Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ACE 💬 6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Enalapril 💬 Enalapril 10件: 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
2 ACE 💬 6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Enalapril maleate 💬 Enalapril 10件: 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
3 ADRA1A 💬 9件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
4 ADRA1A 💬 9件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
5 ADRA1B 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
6 ADRA1B 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
7 ADRA1D 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
8 ADRA1D 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
9 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
10 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol phosphate 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
11 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
12 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol phosphate 💬 Carvedilol 7件: 6, 46, 57, 58, 86, 113, 210 💬
13 AGTR1 💬 17件: Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Valsartan 💬 Valsartan 11件: 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
14 ATP1A1 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
15 ATP1A2 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
16 ATP1A3 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
17 ATP1A4 💬 19件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 7件: 2, 8, 46, 57, 65, 67, 210 💬
18 AVPR1A 💬 5件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 2件: 210, 225 💬
19 AVPR1B 💬 5件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 2件: 210, 225 💬
20 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Vasopressin 💬 Vasopressin 2件: 210, 225 💬
21 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
22 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 12件: 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
23 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 12件: 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
24 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Ambrisentan 💬 Ambrisentan 10件: 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
25 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 12件: 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
26 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 12件: 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
27 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
28 F10 💬 1件: Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban 10件: 46, 48, 49, 56, 58, 75, 91, 210, 222, 271 💬
29 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
30 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin sodium 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
31 MME 💬 4件: Renin-angiotensin system, Hematopoietic cell lineage, Protein digestion and absorption, Alzheimer disease Sacubitril 💬 Sacubitril 4件: 28, 58, 210, 222 💬
32 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Spironolactone 💬 Spironolactone 12件: 46, 57, 58, 67, 86, 113, 210, 214, 218, 222, 223, 225 💬
33 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Eplerenone 💬 Eplerenone 5件: 57, 75, 113, 210, 215 💬
34 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Tadalafil 💬 Tadalafil 8件: 6, 51, 75, 77, 84, 86, 113, 210 💬
35 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Udenafil 💬 Udenafil 2件: 86, 210 💬
36 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
37 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil citrate 💬 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
38 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil 💬 Treprostinil 6件: 51, 84, 85, 86, 88, 210 💬
39 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil diolamine 💬 Treprostinil 6件: 51, 84, 85, 86, 88, 210 💬
40 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil monosodium salt 💬 Treprostinil 6件: 51, 84, 85, 86, 88, 210 💬
41 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Aspirin 💬 Acetylsalicylic acid 5件: 13, 46, 51, 62, 210 💬
42 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Aspirin 💬 Acetylsalicylic acid 5件: 13, 46, 51, 62, 210 💬
43 THRA 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 3件: 13, 210, 212 💬
44 THRA 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Thyroid hormone signaling pathway Liothyronine sodium 💬 Liothyronine 3件: 13, 210, 212 💬
45 THRB 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Thyroid hormone signaling pathway Liothyronine sodium 💬 Liothyronine 3件: 13, 210, 212 💬
46 THRB 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 3件: 13, 210, 212 💬
47 TUBB 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
48 TUBB1 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
49 TUBB2A 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
50 TUBB2B 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
51 TUBB3 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
52 TUBB4A 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
53 TUBB4B 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
54 TUBB6 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
55 TUBB8 💬 12件: Phagocytosis, IgSF CAM signaling, Gap junction, Motor proteins, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 9件: 2, 42, 46, 50, 56, 93, 97, 210, 266 💬