Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
2 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
3 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
4 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
5 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
6 TUBB3 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
7 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
8 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
9 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
10 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
11 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
12 TUBB4A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
13 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
14 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
15 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
16 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
17 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
18 TUBB4B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
19 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00076 Norepinephrine [2] 22, 296
20 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00095 Epinephrine [3] 46, 70, 96
21 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00124 Ephedrine [1] 11
22 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00235 Atenolol [1] 167
23 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00255 Carvedilol [4] 57, 86, 113, 210
24 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00378 Timolol [2] 157, 227
25 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D00432 Nadolol [1] 6
26 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D01277 Droxidopa [5] 5, 6, 17, 169, 170
27 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D02342 Bisoprolol [4] 58, 67, 86, 113
28 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D02349 Dipivefrin [1] 6
29 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D02358 Metoprolol [6] 17, 57, 58, 113, 193, 226
30 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D02910 Amiodarone [2] 28, 127
31 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D03879 Dobutamine [4] 57, 58, 86, 215
32 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D05127 Nebivolol [4] 17, 85, 113, 167
33 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D07660 Celiprolol [1] 168
34 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D07916 Esmolol [1] 58
35 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D08443 Propranolol [6] 6, 158, 167, 227, 278, 296
36 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D08449 Pseudoephedrine [1] 17
37 ADRB1 [5] Neuroactive ligand-receptor interaction, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion D08600 Timolol [2] 157, 227
38 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D00059 Levodopa [6] 6, 17, 90, 140, 164, 201
39 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D01044 Flupentixol [1] 97
40 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D07460 Apomorphine [3] 5, 6, 7
41 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D07870 Dopamine [4] 6, 7, 74, 299
42 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D08339 Pergolide [1] 6
43 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D09886 Dexpramipexole [1] 2
44 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D11431 Tavapadon [1] 6
45 DRD1 [4] Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease, Morphine addiction D11839 Foslevodopa [1] 6
46 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00059 Levodopa [6] 6, 17, 90, 140, 164, 201
47 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00136 Haloperidol [1] 8
48 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00270 Chlorpromazine [1] 254
49 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00426 Risperidone [5] 8, 156, 179, 187, 206
50 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00454 Olanzapine [2] 2, 8
51 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00560 Pimozide [1] 2
52 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00726 Metoclopramide [2] 46, 51
53 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D00987 Cabergoline [3] 6, 74, 75
54 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01044 Flupentixol [1] 97
55 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01164 Aripiprazole [2] 6, 206
56 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01226 Sulpiride [2] 6, 70
57 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01348 Terguride [2] 51, 86
58 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01448 Trifluoperazine [2] 283, 284
59 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D01745 Domperidone [5] 6, 13, 17, 51, 230
60 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D02666 Iloperidone [1] 6
61 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D03165 Bromocriptine [2] 6, 74
62 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D05575 Pramipexole [3] 2, 6, 20
63 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D05768 Rotigotine [1] 6
64 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07305 Piribedil [1] 6
65 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07309 Melperone [1] 6
66 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07460 Apomorphine [3] 5, 6, 7
67 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07593 Buspirone [2] 6, 51
68 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07868 Domperidone [5] 6, 13, 17, 51, 230
69 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D07870 Dopamine [4] 6, 7, 74, 299
70 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08132 Lisuride [2] 6, 86
71 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08339 Pergolide [1] 6
72 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08456 Quetiapine [2] 6, 13
73 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08489 Ropinirole [4] 2, 6, 74, 309
74 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08590 Tiapride [1] 8
75 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D08636 Trifluoperazine [2] 283, 284
76 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D09397 Pardoprunox [1] 6
77 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D09886 Dexpramipexole [1] 2
78 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D09953 Pridopidine [3] 2, 6, 8
79 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D09997 Cariprazine [1] 21
80 DRD2 [4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Parkinson disease D11839 Foslevodopa [1] 6
81 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01977 Gefitinib [1] 75
82 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D03455 Cetuximab [2] 51, 86
83 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D07907 Erlotinib [1] 94
84 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08108 Lapatinib [3] 34, 74, 75
85 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08950 Neratinib [1] 34
86 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11251 Icotinib [1] 34
87 EGFR [28] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11772 Tesevatinib [1] 67
88 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
89 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
90 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
91 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
92 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
93 TUBB [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
94 GUCY1A2 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
95 GUCY1A2 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
96 GUCY1A1 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
97 GUCY1A1 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
98 GUCY1B1 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
99 GUCY1B1 [9] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Gap junction, Platelet activation, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
100 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
101 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00274 Cisapride [1] 13
102 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine [1] 6
103 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00426 Risperidone [5] 8, 156, 179, 187, 206
104 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
105 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D01164 Aripiprazole [2] 6, 206
106 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02092 Cisapride [1] 13
107 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone [1] 6
108 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine [4] 140, 144, 145, 149
109 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08456 Quetiapine [2] 6, 13
110 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
111 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09645 Nelotanserin [1] 6
112 HTR2A [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09997 Cariprazine [1] 21
113 HTR2B [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
114 HTR2B [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
115 HTR2B [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone [1] 6
116 HTR2B [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
117 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
118 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine [1] 6
119 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
120 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02578 Agomelatine [1] 6
121 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone [1] 6
122 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine [4] 140, 144, 145, 149
123 HTR2C [4] Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
124 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
125 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
126 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
127 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
128 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
129 TUBB8 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
130 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
131 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
132 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
133 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
134 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
135 TUBB2B [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
136 PDGFRA [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
137 PDGFRA [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08552 Sunitinib [2] 28, 34
138 PDGFRA [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08953 Nilotinib [5] 6, 8, 34, 51, 86
139 PDGFRA [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D10481 Nintedanib [5] 51, 85, 89, 227, 228
140 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D03658 Dasatinib [2] 51, 85
141 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D06414 Dasatinib [2] 51, 85
142 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08524 Sorafenib [2] 34, 86
143 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08552 Sunitinib [2] 28, 34
144 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D08953 Nilotinib [5] 6, 8, 34, 51, 86
145 PDGFRB [14] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma D10481 Nintedanib [5] 51, 85, 89, 227, 228
146 PRKCB [48] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, mTOR signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Gap junction, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Serotonergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Melanogenesis, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Insulin resistance, Growth hormone synthesis, secretion and action, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Morphine addiction, Leishmaniasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Glioma, Non-small cell lung cancer, Hepatocellular carcinoma D11935 Enzastaurin [1] 168
147 MAP2K1 [59] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
148 MAP2K1 [59] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
149 MAP2K1 [59] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
150 MAP2K1 [59] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
151 MAP2K1 [59] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11675 Mirdametinib [1] 34
152 MAP2K2 [52] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
153 MAP2K2 [52] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
154 MAP2K2 [52] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
155 MAP2K2 [52] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
156 MAP2K2 [52] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11675 Mirdametinib [1] 34
157 RAF1 [53] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08524 Sorafenib [2] 34, 86
158 SRC [25] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D03252 Bosutinib [2] 2, 67
159 SRC [25] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D03658 Dasatinib [2] 51, 85
160 SRC [25] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D06414 Dasatinib [2] 51, 85
161 SRC [25] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D09664 Saracatinib [3] 6, 89, 272
162 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
163 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
164 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
165 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
166 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
167 TUBB2A [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
168 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
169 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
170 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
171 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
172 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
173 TUBB1 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28
174 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00491 Paclitaxel [2] 46, 85
175 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D00570 Colchicine [7] 2, 42, 46, 56, 93, 210, 266
176 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08675 Vinblastine [2] 34, 65
177 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D08679 Vincristine [4] 26, 34, 65, 331
178 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D09587 Brentuximab vedotin [2] 49, 51
179 TUBB6 [8] Phagosome, Gap junction, Parkinson disease, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection D11595 Belantamab mafodotin [1] 28