Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MAPK14 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
2 MAPK14 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
3 CSF2 [4] T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Transcriptional misregulation in cancer D11343 Otilimab [1] 46
4 EGFR [1] Shigellosis D01977 Gefitinib [1] 75
5 EGFR [1] Shigellosis D03455 Cetuximab [2] 51, 86
6 EGFR [1] Shigellosis D07907 Erlotinib [1] 94
7 EGFR [1] Shigellosis D08108 Lapatinib [3] 34, 74, 75
8 EGFR [1] Shigellosis D08950 Neratinib [1] 34
9 EGFR [1] Shigellosis D11251 Icotinib [1] 34
10 EGFR [1] Shigellosis D11772 Tesevatinib [1] 67
11 MTOR [6] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis D00753 Sirolimus [40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
12 MTOR [6] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis D02714 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277
13 MTOR [6] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis D06068 Temsirolimus [1] 13
14 IL1B [7] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Yersinia infection, Tuberculosis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
15 IL1B [7] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Yersinia infection, Tuberculosis D06635 Rilonacept [4] 51, 106, 107, 266
16 IL1B [7] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Yersinia infection, Tuberculosis D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
17 IL1B [7] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Yersinia infection, Tuberculosis D09911 Gevokizumab [4] 41, 50, 56, 269
18 IL1R1 [2] Th17 cell differentiation, Shigellosis D02934 Anakinra [18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
19 NFKB1 [13] Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Small cell lung cancer D01146 Iguratimod [5] 46, 51, 53, 271, 300
20 PIK3CA [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Yersinia infection, Viral carcinogenesis, Small cell lung cancer D11011 Alpelisib [1] 138
21 PIK3CA [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Yersinia infection, Viral carcinogenesis, Small cell lung cancer D11158 Leniolisib [2] 53, 65
22 PIK3CB [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Yersinia infection, Viral carcinogenesis, Small cell lung cancer D11158 Leniolisib [2] 53, 65
23 PIK3CD [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Yersinia infection, Viral carcinogenesis, Small cell lung cancer D11158 Leniolisib [2] 53, 65
24 PIK3CD [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Yersinia infection, Viral carcinogenesis, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
25 PRKCD [3] Vascular smooth muscle contraction, Type II diabetes mellitus, Shigellosis D09671 Sotrastaurin [1] 97
26 PRKCE [5] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Type II diabetes mellitus, Shigellosis D09671 Sotrastaurin [1] 97
27 PRKCQ [5] Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Shigellosis D09671 Sotrastaurin [1] 97
28 MAPK11 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
29 MAPK11 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
30 MAPK13 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
31 MAPK13 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
32 BCL2 [5] Sphingolipid signaling pathway, Shigellosis, Toxoplasmosis, Tuberculosis, Small cell lung cancer D10679 Venetoclax [1] 28
33 RELA [13] Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Small cell lung cancer D12181 Edasalonexent [1] 113
34 ROCK1 [6] Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Shigellosis, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
35 MAPK12 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
36 MAPK12 [13] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
37 SRC [7] VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib [2] 2, 67
38 SRC [7] VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib [2] 51, 85
39 SRC [7] VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib [2] 51, 85
40 SRC [7] VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib [3] 6, 89, 272
41 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
42 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
43 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
44 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
45 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
46 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
47 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
48 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
49 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D05393 Pegsunercept [1] 46
50 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D08976 Pomalidomide [5] 28, 51, 85, 227, 331
51 TNF [13] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D09944 Ozoralizumab [1] 46
52 C3 [5] Shigellosis, Staphylococcus aureus infection, Tuberculosis, Viral carcinogenesis, Systemic lupus erythematosus D11613 Pegcetacoplan [4] 2, 61, 62, 222
53 ROCK2 [6] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Shigellosis, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
54 ROCK2 [6] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Shigellosis, Yersinia infection D11815 Belumosudil [2] 51, 85