Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 DPP4 💬 2件: Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin phosphate 💬 Sitagliptin 5件: 6, 75, 77, 233, 299 💬
2 DPP4 💬 2件: Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin 💬 Sitagliptin 5件: 6, 75, 77, 233, 299 💬
3 DPP4 💬 2件: Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin phosphate 💬 Sitagliptin 5件: 6, 75, 77, 233, 299 💬
4 DRD1 💬 12件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism Dopamine hydrochloride 💬 Dopamine 4件: 6, 7, 74, 77 💬
5 DRD1 💬 12件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism Dopamine 💬 Dopamine 4件: 6, 7, 74, 77 💬
6 DRD2 💬 10件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Cabergoline 💬 Cabergoline 4件: 6, 74, 75, 77 💬
7 DRD2 💬 10件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Dopamine hydrochloride 💬 Dopamine 4件: 6, 7, 74, 77 💬
8 DRD2 💬 10件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Dopamine 💬 Dopamine 4件: 6, 7, 74, 77 💬
9 DRD3 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 77 💬
10 DRD3 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine hydrochloride 💬 Dopamine 4件: 6, 7, 74, 77 💬
11 DRD4 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 77 💬
12 DRD4 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine hydrochloride 💬 Dopamine 4件: 6, 7, 74, 77 💬
13 DRD5 💬 6件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine hydrochloride 💬 Dopamine 4件: 6, 7, 74, 77 💬
14 DRD5 💬 6件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 77 💬
15 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Raloxifene hydrochloride 💬 Raloxifene 2件: 46, 77 💬
16 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomifene 💬 Clomifene 2件: 74, 77 💬
17 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomiphene citrate 💬 Clomifene 2件: 74, 77 💬
18 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Raloxifene 💬 Raloxifene 2件: 46, 77 💬
19 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Raloxifene hydrochloride 💬 Raloxifene 2件: 46, 77 💬
20 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Raloxifene 💬 Raloxifene 2件: 46, 77 💬
21 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomifene 💬 Clomifene 2件: 74, 77 💬
22 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomiphene citrate 💬 Clomifene 2件: 74, 77 💬
23 FDPS 💬 3件: Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid 16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
24 FDPS 💬 3件: Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate disodium 💬 Zoledronic acid 16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
25 FDPS 💬 3件: Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate trisodium 💬 Zoledronic acid 16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
26 FDPS 💬 3件: Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid hemipentahydrate 💬 Zoledronic acid 16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
27 FDPS 💬 3件: Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid 16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
28 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Somatropin 💬 Somatotropin 28件: 2, 3, 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
29 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Pegvisomant 💬 Pegvisomant 2件: 77, 265 💬
30 GLP1R 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Liraglutide 💬 Liraglutide 5件: 6, 13, 75, 77, 193 💬
31 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone 💬 Rosiglitazone 6件: 46, 75, 77, 97, 222, 265 💬
32 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone maleate 💬 Rosiglitazone 6件: 46, 75, 77, 97, 222, 265 💬
33 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Tadalafil 💬 Tadalafil 8件: 6, 51, 75, 77, 84, 86, 113, 210 💬
34 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
35 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
36 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
37 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
38 PRL 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Cabergoline 💬 Cabergoline 4件: 6, 74, 75, 77 💬
39 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Acetaminophen 💬 Acetaminophen 18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
40 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Acetaminophen 💬 Acetaminophen 18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
41 SLC12A2 💬 3件: Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Furosemide 💬 Furosemide 3件: 6, 77, 86 💬
42 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Escitalopram oxalate 💬 Escitalopram 5件: 2, 6, 13, 46, 77 💬
43 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Escitalopram 💬 Escitalopram 5件: 2, 6, 13, 46, 77 💬
44 SSTR1 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 1件: 77 💬
45 SSTR1 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 4件: 67, 74, 75, 77 💬
46 SSTR1 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
47 SSTR1 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
48 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
49 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
50 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide 💬 Pasireotide 4件: 67, 74, 75, 77 💬
51 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Somatostatin 💬 Somatostatin 1件: 77 💬
52 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Lanreotide acetate 💬 Lanreotide 5件: 67, 73, 77, 85, 298 💬
53 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide pamoate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
54 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide pamoate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
55 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide diaspartate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
56 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Paltusotine 💬 Paltusotine 1件: 77 💬
57 SSTR2 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide 8件: 67, 75, 77, 84, 85, 89, 193, 227 💬
58 SSTR3 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 1件: 77 💬
59 SSTR3 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 4件: 67, 74, 75, 77 💬
60 SSTR3 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
61 SSTR3 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
62 SSTR4 💬 2件: Neuroactive ligand-receptor interaction, Hormone signaling Somatostatin 💬 Somatostatin 1件: 77 💬
63 SSTR5 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
64 SSTR5 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 1件: 77 💬
65 SSTR5 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Lanreotide acetate 💬 Lanreotide 5件: 67, 73, 77, 85, 298 💬
66 SSTR5 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide 4件: 67, 74, 75, 77 💬
67 SSTR5 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 4件: 67, 74, 75, 77 💬
68 TNFSF11 💬 8件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Chemical carcinogenesis - receptor activation, Breast cancer, Rheumatoid arthritis Denosumab 💬 Denosumab 10件: 46, 50, 70, 75, 77, 93, 95, 96, 274, 299 💬