Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 TNFSF13B [2] NF-kappa B signaling pathway, Rheumatoid arthritis D03068 Belimumab [13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300
2 TNFSF13B [2] NF-kappa B signaling pathway, Rheumatoid arthritis D09704 Atacicept [4] 13, 46, 49, 66
3 TNFSF13B [2] NF-kappa B signaling pathway, Rheumatoid arthritis D10083 Tabalumab [2] 46, 49
4 TNFSF13B [2] NF-kappa B signaling pathway, Rheumatoid arthritis D11127 Tibulizumab [1] 53
5 TNFRSF13C [2] NF-kappa B signaling pathway, Primary immunodeficiency D12151 Ianalumab [7] 35, 46, 49, 53, 61, 63, 95
6 PARP1 [1] NF-kappa B signaling pathway D09730 Olaparib [2] 86, 285
7 IL1B [17] NF-kappa B signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
8 IL1B [17] NF-kappa B signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Rheumatoid arthritis D06635 Rilonacept [4] 51, 106, 107, 266
9 IL1B [17] NF-kappa B signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Rheumatoid arthritis D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
10 IL1B [17] NF-kappa B signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Rheumatoid arthritis D09911 Gevokizumab [4] 41, 50, 56, 269
11 IL1R1 [5] NF-kappa B signaling pathway, Osteoclast differentiation, Th17 cell differentiation, Pathogenic Escherichia coli infection, Shigellosis D02934 Anakinra [18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
12 LCK [8] NF-kappa B signaling pathway, Osteoclast differentiation, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency D03658 Dasatinib [2] 51, 85
13 LCK [8] NF-kappa B signaling pathway, Osteoclast differentiation, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency D06414 Dasatinib [2] 51, 85
14 LTA [4] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, TNF signaling pathway, Type I diabetes mellitus D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
15 LTA [4] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, TNF signaling pathway, Type I diabetes mellitus D10187 Pateclizumab [1] 46
16 LTB [2] NF-kappa B signaling pathway, Rheumatoid arthritis D08866 Baminercept [4] 13, 46, 53, 97
17 NFKB1 [30] Ras signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Pancreatic cancer, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01146 Iguratimod [5] 46, 51, 53, 271, 300
18 PRKCB [21] Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Parathyroid hormone synthesis, secretion and action, Salivary secretion, Pancreatic secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Non-small cell lung cancer D11935 Enzastaurin [1] 168
19 PRKCQ [7] NF-kappa B signaling pathway, Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Shigellosis, PD-L1 expression and PD-1 checkpoint pathway in cancer D09671 Sotrastaurin [1] 97
20 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00109 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
21 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00118 Naproxen [4] 13, 46, 107, 271
22 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00120 Sulindac [1] 206
23 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
24 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00130 Diflunisal [1] 28
25 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00132 Ketoprofen [1] 46
26 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00141 Indomethacin [3] 225, 271, 298
27 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00217 Acetaminophen [15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
28 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00315 Etodolac [1] 46
29 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00330 Flurbiprofen [3] 13, 21, 46
30 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00428 Salsalate [1] 5
31 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00567 Celecoxib [10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
32 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00568 Rofecoxib [1] 46
33 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00969 Meloxicam [4] 46, 49, 271, 296
34 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01049 Nimesulide [1] 46
35 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01183 Tolfenamic acid [1] 5
36 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01545 Aceclofenac [1] 46
37 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D02709 Valdecoxib [1] 46
38 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03710 Etoricoxib [2] 46, 271
39 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03714 Lumiracoxib [1] 46
40 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03716 Parecoxib [2] 46, 271
41 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D07816 Diclofenac [5] 13, 34, 46, 78, 271
42 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D08104 Ketorolac [2] 70, 226
43 PTGS2 [11] NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D08149 Loxoprofen [2] 46, 271
44 BCL2 [16] Platinum drug resistance, NF-kappa B signaling pathway, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, NOD-like receptor signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Prostate cancer, Small cell lung cancer D10679 Venetoclax [1] 28
45 RELA [30] Ras signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Pancreatic cancer, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D12181 Edasalonexent [1] 113
46 SYK [7] NF-kappa B signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Platelet activation, Tuberculosis, Viral carcinogenesis D09347 Fostamatinib [4] 46, 49, 61, 66
47 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D10223 Ibrutinib [3] 28, 60, 61
48 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D10893 Acalabrutinib [2] 46, 61
49 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D11422 Zanubrutinib [5] 13, 63, 222, 300, 331
50 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D11457 Fenebrutinib [1] 13
51 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D11478 Branebrutinib [3] 46, 49, 53
52 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D12160 Orelabrutinib [4] 13, 49, 61, 63
53 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D12285 Remibrutinib [2] 13, 53
54 BTK [4] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency D12467 Evobrutinib [3] 13, 46, 49
55 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
56 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
57 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
58 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
59 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
60 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
61 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
62 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
63 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D05393 Pegsunercept [1] 46
64 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
65 TNF [25] Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, TGF-beta signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D09944 Ozoralizumab [1] 46
66 TNFSF11 [5] NF-kappa B signaling pathway, Osteoclast differentiation, Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Rheumatoid arthritis D03684 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299
67 CD40 [7] NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11357 Bleselumab [1] 222
68 CD40 [7] NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11597 Ravagalimab [2] 53, 97
69 CD40 [7] NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11610 Iscalimab [2] 49, 53
70 CD40LG [6] NF-kappa B signaling pathway, T cell receptor signaling pathway, Toxoplasmosis, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D06193 Toralizumab [1] 63