Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D00306 Dronabinol [8] 2, 8, 13, 36, 46, 96, 271, 298
2 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05099 Nabilone [3] 6, 13, 127
3 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05731 Rimonabant [1] 193
4 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D10915 Cannabidiol [20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
5 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine [3] 13, 58, 65
6 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
7 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
8 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate [1] 46
9 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D04641 Istradefylline [1] 6
10 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D05711 Regadenoson [1] 58
11 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D09717 Preladenant [1] 6
12 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D10174 Tozadenant [1] 6
13 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D12568 Regadenoson [1] 58
14 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine [3] 13, 58, 65
15 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00227 Aminophylline [1] 63
16 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00371 Theophylline [2] 236, 299
17 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate [1] 46
18 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D06103 Theophylline [2] 236, 299
19 MAPK14 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
20 MAPK14 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
21 CSF1R [4] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Transcriptional misregulation in cancer D08552 Sunitinib [2] 28, 34
22 CSF1R [4] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
23 DRD2 [1] Rap1 signaling pathway D00059 Levodopa [6] 6, 17, 90, 140, 164, 201
24 DRD2 [1] Rap1 signaling pathway D00136 Haloperidol [1] 8
25 DRD2 [1] Rap1 signaling pathway D00270 Chlorpromazine [1] 254
26 DRD2 [1] Rap1 signaling pathway D00426 Risperidone [5] 8, 156, 179, 187, 206
27 DRD2 [1] Rap1 signaling pathway D00454 Olanzapine [2] 2, 8
28 DRD2 [1] Rap1 signaling pathway D00560 Pimozide [1] 2
29 DRD2 [1] Rap1 signaling pathway D00726 Metoclopramide [2] 46, 51
30 DRD2 [1] Rap1 signaling pathway D00987 Cabergoline [3] 6, 74, 75
31 DRD2 [1] Rap1 signaling pathway D01044 Flupentixol [1] 97
32 DRD2 [1] Rap1 signaling pathway D01164 Aripiprazole [2] 6, 206
33 DRD2 [1] Rap1 signaling pathway D01226 Sulpiride [2] 6, 70
34 DRD2 [1] Rap1 signaling pathway D01348 Terguride [2] 51, 86
35 DRD2 [1] Rap1 signaling pathway D01448 Trifluoperazine [2] 283, 284
36 DRD2 [1] Rap1 signaling pathway D01745 Domperidone [5] 6, 13, 17, 51, 230
37 DRD2 [1] Rap1 signaling pathway D02666 Iloperidone [1] 6
38 DRD2 [1] Rap1 signaling pathway D03165 Bromocriptine [2] 6, 74
39 DRD2 [1] Rap1 signaling pathway D05575 Pramipexole [3] 2, 6, 20
40 DRD2 [1] Rap1 signaling pathway D05768 Rotigotine [1] 6
41 DRD2 [1] Rap1 signaling pathway D07305 Piribedil [1] 6
42 DRD2 [1] Rap1 signaling pathway D07309 Melperone [1] 6
43 DRD2 [1] Rap1 signaling pathway D07460 Apomorphine [3] 5, 6, 7
44 DRD2 [1] Rap1 signaling pathway D07593 Buspirone [2] 6, 51
45 DRD2 [1] Rap1 signaling pathway D07868 Domperidone [5] 6, 13, 17, 51, 230
46 DRD2 [1] Rap1 signaling pathway D07870 Dopamine [4] 6, 7, 74, 299
47 DRD2 [1] Rap1 signaling pathway D08132 Lisuride [2] 6, 86
48 DRD2 [1] Rap1 signaling pathway D08339 Pergolide [1] 6
49 DRD2 [1] Rap1 signaling pathway D08456 Quetiapine [2] 6, 13
50 DRD2 [1] Rap1 signaling pathway D08489 Ropinirole [4] 2, 6, 74, 309
51 DRD2 [1] Rap1 signaling pathway D08590 Tiapride [1] 8
52 DRD2 [1] Rap1 signaling pathway D08636 Trifluoperazine [2] 283, 284
53 DRD2 [1] Rap1 signaling pathway D09397 Pardoprunox [1] 6
54 DRD2 [1] Rap1 signaling pathway D09886 Dexpramipexole [1] 2
55 DRD2 [1] Rap1 signaling pathway D09953 Pridopidine [3] 2, 6, 8
56 DRD2 [1] Rap1 signaling pathway D09997 Cariprazine [1] 21
57 DRD2 [1] Rap1 signaling pathway D11839 Foslevodopa [1] 6
58 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D01977 Gefitinib [1] 75
59 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D03455 Cetuximab [2] 51, 86
60 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D07907 Erlotinib [1] 94
61 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08108 Lapatinib [3] 34, 74, 75
62 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08950 Neratinib [1] 34
63 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11251 Icotinib [1] 34
64 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11772 Tesevatinib [1] 67
65 EPHA2 [2] Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib [2] 51, 85
66 EPHA2 [2] Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib [2] 51, 85
67 FGFR1 [5] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
68 FGFR1 [5] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
69 FGFR3 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
70 FGFR3 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
71 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D05338 Palifermin [5] 13, 36, 38, 39, 65
72 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
73 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
74 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib [1] 34
75 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
76 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib [1] 34
77 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib [5] 51, 85, 89, 227, 228
78 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D03218 Axitinib [1] 34
79 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib [2] 34, 86
80 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib [2] 28, 34
81 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08881 Cediranib [1] 34
82 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
83 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D11772 Tesevatinib [1] 67
84 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
85 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
86 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07058 Acamprosate [2] 6, 206
87 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07283 Esketamine [3] 2, 4, 70
88 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07441 Amantadine [4] 6, 8, 13, 127
89 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
90 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08174 Memantine [8] 2, 6, 8, 13, 49, 127, 205, 206
91 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D09917 Latrepirdine [1] 8
92 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
93 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
94 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
95 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
96 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
97 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
98 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine [8] 2, 6, 8, 13, 49, 127, 205, 206
99 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine [1] 8
100 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
101 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
102 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
103 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
104 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
105 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
106 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine [8] 2, 6, 8, 13, 49, 127, 205, 206
107 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine [1] 8
108 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
109 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09680 Teprotumumab [1] 51
110 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09925 Linsitinib [1] 232
111 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03230 Insulin human [2] 96, 156
112 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03250 Insulin glargine [1] 299
113 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D04539 Insulin detemir [1] 299
114 ITGAL [5] Rap1 signaling pathway, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96
115 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D03218 Axitinib [1] 34
116 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08524 Sorafenib [2] 34, 86
117 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08552 Sunitinib [2] 28, 34
118 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08881 Cediranib [1] 34
119 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10062 Cabozantinib [1] 34
120 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
121 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D11772 Tesevatinib [1] 67
122 KIT [2] Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib [2] 51, 85
123 KIT [2] Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib [2] 51, 85
124 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
125 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib [2] 34, 86
126 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib [2] 28, 34
127 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08953 Nilotinib [5] 6, 8, 34, 51, 86
128 KIT [2] Ras signaling pathway, Rap1 signaling pathway D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
129 KIT [2] Ras signaling pathway, Rap1 signaling pathway D11270 Pexidartinib [1] 34
130 MET [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
131 NGF [2] Ras signaling pathway, Rap1 signaling pathway D09387 Tanezumab [2] 226, 298
132 NGFR [4] Virion - Lyssavirus, Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer D11028 Cenegermin [2] 53, 90
133 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
134 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
135 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
136 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
137 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D03658 Dasatinib [2] 51, 85
138 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06414 Dasatinib [2] 51, 85
139 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08524 Sorafenib [2] 34, 86
140 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
141 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
142 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
143 PGF [2] Ras signaling pathway, Rap1 signaling pathway D09574 Aflibercept [2] 90, 166
144 PIK3CA [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11011 Alpelisib [1] 138
145 PIK3CA [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
146 PIK3CB [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
147 PIK3CD [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
148 PIK3CD [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
149 PRKCB [12] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Salivary secretion, Spinocerebellar ataxia D11935 Enzastaurin [1] 168
150 MAPK11 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
151 MAPK11 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
152 MAPK13 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
153 MAPK13 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
154 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
155 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
156 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
157 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
158 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
159 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
160 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
161 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
162 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
163 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
164 RAF1 [14] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib [2] 34, 86
165 MAPK12 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
166 MAPK12 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
167 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib [2] 2, 67
168 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib [2] 51, 85
169 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib [2] 51, 85
170 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib [3] 6, 89, 272
171 BRAF [6] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib [2] 34, 86
172 BRAF [6] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib [1] 34
173 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
174 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [6] 13, 34, 85, 87, 227, 280
175 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
176 VEGFB [3] Ras signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway D09574 Aflibercept [2] 90, 166
177 FGF23 [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10913 Burosumab [1] 238