Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ARSB 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Galsulfase 💬 Galsulfase 1件: 19 💬
2 CTSC 💬 2件: Lysosome biogenesis, Apoptosis Brensocatib 💬 Brensocatib 1件: 299 💬
3 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Duvoglustat hydrochloride 💬 Duvoglustat 1件: 256 💬
4 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Duvoglustat 💬 Duvoglustat 1件: 256 💬
5 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Alglucosidase alfa 💬 Alglucosidase alfa 1件: 256 💬
6 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Acarbose 💬 Acarbose 1件: 298 💬
7 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Clervonafusp alfa 💬 Clervonafusp alfa 1件: 309 💬
8 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Avalglucosidase alfa 💬 Avalglucosidase alfa 1件: 256 💬
9 GAA 💬 3件: Galactose metabolism, Starch and sucrose metabolism, Lysosome biogenesis Cipaglucosidase alfa 💬 Cipaglucosidase alfa 1件: 256 💬
10 GALNS 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Elosulfase alfa 💬 Elosulfase alfa 1件: 19 💬
11 GBA1 💬 4件: Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Velaglucerase alfa 💬 Velaglucerase alfa 1件: 19 💬
12 GBA1 💬 4件: Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Taliglucerase alfa 💬 Taliglucerase alfa 1件: 19 💬
13 GBA1 💬 4件: Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Imiglucerase 💬 Imiglucerase 1件: 19 💬
14 GBA1 💬 4件: Other glycan degradation, Sphingolipid metabolism, Lysosome biogenesis, Cornified envelope formation Alglucerase 💬 Imiglucerase 1件: 19 💬
15 GLA 💬 5件: Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Migalastat hydrochloride 💬 Migalastat 1件: 19 💬
16 GLA 💬 5件: Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Agalsidase beta 💬 Agalsidase beta 1件: 19 💬
17 GLA 💬 5件: Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Agalsidase alfa 💬 Agalsidase alfa 1件: 19 💬
18 GLA 💬 5件: Galactose metabolism, Glycerolipid metabolism, Sphingolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome biogenesis Pegunigalsidase alfa 💬 Pegunigalsidase alfa 1件: 19 💬
19 GUSB 💬 6件: Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Glycosaminoglycan degradation, Porphyrin metabolism, Drug metabolism - other enzymes, Lysosome biogenesis Vestronidase alfa 💬 Vestronidase alfa 1件: 19 💬
20 IDS 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Tividenofusp alfa 💬 Tividenofusp alfa 1件: 19 💬
21 IDS 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Idursulfase beta 💬 Idursulfase beta 1件: 19 💬
22 IDS 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Pabinafusp alfa 💬 Pabinafusp alfa 1件: 19 💬
23 IDS 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Idursulfase 💬 Idursulfase 1件: 19 💬
24 IDUA 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Laronidase 💬 Laronidase 2件: 19, 256 💬
25 LIPA 💬 4件: Steroid biosynthesis, Lysosome biogenesis, Efferocytosis, Cholesterol metabolism Sebelipase alfa 💬 Sebelipase alfa 1件: 19 💬
26 MAN2B1 💬 2件: Other glycan degradation, Lysosome biogenesis Velmanase alfa 💬 Velmanase alfa 1件: 19 💬
27 MTOR 💬 52件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus 46件: 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 54, 57, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 97, 98, 111, 127, 137, 157, 158, 192, 222, 223, 227, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
28 MTOR 💬 52件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
29 MTOR 💬 52件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Everolimus 💬 Everolimus 12件: 34, 67, 89, 96, 137, 157, 158, 228, 277, 278, 279, 280 💬
30 NAGLU 💬 2件: Glycosaminoglycan degradation, Lysosome biogenesis Tralesinidase alfa 💬 Tralesinidase alfa 1件: 19 💬
31 SLC29A2 💬 2件: Lysosome biogenesis, Alcoholism Clervonafusp alfa 💬 Clervonafusp alfa 1件: 309 💬
32 SMPD1 💬 4件: Sphingolipid metabolism, Sphingolipid signaling pathway, Lysosome biogenesis, Necroptosis Olipudase alfa 💬 Olipudase alfa 1件: 19 💬
33 SORT1 💬 3件: Lysosome biogenesis, Neurotrophin signaling pathway, Cholesterol metabolism Latozinemab 💬 Latozinemab 1件: 127 💬
34 TLR7 💬 6件: Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Measles, Influenza A, Coronavirus disease Imiquimod 💬 Imiquimod 2件: 34, 51 💬
35 TLR7 💬 6件: Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Measles, Influenza A, Coronavirus disease Enpatoran 💬 Enpatoran 1件: 49 💬
36 TLR8 💬 4件: Lysosome biogenesis, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Coronavirus disease Enpatoran 💬 Enpatoran 1件: 49 💬
37 TLR9 💬 10件: Lysosome biogenesis, Toll-like receptor signaling pathway, Salmonella infection, Chagas disease, African trypanosomiasis, Malaria, Tuberculosis, Measles, Herpes simplex virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer Cobitolimod 💬 Cobitolimod 1件: 97 💬
38 TPP1 💬 1件: Lysosome biogenesis Cerliponase alfa 💬 Cerliponase alfa 1件: 19 💬