Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D09916 Ivacaftor [1] 299
2 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D10134 Lumacaftor [1] 299
3 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11041 Tezacaftor [1] 299
4 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11423 Deutivacaftor [1] 299
5 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11507 Elexacaftor [1] 299
6 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11724 Galicaftor [1] 299
7 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00113 Atropine [2] 2, 299
8 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00138 Scopolamine [1] 2
9 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine [1] 254
10 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00397 Tropicamide [1] 6
11 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00465 Oxybutynin [3] 6, 13, 53
12 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00525 Pilocarpine [3] 6, 53, 299
13 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00646 Tolterodine [2] 17, 53
14 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03654 Darifenacin [2] 6, 13
15 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07226 Fesoterodine [1] 6
16 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07667 Cevimeline [1] 53
17 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08441 Propiverine [1] 226
18 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08522 Solifenacin [3] 6, 13, 53
19 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08638 Trihexyphenidyl [2] 5, 6
20 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine [1] 156
21 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00295 Cimetidine [2] 2, 254
22 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00318 Famotidine [6] 6, 46, 61, 86, 98, 107
23 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00422 Ranitidine [2] 13, 65
24 KCNQ1 [4] Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone [2] 28, 127
25 KCNQ1 [4] Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine [2] 2, 144
26 ATP1A1 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
27 ATP1A1 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
28 ATP1A2 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
29 ATP1A2 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
30 ATP1A3 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
31 ATP1A3 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
32 ATP1A4 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
33 ATP1A4 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
34 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
35 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole [14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
36 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole [2] 13, 65
37 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
38 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole [2] 2, 51
39 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole [1] 98
40 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan [2] 63, 98
41 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
42 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole [14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
43 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole [2] 13, 65
44 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
45 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole [2] 2, 51
46 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole [1] 98
47 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan [2] 63, 98
48 PRKCB [47] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, mTOR signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Serotonergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Melanogenesis, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Insulin resistance, Growth hormone synthesis, secretion and action, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Morphine addiction, Leishmaniasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Glioma, Non-small cell lung cancer, Hepatocellular carcinoma D11935 Enzastaurin [1] 168
49 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D00442 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
50 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin [2] 67, 78
51 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D10147 Pasireotide [3] 67, 74, 75
52 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
53 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00518 Diclofenamide [1] 114
54 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
55 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D07871 Dorzolamide [1] 90
56 CCKBR [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D01818 Proglumide [1] 298