💬
164 RRM1 💬 [4] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes Fludarabine phosphate 💬 Fludarabine [25] 11, 13, 19, 28, 34, 35, 36, 44, 46, 49, 51, 60, 61, 62, 65, 85, 96, 107, 164, 222, 283, 284, 285, 286, 326 💬
165 RRM1 💬 [4] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes Fludarabine 💬 Fludarabine [25] 11, 13, 19, 28, 34, 35, 36, 44, 46, 49, 51, 60, 61, 62, 65, 85, 96, 107, 164, 222, 283, 284, 285, 286, 326 💬
166 RRM2 💬 [5] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, p53 signaling pathway Hydroxyurea 💬 Hydroxyurea [10] 3, 13, 19, 20, 46, 65, 85, 86, 107, 284 💬
167 RXRB 💬 [13] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Tazarotene 💬 Tazarotene [1] 85 💬
168 SIGMAR1 💬 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
169 SIGMAR1 💬 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan hydrobromide 💬 Dextromethorphan [10] 2, 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
170 SLC6A4 💬 [3] Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine hydrochloride hemihydrate 💬 Paroxetine [4] 6, 13, 46, 85 💬
171 SLC6A4 💬 [3] Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine hydrochloride 💬 Paroxetine [4] 6, 13, 46, 85 💬
172 SLC6A4 💬 [3] Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine mesylate 💬 Paroxetine [4] 6, 13, 46, 85 💬
173 SLC6A4 💬 [3] Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Paroxetine 💬 Paroxetine [4] 6, 13, 46, 85 💬
174 SMO 💬 [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma Taladegib 💬 Taladegib [1] 85 💬
175 SMO 💬 [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma Vismodegib 💬 Vismodegib [1] 85 💬
176 SRC 💬 [41] ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Hormone signaling, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Dasatinib 💬 Dasatinib [2] 51, 85 💬
177 SRC 💬 [41] ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Hormone signaling, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Dasatinib 💬 Dasatinib [2] 51, 85 💬
178 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
179 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide pamoate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
180 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
181 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
182 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Lanreotide acetate 💬 Lanreotide [5] 67, 73, 77, 85, 298 💬
183 SSTR5 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Lanreotide acetate 💬 Lanreotide [5] 67, 73, 77, 85, 298 💬
184 TACR1 💬 [3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling Orvepitant 💬 Orvepitant [1] 85 💬
185 TBXA2R 💬 [3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation Ifetroban sodium 💬 Ifetroban [2] 85, 113 💬
186 TBXA2R 💬 [3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation Ifetroban 💬 Ifetroban [2] 85, 113 💬
187 TGFB1 💬 [35] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Efferocytosis, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Th17 cell differentiation, Intestinal immune network for IgA production, Relaxin signaling pathway, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [4] 51, 85, 222, 274 💬
188 TGFB2 💬 [31] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [4] 51, 85, 222, 274 💬
189 TGFB3 💬 [28] MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease, Rheumatoid arthritis, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Diabetic cardiomyopathy Fresolimumab 💬 Fresolimumab [4] 51, 85, 222, 274 💬
190 TNF 💬 [66] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Thalidomide 💬 Thalidomide [21] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
191 TNF 💬 [66] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
192 TNF 💬 [66] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
193 TNF 💬 [66] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
194 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
195 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
196 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
197 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
198 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
199 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
200 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
201 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
202 TUBB 💬 [11] Phagosome, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Paclitaxel 💬 Paclitaxel [1] 85 💬
203 VDR 💬 [5] Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, Chemical carcinogenesis - receptor activation Cholecalciferol 💬 Cholecalciferol [23] 6, 11, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 65, 84, 85, 96, 97, 98, 162, 228, 271, 298, 299 💬
204 VEGFA 💬 [23] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis Bevacizumab 💬 Bevacizumab [8] 13, 34, 85, 87, 89, 227, 280, 331 💬
205 VKORC1 💬 [1] Ubiquinone and other terpenoid-quinone biosynthesis Warfarin sodium 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
206 VKORC1 💬 [1] Ubiquinone and other terpenoid-quinone biosynthesis Warfarin potassium 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
207 VKORC1 💬 [1] Ubiquinone and other terpenoid-quinone biosynthesis Warfarin 💬 Warfarin [12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
208 YES1 💬 [1] Adherens junction Dasatinib 💬 Dasatinib [2] 51, 85 💬
209 YES1 💬 [1] Adherens junction Dasatinib 💬 Dasatinib [2] 51, 85 💬