Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ADORA1 💬 8件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
2 ADORA1 💬 8件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
3 ADORA2A 💬 8件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
4 ADORA2A 💬 8件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
5 APOC3 💬 2件: PPAR signaling pathway, Cholesterol metabolism Volanesorsen 💬 Volanesorsen 1件: 265 💬
6 APOC3 💬 2件: PPAR signaling pathway, Cholesterol metabolism Volanesorsen sodium 💬 Volanesorsen 1件: 265 💬
7 AR 💬 4件: Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Testosterone 💬 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265 💬
8 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Pegvisomant 💬 Pegvisomant 2件: 77, 265 💬
9 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Mecasermin 💬 Mecasermin 4件: 96, 168, 265, 299 💬
10 GHR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Mecasermin rinfabate 💬 Mecasermin 4件: 96, 168, 265, 299 💬
11 GHRHR 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Tesamorelin acetate 💬 Tesamorelin 1件: 265 💬
12 GHRHR 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Tesamorelin 💬 Tesamorelin 1件: 265 💬
13 GIPR 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling Tirzepatide 💬 Tirzepatide 6件: 67, 96, 97, 193, 233, 265 💬
14 GLP1R 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Tirzepatide 💬 Tirzepatide 6件: 67, 96, 97, 193, 233, 265 💬
15 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin sodium 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
16 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 22件: 6, 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬
17 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin calcium 💬 Atorvastatin 21件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
18 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 21件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
19 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 11件: 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
20 IGF1R 💬 30件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Hormone signaling, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Integrin signaling, Cadherin signaling, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma Mecasermin 💬 Mecasermin 4件: 96, 168, 265, 299 💬
21 IGF1R 💬 30件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Hormone signaling, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Integrin signaling, Cadherin signaling, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma Mecasermin rinfabate 💬 Mecasermin 4件: 96, 168, 265, 299 💬
22 JAK1 💬 27件: PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease, Pathways in cancer, Viral carcinogenesis, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Baricitinib 💬 Baricitinib 24件: 2, 13, 40, 41, 46, 49, 50, 51, 53, 54, 56, 63, 65, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
23 JAK2 💬 25件: Chemokine signaling pathway, Hormone signaling, Efferocytosis, PI3K-Akt signaling pathway, Necroptosis, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Cholinergic synapse, Prolactin signaling pathway, Adipocytokine signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis B, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Baricitinib 💬 Baricitinib 24件: 2, 13, 40, 41, 46, 49, 50, 51, 53, 54, 56, 63, 65, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
24 LEPR 💬 7件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, AMPK signaling pathway, JAK-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease Metreleptin 💬 Metreleptin 1件: 265 💬
25 MC4R 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Setmelanotide 💬 Setmelanotide 5件: 134, 193, 202, 236, 265 💬
26 MC4R 💬 3件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling Setmelanotide acetate 💬 Setmelanotide 5件: 134, 193, 202, 236, 265 💬
27 MTNR1A 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 18件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 159, 202, 265 💬
28 MTNR1B 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 18件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 159, 202, 265 💬
29 NR1H4 💬 1件: Bile secretion Obeticholic acid 💬 Obeticholic acid 3件: 93, 265, 296 💬
30 NR1H4 💬 1件: Bile secretion Cholic acid 💬 Cholic Acid 4件: 20, 234, 265, 310 💬
31 PDE1B 💬 6件: Purine metabolism, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
32 PDE1B 💬 6件: Purine metabolism, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
33 PDE2A 💬 5件: Purine metabolism, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
34 PDE2A 💬 5件: Purine metabolism, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
35 PDE3A 💬 5件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
36 PDE3A 💬 5件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
37 PDE3B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
38 PDE3B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
39 PDE4A 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
40 PDE4A 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
41 PDE4B 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
42 PDE4B 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
43 PDE4C 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
44 PDE4C 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
45 PDE4D 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
46 PDE4D 💬 4件: Purine metabolism, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
47 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Caffeine 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
48 PDE5A 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Caffeine citrate 💬 Caffeine 8件: 2, 6, 13, 21, 46, 96, 97, 265 💬
49 PPARA 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Fenofibrate 💬 Fenofibrate 6件: 8, 79, 93, 94, 97, 265 💬
50 PPARG 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone 💬 Rosiglitazone 7件: 46, 57, 75, 77, 97, 222, 265 💬
51 PPARG 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone hydrochloride 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 223, 229, 265, 298, 299 💬
52 PPARG 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 223, 229, 265, 298, 299 💬
53 PPARG 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone maleate 💬 Rosiglitazone 7件: 46, 57, 75, 77, 97, 222, 265 💬
54 PRKAA1 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 31件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 74, 75, 77, 81, 84, 85, 86, 97, 113, 127, 158, 206, 218, 222, 225, 233, 265, 285, 298, 299, 301 💬
55 PRKAA1 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 31件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 74, 75, 77, 81, 84, 85, 86, 97, 113, 127, 158, 206, 218, 222, 225, 233, 265, 285, 298, 299, 301 💬
56 PRKAA2 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 31件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 74, 75, 77, 81, 84, 85, 86, 97, 113, 127, 158, 206, 218, 222, 225, 233, 265, 285, 298, 299, 301 💬
57 PRKAA2 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 31件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 74, 75, 77, 81, 84, 85, 86, 97, 113, 127, 158, 206, 218, 222, 225, 233, 265, 285, 298, 299, 301 💬