Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01977 Gefitinib [1] 75
2 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D03455 Cetuximab [2] 51, 86
3 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D07907 Erlotinib [1] 94
4 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08108 Lapatinib [3] 34, 74, 75
5 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08950 Neratinib [1] 34
6 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11251 Icotinib [1] 34
7 EGFR [12] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11772 Tesevatinib [1] 67
8 FGFR1 [10] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
9 FGFR1 [10] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib [1] 276
10 MMP13 [2] Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action D08859 Apratastat [1] 46
11 SOST [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action D10156 Romosozumab [1] 274
12 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline [1] 63
13 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
14 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline [2] 236, 299
15 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
16 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast [2] 2, 13
17 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
18 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram [2] 8, 13
19 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast [4] 84, 97, 206, 299
20 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline [2] 236, 299
21 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine [1] 246
22 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate [1] 226
23 PDE4A [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
24 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline [1] 63
25 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline [2] 236, 299
26 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
27 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast [2] 2, 13
28 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
29 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram [2] 8, 13
30 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast [4] 84, 97, 206, 299
31 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline [2] 236, 299
32 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine [1] 246
33 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate [1] 226
34 PDE4B [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
35 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline [1] 63
36 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline [2] 236, 299
37 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
38 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast [2] 2, 13
39 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
40 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram [2] 8, 13
41 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast [4] 84, 97, 206, 299
42 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline [2] 236, 299
43 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine [1] 246
44 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate [1] 226
45 PDE4C [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
46 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline [1] 63
47 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline [2] 236, 299
48 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
49 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast [2] 2, 13
50 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
51 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram [2] 8, 13
52 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast [4] 84, 97, 206, 299
53 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline [2] 236, 299
54 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine [1] 246
55 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate [1] 226
56 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
57 PDE4D [2] Purine metabolism, Parathyroid hormone synthesis, secretion and action D12173 Zatolmilast [1] 206
58 PRKCB [17] Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Salivary secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer D11935 Enzastaurin [1] 168
59 MAP2K1 [27] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
60 MAP2K1 [27] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
61 MAP2K1 [27] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
62 MAP2K1 [27] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
63 MAP2K1 [27] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11675 Mirdametinib [1] 34
64 PTH1R [1] Parathyroid hormone synthesis, secretion and action D05364 Parathyroid hormone [4] 65, 70, 235, 326
65 PTH1R [1] Parathyroid hormone synthesis, secretion and action D06078 Teriparatide [7] 46, 65, 68, 70, 71, 235, 274
66 RAF1 [24] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08524 Sorafenib [2] 34, 86
67 BCL2 [13] Platinum drug resistance, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Prostate cancer, Small cell lung cancer D10679 Venetoclax [1] 28
68 RXRA [9] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
69 RXRA [9] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
70 RXRA [9] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
71 RXRB [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
72 RXRB [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
73 RXRB [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
74 RXRG [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
75 RXRG [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
76 RXRG [8] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
77 BRAF [12] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D08524 Sorafenib [2] 34, 86
78 BRAF [12] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10064 Dabrafenib [1] 34
79 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00122 Calcifediol [2] 113, 299
80 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00129 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326
81 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00187 Ergocalciferol [6] 46, 49, 84, 96, 97, 299
82 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00188 Cholecalciferol [24] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
83 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00299 Dihydrotachysterol [2] 6, 85
84 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D00930 Paricalcitol [5] 19, 66, 218, 238, 298
85 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D01125 Calcipotriol [2] 36, 51
86 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D01518 Alfacalcidol [8] 41, 46, 49, 50, 96, 107, 235, 238
87 VDR [2] Parathyroid hormone synthesis, secretion and action, Tuberculosis D07578 Eldecalcitol [1] 46
88 FGF23 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer D10913 Burosumab [1] 238
89 CASR [1] Parathyroid hormone synthesis, secretion and action D03504 Cinacalcet [1] 238
90 TNFSF11 [3] Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Rheumatoid arthritis D03684 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299