| 1 | 
                
                    DHFR
                
             💬
 | [5]  One carbon pool by folate One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance | Methotrexate 
                
                    Methotrexate
                
             💬
 | 
                
                    Methotrexate
                
             | [38]  11 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
 | 
| 2 | 
                
                    DHODH
                
             💬
 | [3]  Pyrimidine metabolism Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors | Leflunomide 
                
                    Leflunomide
                
             💬
 | 
                
                    Leflunomide
                
             | [12]  11 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬
 | 
| 3 | 
                
                    DHFR2
                
             💬
 | [5]  One carbon pool by folate One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance | Methotrexate 
                
                    Methotrexate
                
             💬
 | 
                
                    Methotrexate
                
             | [38]  11 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
 | 
| 4 | 
                
                    FCER1A
                
             💬
 | [4]  Sphingolipid signaling pathway Sphingolipid signaling pathway, Phospholipase D signaling pathway, Fc epsilon RI signaling pathway, Asthma | Omalizumab 
                
                    Omalizumab
                
             💬
 | 
                
                    Omalizumab
                
             | [7]  46 46, 53, 65, 98, 162, 226, 299 💬
 | 
| 5 | 
                
                    FCGRT
                
             💬
 | - | Efgartigimod alfa 
                
                    Efgartigimod alfa
                
             💬
 | 
                
                    Efgartigimod alfa
                
             | [6]  11 11, 14, 35, 53, 63, 162 💬
 | 
| 6 | 
                
                    ABL1
                
             💬
 | [11]  ErbB signaling pathway ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis | Imatinib 
                
                    Imatinib
                
             💬
 | 
                
                    Imatinib
                
             | [12]  13 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
 | 
| 7 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Dexamethasone 
                
                    Dexamethasone
                
             💬
 | 
                
                    Dexamethasone
                
             | [22]  13 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬
 | 
| 8 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Triamcinolone 
                
                    Triamcinolone
                
             💬
 | 
                
                    Triamcinolone
                
             | [11]  35 35, 46, 53, 56, 70, 90, 96, 107, 162, 226, 298 💬
 | 
| 9 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Methylprednisolone 
                
                    Methylprednisolone
                
             💬
 | 
                
                    Methylprednisolone
                
             | [46]  2 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
 | 
| 10 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Prednisolone 
                
                    Prednisolone
                
             💬
 | 
                
                    Prednisolone
                
             | [42]  3 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
 | 
| 11 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Prednisone 
                
                    Prednisone
                
             💬
 | 
                
                    Prednisone
                
             | [45]  2 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
 | 
| 12 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Mometasone furoate 
                
                    Mometasone furoate
                
             💬
 | 
                
                    Mometasone furoate
                
             | [2]  98 98, 162 💬
 | 
| 13 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Clobetasol propionate 
                
                    Clobetasol propionate
                
             💬
 | 
                
                    Clobetasol propionate
                
             | [2]  46 46, 162 💬
 | 
| 14 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Halometasone 
                
                    Halometasone
                
             💬
 | 
                
                    Halometasone
                
             | [1]  162 162 💬
 | 
| 15 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Clobetasol 
                
                    Clobetasol
                
             💬
 | 
                
                    Clobetasol
                
             | [4]  39 39, 46, 51, 162 💬
 | 
| 16 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Mometasone 
                
                    Mometasone
                
             💬
 | 
                
                    Mometasone
                
             | [2]  98 98, 162 💬
 | 
| 17 | 
                
                    NR3C1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Prednisone acetate 
                
                    Prednisone acetate
                
             💬
 | 
                
                    Prednisone acetate
                
             | [6]  35 35, 41, 46, 49, 162, 224 💬
 | 
| 18 | 
                
                    HMGCR
                
             💬
 | [4]  Terpenoid backbone biosynthesis Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion | Simvastatin 
                
                    Simvastatin
                
             💬
 | 
                
                    Simvastatin
                
             | [21]  6 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
 | 
| 19 | 
                
                    IL4R
                
             💬
 | [8]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Inflammatory bowel disease | Dupilumab 
                
                    Dupilumab
                
             💬
 | 
                
                    Dupilumab
                
             | [5]  51 51, 97, 98, 160, 162 💬
 | 
| 20 | 
                
                    IL5
                
             💬
 | [13]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Intestinal immune network for IgA production, Pathways in cancer, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Allograft rejection | Mepolizumab 
                
                    Mepolizumab
                
             💬
 | 
                
                    Mepolizumab
                
             | [4]  44 44, 45, 98, 162 💬
 | 
| 21 | 
                
                    IL5RA
                
             💬
 | [4]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer | Benralizumab 
                
                    Benralizumab
                
             💬
 | 
                
                    Benralizumab
                
             | [5]  44 44, 45, 98, 162, 299 💬
 | 
| 22 | 
                
                    IL12A
                
             💬
 | [25]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Alcoholic liver disease, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Pathways in cancer, Inflammatory bowel disease, Allograft rejection, Lipid and atherosclerosis | Ustekinumab 
                
                    Ustekinumab
                
             💬
 | 
                
                    Ustekinumab
                
             | [16]  37 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
 | 
| 23 | 
                
                    IL12B
                
             💬
 | [25]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Alcoholic liver disease, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, African trypanosomiasis, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, Inflammatory bowel disease, Allograft rejection, Lipid and atherosclerosis | Ustekinumab 
                
                    Ustekinumab
                
             💬
 | 
                
                    Ustekinumab
                
             | [16]  37 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
 | 
| 24 | 
                
                    IL17A
                
             💬
 | [6]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Alcoholic liver disease, Inflammatory bowel disease, Rheumatoid arthritis | Ixekizumab 
                
                    Ixekizumab
                
             💬
 | 
                
                    Ixekizumab
                
             | [8]  36 36, 37, 46, 107, 160, 162, 269, 271 💬
 | 
| 25 | 
                
                    IMPDH1
                
             💬
 | [4]  Purine metabolism Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism | Mycophenolate mofetil 
                
                    Mycophenolate mofetil
                
             💬
 | 
                
                    Mycophenolate mofetil
                
             | [34]  2 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
 | 
| 26 | 
                
                    IMPDH1
                
             💬
 | [4]  Purine metabolism Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism | Mycophenolic acid 
                
                    Mycophenolic acid
                
             💬
 | 
                
                    Mycophenolic acid
                
             | [36]  2 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
 | 
| 27 | 
                
                    IMPDH2
                
             💬
 | [4]  Purine metabolism Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism | Mycophenolate mofetil 
                
                    Mycophenolate mofetil
                
             💬
 | 
                
                    Mycophenolate mofetil
                
             | [34]  2 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
 | 
| 28 | 
                
                    IMPDH2
                
             💬
 | [4]  Purine metabolism Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism | Mycophenolic acid 
                
                    Mycophenolic acid
                
             💬
 | 
                
                    Mycophenolic acid
                
             | [36]  2 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
 | 
| 29 | 
                
                    JAK1
                
             💬
 | [27]  EGFR tyrosine kinase inhibitor resistance EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Viral carcinogenesis, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer | Baricitinib 
                
                    Baricitinib
                
             💬
 | 
                
                    Baricitinib
                
             | [13]  2 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
 | 
| 30 | 
                
                    JAK2
                
             💬
 | [24]  EGFR tyrosine kinase inhibitor resistance EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, PI3K-Akt signaling pathway, Necroptosis, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Cholinergic synapse, Prolactin signaling pathway, Adipocytokine signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis B, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Baricitinib 
                
                    Baricitinib
                
             💬
 | 
                
                    Baricitinib
                
             | [13]  2 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
 | 
| 31 | 
                
                    KIT
                
             💬
 | [11]  MAPK signaling pathway MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer | Imatinib 
                
                    Imatinib
                
             💬
 | 
                
                    Imatinib
                
             | [12]  13 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
 | 
| 32 | 
                
                    PDE4A
                
             💬
 | [5]  Purine metabolism Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction | Apremilast 
                
                    Apremilast
                
             💬
 | 
                
                    Apremilast
                
             | [7]  46 46, 50, 56, 97, 107, 162, 271 💬
 | 
| 33 | 
                
                    PDE4B
                
             💬
 | [5]  Purine metabolism Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction | Apremilast 
                
                    Apremilast
                
             💬
 | 
                
                    Apremilast
                
             | [7]  46 46, 50, 56, 97, 107, 162, 271 💬
 | 
| 34 | 
                
                    PDE4C
                
             💬
 | [5]  Purine metabolism Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction | Apremilast 
                
                    Apremilast
                
             💬
 | 
                
                    Apremilast
                
             | [7]  46 46, 50, 56, 97, 107, 162, 271 💬
 | 
| 35 | 
                
                    PDE4D
                
             💬
 | [5]  Purine metabolism Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction | Apremilast 
                
                    Apremilast
                
             💬
 | 
                
                    Apremilast
                
             | [7]  46 46, 50, 56, 97, 107, 162, 271 💬
 | 
| 36 | 
                
                    IL23A
                
             💬
 | [9]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Inflammatory bowel disease, Rheumatoid arthritis | Ustekinumab 
                
                    Ustekinumab
                
             💬
 | 
                
                    Ustekinumab
                
             | [16]  37 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
 | 
| 37 | 
                
                    IL23A
                
             💬
 | [9]  Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Inflammatory bowel disease, Rheumatoid arthritis | Tildrakizumab 
                
                    Tildrakizumab
                
             💬
 | 
                
                    Tildrakizumab
                
             | [2]  162 162, 271 💬
 | 
| 38 | 
                
                    PDGFRA
                
             💬
 | [20]  EGFR tyrosine kinase inhibitor resistance EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer | Imatinib 
                
                    Imatinib
                
             💬
 | 
                
                    Imatinib
                
             | [12]  13 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
 | 
| 39 | 
                
                    PPP3CA
                
             💬
 | [33]  MAPK signaling pathway MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Cyclosporine 
                
                    Cyclosporine
                
             💬
 | 
                
                    Cyclosporine
                
             | [44]  11 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 | 
| 40 | 
                
                    PPP3CB
                
             💬
 | [33]  MAPK signaling pathway MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Cyclosporine 
                
                    Cyclosporine
                
             💬
 | 
                
                    Cyclosporine
                
             | [44]  11 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 | 
| 41 | 
                
                    PPP3CC
                
             💬
 | [33]  MAPK signaling pathway MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Cyclosporine 
                
                    Cyclosporine
                
             💬
 | 
                
                    Cyclosporine
                
             | [44]  11 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 | 
| 42 | 
                
                    PPP3R1
                
             💬
 | [32]  MAPK signaling pathway MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Cyclosporine 
                
                    Cyclosporine
                
             💬
 | 
                
                    Cyclosporine
                
             | [44]  11 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 | 
| 43 | 
                
                    PPP3R2
                
             💬
 | [32]  MAPK signaling pathway MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis | Cyclosporine 
                
                    Cyclosporine
                
             💬
 | 
                
                    Cyclosporine
                
             | [44]  11 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 | 
| 44 | 
                
                    TNF
                
             💬
 | [67]  Antifolate resistance Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis | Infliximab 
                
                    Infliximab
                
             💬
 | 
                
                    Infliximab
                
             | [27]  35 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
 | 
| 45 | 
                
                    C5
                
             💬
 | [11]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus | Nomacopan 
                
                    Nomacopan
                
             💬
 | 
                
                    Nomacopan
                
             | [3]  62 62, 109, 162 💬
 | 
| 46 | 
                
                    VDR
                
             💬
 | [5]  Parathyroid hormone synthesis, secretion and action Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, Chemical carcinogenesis - receptor activation | Cholecalciferol 
                
                    Cholecalciferol
                
             💬
 | 
                
                    Cholecalciferol
                
             | [24]  6 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
 | 
| 47 | 
                
                    MS4A1
                
             💬
 | [1]  Hematopoietic cell lineage Hematopoietic cell lineage | Rituximab 
                
                    Rituximab
                
             💬
 | 
                
                    Rituximab
                
             | [48]  11 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
 |