Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CHRM1 [1] Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
2 CHRM1 [1] Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
3 CHRM1 [1] Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
4 CHRM1 [1] Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
5 CHRM1 [1] Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
6 CHRM1 [1] Regulation of actin cytoskeleton D08441 Propiverine [1] 226
7 CHRM1 [1] Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
8 CHRM1 [1] Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
9 CHRM2 [1] Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
10 CHRM2 [1] Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
11 CHRM2 [1] Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
12 CHRM2 [1] Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
13 CHRM2 [1] Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
14 CHRM2 [1] Regulation of actin cytoskeleton D00525 Pilocarpine [3] 6, 53, 299
15 CHRM2 [1] Regulation of actin cytoskeleton D07226 Fesoterodine [1] 6
16 CHRM2 [1] Regulation of actin cytoskeleton D08441 Propiverine [1] 226
17 CHRM2 [1] Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
18 CHRM2 [1] Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
19 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00113 Atropine [2] 2, 299
20 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00138 Scopolamine [1] 2
21 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00270 Chlorpromazine [1] 254
22 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00397 Tropicamide [1] 6
23 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00465 Oxybutynin [3] 6, 13, 53
24 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00525 Pilocarpine [3] 6, 53, 299
25 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00646 Tolterodine [2] 17, 53
26 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D03654 Darifenacin [2] 6, 13
27 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D07226 Fesoterodine [1] 6
28 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D07667 Cevimeline [1] 53
29 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08441 Propiverine [1] 226
30 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08522 Solifenacin [3] 6, 13, 53
31 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08638 Trihexyphenidyl [2] 5, 6
32 CHRM3 [3] Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D11383 Blarcamesine [1] 156
33 CHRM4 [1] Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
34 CHRM4 [1] Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
35 CHRM4 [1] Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
36 CHRM4 [1] Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
37 CHRM4 [1] Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
38 CHRM4 [1] Regulation of actin cytoskeleton D08441 Propiverine [1] 226
39 CHRM4 [1] Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
40 CHRM4 [1] Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
41 CHRM5 [1] Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
42 CHRM5 [1] Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
43 CHRM5 [1] Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
44 CHRM5 [1] Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
45 CHRM5 [1] Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
46 CHRM5 [1] Regulation of actin cytoskeleton D08441 Propiverine [1] 226
47 CHRM5 [1] Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
48 CHRM5 [1] Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
49 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D01977 Gefitinib [1] 75
50 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D03455 Cetuximab [2] 51, 86
51 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D07907 Erlotinib [1] 94
52 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08108 Lapatinib [3] 34, 74, 75
53 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08950 Neratinib [1] 34
54 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11251 Icotinib [1] 34
55 EGFR [3] Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11772 Tesevatinib [1] 67
56 F2 [1] Regulation of actin cytoskeleton D06410 Thrombomodulin Alfa [1] 85
57 F2 [1] Regulation of actin cytoskeleton D07144 Dabigatran etexilate [2] 51, 75
58 F2 [1] Regulation of actin cytoskeleton D09707 Dabigatran [5] 51, 75, 85, 91, 124
59 FGFR1 [3] Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
60 FGFR1 [3] Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
61 FGFR3 [2] Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
62 FGFR3 [2] Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
63 FGFR2 [2] Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D05338 Palifermin [5] 13, 36, 38, 39, 65
64 FGFR2 [2] Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
65 FGFR2 [2] Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
66 ITGA4 [2] Regulation of actin cytoskeleton, Yersinia infection D06590 Firategrast [1] 13
67 ITGA4 [2] Regulation of actin cytoskeleton, Yersinia infection D06886 Natalizumab [6] 13, 15, 25, 46, 63, 96
68 ITGA4 [2] Regulation of actin cytoskeleton, Yersinia infection D08083 Vedolizumab [3] 94, 96, 97
69 ITGA4 [2] Regulation of actin cytoskeleton, Yersinia infection D10540 Abrilumab [2] 96, 97
70 ITGAL [4] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96
71 ITGB7 [2] Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D08083 Vedolizumab [3] 94, 96, 97
72 ITGB7 [2] Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D09901 Etrolizumab [2] 96, 97
73 ITGB7 [2] Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D10540 Abrilumab [2] 96, 97
74 PDGFRA [1] Regulation of actin cytoskeleton D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
75 PDGFRA [1] Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
76 PDGFRA [1] Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
77 PDGFRA [1] Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
78 PDGFRB [1] Regulation of actin cytoskeleton D03658 Dasatinib [2] 51, 85
79 PDGFRB [1] Regulation of actin cytoskeleton D06414 Dasatinib [2] 51, 85
80 PDGFRB [1] Regulation of actin cytoskeleton D08524 Sorafenib [2] 34, 86
81 PDGFRB [1] Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
82 PDGFRB [1] Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
83 PDGFRB [1] Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
84 PIK3CA [18] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11011 Alpelisib [1] 138
85 PIK3CA [18] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
86 PIK3CB [18] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
87 PIK3CD [18] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
88 PIK3CD [18] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
89 MAP2K1 [15] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
90 MAP2K1 [15] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
91 MAP2K1 [15] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
92 MAP2K1 [15] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
93 MAP2K1 [15] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
94 MAP2K2 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
95 MAP2K2 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
96 MAP2K2 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
97 MAP2K2 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
98 MAP2K2 [13] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib [1] 34
99 RAF1 [12] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib [2] 34, 86
100 ROCK1 [7] Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
101 SRC [9] VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib [2] 2, 67
102 SRC [9] VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib [2] 51, 85
103 SRC [9] VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib [2] 51, 85
104 SRC [9] VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib [3] 6, 89, 272
105 BRAF [5] Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib [2] 34, 86
106 BRAF [5] Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib [1] 34
107 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D03940 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222
108 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11054 Ravulizumab [7] 2, 11, 13, 50, 62, 66, 109
109 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11473 Nomacopan [3] 62, 109, 162
110 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11477 Pozelimab [2] 11, 62
111 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11696 Crovalimab [2] 62, 109
112 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11838 Vilobelimab [3] 43, 44, 269
113 C5 [3] Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D12357 Zilucoplan [3] 2, 11, 62
114 CXCR4 [4] Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with cytokine and cytokine receptor, Regulation of actin cytoskeleton D08971 Plerixafor [5] 19, 20, 65, 285, 299
115 FGF23 [1] Regulation of actin cytoskeleton D10913 Burosumab [1] 238
116 ROCK2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
117 ROCK2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection D11815 Belumosudil [2] 51, 85