Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ACE 💬 6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Enalapril 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
2 ADRA1A 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
3 ADRA1B 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
4 ADRA1D 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
5 ADRB1 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
6 ADRB2 💬 9件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
7 ATP1A1 💬 18件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
8 ATP1A2 💬 18件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
9 ATP1A3 💬 18件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
10 ATP1A4 💬 18件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin 3件: 8, 46, 210 💬
11 AVPR1A 💬 4件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 1件: 210 💬
12 AVPR1B 💬 4件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction Vasopressin 💬 Vasopressin 1件: 210 💬
13 AVPR2 💬 3件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vasopressin-regulated water reabsorption Vasopressin 💬 Vasopressin 1件: 210 💬
14 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
15 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Ambrisentan 💬 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211 💬
16 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
17 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
18 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
19 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
20 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
21 F10 💬 1件: Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban 4件: 46, 49, 91, 210 💬
22 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Eplerenone 💬 Eplerenone 4件: 75, 113, 210, 215 💬
23 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Spironolactone 💬 Spironolactone 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
24 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
25 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Udenafil 💬 Udenafil 2件: 86, 210 💬
26 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Tadalafil 💬 Tadalafil 7件: 6, 51, 75, 84, 86, 113, 210 💬
27 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil 💬 Treprostinil 6件: 51, 84, 85, 86, 88, 210 💬
28 PTGS1 💬 5件: Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Aspirin 💬 Acetylsalicylic acid 14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
29 PTGS2 💬 22件: Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Aspirin 💬 Acetylsalicylic acid 14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
30 THRA 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 4件: 13, 78, 210, 212 💬
31 THRB 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 4件: 13, 78, 210, 212 💬
32 TUBB 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
33 TUBB1 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
34 TUBB2A 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
35 TUBB2B 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
36 TUBB3 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
37 TUBB4A 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
38 TUBB4B 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
39 TUBB6 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬
40 TUBB8 💬 10件: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection Colchicine 💬 Colchicine 7件: 2, 42, 46, 56, 93, 210, 266 💬