Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MET [2] Transcriptional misregulation in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
2 PIK3CA [15] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11011 Alpelisib [1] 138
3 PIK3CA [15] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
4 PIK3CB [15] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
5 PIK3CD [15] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
6 PIK3CD [15] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
7 MAP2K1 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
8 MAP2K1 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
9 MAP2K1 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
10 MAP2K1 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
11 MAP2K1 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
12 MAP2K2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
13 MAP2K2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
14 MAP2K2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
15 MAP2K2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
16 MAP2K2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
17 RAF1 [10] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Thyroid hormone signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib [2] 34, 86
18 BRAF [4] Vascular smooth muscle contraction, Serotonergic synapse, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib [2] 34, 86
19 BRAF [4] Vascular smooth muscle contraction, Serotonergic synapse, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib [1] 34
20 TGFB1 [6] TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
21 TGFB2 [5] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
22 TGFB3 [5] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
23 VEGFA [3] VEGF signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
24 VEGFA [3] VEGF signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [6] 13, 34, 85, 87, 227, 280
25 VEGFA [3] VEGF signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166