Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CDK4 [5] PI3K-Akt signaling pathway, Tight junction, T cell receptor signaling pathway, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
2 CDK6 [3] PI3K-Akt signaling pathway, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
3 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
4 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
5 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
6 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
7 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
8 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08441 Propiverine [1] 226
9 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
10 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
11 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
12 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
13 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
14 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00397 Tropicamide [1] 6
15 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
16 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00525 Pilocarpine [3] 6, 53, 299
17 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D07226 Fesoterodine [1] 6
18 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08441 Propiverine [1] 226
19 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
20 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
21 CSF1R [5] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D08552 Sunitinib [2] 28, 34
22 CSF1R [5] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
23 CSF3R [1] PI3K-Akt signaling pathway D03235 Filgrastim [35] 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
24 CSF3R [1] PI3K-Akt signaling pathway D03247 Lenograstim [7] 2, 13, 16, 18, 19, 57, 65
25 CSF3R [1] PI3K-Akt signaling pathway D06889 Pegfilgrastim [1] 60
26 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D01977 Gefitinib [1] 75
27 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D03455 Cetuximab [2] 51, 86
28 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D07907 Erlotinib [1] 94
29 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib [3] 34, 74, 75
30 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D08950 Neratinib [1] 34
31 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11251 Icotinib [1] 34
32 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib [1] 67
33 EPHA2 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03658 Dasatinib [2] 51, 85
34 EPHA2 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06414 Dasatinib [2] 51, 85
35 EPOR [1] PI3K-Akt signaling pathway D09946 Peginesatide [1] 283
36 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib [3] 34, 74, 75
37 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D08950 Neratinib [1] 34
38 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib [1] 67
39 ERBB4 [2] PI3K-Akt signaling pathway, Proteoglycans in cancer D08950 Neratinib [1] 34
40 FGFR1 [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
41 FGFR1 [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib [1] 276
42 FGFR3 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
43 FGFR3 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
44 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D05338 Palifermin [5] 13, 36, 38, 39, 65
45 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
46 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D11589 Infigratinib [1] 276
47 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib [1] 34
48 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
49 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib [1] 34
50 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib [5] 51, 85, 89, 227, 228
51 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D08524 Sorafenib [2] 34, 86
52 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D08552 Sunitinib [2] 28, 34
53 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
54 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03218 Axitinib [1] 34
55 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08524 Sorafenib [2] 34, 86
56 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08552 Sunitinib [2] 28, 34
57 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08881 Cediranib [1] 34
58 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
59 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D11772 Tesevatinib [1] 67
60 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D00753 Sirolimus [40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
61 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D02714 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277
62 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D06068 Temsirolimus [1] 13
63 GHR [1] PI3K-Akt signaling pathway D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
64 GHR [1] PI3K-Akt signaling pathway D05394 Pegvisomant [2] 78, 265
65 GHR [1] PI3K-Akt signaling pathway D11193 Somavaratan [1] 78
66 GHR [1] PI3K-Akt signaling pathway D11194 Somapacitan [2] 78, 195
67 GHR [1] PI3K-Akt signaling pathway D11486 Lonapegsomatropin [1] 78
68 IFNA1 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
69 IFNA1 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
70 IFNA2 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
71 IFNA2 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
72 IFNA4 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
73 IFNA4 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
74 IFNA5 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
75 IFNA5 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
76 IFNA6 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
77 IFNA6 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
78 IFNA7 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
79 IFNA7 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
80 IFNA8 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
81 IFNA8 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
82 IFNA10 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
83 IFNA10 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
84 IFNA13 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
85 IFNA13 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
86 IFNA14 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
87 IFNA14 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
88 IFNA16 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
89 IFNA16 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
90 IFNA17 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
91 IFNA17 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
92 IFNA21 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
93 IFNA21 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
94 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
95 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
96 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
97 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
98 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
99 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
100 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D11082 Anifrolumab [3] 46, 49, 53
101 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
102 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
103 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
104 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
105 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
106 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
107 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D11082 Anifrolumab [3] 46, 49, 53
108 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
109 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09680 Teprotumumab [1] 51
110 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09925 Linsitinib [1] 232
111 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
112 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D03058 Basiliximab [6] 2, 50, 66, 97, 222, 228
113 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D03639 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284
114 IL2RB [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
115 IL2RG [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Primary immunodeficiency D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
116 IL4 [4] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway D03117 Binetrakin [1] 46
117 IL4R [3] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D10354 Dupilumab [5] 51, 97, 98, 160, 162
118 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
119 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
120 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D09669 Siltuximab [2] 28, 331
121 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D10080 Sirukumab [2] 41, 46
122 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D12487 Olokizumab [2] 46, 96
123 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D02596 Tocilizumab [21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
124 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D10161 Sarilumab [5] 41, 46, 84, 107, 271
125 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D11079 Satralizumab [3] 11, 13, 86
126 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03230 Insulin human [2] 96, 156
127 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03250 Insulin glargine [1] 299
128 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D04539 Insulin detemir [1] 299
129 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D06590 Firategrast [1] 13
130 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D06886 Natalizumab [6] 13, 15, 25, 46, 63, 96
131 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D08083 Vedolizumab [3] 94, 96, 97
132 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D10540 Abrilumab [2] 96, 97
133 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D08083 Vedolizumab [3] 94, 96, 97
134 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D09901 Etrolizumab [2] 96, 97
135 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D10540 Abrilumab [2] 96, 97
136 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib [3] 60, 65, 228
137 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
138 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10308 Baricitinib [13] 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
139 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10653 Peficitinib [1] 46
140 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10871 Filgotinib [6] 46, 53, 96, 97, 222, 271
141 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10944 Itacitinib [4] 46, 51, 97, 228
142 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10994 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271
143 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D11400 Abrocitinib [1] 84
144 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D09959 Ruxolitinib [3] 60, 65, 228
145 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
146 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D10308 Baricitinib [13] 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
147 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D10653 Peficitinib [1] 46
148 JAK3 [6] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
149 JAK3 [6] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D10653 Peficitinib [1] 46
150 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D03218 Axitinib [1] 34
151 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08524 Sorafenib [2] 34, 86
152 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08552 Sunitinib [2] 28, 34
153 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08881 Cediranib [1] 34
154 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D10062 Cabozantinib [1] 34
155 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
156 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D11772 Tesevatinib [1] 67
157 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03658 Dasatinib [2] 51, 85
158 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06414 Dasatinib [2] 51, 85
159 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
160 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08524 Sorafenib [2] 34, 86
161 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08552 Sunitinib [2] 28, 34
162 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08953 Nilotinib [5] 6, 8, 34, 51, 86
163 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
164 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D11270 Pexidartinib [1] 34
165 MET [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Proteoglycans in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
166 NFKB1 [20] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D01146 Iguratimod [5] 46, 51, 53, 271, 300
167 NGF [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D09387 Tanezumab [2] 226, 298
168 NGFR [5] Virion - Lyssavirus, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11028 Cenegermin [2] 53, 90
169 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
170 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib [2] 28, 34
171 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
172 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
173 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D03658 Dasatinib [2] 51, 85
174 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06414 Dasatinib [2] 51, 85
175 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08524 Sorafenib [2] 34, 86
176 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib [2] 28, 34
177 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
178 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
179 PGF [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D09574 Aflibercept [2] 90, 166
180 PIK3CA [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11011 Alpelisib [1] 138
181 PIK3CA [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
182 PIK3CB [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
183 PIK3CD [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
184 PIK3CD [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
185 PRKAA1 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D04966 Metformin [25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
186 PRKAA2 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D04966 Metformin [25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
187 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib [1] 34
188 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
189 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib [1] 280
190 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib [1] 34
191 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D11675 Mirdametinib [1] 34
192 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib [1] 34
193 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
194 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib [1] 280
195 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib [1] 34
196 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D11675 Mirdametinib [1] 34
197 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D00987 Cabergoline [3] 6, 74, 75
198 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D01348 Terguride [2] 51, 86
199 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D03165 Bromocriptine [2] 6, 74
200 RAF1 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer D08524 Sorafenib [2] 34, 86
201 BCL2 [10] Platinum drug resistance, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer D10679 Venetoclax [1] 28
202 RELA [20] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D12181 Edasalonexent [1] 113
203 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
204 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
205 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
206 SYK [4] PI3K-Akt signaling pathway, Platelet activation, Tuberculosis, Viral carcinogenesis D09347 Fostamatinib [4] 46, 49, 61, 66
207 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
208 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [6] 13, 34, 85, 87, 227, 280
209 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
210 VEGFB [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Relaxin signaling pathway D09574 Aflibercept [2] 90, 166
211 VWF [2] PI3K-Akt signaling pathway, Platelet activation D11160 Caplacizumab [1] 64
212 FGF23 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D10913 Burosumab [1] 238
213 CASP9 [10] Platinum drug resistance, PI3K-Akt signaling pathway, VEGF signaling pathway, Thyroid hormone signaling pathway, Prion disease, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer, Viral myocarditis D11195 Rimiducid [6] 19, 60, 65, 284, 285, 326
214 CD19 [2] PI3K-Akt signaling pathway, Primary immunodeficiency D11496 Obexelimab [1] 300
215 CD19 [2] PI3K-Akt signaling pathway, Primary immunodeficiency D11757 Inebilizumab [4] 11, 13, 51, 300