Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
2 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
3 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
4 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
5 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
6 CA5B [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
7 CA5B [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
8 CA5B [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
9 TPH2 [3] Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D09973 Telotristat [1] 97
10 ADH1A [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
11 ADH1B [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
12 ADH1C [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
13 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D00781 Entacapone [2] 6, 17
14 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D00786 Tolcapone [3] 6, 28, 127
15 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D10825 Opicapone [1] 6
16 CPS1 [2] Nitrogen metabolism, Metabolic pathways D07130 Carglumic acid [3] 245, 246, 251
17 CYP11A1 [3] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D10950 Levoketoconazole [1] 75
18 CYP11B1 [2] Steroid hormone biosynthesis, Metabolic pathways D00410 Metyrapone [1] 75
19 CYP11B1 [2] Steroid hormone biosynthesis, Metabolic pathways D10950 Levoketoconazole [1] 75
20 CYP11B2 [2] Steroid hormone biosynthesis, Metabolic pathways D11061 Osilodrostat [1] 75
21 CYP17A1 [4] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway D00351 Ketoconazole [3] 8, 13, 75
22 CYP17A1 [4] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway D10950 Levoketoconazole [1] 75
23 CYP19A1 [3] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D00960 Anastrozole [3] 78, 86, 193
24 CYP19A1 [3] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D00964 Letrozole [2] 81, 89
25 DDC [5] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D00558 Carbidopa [7] 6, 13, 17, 90, 140, 164, 201
26 DDC [5] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D03082 Benserazide [1] 6
27 DHFR [2] One carbon pool by folate, Metabolic pathways D00142 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
28 DHODH [2] Pyrimidine metabolism, Metabolic pathways D00749 Leflunomide [12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
29 DHODH [2] Pyrimidine metabolism, Metabolic pathways D10172 Teriflunomide [3] 13, 25, 26
30 NQO1 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer D08682 Warfarin [11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
31 DNMT1 [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
32 DNMT3A [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
33 DNMT3B [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
34 ABAT [3] Valine, leucine and isoleucine degradation, Propanoate metabolism, Metabolic pathways D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
35 ABAT [3] Valine, leucine and isoleucine degradation, Propanoate metabolism, Metabolic pathways D00535 Vigabatrin [2] 145, 158
36 DHFR2 [2] One carbon pool by folate, Metabolic pathways D00142 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
37 ALAS1 [2] Porphyrin metabolism, Metabolic pathways D10003 Hemin [1] 254
38 ALAS1 [2] Porphyrin metabolism, Metabolic pathways D11702 Givosiran [1] 254
39 ALAS2 [2] Porphyrin metabolism, Metabolic pathways D10003 Hemin [1] 254
40 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D01968 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
41 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D07119 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299
42 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D07281 Pamidronic acid [3] 270, 271, 274
43 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D08484 Risedronic acid [9] 46, 50, 66, 93, 95, 96, 107, 113, 274
44 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D08689 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
45 CA14 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
46 CA14 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
47 CA14 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
48 ALOX5 [4] Metabolic pathways, Serotonergic synapse, Ovarian steroidogenesis, Toxoplasmosis D00414 Zileuton [3] 85, 160, 164
49 ALOX5 [4] Metabolic pathways, Serotonergic synapse, Ovarian steroidogenesis, Toxoplasmosis D01773 Oxatomide [1] 113
50 ALPL [2] Thiamine metabolism, Metabolic pathways D10595 Asfotase alfa [1] 172
51 GAA [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
52 GAA [2] Starch and sucrose metabolism, Metabolic pathways D03207 Alglucosidase alfa [1] 256
53 GAA [2] Starch and sucrose metabolism, Metabolic pathways D09605 Duvoglustat [1] 256
54 GAA [2] Starch and sucrose metabolism, Metabolic pathways D11744 Avalglucosidase alfa [1] 256
55 GAA [2] Starch and sucrose metabolism, Metabolic pathways D11798 Cipaglucosidase alfa [1] 256
56 GAD1 [3] Taurine and hypotaurine metabolism, Metabolic pathways, Type I diabetes mellitus D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
57 GAD2 [3] Taurine and hypotaurine metabolism, Metabolic pathways, Type I diabetes mellitus D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
58 GALNS [1] Metabolic pathways D10333 Elosulfase alfa [1] 19
59 GANC [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
60 GBA1 [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D02810 Alglucerase [1] 19
61 GBA1 [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D03020 Imiglucerase [1] 19
62 GBA1 [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D09029 Velaglucerase alfa [1] 19
63 GBA1 [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D09675 Taliglucerase alfa [1] 19
64 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
65 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
66 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
67 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
68 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
69 GLA [2] Sphingolipid metabolism, Metabolic pathways D02784 Agalsidase alfa [1] 19
70 GLA [2] Sphingolipid metabolism, Metabolic pathways D03228 Agalsidase beta [1] 19
71 AMY2A [4] Starch and sucrose metabolism, Metabolic pathways, Salivary secretion, Pancreatic secretion D00216 Acarbose [1] 298
72 AMY2B [4] Starch and sucrose metabolism, Metabolic pathways, Salivary secretion, Pancreatic secretion D00216 Acarbose [1] 298
73 ANPEP [2] Metabolic pathways, Renin-angiotensin system D00087 Ubenimex [1] 86
74 GUCY1A2 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
75 GUCY1A2 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
76 GUCY1A1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
77 GUCY1A1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
78 GUCY1B1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
79 GUCY1B1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
80 GUCY2C [2] Purine metabolism, Metabolic pathways D09355 Linaclotide [2] 6, 97
81 GUSB [3] Pentose and glucuronate interconversions, Porphyrin metabolism, Metabolic pathways D11004 Vestronidase alfa [1] 19
82 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00359 Lovastatin [11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
83 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00434 Simvastatin [21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
84 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D07474 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
85 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D07983 Fluvastatin [3] 79, 218, 222
86 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D08410 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
87 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D08492 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
88 HMOX1 [5] Porphyrin metabolism, Metabolic pathways, Mineral absorption, Pathways in cancer, MicroRNAs in cancer D05922 Stannsoporfin [1] 254
89 HMOX2 [3] Porphyrin metabolism, Metabolic pathways, Mineral absorption D05922 Stannsoporfin [1] 254
90 HPD [4] Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways D05177 Nitisinone [3] 6, 164, 241
91 HPRT1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D00161 Mercaptopurine [4] 65, 96, 97, 164
92 HPRT1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D04931 Mercaptopurine [4] 65, 96, 97, 164
93 HPRT1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D08603 Tioguanine [2] 13, 37
94 IDS [1] Metabolic pathways D04499 Idursulfase [1] 19
95 IDS [1] Metabolic pathways D11025 Idursulfase beta [1] 19
96 IDS [1] Metabolic pathways D11812 Pabinafusp alfa [1] 19
97 IDUA [1] Metabolic pathways D04670 Laronidase [2] 19, 256
98 IMPDH1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
99 IMPDH1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
100 IMPDH1 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
101 IMPDH2 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
102 IMPDH2 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
103 IMPDH2 [3] Purine metabolism, Metabolic pathways, Nucleotide metabolism D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
104 CA13 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
105 CA13 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
106 CA13 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
107 ARSB [1] Metabolic pathways D06565 Galsulfase [1] 19
108 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02561 Moclobemide [1] 6
109 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02579 Iproniazid [1] 6
110 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05458 Phentermine [1] 97
111 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08349 Phenelzine [1] 6
112 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02579 Iproniazid [1] 6
113 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D03731 Selegiline [1] 6
114 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05458 Phentermine [1] 97
115 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08349 Phenelzine [1] 6
116 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08469 Rasagiline [6] 2, 5, 6, 17, 58, 66
117 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D10158 Safinamide [2] 6, 17
118 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D10829 Rasagiline [6] 2, 5, 6, 17, 58, 66
119 NPR1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Thermogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion D04051 Erythrityl tetranitrate [1] 46
120 NPR1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Thermogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion D05147 Nesiritide [2] 46, 58
121 NPR2 [4] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Oxytocin signaling pathway D04051 Erythrityl tetranitrate [1] 46
122 NPR2 [4] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Oxytocin signaling pathway D11190 Vosoritide [1] 276
123 ODC1 [1] Metabolic pathways D07883 Eflornithine [1] 65
124 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
125 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D00455 Omeprazole [14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
126 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D05353 Pantoprazole [2] 13, 65
127 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
128 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D08463 Rabeprazole [2] 2, 51
129 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D08903 Dexlansoprazole [1] 98
130 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D11784 Vonoprazan [2] 63, 98
131 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
132 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D00455 Omeprazole [14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
133 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D05353 Pantoprazole [2] 13, 65
134 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
135 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D08463 Rabeprazole [2] 2, 51
136 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D08903 Dexlansoprazole [1] 98
137 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D11784 Vonoprazan [2] 63, 98
138 PAH [3] Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways D11077 Pegvaliase [1] 240
139 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
140 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
141 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
142 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
143 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
144 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
145 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
146 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
147 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
148 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
149 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
150 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
151 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
152 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
153 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
154 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00227 Aminophylline [1] 63
155 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00371 Theophylline [2] 236, 299
156 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
157 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
158 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D06103 Theophylline [2] 236, 299
159 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D07546 Bucladesine [1] 246
160 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D07961 Flavoxate [1] 226
161 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
162 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
163 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00417 Milrinone [1] 294
164 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
165 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01385 Ibudilast [2] 2, 13
166 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
167 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01896 Cilostazol [3] 46, 51, 70
168 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D04720 Levosimendan [1] 2
169 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
170 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
171 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
172 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
173 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
174 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00417 Milrinone [1] 294
175 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
176 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01385 Ibudilast [2] 2, 13
177 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
178 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01896 Cilostazol [3] 46, 51, 70
179 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D04720 Levosimendan [1] 2
180 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
181 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
182 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
183 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
184 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
185 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
186 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
187 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
188 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
189 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
190 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [4] 84, 97, 206, 299
191 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
192 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
193 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
194 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
195 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
196 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
197 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
198 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
199 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
200 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
201 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [4] 84, 97, 206, 299
202 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
203 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
204 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
205 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
206 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
207 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
208 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
209 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
210 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
211 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
212 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [4] 84, 97, 206, 299
213 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
214 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
215 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
216 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
217 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
218 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
219 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
220 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
221 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
222 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
223 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [4] 84, 97, 206, 299
224 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
225 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
226 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
227 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
228 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D12173 Zatolmilast [1] 206
229 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
230 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
231 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
232 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
233 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
234 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
235 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
236 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
237 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
238 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
239 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
240 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
241 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
242 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
243 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
244 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
245 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
246 ENPP2 [1] Metabolic pathways D11844 Ziritaxestat [2] 51, 85
247 PIK3CA [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11011 Alpelisib [1] 138
248 PIK3CA [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
249 PIK3CB [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
250 PIK3CD [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
251 PIK3CD [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11437 Parsaclisib [3] 35, 53, 61
252 HAO1 [2] Metabolic pathways, Peroxisome D11925 Lumasiran [1] 234
253 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00109 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
254 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00118 Naproxen [4] 13, 46, 107, 271
255 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00120 Sulindac [1] 206
256 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
257 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00132 Ketoprofen [1] 46
258 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00141 Indomethacin [3] 225, 271, 298
259 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00217 Acetaminophen [15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
260 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00330 Flurbiprofen [3] 13, 21, 46
261 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00428 Salsalate [1] 5
262 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01183 Tolfenamic acid [1] 5
263 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01545 Aceclofenac [1] 46
264 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D07816 Diclofenac [5] 13, 34, 46, 78, 271
265 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08104 Ketorolac [2] 70, 226
266 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08149 Loxoprofen [2] 46, 271
267 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00109 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
268 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00118 Naproxen [4] 13, 46, 107, 271
269 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00120 Sulindac [1] 206
270 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
271 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00130 Diflunisal [1] 28
272 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00132 Ketoprofen [1] 46
273 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00141 Indomethacin [3] 225, 271, 298
274 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00217 Acetaminophen [15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
275 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00315 Etodolac [1] 46
276 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00330 Flurbiprofen [3] 13, 21, 46
277 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00428 Salsalate [1] 5
278 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00567 Celecoxib [10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
279 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00568 Rofecoxib [1] 46
280 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00969 Meloxicam [4] 46, 49, 271, 296
281 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01049 Nimesulide [1] 46
282 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01183 Tolfenamic acid [1] 5
283 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01545 Aceclofenac [1] 46
284 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D02709 Valdecoxib [1] 46
285 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03710 Etoricoxib [2] 46, 271
286 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03714 Lumiracoxib [1] 46
287 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03716 Parecoxib [2] 46, 271
288 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D07816 Diclofenac [5] 13, 34, 46, 78, 271
289 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D08104 Ketorolac [2] 70, 226
290 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D08149 Loxoprofen [2] 46, 271
291 RRM1 [4] Purine metabolism, Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism D01370 Cladribine [3] 11, 13, 94
292 RRM1 [4] Purine metabolism, Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism D03546 Clofarabine [5] 19, 20, 60, 234, 326
293 RRM1 [4] Purine metabolism, Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism D07966 Fludarabine [20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
294 RRM2 [5] Purine metabolism, Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism, p53 signaling pathway D00341 Hydroxyurea [8] 3, 13, 19, 20, 65, 85, 86, 284
295 SMPD1 [4] Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, Necroptosis D10820 Olipudase alfa [1] 19
296 SRD5A1 [2] Steroid hormone biosynthesis, Metabolic pathways D03820 Dutasteride [2] 1, 2
297 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D00321 Finasteride [1] 6
298 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D03820 Dutasteride [2] 1, 2
299 TPH1 [3] Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D09973 Telotristat [1] 97
300 TPO [3] Tyrosine metabolism, Metabolic pathways, Thyroid hormone synthesis D00401 Methimazole [1] 50
301 TYMS [4] Pyrimidine metabolism, One carbon pool by folate, Metabolic pathways, Nucleotide metabolism D01244 Tegafur [1] 46
302 UGCG [2] Sphingolipid metabolism, Metabolic pathways D05032 Miglustat [3] 19, 256, 299
303 UGCG [2] Sphingolipid metabolism, Metabolic pathways D09893 Eliglustat [1] 19
304 UGCG [2] Sphingolipid metabolism, Metabolic pathways D11439 Lucerastat [1] 19
305 UGCG [2] Sphingolipid metabolism, Metabolic pathways D11633 Venglustat [3] 6, 19, 67
306 XDH [4] Purine metabolism, Metabolic pathways, Nucleotide metabolism, Peroxisome D00224 Allopurinol [7] 6, 46, 57, 60, 66, 96, 97
307 XDH [4] Purine metabolism, Metabolic pathways, Nucleotide metabolism, Peroxisome D01206 Febuxostat [3] 2, 6, 13
308 CA1 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
309 CA1 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
310 CA1 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
311 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
312 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00518 Diclofenamide [1] 114
313 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
314 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D07871 Dorzolamide [1] 90
315 CA3 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
316 CA3 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
317 CA3 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
318 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
319 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00518 Diclofenamide [1] 114
320 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
321 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D07871 Dorzolamide [1] 90
322 CA5A [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
323 CA5A [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
324 CA5A [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
325 CA6 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
326 CA6 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
327 CA6 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
328 CA7 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
329 CA7 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
330 CA7 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
331 CA8 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
332 CA8 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
333 CA8 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
334 CA9 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
335 CA9 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
336 CA9 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
337 CA12 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
338 CA12 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
339 CA12 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
340 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D08354 Phenindione [1] 65
341 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D08682 Warfarin [11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
342 ALDH5A1 [1] Metabolic pathways D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
343 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
344 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
345 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
346 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
347 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
348 AOC3 [3] Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways D08044 Hydralazine [1] 67
349 PDE5A [2] Purine metabolism, Metabolic pathways D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
350 PDE5A [2] Purine metabolism, Metabolic pathways D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
351 PDE5A [2] Purine metabolism, Metabolic pathways D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
352 PDE5A [2] Purine metabolism, Metabolic pathways D02008 Tadalafil [7] 6, 51, 75, 84, 86, 113, 210
353 PDE5A [2] Purine metabolism, Metabolic pathways D08514 Sildenafil [17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
354 PDE5A [2] Purine metabolism, Metabolic pathways D08668 Vardenafil [3] 13, 86, 299
355 PDE5A [2] Purine metabolism, Metabolic pathways D10027 Udenafil [2] 86, 210
356 MGAM [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
357 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D10777 Daratumumab [5] 13, 28, 48, 49, 63
358 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D11050 Isatuximab [3] 28, 61, 283
359 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D11945 Mezagitamab [2] 63, 66
360 PTGES [1] Metabolic pathways D01545 Aceclofenac [1] 46